[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spirometry\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spirometry":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,78,90,115,137,172,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053778","phase-4-the-intervening-for-lung-health-trial-100053778",false,"NCT07540000","The INTERvening for LUNG Health Trial","The INTERvening for LUNG Health (INTERLUNG) Trial: A Pragmatic Hybrid Implementation-Effectiveness Trial of Community-Based Interventions to Improve Respiratory Health in Bhaktapur, Nepal","INTERLUNG","Inclusion Criteria\n\n* Age ≥9 years at enrollment.\n* Resident of the Bhaktapur district and member of a household willing to participate in study procedures.\n* Pre-bronchodilator FEV1\u002FFVC at or below the 10th percentile (Z-score ≤ -1.28) based on Global Lung Function Initiative reference equations.\n* Presence of at least one respiratory risk factor, including:\n* usual cough or phlegm, wheezing in the past 12 months, self-reported prior pulmonary tuberculosis, physician-diagnosed asthma, ever smoking, or occupational exposure to dust or smoke.\n* Willing and able to provide written informed consent (or assent with parental\u002Fguardian permission for participants \\\u003C18 years).\n* Willing to participate in study assessments and follow-up visits during the 40-month study period.\n\nExclusion Criteria\n\n* Medical condition that precludes safe performance of spirometry.\n* Acute respiratory illness at the time of enrollment that would prevent reliable baseline spirometry testing.\n* Plans to move out of the study area during the follow-up period. Inability or unwillingness to comply with study procedures or follow-up visits.\n* Any other condition that, in the opinion of the investigators, would interfere with participation or interpretation of study results.\n\nHousehold members:\n\n* Household members of enrolled index participants may participate in certain assessments and receive selected intervention components if the index participant is randomized to the intervention arm and provides informed consent or assent.","ALL","9 Years",{"count":20,"type":21},800,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This research study is being done to find out whether a community health volunteer-delivered, multi-component program can improve lung health for people at risk of chronic respiratory diseases (such as asthma or COPD) in Bhaktapur, Nepal. The program focuses on reducing tobacco smoke exposure, reducing indoor and outdoor air pollution exposure, preventing respiratory infections (including vaccination and mask use during viral seasons), and encouraging safe physical activity. The \"index participant\" is the main enrolled participant in the household who is randomized to the intervention or control arm.\n\nThe participant will be in the study for about 40 months and will have 11 research visits: one at baseline and then every 4 months through month 40. At visits, staff will do breathing tests (spirometry before and after an inhaled medicine), measure exhaled carbon monoxide, check blood pressure, measure height\u002Fweight at selected visits, and ask questions about symptoms, smoking, infections, vaccines, and quality of life. The participant will also wear an activity monitor (accelerometer) for 2 weeks at baseline and at follow-up visits. If individual is a household member (not the index participant), the participant may be asked to complete baseline and follow-up assessments every 4 months through month 40, will receive the influenza vaccine and will primarily be asked to use masks and handwashing during household respiratory illness episodes (only if the index participant is randomized to the intervention) and will not be asked to wear an activity monitor. If the participant is in the pilot phase, participation will last about 2 months. the participant will complete baseline procedures and pilot follow-up visits during those 2 months instead of the full 40-month schedule.",[27],"Spirometry",[29,30,31,32,33,34],"Tobacco Prevention","Air Pollution","Physical Activity","Behavioral Intervention","Human-Centered Design","Infectious Risk","NOT_YET_RECRUITING","2026-07-10",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":21},"2026-08-10",{"date":43,"type":21},"2030-07-01",{"name":45,"class":46},"Johns Hopkins University","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100627330","comparing-ultrasonic-and-conventional-spirometry-in-chronic-respiratory-disease-100627330","NCT07447232","Comparing Ultrasonic and Conventional Spirometry in Chronic Respiratory Disease","A Comparative Study of Ultrasonic and Conventional Spirometers in Patients With Chronic Respiratory Diseases","Inclusion Criteria:\n\n* Adults aged 18 to 80 years.\n* Diagnosed with a chronic respiratory disease (e.g., COPD, asthma, bronchiectasis, or interstitial lung disease).\n* Willing to follow the instructions for using the ultrasonic spirometer.\n* Clinically stable and able to understand the study purpose and procedures, and who provide informed consent.\n\nExclusion Criteria:\n\n* Individuals who, after explanation, are still unable to properly perform the ultrasonic spirometry procedure.\n* Individuals who, after explanation, refuse to participate in the study.\n* Patients with unstable vital signs.\n* Pregnant or suspected pregnant women.","18 Years","80 Years",{"count":58,"type":21},100,[60],"NA","This study compares a handheld ultrasonic spirometer with a standard hospital spirometer in adults with chronic respiratory diseases. Each participant will complete lung function tests using both devices. The study aims to determine whether the ultrasonic device provides accurate and reliable measurements for use in clinical or home settings.",[63,27],"Chronic Obstructive Pulmonary Disease (COPD)",[63,27,65,66],"Ultrasonic Flow Sensor","Pulmonary Function Test","RECRUITING","2026-07-01",{"date":70,"type":39},"2026-07-02",{"date":72,"type":39},"2026-06-29",{"date":74,"type":21},"2026-07-31",{"name":76,"class":46},"Fu Jen Catholic University",1,{"id":79,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":25,"conditions":82,"keywords":83,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":89,"locationsCount":47},"100634462",{"count":20,"type":21},[24],[27],[29,30,31,32,33,34],"2026-06-05",{"date":86,"type":39},"2026-06-08",{"date":68,"type":21},{"date":43,"type":21},{"name":45,"class":46},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":55,"enrollmentInfo":98,"targetDuration":4,"studyType":100,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":77},"100627689","tb-type-and-spirometry-result-vs-functional-capacity-based-on-6mwt-in-people-with-post-tb-lung-disease-100627689","NCT07451899","TB Type and Spirometry Result vs. Functional Capacity Based on 6MWT in People With Post-TB Lung Disease","Correlation Between Types of Tuberculosis, Spirometry Result, and Functional Capacity Based on the 6-Minute Walk Test (6MWT) in Adolescents With Post-Tuberculosis Lung Disease.","Inclusion Criteria:\n\n* Adolescents (10-18 year old)\n* Diagnosed with post tuberculosis lung disease by pediatrician\n* Capable of performing the 6MWT\n\nExclusion Criteria:\n\n* Diagnosed with another lung disease\n* Having physical limitations that hinder the 6MWT","10 Years",{"count":99,"type":21},20,"OBSERVATIONAL","Post-Tuberculosis Lung Disease (PTLD) is defined as chronic respiratory impairment due to previous pulmonary TB. Children recovering from pulmonary TB undergo ongoing respiratory health challenges, including more frequent respiratory symptoms, reduced lung volumes, and a threefold higher rate of pulmonary dysfunction compared to healthy children. These conditions could lead to long-term health consequences such as difficulties in performing daily activities. Pulmonary function impairment in PTLD includes approximately 10% of patients losing more than 50% of lung function. Adolescents who have undergone TB treatment often experience pulmonary function impairment and reduced physical capacity. This aims of this study is to analyze the correlation between type of tuberculosis, spirometry result, and functional capacity in adolescents with post-tuberculosis lung disease.\n\nThis study is an analytical observational study with a cross-sectional approach. This study is conducted at Department of Physical Medicine and Rehabilitation, Hasan Sadikin Hospital, Bandung, starting in March until May 2026. Inclusion criteria including: adolescents (10-18 year old), and diagnosed with post tuberculosis lung disease by pediatrician, and capable of performing the 6MWT. The participants with post TB lung disease will undergo spirometry and functional capacity assessment using the 6-minute walk test (6MWT). Outcomes include spirometry result and functional capacity using 6MWT.",[103,104,105,27],"Post Tuberculosis","Lung Disease","Functional Capacity","2026-05-09",{"date":108,"type":39},"2026-05-12",{"date":110,"type":39},"2026-03-01",{"date":112,"type":21},"2026-05-31",{"name":114,"class":46},"Universitas Padjadjaran",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":77},"100447358","evaluation-of-serratus-plane-block-on-the-respiratory-pattern-in-patients-with-multiple-rib-fractures-100447358","NCT05105399","Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures","Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures: a Perspective Randomized Controlled Study","Inclusion Criteria:\n\n1. Chest trauma with at least 2 monolateral rib fractures (monofocal or multifocal) with no flail chest\n2. Age\\>18 years\n3. Hospital admission\n4. Ability to provide written informed consensus\n5. Awake patient, spontaneous ventilation",{"count":123,"type":21},72,[60],"In patients admitted following a trauma, the incidence of multiple rib fractures is reported to be 9,7%, and this can be even higher in high energy trauma like motor vehicle accidents (1). Pain deriving from rib fractures cause the patient to breath shallow in order to limit discomfort and this bring about negative consequences: shallow breathing and inability to clear secretions may cause pulmonary atelectasis eventually evolving to pneumonia. Given the aforementioned concerns, it is easy to understand why, in a context like this, control of chest pain become crucial. The best way to achieve adequate pain control have not yet been established: the aim of this study is to investigate on this clinical dilemma. In this study, 72 people with at least two monolateral rib fractures are going to be randomized into three groups: 1) standard treatment alone (intravenous analgesia: acetaminophen + morphine PCA); 2) continuous serratus plane block + standard treatment; 3) single-shot serratus plane block + standard treatment. The variables that are going to be recorded are the following: pain through the NRS scale, FEV1 and FVC through spirometry and finally an arterious gas analysis. Recording are going to be repeated at 72h after admission. The primary endpoint is to evaluate if the continuous serratus plane block is able to improve the FEV1\u002FFVC compared to single shot or standard treatment alone. Secondary endpoints will be: the effect of continuous block on 1) resting and incident pain; 2) opioid consumption; 3) blood gas analysis parameters; 4) pulmonary complications at 1 month; 5) length of stay",[127,27],"Rib Fractures","2026-04-13",{"date":130,"type":39},"2026-04-16",{"date":132,"type":21},"2026-06-01",{"date":134,"type":21},"2027-05-01",{"name":136,"class":46},"Niguarda Hospital",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":145,"sex":17,"minAge":55,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":156,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":77},"100630073","transcutaneous-auricular-vagus-nerve-stimulation-and-spirometry-sham-controlled-randomized-trial-100630073","NCT07482930","Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial","Acute Effects Transcutaneous Auricular Vagus Nerve Stimulation on Spirometric Parameters in Healthy Individuals: A Sham-Controlled Randomized Study","taVNS-SPIRO","Inclusion Criteria:\n\n* Aged 18-40 years.\n* Healthy volunteers.\n* Able to perform spirometry and follow study instructions.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Any cardiovascular disease, cardiac arrhythmia, hypertension, or related condition.\n* Any neurological disorder (e.g., diabetes mellitus, peripheral neuropathy, epilepsy).\n* Any diagnosed psychiatric disorder.\n* Any respiratory disease (e.g., asthma, chronic obstructive pulmonary disease).\n* Pregnancy or suspected pregnancy.\n* Ear conditions that prevent stimulation (infection, open wound, pain\u002Ftenderness) or presence of a piercing at\u002Fnear the stimulation site.\n* Vigorous exercise within 24 hours prior to measurement.\n* Caffeine intake, smoking, or alcohol consumption within 4-6 hours prior to measurement.\n* Marked intolerance or hypersensitivity to the device or the procedure.\n* Inability to follow instructions during measurements or refusal to complete the session.",true,"40 Years",{"count":148,"type":21},50,[60],"This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults. The vagus nerve is involved in many automatic body functions, and ear-based stimulation has been used in research to explore its possible effects on different physiological systems. However, it is not clear whether a brief stimulation session can acutely influence breathing test results in people without respiratory disease.\n\nHealthy volunteers aged 18-40 will take part in one laboratory visit. Participants will be randomly assigned to one of two groups: (1) active bilateral stimulation applied to specific ear regions that are known to be innervated by the vagus nerve, or (2) sham stimulation using the same device setup but designed to minimize vagal activation. The stimulation session will last approximately 10 minutes. Before and after the stimulation, participants will perform standard spirometry (breathing) tests. Primary spirometric outcomes will include common measures of lung function such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF). Heart rate, heart rate variability, and blood pressure may also be recorded to monitor physiological responses and safety during the visit.\n\nParticipation is voluntary and participants may withdraw at any time. The procedure is considered minimal risk. Possible side effects are usually mild and temporary, such as tingling, warmth, or mild discomfort at the ear. Rarely, participants may feel lightheaded; if this occurs, the procedure will be stopped and the participant will be monitored until symptoms resolve. There is no guaranteed direct benefit to participants. The results may help clarify whether short-term ear-based vagus nerve stimulation can influence spirometric parameters and may inform future studies on autonomic and respiratory interactions.",[152,27,153,154,155],"Vagus Nerve Stimulations","Autonomic Nervous System (ANS) Functioning and Mood State","Blood Pressure Monitoring","Respiratory Function Tests",[157,158,159,160,161,162],"transcutaneous auricular vagus nerve stimulation","spirometry","autonomic nervous system","sham stimulation","pulmonary function test","blood pressure","2026-03-16",{"date":165,"type":39},"2026-03-19",{"date":167,"type":39},"2026-03-17",{"date":169,"type":21},"2026-04-25",{"name":171,"class":46},"SEFA HAKTAN HATIK",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":100,"phases":4,"briefSummary":180,"conditions":181,"keywords":187,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":4},"100620943","bronchodilator-response-in-copd-and-asthma-correlation-between-spirometry-ios-indices-and-dyspnea-relief-100620943","NCT07364188","Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief","Inclusion Criteria:\n\n* Both asthma and COPD patients:\n\n  1. Written informed consent.\n  2. FEV1\u002FForced Vital Capacity (FVC) \\\u003C0.7 at baseline (7)\n  3. Visual Analog Scale (VAS) dyspnea score ≥10 (0-100, 100 max) (25,26).\n* Asthma: Doctor diagnosed asthma\n\n  1\\. less than 10 packyears.\n* COPD: Doctor diagnosed COPD with FEV1\u002FFVC \\\u003C0.7 post-bronchodilation 1. Smokers or ex-smokers with ≥10 packyears\n\nExclusion Criteria:\n\n* Patients aged less than 18 years old.\n* Not able to perform spirometry or impulse oscillometry.\n* Cognitive disorders and not able to answer Asthma Control Questionnaire (ACQ), VAS dyspnea score, and COPD Assessment Test (CAT) score (25-28).\n* Short-acting beta-agonists 6 h, long-acting beta-agonists 2 days, short-acting anti-muscarinic agent 12 h, Long-acting anti-muscarinic agents 2 days.\n* Comorbidities with significant influence on dyspnea eg. bronchiectasis, ILS, mb. Cordis, lung resection, anemia, and active malignant disease\n* BMI ≥40 kg\u002Fm2.",{"count":179,"type":21},120,"A bronchodilator reversibility test is widely used in the diagnosis and management of obstructive lung diseases.\n\nBronchodilators relieve symptoms in asthma and COPD. Traditionally, their effectiveness has been assessed using spirometric indices, particularly FEV₁. However, changes in FEV₁ often do not correlate well with patients' subjective experience of dyspnoea relief or with changes in small airway function.\n\nImpulse oscillometry (IOS) provides an effort-independent assessment of respiratory mechanics during tidal breathing and is more sensitive to small airway dysfunction than spirometry. Despite this, the clinical utility of IOS in routine COPD and asthma assessment remains underexplored, and its relationship to both spirometric response and symptom relief is not fully established, and the Minimal Clinically Important Difference (MCID) for IOS parameters has not been firmly established. Determining the MCID is essential for interpreting individual patient responses in a clinically meaningful way and for guiding treatment decisions in both research and practice.\n\nHypothesis \\& Aims\n\nIn patients with either asthma or COPD baseline values and bronchodilator responses are compared. More specifically, this study aims to:\n\n1. assess baseline correlations: Evaluate the correlation between ΔX5-baseline (EFL expiratory flow limitation=small airway collapse during expiration), RV\u002FTLC-baseline, X5-average at baseline, FEV1-baseline, VAS-dyspnea at baseline, and ACQ-6-baseline.\n2. compare bronchodilator responses across methods: Examine the correlation between bronchodilator-induced changes in FEV₁ and IOS parameters (including both average and delta values) and explore their relationship with short-term changes in dyspnea.\n3. establish clinical relevance: Determine the MCID for key IOS variables using both anchor-based and distribution-based approaches, anchored to perceived changes in lung symptoms.",[182,183,184,27,185,186],"Asthma Bronchiale","COPD","Bronchodilation","Impedance","Small Airways Disease",[188,183,189,190,191],"asthma","Correlation","Bronchodilator response","MCID","2026-01-23",{"date":194,"type":39},"2026-01-26",{"date":196,"type":21},"2026-02-01",{"date":198,"type":21},"2027-12-31",{"name":200,"class":201},"Allergi- og Lungeklinikken, Elsinore","NETWORK",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":219,"leadSponsor":221,"locationsCount":77},"100533170","breathing-exercise-for-rib-fracture-100533170","NCT06222333","Breathing Exercise for Rib Fracture","Can Breathing Exercise Reduce Pulmonary Complications in Rib Fractures: Randomized Prospective Study","Inclusion Criteria:\n\n* Isolated thoracic injury within 24 hours\n* Age between 18-100\n\nExclusion Criteria:\n\n* Pneumothorax and hemothorax requiring intervention at admission\n* Injury severity index \\>16\n* COPD, Atshma\n* Extrathoracic trauma","100 Years",{"count":211,"type":21},62,[60],"Respiratory physiotherapy is routinely performed after thoracic surgery operations to increase lung expansion and prevent pulmonary complications such as atelectasis and pneumonia. It is a controversial issue whether respiratory physiotherapy reduces pulmonary complications in rib fractures. In our study, patients with rib fractures will be divided into two groups. In the control group, standard treatment consisting of routine analgesic treatments will be applied. In the other group, respiratory physiotherapy will be applied with triflu for 8 hours a day. At the end of the study, pulmonary complications in both groups will be compared.",[127,27],"2024-11-13",{"date":217,"type":39},"2024-11-14",{"date":215,"type":39},{"date":220,"type":21},"2026-04-01",{"name":222,"class":46},"Kastamonu University"]