[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spleen-stiffness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spleen-stiffness":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100617480","the-value-of-spleen-stiffness-measurement-in-patients-with-pbc-100617480",false,"NCT07319169","The Value of Spleen Stiffness Measurement in Patients With PBC","Inclusion Criteria:\n\n* ≥18y\n* Out-patient, followed at the UZ Brussels\n* Diagnosis of PBC based on cholestasis, AMA positivity and\u002For biopsy.\n* Under treatment with ursodeoxycholic acid and\u002For bezafibrate\n\nExclusion Criteria:\n\n* \\\u003C18y\n* Contra-indication for transient elastography (Fibroscan®) such as ascites or overt heart failure.","ALL","18 Years",{"count":18,"type":19},125,"ESTIMATED","INTERVENTIONAL",[22],"NA","Recent evidence suggests that combining liver stiffness measurement (LSM) with spleen stiffness measurement (SSM) significantly improves risk stratification in patients with PBC. In a study the addition of spleen stiffness to liver stiffness enhanced the prediction of liver decompensation, providing a more precise evaluation of portal hypertension. Furthermore, when combined with platelet count, this approach effectively identified patients with a low probability of harboring HRVs. This could allow clinicians to safely avoid unnecessary endoscopic procedures in selected patients, improving patient comfort and reducing healthcare costs. Therefore, our patients participating in this trial will undergo follow up (every 6 months) as per Standard of care. This includes a blood draw, FibroScan and Ultrasound. Together with this, 2 questionnaires will be completed (not as per SOC) and during the FibroScan, a spleen stiffness measurement will be performed.",[25,26],"Primary Biliary Cholangitis","Spleen Stiffness",[28,29],"spleen stiffness","primary biliairy cholangitis","NOT_YET_RECRUITING","2026-04-30",{"date":33,"type":34},"2026-05-01","ACTUAL",{"date":36,"type":19},"2026-07",{"date":38,"type":19},"2028-01",{"name":40,"class":41},"Universitair Ziekenhuis Brussel","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":15,"minAge":52,"maxAge":16,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100587750","effect-of-malnutrition-on-liver-and-spleen-stiffness-in-children-100587750","NCT06932445","Effect of Malnutrition on Liver and Spleen Stiffness in Children","Impact of Malnutrition on Liver and Spleen Stiffness in Children Evaluated by Shear Wave Elastography","SWE","Inclusion Criteria:\n\n* Children aged 6 to 18 years.\n* Diagnosis of malnutrition based on World Health Organization (WHO) criteria (for malnutrition group).\n* Healthy children without any chronic illness (for control group).\n\nExclusion Criteria:\n\n* Children with chronic diseases (e.g., liver disease, diabetes, immunocompromised conditions).\n* Children who have previously undergone liver or spleen surgery.\n* Children with inability to cooperate during elastography measurement.",true,"1 Month",{"count":54,"type":19},300,"OBSERVATIONAL","This prospective observational study aims to evaluate the effect of malnutrition on liver and spleen stiffness in children using shear wave elastography. Two groups of participants will be enrolled: children diagnosed with malnutrition and age-matched healthy controls. Organ stiffness measurements will be compared between the two groups to assess the impact of malnutrition on liver and spleen tissue properties.",[58,59,26,60],"Malnutrition in Children","Liver Stiffness","Shear Wave Elastography",[62,59,26,60,63],"Malnutrition","Children","RECRUITING","2025-04-10",{"date":67,"type":34},"2025-04-17",{"date":65,"type":34},{"date":70,"type":19},"2025-05-20",{"name":72,"class":41},"Mehmet Akif AĞIR"]