[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"splints\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:splints":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,78,102,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100592600","splinting-vs-exercise-in-de-quervains-tenosynovitis-100592600",false,"NCT06995534","Splinting vs Exercise in De Quervain's Tenosynovitis","Comparison of Static Hand-Wrist Splinting and Exercise Therapy in the Management of De Quervain's Tenosynovitis","Inclusion Criteria:\n\n* Adults aged between 18 and 65 years\n\nPatients experiencing wrist pain and tenderness for less than 3 months and clinically diagnosed with acute or subacute De Quervain's tenosynovitis\n\nVisual Analog Scale (VAS) pain score ≥ 3\n\nExclusion Criteria:\n\n* History of trauma\n\nWrist fractures\n\nLocal infection\n\nPresence of rheumatologic diseases (e.g., rheumatoid arthritis, psoriatic arthritis)\n\nPresence of symptomatic hand osteoarthritis\n\nContinuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids\n\nReceipt of physical therapy for the hand or wrist within the past 3 months\n\nCorticosteroid injection into the hand or wrist within the past 3 months\n\nDiagnosed with significant neurological disorders (e.g., upper motor neuron disease)\n\nPresence of uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, congestive heart failure, chronic kidney disease, hepatic failure)\n\nMajor psychiatric disorders\n\nCommunication difficulties","ALL","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","De Quervain's disease is a painful tenosynovitis of the abductor pollicis longus and extensor pollicis brevis muscle tendons located in the first dorsal compartment. The primary treatment for De Quervain's disease is conservative; surgical intervention is rarely required. Currently, there is no standardized treatment protocol supported by strong, up-to-date evidence.\n\nThe aim of this study is to compare the effectiveness of a static hand-wrist resting splint and exercise therapy in the conservative treatment of De Quervain's tenosynovitis. Patients will be evaluated in terms of pain levels, functional\u002Fsymptom status, hand-finger strength, pressure pain threshold (PPT), tendon cross-sectional area measured by ultrasound, and the presence of effusion findings (semiquantitative; 0-3), and patient satisfaction.",[27,28,29,30,31],"Splints","Exercise Therapy","De Quervains Tenosynovitis","Pain Management","Ultrasonographic",[33,29,34,35,31],"pain","exercise therapy","splints","RECRUITING","2026-03-21",{"date":39,"type":40},"2026-03-24","ACTUAL",{"date":42,"type":40},"2025-05-29",{"date":44,"type":21},"2026-04-30",{"name":46,"class":47},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100622328","evaluation-of-eight-strand-flexor-tendon-repair-without-splinting-100622328","NCT07382193","Evaluation of Eight-Strand Flexor Tendon Repair Without Splinting","Evaluation of the Eight - Strand Repair of Flexor Tendon Injuries Without Splinting a Prospective Cohort Study","Inclusion Criteria:\n\n* Adult patients (18+ years).\n* Single or multiple clean-cut flexor tendon injuries.\n* Primary repair performed within 2 weeks.\n* Patients with concurrent digital nerve injuries will include if the nerve could be directly repaired.\n\nExclusion Criteria:\n\n* Crush or avulsion injuries.\n* Associated fractures or neurovascular compromise.\n* Recurrent or chronic tendon injuries.",{"count":20,"type":21},"OBSERVATIONAL","This prospective cohort study evaluates functional outcomes of primary eight-strand flexor tendon repair in zone II without postoperative splinting in 40 adults (≥18 years) at Assiut University Hospitals. Patients undergo wide-awake local anesthesia no tourniquet (WALANT) surgery followed by immediate gentle active motion. Primary outcome: total active motion via Strickland score at 6 weeks and 6 months. Secondary: grip strength, DASH score, patient satisfaction.",[60,27,61,62],"Flexor Tendon Injury","Flexor Tendon Repair","Flexor Tendon",[64,65,66],"Eight-strand repair","Flexor tendon injury","no splint","NOT_YET_RECRUITING","2026-01-26",{"date":70,"type":40},"2026-02-02",{"date":72,"type":21},"2026-03",{"date":74,"type":21},"2027-04",{"name":76,"class":77},"Assiut University","OTHER",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":48},"100620565","effects-of-neurodynamic-and-carpal-bone-mobilization-in-mild-to-moderate-carpal-tunnel-syndrome-100620565","NCT07359274","Effects of Neurodynamic and Carpal Bone Mobilization in Mild-to-Moderate Carpal Tunnel Syndrome","Clinical and Morphological Effects of Neurodynamic Mobilization and Carpal Bone Mobilization Techniques in Patients With Mild-to-Moderate Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Diagnosis of mild-to-moderate carpal tunnel syndrome confirmed by electrodiagnostic testing\n* CTS symptoms for at least 3 months\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous carpal tunnel surgery\n* Diabetes mellitus or polyneuropathy\n* Cervical radiculopathy\n* Pregnancy or breastfeeding\n* Central nervous system disorders","20 Years","55 Years",{"count":88,"type":21},93,[24],"Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Neurodynamic mobilization and carpal bone mobilization aim to improve neural and soft tissue mobility; however, their comparative effects on clinical outcomes and median nerve morphology are not fully understood.\n\nThis interventional, non-randomized clinical study aims to compare the clinical and ultrasonographic effects of neurodynamic mobilization plus splinting, carpal bone mobilization plus splinting, and splinting alone in patients with mild-to-moderate CTS. Ninety-three participants diagnosed with mild-to-moderate carpal tunnel syndrome based on electrodiagnostic criteria will be included. Participants will be allocated into three parallel groups without randomization. All participants will receive a neutral-position wrist splint as standard conservative care.\n\nTwo intervention groups will additionally receive either neurodynamic mobilization exercises or carpal bone mobilization techniques administered by a physiotherapist for four weeks. Clinical outcomes and median nerve morphology will be evaluated at baseline and immediately after the intervention period.\n\nThe primary outcome is the change in the Boston Carpal Tunnel Questionnaire score. Secondary outcomes include pain intensity, neuropathic pain, functional disability, muscle strength, pressure pain threshold, and ultrasonographic measurements of the median nerve.",[92,27],"Carpal Tunnel Syndrome","2026-01-13",{"date":95,"type":40},"2026-01-22",{"date":97,"type":21},"2026-01-15",{"date":99,"type":21},"2027-03-15",{"name":101,"class":77},"Kutahya Health Sciences University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":48},"100509032","gait-analysis-in-patients-with-hemiplegia-using-insole-splint-100509032","NCT05908149","Gait Analysis in Patients With Hemiplegia Using Insole Splint.","Inclusion Criteria:\n\n* Patients that can walk with or without the splint, having their first stroke episode at least two months ago and their hospitalisation period does not overcome six months, having also a diagnosis from a neurologist coming with a Brain CT-scan.\n* Patients must have use the insole splint during physiotherapy sessions for at least 1 week before their inclusion in the trial.\n* Patients must be able to communicate and fully understand the instructions given by the researchers.\n* Researchers are going to try to have a sex ratio 50\u002F50.\n* Patients' age is going to be between 18-70 years.\n* Functional Ambulation Category: FAC \\> 2\n* Modified Ashworth Scale of the affected lower Limb (MAS): MAS ≤2\n* Normal Gait before the stroke.\n\nExclusion Criteria:\n\n* Peripheral Neurological Damage.\n* Past or ongoing orthopedic or reumatologic disease that bothers patient's gait.\n* Past damage of the Central Nervous System.\n* Dermatologic problems or human factors that limitate the use of insole splint.\n* Patients must not have used intramuscular botox injection recently.\n* Patients with low motivation and low perception are also excluded.","70 Years",{"count":110,"type":21},12,[24],"The goal of this clinical trial is to compare the gait of patients with hemiplegia, with or without the use of insole splint. The main questions it aims to answer are:\n\nDoes the insole splint improve the gait of these patients? Does any difference exist in the use of muscles?\n\nParticipants will have to walk in the gait analysis' aisle with and without the insole splint, using wireless EMG device.",[114,27,115],"Gait, Hemiplegic","EMG","2024-12-04",{"date":118,"type":40},"2024-12-06",{"date":120,"type":40},"2023-04-12",{"date":122,"type":21},"2025-12-31",{"name":124,"class":77},"University of Ioannina",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":133,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":48},"100397853","phase-4-the-acts-trial-n-acetylcysteine-nac-and-night-splinting-as-a-non-operative-treatment-for-carpal-tunnel-syndrome-100397853","NCT04460521","The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome","The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial","ACTS","Inclusion Criteria:\n\n1. The patient has a confirmed diagnosis of mild to moderate idiopathic unilateral or bilateral CTS as determined by both clinical exam findings and electrodiagnostic nerve conduction studies (median nerve distal motor latency ≥ 4.3 milliseconds and\u002For median nerve sensory distal latency ≥ 3.5 milliseconds at the wrist) performed within the preceding year prior to enrollment\n2. Symptoms of CTS must have been present for ≥ 6 weeks\n3. The patient must be ≥ 18 years of age.\n\nExclusion Criteria:\n\n1. Any previous carpal tunnel release procedure on the ipsilateral limb\n2. Any previous corticosteroid injection in the last 6 months on the ipsilateral limb\n3. Severe CTS\u002Fsigns of median nerve denervation with axonal loss determined by constant wrist or hand pain, constant parasthesias in the median nerve distribution, or thenar muscle atrophy in the ipsilateral limb\n4. Any known or suspected allergy to NAC\n5. Any current medications which preclude use of NAC including antibiotics or nitroglycerin\n6. Breastfeeding patients or patients with nephrolithiasis\n7. Any history of proximal ipsilateral neck or proximal limb injury\n8. Secondary CTS related to pregnancy\n9. Unable for financial reasons to obtain a night splint (i.e. lack of insurance coverage or lack of financial means).",true,{"count":135,"type":21},240,[137],"PHASE4","Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome worldwide, causing significant chronic pain, functional impairment, and lowered quality of life for individuals of various backgrounds. CTS is caused by chronic compression of the median nerve in the carpal tunnel of the wrist, causing numbness and pain in the palm, thumb, index, and middle fingers and eventual weakness of the hand. Many different treatments for CTS have been proposed and studied, including but not limited to non-operative treatments such as wrist splinting, steroid injections, and lifestyle modifications as well as operative treatments, such as surgical carpal tunnel release (CTR). To date, very few oral medications have been shown to be effective as conservative treatments for CTS. In this study the investigators will examine whether there is any benefit to using oral N-acetylcysteine (NAC) as an adjunctive treatment for mild to moderate CTS in addition to a standard 8-week trial of night splinting. NAC has been used in humans for various purposes, is extremely safe and has very few side effects, and has been shown to have anti-inflammation properties which may help treat CTS. The investigators will study this by performing a randomized controlled trial, comparing patients receiving oral NAC and standard night splinting to patients receiving an identical placebo and standard night splinting. Both patient groups will be assessed using a questionnaire to assess for severity of their CTS symptoms both before and after the 8-week treatment. The primary objective will be to determine whether supplementation with oral NAC in addition to night splinting has any significant impact on patient-reported symptoms and functional impairment when compared to night splinting alone. The investigators will also measure secondary outcomes including whether patients decide to have surgery for their CTS after treatment and\u002For continued use of other treatments. This study has the potential to have a significant positive impact on patients by identifying a safe, inexpensive, accessible, and well tolerated conservative treatment for mild to moderate carpal tunnel syndrome, and potentially preventing the need for additional, more invasive treatments such as surgery.",[92,140,141,27,142,143],"Hand Injuries and Disorders","Nerve Compression","Carpal Tunnel","Carpal Tunnel Release",[145,146,147,148,149,150,151,152,153,154],"Wrist splint","Carpal tunnel syndrome","Carpal tunnel release","Compression neuropathy","NAC","Conservative treatment","Hand surgery","Plastic surgery","N-acetylcysteine","Night splint","2024-08-21",{"date":157,"type":40},"2024-08-23",{"date":159,"type":40},"2022-04-01",{"date":161,"type":21},"2026-10-01",{"name":163,"class":77},"Emily Krauss"]