[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spondylolisthesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spondylolisthesis":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,53,97,127,173,202,228,253,279,309,338,363,390,421,450,479,504],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100444723","advanced-spinal-innovations-with-robotics-and-enabling-technology-registry-100444723",false,"NCT05071144","Advanced SPinal Innovations With Robotics and Enabling Technology Registry","ASPIRE","Inclusion Criteria:\n\n* Diagnosis of a spine deformity\n* Scheduled for surgery using robotics and navigation and\u002For patient-specific rods\n* Up to and including 21 years of age\n* Speak and read English or Spanish\n\nExclusion Criteria:\n\n• None",true,"ALL","0 Years","21 Years",{"count":21,"type":22},700,"ESTIMATED","5 Years","OBSERVATIONAL","Creation of a pediatric robotic spine surgery registry will allow for data collection and analysis on the coupled use of robotics and navigation, as well as patient-specific rods in pediatric spine deformity surgery across participating study institutions. Eventually, an educational and informative framework for this technology will be established.",[27,28,29,30,31,32],"Spine Deformity","Idiopathic Scoliosis","Adolescent Idiopathic Scoliosis","Spondylolisthesis","Congenital Scoliosis","Neuromuscular Scoliosis",[34,35,36,37,38,39],"Pediatric","Spine","Surgery","Registry","Robotic","Navigation","RECRUITING","2026-06-18",{"date":43,"type":44},"2026-06-22","ACTUAL",{"date":46,"type":44},"2021-12-13",{"date":48,"type":22},"2031-12",{"name":50,"class":51},"Boston Children's Hospital","OTHER",10,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":64,"conditions":65,"keywords":73,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":96},"100640600","pmcf-study-on-the-effectiveness-and-safety-of-metrosan-spinal-systems-and-bonegraft-filling-materials-100640600","NCT07615491","PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials","A Prospective, Multi-Center, Observational Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials Used in Spinal Instrumentation and Fusion Surgery","INFO SPINE","Inclusion Criteria:\n\n* 18 years of age or older.\n* Skeletally mature.\n* Male or female.\n* Undergone spinal surgery (cervical or thoracolumbar) for any indication under current medical practice.\n* Titania® spinal stabilization\u002Ffusion systems and\u002For BONEGRAFT® bone cements or BONEGRAFT® bone graft materials used during the operation.\n* No general health condition contraindicating surgery.\n* No legal restriction (military service, incarceration, or equivalent).\n* Provision of signed and dated Informed Consent Form (ICF)\n\nExclusion Criteria:\n\n* Participation in another interventional clinical investigation\n* Suspected or confirmed pregnancy\n* Morbid obesity\n* Neurological or psychiatric conditions preventing compliance with postoperative care and instructions\n* Active spinal or systemic infection\n* High fever or leukocytosis\n* Severe osteoporosis and\u002For disease affecting bone metabolism\n* Known allergy or hypersensitivity to PEEK, Titanium, or PMMA\n* Congenital abnormality, tumor, or other condition preventing secure implant fixation or likely to shorten implant useful life\n* Inadequate tissue coverage at the operative site\n* Legally restricted individuals (military personnel, prisoners, etc.)","18 Years",{"count":63,"type":22},561,"This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems, and Bonegraft® bone filling materials (synthetic bone grafts and bone cements). The study aims to evaluate short-term (12-month) safety and effectiveness, identify previously unknown side effects, monitor defined complications, and assess risks based on real-world evidence in patients undergoing spinal surgery. All investigated products are used within their intended purpose under routine clinical practice.",[66,67,30,68,69,70,71,72],"Degenerative Disc Disease (DDD)","Spinal Stenosis","Spinal Deformities","Spinal Tumors","Spinal Infections","Spinal Trauma","Vertebral Fractures",[74,75,76,77,78,79,80,81,82,83,84,85],"Post-Market Clinical Follow-Up (PMCF)","Spinal Instrumentation","Spinal Fusion","Interbody Fusion","Spinal Stabilization","Spinal Cages","Pedicle Screws","Cervical Plate System","Interspinous Fusion Device","Spinal Implants","Synthetic Bone Graft","Bone Cement","2026-05-22",{"date":88,"type":44},"2026-05-29",{"date":90,"type":44},"2026-04-27",{"date":92,"type":22},"2028-09-26",{"name":94,"class":95},"Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.","INDUSTRY",3,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":104,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":109,"phases":110,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100635075","effect-of-hip-extension-mobilization-on-functional-disability-in-patients-with-spondylolisthesis-100635075","NCT07547969","Effect of Hip Extension Mobilization on Functional Disability in Patients With Spondylolisthesis","EM","Inclusion Criteria:\n\n* Chronic female Patients diagnosed as grade 1 lumbar degenerative spondylolisthesis (anterolisthesis) referred from Orthopedists was confirmed by lumbosacral x-ray\n* Patients age ranged from 40 to 60 years.\n* BMI(25:35)\n* Ambulant patient with or without cane.\n* Cooperative patients with ability to understand instructions and follow simple verbal commands.\n\nExclusion Criteria:\n\n* Osteoporosis.\n* Pregnancy.\n* Signs consistent with nerve root compression (reproduction of low-back or leg pain with a straight leg raise at less than 45°, muscle weakness involving a major muscle group of the lower extremity, diminished lower extremity muscle stretch reflex, or diminished or absent sensation to pinprick in any lower extremity dermatome).\n* General tumors, spinal tumor, fracture, cauda equina syndrome, and previous surgery.\n* Other causes of spondylolisthesis.\n* Patients with (BMI ≥ 35)\n* Severe or life-threatening psychiatric illness.","FEMALE","40 Years","60 Years",{"count":108,"type":22},32,"INTERVENTIONAL",[111],"NA","this study will be conducted to investigate the effect of hip extension mobilization on lumber disability, pain and flexion range of motion in patients with spondylolisthesis",[30],[115,30,116],"hip extension mobilization","functional disability","NOT_YET_RECRUITING","2026-04-17",{"date":120,"type":44},"2026-04-23",{"date":122,"type":22},"2026-04-25",{"date":124,"type":22},"2026-06-01",{"name":126,"class":51},"Cairo University",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":135,"maxAge":61,"enrollmentInfo":136,"targetDuration":4,"studyType":109,"phases":138,"briefSummary":139,"conditions":140,"keywords":148,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":172},"100523273","studying-melatonin-and-recovery-in-teens-100523273","NCT06093477","Studying Melatonin and Recovery in Teens","SurgerySMART: Studying Melatonin and Recovery in Teens","SurgerySMART","Inclusion Criteria:\n\nPatients\u002Fyouth:\n\n* Age 12-18 years\n* Participants undergoing elective major musculoskeletal surgery for eligible conditions\n* California state resident\n* Regular access to internet and smartphone\n* Can read and understand English or Spanish\n\nParents\u002Fcaregivers\n\n* Biological parent or legal guardian of youth\n* Can read and understand English or Spanish\n\nExclusion Criteria:\n\nPatients\u002Fyouth\n\n* Prescription medication for premorbid insomnia\n* Cognitive impairment or developmental delay\n* Does not agree to a 1-week washout if taking over the counter supplements or other sleep aids prior to the start of the study medication\n* High risk for sleep related breathing disorder\n* Chronic medical condition that is severe\u002Fsystemic or requires regular treatment regimen\n* Psychiatric admission in prior 30 days\n* Patients that underwent major surgery in the last 3 months, or those that have not fully recovered from a prior surgery\n* BMI ≥ 99th percentile\n* Enrollment in another therapeutic study\n* Any serious underlying medical or psychiatric condition, that, in the opinion of the investigator, would contraindicate the patient's participation in the study","12 Years",{"count":137,"type":22},45,[111],"The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep. Melatonin is available as a dietary supplement that may be effective in promoting longer, higher quality sleep. This study will assess the feasibility and acceptability of melatonin for teens undergoing major musculoskeletal surgery, as well as determine optimal measured outcomes (sleep, pain, health-related quality of life) at short- and long-term follow-up.",[141,142,143,144,145,30,146,147],"Juvenile; Scoliosis","Scoliosis Idiopathic","Scoliosis; Adolescence","Scoliosis;Congenital","Kyphosis","Pectus Surgery","Hip Surgery",[149,150,151,152,153,154,155,156,157,158,159,160,161,162],"sleep","pain medicine","pediatric pain medicine","melatonin","pilot feasibility trial","acute pain","chronic pain","CPSP","chronic postsurgical pain","spinal fusion surgery","adolescent","perioperative melatonin","hip surgery","pectus surgery","2026-03-16",{"date":165,"type":44},"2026-03-18",{"date":167,"type":44},"2024-05-30",{"date":169,"type":22},"2028-03-31",{"name":171,"class":51},"Stanford University",1,{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":16,"sex":17,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":109,"phases":184,"briefSummary":185,"conditions":186,"keywords":190,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":172},"100611622","evaluation-of-balance-using-the-biodex-balance-system-among-different-subcategories-of-low-back-pain-100611622","NCT07242976","Evaluation of Balance Using the Biodex Balance System Among Different Subcategories of Low Back Pain","Biodex","Inclusion Criteria:\n\n* Diagnosis of chronic low back pain (≥3 months duration) (Ge et al., 2021). Referred from orthopedic surgeons with confirmed diagnosis of lumbar spondylosis, spondylolisthesis or lumber disc prolapse affecting L4-L5 or L5 S1( Hlaing et al., 2020) depending on imaging findings (MRI, CT or X-ray scan within the last 6 months):\n\n  * Lumbar spondylosis; defined as degenerative disc disease, osteophyte formation with or without facet joint arthropathy (Natarajan et al., 2021; Christe et al., 2020).\n  * Lumbar spondylolisthesis; defined as anterolisthesis of one vertebral body over another, graded via the Meyerding scale (grade 1 or 2) (Giordan et al., 2023; Chuang et al., 2018).\n  * Lumbar disc prolapse; defined as protrusion, herniation of intervertebral disc (Kang et al., 2016; Hahne et al., 2019).\n\n    * Age of patients ranges from 35 to 55 years (Albeshri, et.al., 2017)\n    * Both genders will be included in the study\n    * Pain intensity: ≥ 4\u002F10 on a numerical pain rating scale (Thong et al., 2011).\n    * BMI ranged from (18.5-29.9 kg\u002Fm²) (Karimi et al., 2008; Soliman et al., 2017).\n    * Healthy subjects are healthy volunteers and without any Musculoskeletal disorders (Karimi et al., 2008).\n\nExclusion Criteria:\n\n* The following patients will be excluded from the study patients with:\n\n  * Prior lumbar spine surgery or neurological disorders (e.g., parkinson's, stroke) that may influence balance (soliman et al., 2017).\n  * Fractures of the spine, pelvis or lower extremities, (Karimi et al., 2008).\n  * Leg length discrepancy(Karimi et al., 2008).\n  * Systemic disease such as arthritis, tuberculosis, liver or kidney failure. (Karimi et al., 2008).\n  * Patients with chronic non-specific low back pain.\n  * Patients exhibiting red flag symptoms such as urinary or fecal incontinence, saddle anesthesia, progressive motor deficits (e.g., foot drop), or other signs of serious neurological compromis (Ruhe et al., 2011).\n  * Participants experiencing low back pain with pain radiating distaly below the level of knee (Hlaing et al., 2020).","35 Years","55 Years",{"count":183,"type":22},80,[111],"this study aims to evaluate balance using the biodex balance system among patients with spondylosis, spondylolisthesis, and lumber disc prolapse.",[187,30,188,189],"Low Back Pain","Spondylosis Lumbar","Balance Assessment",[191,192,193],"biodex","balance","subcategories of low back pain","2025-11-19",{"date":196,"type":44},"2025-11-21",{"date":198,"type":22},"2025-12-01",{"date":200,"type":22},"2026-02-03",{"name":126,"class":51},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":209,"enrollmentInfo":210,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":172},"100467390","thoracic-lumbar-arthrodesis--implanet-jazz-100467390","NCT05366140","Thoracic-Lumbar Arthrodesis- Implanet Jazz","Prospective Follow-up of Patients Undergoing Instrumented Thoracic and Lumbar Arthrodesis Supplemented by the Implanet Jazz System TM.","Inclusion Criteria:\n\n* Male and female patients, 18 years of age and older\n* Qualified candidate for hybrid thoracolumbar fixation with the Implanet Jazz System TM during arthrodesis surgery.\n\nExclusion Criteria:\n\n* Individuals who have not yet reached the age of 18.","100 Years",{"count":211,"type":22},300,"Establish a data repository of patients who have undergone single, two-, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz System.",[30,67,214],"Degenerative Disease",[216,217,218],"Thoracic-Lumbar Arthrodesis","Spinal fusion","back pain","2025-10-23",{"date":221,"type":44},"2025-10-27",{"date":223,"type":44},"2022-02-03",{"date":225,"type":22},"2028-09",{"name":227,"class":51},"Francis Farhadi",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":109,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":252},"100543432","post-market-clinical-study-of-functional-motion-outcomes-in-subjects-treated-with-the-minuteman-device-100543432","NCT06355791","Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device","The Stability Study: Open-Label, Multi-Center, Post-Market Study of Functional Motion Outcomes In Subjects Treated With the Spinal Simplicity Minuteman G5 Fusion Plate","STABILITY","Inclusion Criteria\n\nA subject must MEET ALL of the following inclusion criteria:\n\n1. Be a candidate for Spinal Simplicity Minuteman G5 Fusion Plate device per labeled indication\n2. Be willing and capable of giving written consent to participate in this clinical study based on voluntary agreement after a thorough explanation of the subject's participation has been provided\n3. Be willing and capable of subjective evaluation, read and understand written questionnaires, and read, understand the written informed consent\n4. Be 18 years of age or older at the time of enrollment\n5. Have been diagnosed with degenerative conditions of the lumbar spine resulting in chronic low back pain with lower extremity symptoms and concurrent neurogenic claudication\n6. Received at least 3 months of non-operative or conservative treatment without significant benefit in the opinion of the Investigator\n7. Be willing and able to comply with study-related requirements, procedures and visits\n8. Be on a stable pain medication regimen, as determined by the Investigator, for at least 30 days prior to enrolling in this study.\n9. Must disclose any unresolved major issues of secondary gain (e.g., social, financial, legal), as determined by the Investigator. Including being involved in an injury claim under current litigation or has a pending or approved worker's compensation claim. Subjects will not be excluded due to secondary gain, but it should be disclosed at Enrollment.\n\nExclusion Criteria\n\nA subject must NOT MEET ANY of the following exclusion criteria:\n\n1. Had previous spinal surgery at the level of intervention (e.g. lumbar fusion, discectomy, Laminectomy) MILD procedure is not considered an exclusion.\n2. Patient physically unable to perform the Gait and\u002For Balance tests.\n3. Current systemic infection or local infection increasing the risk of surgery\n4. History of medications decreasing bone quality or soft tissue healing in the opinion of the Investigator\n5. Grade II-V spondylolisthesis\n6. Significant scoliosis with Cobb angle \\>10 degrees\n7. Unremitting back pain in a spinal flexion position\n8. Active systemic disease that may affect the welfare of the subject in the opinion of the Investigator\n9. Be concurrently participating in another clinical drug and\u002For device study that may alter or confound the results of the assessment (investigational device, investigational drug, new indication for a device or drug, or additional testing beyond standard of care procedures) as determined by the investigator.\n10. Vertebral osteoporosis or history of vertebral fracture\n11. Be pregnant\u002F lactating or plan to become pregnant from study enrollment through 3 months post-operatively. (determined by urine testing unless female subject is surgical sterile or post-menopausal). If female, sexually active and childbearing age, subject must be willing to use a reliable form of birth control through the 3-month visit.\n12. Malformation or dysplasia of spinous process\n13. Severe osteoporosis with T score \\\u003C-2.5 SD",{"count":237,"type":22},150,[111],"This is a prospective, multi-center open-label single arm post-market study where the purpose is to evaluate the effectiveness and safety of the market approved Spinal Simplicity Minuteman G5 MIS Fusion Plate and bone graft material in patients with degenerative conditions of the lumbar spine resulting in chronic low back pain with lower extremity symptoms and concurrent neurogenic claudication. The indication for the device under study is degenerative conditions of the lumbar spine resulting in back pain with lower extremity symptoms and neurogenic claudication.",[241,242,30],"Degenerative Conditions of the Lumbar Spine","Lumbar Spinal Stenosis","2025-10-01",{"date":245,"type":44},"2025-10-03",{"date":247,"type":44},"2024-05-29",{"date":249,"type":22},"2030-12",{"name":251,"class":95},"Spinal Simplicity LLC",6,{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":262,"conditions":263,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":172},"100608247","rate-of-bone-union-after-surgery-with-stand-alone-fibergraft-100608247","NCT07199075","Rate of Bone Union After Surgery With Stand-alone Fibergraft","Fusion Rate of Anterior Lumbar Interbody Fusion and Extreme Lateral Interbody Fusion Using Titanium Cages Filled With Stand-alone Fibergraft in Lumbar Spinal Fusion","Fibergraft","Inclusion Criteria:\n\n* Adults ≥ 18 years old\n* Diagnosed with the following lumbar spine disorders: foraminal nerve root compression, isthmic spondylolisthesis, and short-segment (1-2 levels) deformity.\n* Undergone primary surgery of ALIF or XLIF using titanium cages filled with standalone Fibergraft and with the following criteria fulfilled (ie, the index surgery):\n\n  * ALIF (up to 2 levels) as either standalone (ie, no posterior procedure) or as an anterior first procedure with posterior procedure as a second procedure.\n  * XLIF (up to 2 levels) as an anterior first procedure with posterior procedure as a second procedure.\n* Consenting to have CT scans taken to allow assessment of fusion status at 12-24 months post index surgery\n\n  * This criterion is applicable to patients who have not undergone revision surgery.\n  * For patients who have undergone revision surgery due to any reason other than nonunion, which typically occurs within 1 year of the index surgery, this criterion is only applicable if it is possible to obtain the CT scan within 12-24 months of the index surgery. If no CT scan can be taken during this window, the patient does not need to undergo the CT scan; in such cases, the CT scan that has been taken as part of the standard of care before the revision surgery will be retrospectively retrieved to assess the fusion status at the time of the revision surgery.\n  * This criterion is not applicable to patients who underwent revision surgery due to nonunion, which typically occurs 1 year after the index surgery; these patients do not need to undergo the CT scan. In such cases, the CT scan that has been taken as part of the standard of care before the revision surgery will also be retrospectively retrieved to assess and grade the fusion status at the time of the revision surgery.\n* Ability to provide informed consent according to the IRB\u002FEC defined and approved procedures\n\nExclusion Criteria:\n\n* Revision surgery\n* Standalone XLIF\n* Posterior lumbar interbody fusion\n* Diagnosis of fractures, malignancies, ankylosing spondylitis, or acute cauda equina syndrome\n* Diagnosis of Parkinson's disease\n* Body mass index \\> 35kg\u002Fm2",{"count":183,"type":22},"Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking. A common treatment is a type of back surgery called lumbar interbody fusion, which helps stabilize the spine.\n\nAt the St. Maartenskliniek in the Netherlands, doctors have been using a special material called Fibergraft Bioactive Glass Putty for such surgeries since 2023. This material helps bones grow and heal, and it's placed inside the spine without needing extra bone from another part of the body.\n\nThis study will look at how well this material works by evaluating how many patients' bones successfully healed after surgery using this material. It will also look at how patients feel and recover after the procedure",[264,265,266,267,268,269,30],"Spine Degeneration","Spine Disorder","Spine Pain","Spine Fusion","Spine Fusion for Degenerative Spine Disease","Nerve Root Compress;Lumbosac","2025-09-22",{"date":272,"type":44},"2025-09-30",{"date":274,"type":22},"2025-10-31",{"date":276,"type":22},"2026-05-30",{"name":278,"class":51},"AO Innovation Translation Center",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":109,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":172},"100457603","comparison-of-radiographic-fusion-rate-and-clinical-outcome-of-alif-and-xlif-performed-with-either-recombinant-human-bone-morphogenetic-protein-2-or-vivigen-100457603","NCT05238740","Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant Human Bone Morphogenetic Protein-2 or ViviGen®","Comparison of Radiographic Fusion Rate and Clinical Outcome of Anterior Lumbar and Extreme Lateral Interbody Fusion Performed With Either Recombinant Human Bone Morphogenetic Protein-2 or ViviGen® Cellular Bone Matrix, a Prospective Randomised Assessor Blind, Monocentric Trial","Inclusion criteria:\n\nPatients who have an indication for a monosegmental ALIF procedure on the L5\u002FS1 segment or a monosegmental XLIF procedure on L4\u002F5 (both ALIF and XLIF procedure with or without an additional pedicular stabilisation), e.g., treating conditions such as spondylosis, spondylolisthesis and degenerative disc disorders with back and\u002For leg pain\n\n* Patients must be 18 - 70 years of age\n* Patients must have understood and signed the study information and the informed consent form\n* Patients are willing and able to complete scheduled follow-up evaluations \u002F questionnaires as described in the Informed Consent\n\nExclusion criteria:\n\n* Patients under 18 years and over 70 years of age\n* Patients with tumour \u002F spine trauma \u002F known bone disease \u002F Parkinson's disease and similar CNS disorders \u002F diseases or injuries of the peripheral nerves\n* Other procedures or segment than mentioned in the inclusion citeriaAdditional planed spine surgeries after index surgery\n* Current smoking\n* Pregnant or breastfeeding patients (or patient planning a pregnancy within one year after surgery)\n* Insufficient language skills in German\n* Inability to give informed consent\n* Refusal to participate in the study, unsigned study consent\n* Participation in another interventional study within the 30 days preceding and during the present study","70 Years",{"count":288,"type":22},168,[111],"The aim of this study is to prospectively investigate the potential for bony fusion of ViviGen® bone graft substitute in comparison to rhBMP-2 in monosegmental ALIF procedure L5\u002FS1 and in monosegmental XLIF procedure L4\u002F5",[292,30,293],"Spondylosis","Degenerative Disc Disease",[295,296,297,298,292,30,293,299],"ViviGen","Radiographic fusion rate","Anterior lumbar interbody fusion","Recombinant human bone morphogenetic protein-2","Extreme lateral interbody fusion","2025-06-04",{"date":302,"type":44},"2025-06-08",{"date":304,"type":44},"2022-10-27",{"date":306,"type":22},"2027-12",{"name":308,"class":95},"Lindenhofgruppe AG",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":109,"phases":319,"briefSummary":320,"conditions":321,"keywords":324,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":4},"100592108","effects-of-orthosis--exercise-on-spondylolisthesis-100592108","NCT06989138","Effects of Orthosis & Exercise on Spondylolisthesis","The Effect of Orthosis and Exercise Training on Pain, Physical Function and Quality of Life in Patients With Spondylolisthesis","Inclusion Criteria:\n\n* Individuals aged 18-65\n* Individuals without indication for surgery\n* Individuals diagnosed with grade 1-2 spondylolysis\n* Individuals without neurological deficits\n* Individuals diagnosed with radicular pain or non-specific chronic low back pain for more than 3 months\n\nExclusion Criteria:\n\n* Surgery recommended after diagnosis\n* History of lumbar surgery\n* Presence of rheumatic inflammatory diseases or diabetic polyneuropathy\n* Individuals with symptoms of cauda equina or ischemic heart disease\n* Presence of back pain with non-mechanical causes or non-radicular neuropathic pain\n* Having received this type of exercise therapy before","65 Years",{"count":318,"type":22},48,[111],"In the treatment of spondylolisthesis, conservative methods are initially preferred unless severe neurological symptoms are present; surgical treatment is only performed in refractory cases lasting at least 3-6 months. Conservative treatment consists of orthotic use, activity restriction, pain control, physiotherapy and exercise. Orthotics may promote healing by restricting movement; however, there are not enough studies on this subject. Exercise is the intervention with the highest level of evidence in chronic low back pain. The efficacy of stabilisation exercises in providing positive and long-lasting effects on pain and functional disability in patients with spondylolisthesis has been demonstrated. However, studies evaluating the effect of exercise on spinal stability and radiological findings are limited. Therefore, this study aims to compare the effects of stabilization and conventional exercises with orthosis on radiographic findings, pain, physical function and quality of life.",[30,322,323],"Orthosis","Exercise Training",[30,322,325,326,327,328],"Exercise","Stabilization","Physical function","Kinesiophobia","2025-05-21",{"date":331,"type":44},"2025-05-25",{"date":333,"type":22},"2025-05",{"date":335,"type":22},"2026-07",{"name":337,"class":51},"Medipol University",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":347,"conditions":348,"keywords":349,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":362},"100589164","escape--evaluation-of-spinal-conservation-by-endoscopic-procedures-to-avoid-fusion-100589164","NCT06950853","ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion","ESCAPE","Inclusion Criteria:\n\n* Patient ≥ 18 years old\n* Patient consulting for a medical reason involving a spinal pathology in the investigating center :\n\nSyndrome adjacent to an old lumbar arthrodesis defined on preoperative radiographs by an antero-posterior translation \\> 3 mm, segmental kyphosis \\> 10° or a disc height reduced by more than 50%, or on preoperative MRI by central stenosis of grade C or D of the Schizas classification or a herniated disc Grade 1 or 2 degenerative spondylolisthesis, i.e. with slippage less than 50% of the depth of the underlying vertebral body.\n\nLumbar stenosis complicating lumbar scoliosis defined by a deformation with rotation of the vertebral bodies on a frontal radiograph (absence of centering of the spinous process between the two pedicles of the vertebra concerned) and a Cobb angle greater than 20° or a rotational dislocation .\n\n\\- Indication for spinal surgery by endoscopy\n\nExclusion Criteria:\n\n* Patient under guardianship or curatorship,\n* Persons deprived of liberty by judicial or administrative decision,\n* Persons undergoing psychiatric treatment under duress requiring the consent of the legal representative\n* Persons unable to express their consent,\n* Persons under legal protection,\n* Patient not affiliated to a social protection scheme.",{"count":346,"type":22},375,"The recent development and expansion of endoscopic surgery has made it possible to offer an alternative to this therapeutic escalation. This method allows decompression procedures to be performed using optimized and minimally destructive surgical approaches, which contributes to preserving the physiological function of the lumbar spine and in particular its stability.\n\nThe main hypothesis of the research is that the use of endoscopic techniques for decompression of the lumbar spine allows a reduction in the indication for lumbar arthrodesis.",[67,30],[350,351,352],"spine","care","surgery","2025-04-22",{"date":355,"type":44},"2025-04-30",{"date":357,"type":44},"2024-02-01",{"date":359,"type":22},"2028-08-13",{"name":361,"class":51},"University Hospital, Bordeaux",13,{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":370,"targetDuration":4,"studyType":109,"phases":372,"briefSummary":373,"conditions":374,"keywords":375,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":172},"100577567","effects-of-a-single-session-of-physiotherapy-on-patients-operated-for-lumbar-spondylolisthesis-100577567","NCT06799975","Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar Spondylolisthesis","Effects of a Single Session of Physiotherapy on Pain, Disability and Psychological Risk Factors in Patients Operated for Lumbar Spondylolisthesis: a Randomized Controlled Study","Inclusion Criteria:\n\n* Age \\> 18 years\n* Patients who have undergone lumbar fusion surgery due to monosegmental lumbar spondylolisthesis.\n\nExclusion Criteria:\n\n* Patients who have undergone previous lumbar surgeries\n* Patients operated on for other lumbar pathologies\n* Patients with pre-existing neurological deficits not related to the condition being treated\n* Patients with systemic conditions (inflammatory, infectious, neoplastic, etc.) or neuromuscular disorders\n* Patients with cognitive deficits or psychiatric disorders\n* Patients who do not speak Italian fluently",{"count":371,"type":22},50,[111],"The goal of this clinical trial is to investigate whether a meeting with physiotherapist before hospital discharge can improve the post-operative outcomes in patients who have undergone lumbar fusion surgery for spondylolisthesis.\n\nThe main question it aims to answer is:\n\n* The primary endpoint investigated is the degree of disability measured using the ODI-I one month after the surgical intervention.\n* The secondary endpoints are the level of pain measured using the NRS scale at 1 and 3 months post-surgery; disability at 3 months measured using the ODI-I questionnaire; physical function assessed using the UWT at 1 and 3 months post-surgery; psychological factors such as self-efficacy and fear of movement measured using the TSK and PSEQ-I at 1 and 3 months after lumbar fusion surgery; health status and quality of life measured at 3 months with the HADS-I and SF-36-I questionnaires; and the patient's satisfaction regarding their hospital stay, assessed using a PREMs questionnaire administered at the time of discharge.\n\nThe \"usual care\" group will instead be discharged by the spinal surgeon following the standard procedures.\n\nThe physiotherapist will provide the patient with advice regarding their return home and will suggest simple exercise to be performed at home until the next visit, one month after surgery. Additionally, the patient will have the opportunity to communicate, either by email or phone, with the physiotherapist until the follow-up visit with the spinal surgeon.",[30],[376,377,378,379,380],"lumbar spondylolisthesis","physiotherapy","disability","psychological factors","randomized controlled trial","2025-01-24",{"date":383,"type":44},"2025-01-29",{"date":385,"type":22},"2025-03-01",{"date":387,"type":22},"2025-12",{"name":389,"class":51},"Istituto Clinico Humanitas",{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":396,"eligibilityCriteria":397,"healthyVolunteers":11,"sex":17,"minAge":398,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":109,"phases":401,"briefSummary":402,"conditions":403,"keywords":407,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":172},"100462821","preventing-pain-after-surgery-100462821","NCT05306665","PREventing Pain After Surgery","PREventing Pain After Surgery: a Feasibility and Acceptability Study of Acceptance and Commitment Therapy for the Prevention of Chronic Post-surgical Pain (PREPS)","PREPS","Inclusion Criteria:\n\n* scheduled to undergo fusion, discectomy, vertebroplasty, kyphoplasty, or foraminotomy\n* age 22 and older\n* able to communicate fluently in English\n\nExclusion Criteria:\n\n* inability to complete study procedures due to delirium, dementia, psychosis, or other cognitive impairment\n* have a history of severe neurologic movement disorder\n* are pregnant or intent to become pregnant during study\n* have undergone previous spinal surgery\n* have spinal deformity, pseudarthrosis, trauma, infection, or tumor as primary indication for surgery\n* have undergone Acceptance and Commitment Therapy in last 2 years","22 Years",{"count":400,"type":22},140,[111],"The present study aims to adapt and modify a brief presurgical Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use. Investigators will then assess the acceptability, feasibility, and preliminary efficacy of the finalized intervention to prevent the transition to CPSP and reduce post-surgical opioid use six months following lumbar spine surgery. Finally, investigators will identify psychosocial and psychophysical phenotypes associated with response to this intervention.",[404,67,405,292,30,406],"Pain, Back","Disc Herniation","Back Injuries",[408,36,409,410,411],"Chronic pain","opioid","acceptance and commitment therapy","Prevention","2024-10-25",{"date":414,"type":44},"2024-10-28",{"date":416,"type":44},"2023-01-13",{"date":418,"type":22},"2026-08-01",{"name":420,"class":51},"Brigham and Women's Hospital",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":428,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":430,"conditions":431,"keywords":436,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":172},"100489081","intraoperative-monitoring-for-the-lateral-lumbar-interbody-fusion-procedure-100489081","NCT05648474","Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure","Advanced Techniques in Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure: a Utility Study","Inclusion Criteria:\n\n* At least 18 years of age at the time of planned surgery.\n* Indicated for 1- or 2-level instrumented LLIF surgery (in either prone or lateral decubitus positions), inclusive of the L4-5 disc space.\n* Written informed consent obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study.\n\nExclusion Criteria:\n\n* Patients requiring surgical treatment at more than 2 lumbar levels.\n* Patients with peripheral neuropathy such as from diabetes or other conditions that might affect the reliability of intraoperative neuromonitoring.\n* Patients with prior history of partial\u002Ffull hip or knee joint replacement surgery (i.e., arthroplasty or resurfacing) on the leg targeted for saphenous monitoring and electrode placement.\n* Patients with presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.\n* Female patients who are pregnant or wanting to become pregnant during the timeframe of study participation.\n* Patients participating in another clinical study which may compromise this study's results or compliance with this study's procedures.",{"count":429,"type":22},400,"This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk during the lateral lumbar interbody fusion (LLIF) procedure.",[432,433,30,434,435],"Intervertebral Disc Degeneration","Stenosis, Spinal","Spinal Deformity","Spinal Instability",[35,36,437,438,439,440],"Adult","Neuromonitoring","Electromyography","Somatosensory evoked potentials","2024-10-22",{"date":443,"type":44},"2024-10-24",{"date":445,"type":44},"2022-07-13",{"date":447,"type":22},"2025-12-31",{"name":449,"class":95},"Alphatec Spine, Inc.",{"id":451,"slug":452,"hasResults":11,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":457,"enrollmentInfo":458,"targetDuration":4,"studyType":109,"phases":460,"briefSummary":461,"conditions":462,"keywords":466,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":475,"leadSponsor":477,"locationsCount":172},"100536454","confirmatory-investigation-to-evaluate-the-performance-and-safety-of-respace-ticell-cage-implants-in-tlif-100536454","NCT06265038","Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in TLIF","A Prospective, Single Center, Confirmatory Investigation to Evaluate the Performance and Safety of ReSpace TiCell Cage Implants in Transforaminal Lumbar Interbody Fusion","Inclusion Criteria:\n\nEach subject must meet all the following criteria to be enrolled in this study:\n\nAll subjects who had previously indicated for TLIF surgery can participate in this study, with the following evidence:\n\n1. Has degenerative disease of the lumbosacral spine in one or two adjacent levels (L1 to S1), manifested by:\n\n   1. Low back pain, or\n   2. Irradiating leg or buttock pain, paresthesia, numbness, or weakness, or\n   3. History of neurogenic claudication.\n2. Has radiographic evidence (e.g. CT, MRI, x-ray, etc.) of degenerative lumbosacral disease including at least one of the following:\n\n   1. Instability as defined by ≥3 mm translation or ≥5-degree angulation\n   2. Decreased disc height, on average by ≥2 mm, but dependent upon the spinal level\n   3. Scarring\u002Fthickening of ligamentum flavum or annulus fibrosis\n   4. Herniated nucleus pulposus\n   5. Vacuum phenomenon\n   6. Grade 1 spondylolisthesis\u002Fretrolisthesis based on the Meyerding classification (Meyerding, Henry William, 1932), or lateral listhesis demonstrated by coronal plane translation (slippage) of the superior (cranial) vertebral body lateral to the inferior (caudal) vertebral body less than or equal to 3mm, or\n   7. Stenosis, or narrowing, of the lumbar spinal canal and\u002For intervertebral foramen requiring significant decompression leading to segmental instability, or\n   8. Recurrent disc herniation\n\nFurther inclusion criteria:\n\n* Skeletally mature adults ages 18 - 80 years of age\n* Able to read and understand all documents used in this study, including the informed consent and patient-reported outcome questionnaires\n\nExclusion Criteria:\n\nSubjects meeting any of the following criteria will be excluded from the study:\n\n1. Prior surgical procedure at the involved or adjacent spinal levels (e.g. stabilization, fusion, arthroplasty and\u002For other non-fusion procedures). Prior microdiscectomy, discectomy, laminectomy, decompression surgery at the target or adjacent levels is allowed.\n2. Significant lumbar instability defined as sagittal listhesis greater than Grade 2 at any involved level using the Meyerding Classification or lateral listhesis greater than 3 mm at any involved level.\n3. Planned use of an internal or external bone growth stimulator.\n4. Lumbar scoliosis \\>30 degrees.\n5. Patients who had a previous diagnosis of osteoporosis with a Tscore of -2.5 or below in the last 12 months. If subject has a prevalent fragility fracture and a T-score hasn't been assessed in the last 12 months, a DEXA (dual x-ray absorptiometry) scan will need to be obtained.\n6. Morbidly obese, as defined by a Body Mass Index (BMI) \\>40.\n7. Presence of active malignancy or prior history of malignancy (noninvasive basal cell carcinoma of the skin and non-invasive squamous cell carcinoma localized only to the skin is allowed).\n8. Overt or active bacterial infection, either local to surgical space or systemic.\n9. Has undergone administration of any type of corticosteroid, antineoplastic, immunostimulant, or immunosuppressive agents, or medications known to inhibit with the healing of bone or soft tissue within 30 days prior to implantation of the assigned treatment\n\n   1. This includes patients ≥ 65 years of age taking warfarin with documented diagnosed osteoporosis. All other patients taking warfarin should washout for at least 5 days prior to treatment\n   2. Use of steroidal inhalers, short-term NSAID use, and shortterm steroidal use (e.g. Medrol Dosepak) is allowed pre and postoperatively. For this clinical study, short-term use is defined as ≤ two weeks.\n   3. Use of NSAIDs and\u002For steroids for longer than two weeks postoperatively through the 24 Month Follow-Up Visit is not recommended. Such patients must be excluded from data analysis in case of non-fusion.\n10. Co-morbidities, which in the investigator's opinion, precludes the subject from being a surgical candidate.\n11. Autoimmune disease, which in the investigator's opinion, is known to affect bone metabolism or the spine (e.g., spondyloarthropathies, juvenile arthritis, rheumatoid arthritis, Graves' disease, Hashimoto's thyroiditis).\n12. Any endocrine or metabolic disorder, which in the investigator's opinion, is known to affect osteogenesis (e.g., Paget's disease, renal osteodystrophy, Ehlers-Danlos syndrome, or osteogenesis imperfecta).\n13. Known hypersensitivity or allergy to any components of the study treatments including, but not limited to bone morphogenetic proteins (BMPs); injectable collagen; protein pharmaceuticals (e.g.: monoclonal antibodies or gamma globulins); bovine collagen products; and\u002For instrumentation materials (e.g., titanium, titanium alloy, cobalt chrome, cobalt chrome alloy, or PEEK).\n14. History of any allergy resulting in anaphylaxis.\n15. Is mentally incompetent. If questionable, obtain psychiatric consult.\n16. Treatment with an investigational therapy (drug, device, and\u002For biologic) targeting spinal conditions within 3 months prior to implantation surgery, treatment with any other investigational therapies within 30 days prior to implantation surgery, or such treatment is planned during the 24-month period following implantation of the study treatment.\n17. Pregnancy and breastfeeding.\n18. A documented diagnosis of substance use disorder (Nicotine use is allowed.)\n19. Any condition, which in the investigator's opinion, would interfere with the subject's ability to comply with study instructions, which might confound data interpretation.\n20. Subject is considered to belong to a vulnerable population.","80 Years",{"count":459,"type":22},99,[111],"The primary objective of this study is to confirm superiority for the efficacy of the ReSpace Ticell Cage implants in Transforaminal Lumbar Interbody Fusion compared to state-of-the-art.\n\nThe secondary objective of the study is to evaluate further efficacy and safety of the ReSpace Ticell Cage implants in Transforaminal Lumbar Interbody Fusion with the following secondary efficacy and safety objectives:\n\n* To evaluate if implantation causes significant reduction in patient's back, hip\u002Fbuttock, and leg pain.\n* To evaluate if implantation causes significant increase quality of life of the patients.\n* To evaluate if using the device can be considered as safe overall.",[463,30,464,465],"Degenerative Instability","Post-discectomy Syndrome","Post-traumatic Instability",[467,468,469,470],"lumbar spinal","interbody fusion","interbody cage","3D printing","2024-02-19",{"date":473,"type":44},"2024-02-21",{"date":357,"type":44},{"date":476,"type":22},"2026-10-01",{"name":478,"class":95},"Sanatmetal Orthopaedic and Traumatologic Equipment Manufacturer Ltd.",{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":457,"enrollmentInfo":487,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":489,"conditions":490,"keywords":492,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":500,"leadSponsor":502,"locationsCount":172},"100513311","the-spine-promco-study-100513311","NCT05963815","The Spine PROMCO Study","Spine Patient Reported Outcome Measures: a Cohort Observational Study","Spine PROMCO","Inclusion Criteria:\n\n* All patients who are eligible for elective surgery of the lumbar spine.\n* All patients with degenerative disorder of the lumbar spine including: herniated disk, stenosis, discopathy and spondylolisthesis.\n* Patients must be able to fill in the questionnaire online\n* Patients with imaging (Magnetic resonance imaging (MRI)) confirmed lumbar disc herniation, stenosis, discopathy, or listhesis.\n* Elective cases\n* Patients operated with laminectomy, microscopic discectomy, percutaneous transforaminal endoscopic discectomy, and spondylodesis.\n\nExclusion Criteria:\n\n* Patients who cannot speak nor read the Dutch language\n* Patients who are not able to complete the digital questionnaires, according to the including doctor\n* Patients with fractures, primary infections of the spine, or with spinal malignant- cies.\n* Patients in a traumatic setting.",{"count":488,"type":22},4000,"Our primary objective is to design a cohort to determine the treatment outcome of different surgical interventions of the degenerative lumbar spine highlighting the expediency and value of the current surgical treatment program.",[491,30,67],"Lumbar Disc Herniation",[493,494,495],"Patient related outcome measures","Prognosis","Degenerative Spine disease","2023-09-26",{"date":498,"type":44},"2023-09-28",{"date":416,"type":44},{"date":501,"type":22},"2030-01-13",{"name":503,"class":51},"Park Medical centrum",{"id":505,"slug":506,"hasResults":11,"nctId":507,"briefTitle":508,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":11,"sex":17,"minAge":510,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":109,"phases":512,"briefSummary":513,"conditions":514,"keywords":515,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":172},"100353525","vancomycin-powder-combined-with-autogenous-bone-graft-as-a-prevention-for-post-operative-infection-for-spine-surgery-100353525","NCT03883022","Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery","Inclusion Criteria:\n\n* Patients who have instrumented spine fusion surgery due to failed conservative treatment (bed rest, medication, rehabilitation programs) for 3 to 6 months\n* Patients who are willing to sign the surgical permit after the surgeon explains all surgical procedures along with the surgical risks\n* Patients who fully understand the surgical procedures as well as the surgical risks and are willing to sign the surgical permit and the inform consent\n* Patients who agree one more blood withdrawal after operation\n\nExclusion Criteria:\n\n* Patients who agree to accept the spine surgery but do not agree to sign the inform consent\n* Patients who have allergic reaction to vancomycin","20 Years",{"count":429,"type":22},[111],"Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome. This ambispective study was designed to examine the effect of vancomycin powder mixed with autogenous bone graft and bone substitute on preventing deep surgical site infection (DSSI) in degenerative lumbar fusion surgeries as well as any interference with bony fusion.",[76,67,30],[516,517,518,519],"Deep surgical site infection","Vancomycin-impregnated bone graft","Spine surgery","Degenerative lumbar disorder","2019-03-18",{"date":522,"type":44},"2019-03-20",{"date":524,"type":44},"2018-09-03",{"date":526,"type":22},"2027-12-31",{"name":528,"class":529},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV"]