[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spontaneous-coronary-artery-dissection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spontaneous-coronary-artery-dissection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,46,71,99,124,143,165,186,204,227,248,274],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100206702","defining-the-basis-of-fibromuscular-dysplasia-fmd-100206702",false,"NCT01967511","Defining the Basis of Fibromuscular Dysplasia (FMD)","Defining the Basis of Fibromuscular Dysplasia: The Define-FMD Study","DEFINE","Inclusion Criteria:\n\n* Patients of any age and freely willing to participate. For patients \\\u003C 18 years of age consent will be via parents.\n* Fluency in either English or Spanish.\n* Signed, informed consent\n* For FMD, SCAD or CvAD subjects - a clinical diagnosis of FMD, SCAD or CvAD with fulfillment of standard diagnostic criteria.\n* For healthy controls - no clinical features of FMD, SCAD or CvAD and absence of any major ongoing systemic disease including any condition requiring hospitalization, immune suppression, intravenous or injected medications or that result in functional impairment in the performance of activities of daily living. Healthy controls will be matched to enrolled FMD patients on the basis of gender and approximate age (within a 5 year window of another FMD subject).\n\nExclusion Criteria:\n\n* Patients who have co-morbidities which reduces life expectancy to one year.\n* Patients with any solid organ or hematological transplantation, or those in whom transplantation is considered.\n* Active autoimmune disease.\n* Illicit drug use.\n* HIV positive.\n* Prior malignancy.\n* Any other form of vascular disease, including other arteriopathy coronary artery disease or peripheral vascular disease\n* Family history of arteriopathy other than FMD, SCAD or CvAD (e.g. Ehlers-Danlos syndrome)",true,"ALL","18 Years",{"count":21,"type":22},600,"ESTIMATED","OBSERVATIONAL","The purpose of this study has evolved and expanded since its inception. Originally the intent was to establish the functional, molecular and genetic profile of fibroblasts from Fibromuscular Dysplasia (FMD) patients as compared to carefully matched control subjects. While this remains among the objectives, the study has been expanded to undertake a fully powered cross-tissue systems genetics analysis of FMD, and now also the related arteriopathies spontaneous coronary artery dissection (SCAD) and cervical artery dissection (CvAD). The overall objective is to disclose the core biologic mechanisms of these disorders.",[26,27,28],"Fibromuscular Dysplasia","Spontaneous Coronary Artery Dissection","Cervical Artery Dissection",[30,31,32,27,28],"Cross-sectional study","Fibromuscular dysplasia","Fibroblast","RECRUITING","2026-06-22",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":37},"2013-10-01",{"date":41,"type":22},"2030-12",{"name":43,"class":44},"Icahn School of Medicine at Mount Sinai","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":17,"sex":53,"minAge":19,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100492980","a-study-to-analyze-the-role-of-sympathetic-nervous-system-in-spontaneous-coronary-artery-dissection-100492980","NCT05699200","A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection","Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)","Inclusion Criteria:\n\n* For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography\n* For controls: no cardiac disease history\n\nExclusion Criteria:\n\n* Pregnancy\n* Known or suspected unstable cardiac condition within 4 weeks of the study\n* Active treatment with anticoagulation or dual antiplatelet therapy\n* Prisoner","FEMALE",{"count":55,"type":22},50,"INTERVENTIONAL",[58],"NA","The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.",[27,61],"Healthy","2026-06-15",{"date":64,"type":37},"2026-06-17",{"date":66,"type":37},"2023-06-01",{"date":68,"type":22},"2027-08",{"name":70,"class":44},"Mayo Clinic",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":53,"minAge":19,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":56,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":45},"100589534","exercise-support-and-rehabilitation-for-patients-after-spontaneous-coronary-artery-dissection-100589534","NCT06955663","Exercise Support and Rehabilitation for Patients After Spontaneous Coronary Artery Dissection","Exercise Support and Rehabilitation for Patients After Spontaneous Coronary Artery Dissection- a Feasibility Study","EXERCISE-SCAD","Inclusion Criteria:\n\n* Female\n* Aged ≥18 years.\n* Diagnosed with angiographically confirmed SCAD and referred to the Leicester SCAD clinic.\n* Ejection fraction \\>45%.\n* Blood pressure \\\u003C180\u002F100. Resting heart rate \\\u003C100bpm\n\nExclusion Criteria:\n\n* No SCAD diagnosis.\n* Unable to travel to Leicester Hospital for their SCAD clinic appointment.\n* Unable to give informed consent.\n* No smart phone or internet access\n* Unable to understand verbal explanations in English.",{"count":80,"type":22},120,[58],"The study aims to examine the feasibility of a remote exercise program in women recovering from spontaneous coronary artery dissection (SCAD) events (heart attacks). Heart attacks caused by SCAD are different to the traditional heart attacks. In SCAD a tear happens within the blood vessels causing partial or full blockage. The population affected by SCAD is hugely different to the population affected by other 'traditional' heart attacks; as SCAD mainly happens in otherwise healthy women. From historical cases, SCAD has been associated with strenuous exercise, however, medical research did not find a link. The recovery after SCAD is also very different from other 'traditional' heart attacks. Cardiac rehab programmes are designed for an older population therefore they may not be suitable for a younger predominantly female population. This study will examine if a remote-exercise programme is achievable in people after a SCAD event.",[27],[85,86,87,88,89],"Sponaneous coronary artery dissection","Exercise","Randomised controlled trial","Rehabilitaiton","Fesability","2026-05-11",{"date":92,"type":37},"2026-05-14",{"date":94,"type":37},"2025-05-01",{"date":96,"type":22},"2027-12-31",{"name":98,"class":44},"University of Leicester",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":120,"leadSponsor":122,"locationsCount":45},"100633669","survey-on-physical-activity-and-qualify-of-life-in-fibromuscular-dysplasia-100633669","NCT07529691","Survey on Physical Activity and Qualify of Life in Fibromuscular Dysplasia","National Survey of Physical Activity Restrictions and Quality of Life Among Patients With Fibromuscular Dysplasia","Inclusion criteria:\n\n* Participants with a diagnosis of fibromuscular dysplasia\n* Age range = 18-100 years\n\nExclusion Criteria:\n\n* Subjects who have an inability to complete the electronic consent form or electronic survey for any reason\n* Subjects who are non-English speaking who cannot read the electronic consent form or electronic survey","100 Years",{"count":108,"type":22},2000,"Fibromuscular dysplasia (FMD) is a disease of the arteries that is not due to plaque build-up or inflammation. While some patients with FMD are health, some may experience heart attacks, strokes, aneurysms or blood vessel dissection\u002Ftearing which can be life-threatening. It predominantly impacts women and younger patients. As a result of this diagnosis, many patients are counseled to restrict or avoid certain physical activities out of concern for provoking or worsening vascular complications. There are no guidelines or consensus recommendations regarding appropriate physical activity for patients with FMD. The lack of consensus may lead to confusion for patients and may negatively impact their quality of life. This study will conduct a large, national survey of patients with FMD to assess the type of physical activity restrictions and impact on quality of life and emotional well-being.",[111,26,27],"Fibromuscular Dysplasia of Arteries",[113,31,114,86,115],"FMD","SCAD","Quality of life","2026-04-14",{"date":118,"type":37},"2026-04-20",{"date":116,"type":37},{"date":121,"type":22},"2027-06-30",{"name":123,"class":44},"Vanderbilt University Medical Center",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":130,"targetDuration":131,"studyType":23,"phases":4,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":142,"locationsCount":45},"100165474","genetic-investigations-in-spontaneous-coronary-artery-dissection-scad-100165474","NCT01427179","Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)","Inclusion Criteria:\n\n* Men and women able to give informed consent and complete a 2 page questionnaire\n* Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD)\n* Biological parent of individual with SCAD\n* Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection\n\nExclusion Criteria:\n\n* Lack of confirmation of SCAD diagnosis",{"count":108,"type":22},"15 Years","The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.\n\nSome mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.",[27,114],[135,114],"Spontaneous coronary artery dissection","2026-04-10",{"date":138,"type":37},"2026-04-15",{"date":140,"type":4},"2011-05",{"date":41,"type":22},{"name":70,"class":44},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":18,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":56,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":45},"100633444","a-study-of-exercise-in-patients-with-spontaneous-coronary-artery-dissection-and-fibromuscular-dysplasia-100633444","NCT07526766","A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia","Cardiopulmonary, Hemodynamic, And Symptom Responses To Aerobic And Resistance Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia: A Single-center, Single-arm Prospective Clinical Trial.","Inclusion criteria:\n\n* History of Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain.\n* Able to provide written informed consent\n\nExclusion criteria:\n\n* Individuals who are clinically obese (BMI ≥36) and\u002For who suffer from musculoskeletal or other conditions that would limit exercise participation.\n* Individuals who are deemed medically unstable\n* Participants who are unable to comply with study requirements.\n* Pregnancy","21 Years","65 Years",{"count":153,"type":22},28,[58],"The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD).",[26,27],"2026-04-06",{"date":159,"type":37},"2026-04-13",{"date":161,"type":22},"2026-04-01",{"date":163,"type":22},"2027-07-01",{"name":70,"class":44},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":114,"eligibilityCriteria":170,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":173,"conditions":174,"keywords":175,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":45},"100165668","the-virtual-multicenter-spontaneous-coronary-artery-dissection-scad-registry-100165668","NCT01429727","The \"Virtual\" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry","Inclusion Criteria:\n\n* Individuals who have been cared for at Mayo Clinic with a diagnosis of SCAD\n* SCAD in women who are pregnant or within 12 months postpartum at the time of SCAD\n* SCAD in individuals who self-identify as a member of a racial or ethnic group that is currently underrepresented in the registry. This would include anyone who identifies as: Black\u002FAfrican American, Asian, American Indian or Alaska Native, Native Hawaiian or Other Pacific Islander, and any race with Hispanic ethnicity\n* SCAD in a man\n* SCAD in persons younger than 30 years of age\n* SCAD within the past 2 weeks (acute)\n* SCAD patient enrolling into any other Mayo Clinic SCAD Research Study\n* SCAD in individuals who have a relative that has had a SCAD event\n\nPersons with history of SCAD who are interested in participating in the study but do not meet the updated inclusion criteria will not be enrolled at this time. However, they will be given the option to share their contact information in order to be invited to future Mayo Clinic SCAD studies.",{"count":172,"type":22},2500,"The primary goal of this project is to describe the clinical and physiologic characteristics of Spontaneous Coronary Artery Dissections (SCAD) in order to increase awareness, understanding, treatment and prevention of a potentially fatal cardiovascular event.\n\nThis study will be a retrospective and prospective review of medical course and current health of men and women with SCAD.",[27,114],[135,114,176,177,178],"coronary artery disease","myocardial infarction","coronary dissection","2026-01-21",{"date":181,"type":37},"2026-01-23",{"date":183,"type":4},"2011-07",{"date":41,"type":22},{"name":70,"class":44},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":45},"100606665","a-study-of-scad-using-stress-contrast-echocardiography-100606665","NCT07178509","A Study of SCAD Using Stress Contrast Echocardiography","Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography","Inclusion Criteria:\n\n* Adult \\>18 years old\n* Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history\n\nExclusion Criteria:\n\n* Unable to give consent\n* Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.\n* Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.\n* Pregnant.\n* Unable to interrupt breastfeeding.\n* Within 3 months of a heart attack.\n* Severe aortic stenosis.\n* Severe, uncontrolled hypertension (\\>200\u002F110 mmHg at baseline).",{"count":55,"type":22},"This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.",[27],"2026-01-06",{"date":198,"type":37},"2026-01-07",{"date":200,"type":37},"2025-11-25",{"date":202,"type":22},"2027-09",{"name":70,"class":44},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":114,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":211,"targetDuration":213,"studyType":23,"phases":4,"briefSummary":214,"conditions":215,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":226},"100562292","scad--a-registry-of-spontaneous-coronary-artery-dissection-100562292","NCT06601270","SCAD : a Registry of Spontaneous Coronary Artery Dissection","A Registry of Spontaneous Coronary Artery Dissection","Inclusion Criteria:\n\n* Patient having signed an Informed Consent\n* Patient aged 18 years and over\n* SCAD clinical diagnosis within the past 10 years and available coronary angiographic imagery\n\nExclusion Criteria:\n\n* Patient unwilling or unable to consent\n* Patients with iatrogenic or atherosclerotic coronary dissection",{"count":212,"type":22},1500,"5 Years","Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes (ACS), predominantly afflicting young women without conventional atherosclerotic risk factors. Knowledge of SCAD has advanced considerably in the last few years as a result of data from a number of local and national registries 1-6. Like all rarer diseases however, a better understanding of SCAD will require international collaboration. At present, there is no European or International SCAD registry despite increasing recognition that there are key differences in the diagnosis, interventional and medical management of SCAD compared with conventional atherosclerotic ACS. The ESC-ACCA Study Group on Spontaneous Coronary Artery Dissection supported by the European Observational Research Programme will now build the first pan-European SCAD registry to advance our understanding of current management of this condition, inform guidelines, educate clinical colleagues and advance research.",[27],"2024-10-28",{"date":218,"type":37},"2024-10-29",{"date":220,"type":37},"2021-01-30",{"date":222,"type":22},"2027-10",{"name":224,"class":225},"European Society of Cardiology","NETWORK",73,{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":235,"targetDuration":213,"studyType":23,"phases":4,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":45},"100397624","spontaneous-coronary-artery-dissection-national-swiss-registry-100397624","NCT04457544","Spontaneous Coronary Artery Dissection National Swiss Registry","Spontaneous Coronary Artery Dissection (SCAD) National Swiss Registry (SwissSCAD)","SwissSCAD","Inclusion Criteria:\n\n* Subject is ≥18 years of age.\n* Patient presenting newly diagnosed SCAD or diagnosed with SCAD within the last 5 years.\n* Subject must be willing to sign a Patient Informed Consent (PIC).\n\nExclusion Criteria:\n\n* Patient unwilling or unable to provide informed consent.\n* Patients with atherosclerotic or iatrogenic coronary dissection.",{"count":236,"type":22},1000,"Spontaneous coronary artery dissection (SCAD), is an underdiagnosed pathology, affecting predominantly young women without traditional cardiovascular risk factors and is associated with major adverse outcomes including myocardial infarction, cardiac arrest, or death.\n\nTimely diagnosis of SCAD as well as clinical follow-up are of the essence in this pathology associated with major cardiac adverse outcomes. Despite recent improvements in diagnosis and recognition of the importance of SCAD, it remains poorly studied and understood.\n\nIn this context, we designed the SwissSCAD registry, a large, observational, prospective, cohort study, to describe the natural history of SCAD, its outcomes and its treatments.",[27],"2022-11-13",{"date":241,"type":37},"2022-11-16",{"date":243,"type":37},"2020-08-12",{"date":245,"type":22},"2030-06-30",{"name":247,"class":44},"Dr. Sophie Degrauwe",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":257,"conditions":258,"keywords":259,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":45},"100432072","canadian-scad-study-100432072","NCT04906356","Canadian SCAD Study","Canadian Spontaneous Coronary Artery Dissection (SCAD) Study and Genetic Sub-study (Prospective, Observational Registry With 10 Year Follow-up)","Inclusion Criteria:\n\n1. Patients admitted with ACS (STEMI, NSTEMI or unstable angina)\n2. Documented SCAD on a coronary angiogram (including diagnosis with OCT or IVUS)\n\nExclusion Criteria:\n\n1\\. Patients where SCAD is attributed to atherosclerotic coronary artery disease, with atherosclerotic coronary artery disease stenosis ≥50%",{"count":256,"type":22},3000,"Natural history multicenter, prospective, observational registry with 10-year follow-up",[27,114,26],[260,261,262,263,264,114,27],"Fibromuscular displasia (FMD)","Myocardial Infarction","Myocardial Infarction in women","Non-atherosclerotic coronary artery disease (NACAD)","Myocardial Infarction with no obstructive coronary artery disease (MINOCA)","2021-05-25",{"date":267,"type":37},"2021-05-28",{"date":269,"type":37},"2018-12-01",{"date":271,"type":22},"2033-12-01",{"name":273,"class":44},"Cardiology Research UBC",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":56,"phases":284,"briefSummary":286,"conditions":287,"keywords":288,"overallStatus":295,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":4},"100427777","phase-4-randomized-study-of-beta-blockers-and-antiplatelets-in-patients-with-spontaneous-coronary-artery-dissection-100427777","NCT04850417","Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection","Randomized Clinical Trial Assessing the Value of Beta-Blockers and Antiplatelet Agents in Patients With Spontaneous Coronary Artery Dissection. (The BA-SCAD Randomized Clinical Trial)","BA-SCAD","Inclusion Criteria:\n\n* Angiographic diagnosis of SCAD\n* Admission for ACS or other manifestations of ischemia\n* Informed consent\n\nExclusion Criteria:\n\n* Cardiogenic shock or severe hemoynamic instability\n* Concomitant severe heart disease requiring surgical correction (in \\\u003C2 years)\n* Medical condition seriously limiting life expectancy (\\\u003C 2 years)\n* Allergies or contraindication to drugs required in one of the study arms; the patient may be randomized in the other arm (factorial design)","90 Years",{"count":21,"type":22},[285],"PHASE4","Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome (ACS). Most patients are treated with beta-blockers (BB) and antiplatelet drugs (AP) on empiric basis. The Beta-Blockers and Antiplatelet Agents in Patients with Spontaneous Coronary Artery Dissection (BA-SCAD) randomized clinical trial is an academic, pragmatic, nation-wide, prospective study developed under the auspices of the Spanish Society of Cardiology (SEC) that aims to assess the efficacy of medical therapy in SCAD patients. Using a factorial 2x2 design, patients will be randomized (1:1\u002F1:1) to: 1) BB (yes\u002Fno) and 2) short AP regimen (1 month) vs prolonged dual AP therapy (DAPT) (12 months).Only patients with preserved left ventricular ejection fraction (LVEF) will be randomized to BB (yes\u002Fno) because patients with LVEF \\\u003C40% will receive BB according to current guidelines. Likewise, only medically managed patients will be randomized to short AP therapy vs 1-year DAPT. The study will have a pragmatic, open label, blind outcomes design (PROBE). A total of 600 SCAD patients will be randomized within 2 years (300 per arm in a factorial 2x2 design). The primary efficacy endpoint will include the composite of death, acute myocardial infarction (MI), stroke, coronary revascularization, recurrent SCAD, and unplanned hospitalization for ACS or heart failure at 1 year. The primary safety endpoint will be bleeding. All patients will be clinically followed yearly. The main study will be pragmatic but a comprehensive set of additional studies (clinical, imaging, biomarkers, inflammatory, immunologic, pharmacogenetic and genetic) will be organized to ensure an holistic view on this challenging condition.",[27],[135,289,290,291,292,293,294],"Beta-blockers","Antiplatelets","Coronary angiography","Intracoronary imaging","Biomarkers","Myocardial infarction","NOT_YET_RECRUITING","2021-04-14",{"date":298,"type":37},"2021-04-20",{"date":300,"type":22},"2021-04-30",{"date":302,"type":22},"2028-12-31",{"name":304,"class":44},"Spanish Society of Cardiology"]