[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"spontaneous-intracranial-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:spontaneous-intracranial-hypotension":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,66,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642218","cvfs-in-sih-eid-vs-pcd-ctm-100642218",false,"NCT07582744","CVFs in SIH: EID vs. PCD CTM","CSF-Venous Fistula Detection in Spontaneous Intracranial Hypotension: Comparative Diagnostic Yields of Energy Integrating Detector Versus Photon Counting Detector CT Myelography","Inclusion Criteria:\n\n1. Adult patient,\n2. Confirmed diagnosis of SIH using International Classification of Headache Disorders criteria (third edition), and\n3. Brain MRI demonstrating at least one positive imaging finding for SIH (e.g., dural enhancement, venous sinus distention, brain sagging, pituitary engorgement, spontaneous subdural fluid collections).\n\nExclusion Criteria:\n\n1. Prior treatment of a CVF,\n2. Inability to undergo both exams (EID-CTM and PCD-CTM) if needed for diagnosis,\n3. Spine MRI demonstrating extradural CSF (confirming CSF leak type other than CVF), and\n4. inability to provide informed consent.","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research study is to compare two types of Computed Tomography Myelography (CTM) scans, one on the photon counting detector scanner (called PCD-CTM) and the other on the energy integrating detector scanner (called EID-CTM); both of which doctors usually use to diagnose abnormal connections between the cerebrospinal fluid and the venous system, or CSF-venous fistulas. This study will help to see if the newer PCD-CTM scan can find more spinal fluid leaks \\[CSF-venous fistulas (CVF)\\] than the scan that is normally used (EID-CTM).",[26],"Spontaneous Intracranial Hypotension",[28,29,30],"CSF-venous fistula","Photon counting detector CT myelography","Energy integrating detector myelography","RECRUITING","2026-06-11",{"date":34,"type":35},"2026-06-15","ACTUAL",{"date":37,"type":35},"2026-05-21",{"date":39,"type":20},"2028-08",{"name":41,"class":42},"Duke University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100639311","autologous-platelet-rich-plasma-versus-whole-blood-for-epidural-patch-in-spontaneous-intracranial-hypotension-100639311","NCT07602556","Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension","Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension: A Multi-center, Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Informed consent to participate the research obtained from the patient\n* Satisfies the criteria for SIH according to the International Classification of Headache Disorders.\n\nExclusion Criteria:\n\n* There was concern for other causes of intracranial hypotension, such as postdural puncture, postsurgical and post-traumatic CSF leaks\n* Prior treatment with EBP at any time previously\n* Any contraindication to epidural puncture, such as space-occupying intracranial or intraspinal lesions, spinal defect, suspected infection over the puncture site, bleeding disorder and current anticoagulation therapy\n* History of drug and alcohol abuse, cognitive dysfunction, or mental illness\n* Unable to cooperate with postoperative evaluation, treatment, rehabilitation, and follow-up visits",{"count":52,"type":20},218,[23],"Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF). Epidural patch with autologous platelet-rich plasma (PRP), which contains numerous growth factors and cytokines, has been reported as a new and promising alternative for current standard whole blood patching. However, there is no study comparing the efficacy and safety of the two approaches. In this study, we aimed to provide data concerning the outcomes of PRP patching versus conventional whole blood patching for treatment of refractory SIH cases failing in conservative therapy.",[26],"NOT_YET_RECRUITING","2026-05-22",{"date":59,"type":35},"2026-05-27",{"date":61,"type":20},"2026-05",{"date":63,"type":20},"2029-03",{"name":65,"class":42},"Beijing Tiantan Hospital",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":75,"phases":4,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":43},"100544871","greater-occipital-nerve-block-for-spontaneous-intracranial-hypotension-100544871","NCT06374524","Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension","Role of Greater Occipital Nerve Block in Headache From Spontaneous Intracranial Hypotension: a Prospective Observational Study","Inclusion criteria\n\n1. Adults of \\> 18 years of age\n2. Diagnosis of SIH, according to the International Classification of Headache Disorder (ICHD-3) classification (2)\n3. Characteristics of pain:\n\n   1. Baseline pain intensity NRS \\> 4\u002F10 (in upright position)\n\nExclusion criteria\n\n1. Contraindications to GONB: ongoing infection (systemic or located at the site of injection), intake of anticoagulants (not aspirin), allergy to injectate, contra-indication to injectate of steroids\n2. Any significant cognitive or language barrier that impedes participation\n3. Patients taking opioid medications with daily Oral Morphine Equivalent (OME) of 50 mg or higher\n4. Patient refusal",{"count":74,"type":20},34,"OBSERVATIONAL","Spontaneous Intracranial Hypotension (SIH) is a debilitating neurological disorder caused by a cerebrospinal fluid leak (CSF), with an estimated incidence of 5 per 100,000 persons per year, of which mostly women between the ages of 35 years and 55 years. The typical presentation is moderate-to-severe orthostatic headache and several other possible neurological symptoms, that significantly impact patients' quality of life.\n\nTreatment of SIH usually starts with conservative measures, consisting of strict supine bed rest, hydration, caffeine, and simple analgesics. The vast majority of patients will require invasive treatments for their CSF leak, such as epidural blood patches, fibrin glue patches, endovascular coiling, and\u002For surgical repair. These specialized treatments are only offered in tertiary care centers and require specialized personnel and resources, which implicates a certain waiting time for the patients before permanent treatment is offered. In the meantime, due to the lack of an effective and accessible alternative, patients continue to suffer.\n\nThe greater occipital nerve block (GONB) has been reported as a simple, safe, and effective treatment to provide short-to-intermediate term relief of migraine, cervicogenic headache, cluster headache, occipital neuralgia, and more recently, post-dural puncture headaches (PDPH). As the pathophysiology of intracranial hypotension caused by SIH or PDPH is very similar, it is stipulated that the effect of GONB will be similar for SIH patients. However, to date, no studies exploring the efficacy of GONB for SIH have been performed.\n\nThe investigators propose to do a prospective observational study to explore the outcome of GONB for SIH. GONB can serve as a bridge therapy to control the debilitating headache of SIH while patients are awaiting permanent SIH treatment. Moreover, GONB can be performed by physicians of different specialties including neurology, which makes it an accessible treatment for all patients. Lastly, by offering better symptom control, this intervention could potentially restore patients' ability to work and reduce healthcare costs.",[26],"2026-01-14",{"date":80,"type":35},"2026-01-16",{"date":82,"type":35},"2024-08-01",{"date":84,"type":20},"2027-12-31",{"name":86,"class":42},"University Health Network, Toronto",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":95,"studyType":75,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":43},"100510136","a-clinical-registry-of-spontaneous-intracranial-hypotension-100510136","NCT05922514","A Clinical Registry of Spontaneous Intracranial Hypotension","Spontaneous Intracranial Hypotension Registry","Inclusion Criteria:\n\n* Study subjects will be patients who meet the International Classification of Headache - Disorders 3rd Edition (ICHD-3) criteria for a diagnosis of SIH or the Schievink criteria with imaging confirmed CSF-venous fistulas on DSM or CTM.\n* Availability of a clinically prescribed contrast enhanced MRI positive for SIH.\n* Negative urine or serum pregnancy test at time of study consent and three-months.\n\nExclusion Criteria:\n\n* Patients who have a contraindication or inability to undergo the procedure (i.e., severe contrast allergy).\n* Inability to provide informed consent.\n* Expected inability to complete the follow-up assessment.\n* Current pregnancy or breast-feeding during study enrollment (from consent to study conclusion approximately 90-days).",{"count":19,"type":20},"6 Months","The purpose of this research is to determine the efficacy of paraspinal vein embolization for treatment of digital subtraction myelography (DSM) or CT myelography (CTM) confirmed cerebrospinal fluid (CSF)-venous fistulas so that researchers can inform the development and design of future clinical trials of this technique.",[26],"2025-11-25",{"date":100,"type":35},"2025-12-03",{"date":102,"type":35},"2023-06-18",{"date":104,"type":20},"2026-07",{"name":106,"class":42},"Mayo Clinic"]