[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sport-recovery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sport-recovery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100569745","the-effects-of-cold-water-immersion-on-exercise-performance-recovery-and-postprandial-plasma-aminoacidemia-100569745",false,"NCT06698237","The Effects of Cold-water Immersion on Exercise Performance Recovery and Postprandial Plasma Aminoacidemia","The Effects of Delayed Versus Immediate Cold-water Immersion on Exercise Performance Recovery and Postprandial Plasma Aminoacidemia Following Exercise and Protein Consumption in Athletes","Inclusion Criteria\n\nTo be eligible to participate in this study, a participant must meet all the following criteria:\n\n1. Healthy adult between 18 - 40 years (inclusive).\n2. Individual with a BMI between \\>18.5 and \\\u003C30 kg\u002Fm2 (inclusive).\n3. Individual who is in good general health (no uncontrolled diseases or conditions).\n4. individual with a history of regular resistance training ≥2 per week for the past six-months.\n5. Individual who is currently competing at the varsity, provincial, national or international level in their respective sport.\n6. Individual who is free from any musculoskeletal injuries and\u002For conditions that might affect their ability to perform resistance exercises or undergo cold-water immersion.\n7. Individual who has maintained stable use of medication and\u002For supplements, stable dietary and lifestyle habits, and stable body weight (weight loss or gain \\\u003C3 kg), for the last three-months prior to screening.\n8. Individual who agrees to maintain usual training habits between sessions.\n\nExclusion Criteria\n\n1. Individual who is lactating, pregnant or planning to become pregnant during the study.\n2. Females with irregular menstrual cycles (defined as outside 24-38 days cycle range, based on self-reports).\n3. Individual who adheres to a diet (e.g., vegan diet) that restricts consumption of dairy products.\n4. Has a known sensitivity, intolerability, or allergy to any of the study products or their excipients (i.e., lactose intolerant).\n5. Weight loss or gain \\> 3 kg in the 3 months prior to study visit 1.\n6. Currently or planning to be on a weight loss regimen during the study.\n7. Recent (within 2 weeks of screening visit) history of an episode of acute GI illness such as nausea\u002Fvomiting or diarrhea.\n8. Have a history of irritable bowel disease (IBS), inflammatory bowel disease (IBD, including ulcerative colitis and Crohn's disease), functional constipation or diarrhea (defined by the Rome IV diagnostic criteria), celiac disease, malabsorption, gastroparesis, diverticulosis, gastric or duodenal ulcers, pancreatitis, or eating disorder; or have a history of intestinal surgery (excluding appendectomy or herniorrhaphy) or bariatric surgery.\n9. Have an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and\u002For digestion (e.g., history of bowel obstruction).\n10. Participated in upper gastrointestinal endoscopy and\u002For colonoscopy or preparation within 3 months prior to screening visit.\n11. Diagnosed with hypercholesterolemia or hypertriglyceridemia (i.e., elevated fasting low- density lipoprotein (LDL) (≥ 135 mg·dL-1; ≥ 3.5 mmol·L-1) or elevated triglycerides (≥ 150 mg·dL-1; ≥1.7 mmol·L-1).\n12. Has a history of heart disease\u002Fcardiovascular disease, uncontrolled hypertension (≥ 140 systolic or ≥ 90 diastolic mmHg), kidney disease (dialysis or renal failure), hepatic impairment or disease.\n13. Is Type I or Type II diabetic or pre-diabetic \\[i.e., elevated fasting blood glucose levels (≥ 100 mg·dL-1; ≥ 5.6 mmol·L-1) and\u002For elevated hemoglobin A1c (≥ 6.0%)\\].\n14. Has a history of liver or gallbladder disease or stomach ulcers.\n15. Has a positive medical history of unstable thyroid disease, previously diagnosed major affective disorder, psychiatric disorder that required hospitalization in the prior year, immune disorders and\u002For immunocompromised (e.g., HIV\u002FAIDS).\n16. Diagnosed with cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to the screening visit, or any clinically significant disease or disorder which, in the opinion of the investigator, may either put the potential participant at risk because of participation in the study, or influences the results or the potential participant's ability to participate in the study.\n17. Major surgery in 3 months prior to screening or planned major surgery during the study.\n18. History of alcohol or substance abuse (including cannabinoids) in the 12 months prior to screening (including having been hospitalized for such in an in-patient or out-patient intervention program).\n19. Current or previous tobacco use within the last 6 months.\n20. Self-report of blood donation totaling between 101 mL to 449 mL of blood within 30 days prior to screening or a blood donation of more than 450 mL within 56 days prior to baseline.\n21. Self-report of donating plasma (e.g., plasmapheresis) within 14 days prior to screening.\n22. Any other active or unstable medical conditions or use of medications\u002Fsupplements\u002Ftherapies that, in the opinion of the investigator, may adversely affect the participant's ability to complete the study or its measures or pose a significant risk to the participant.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","In order to optimize sports performance, high-level athletes are required to manage conflicting training objectives, which often result in periods of high-volume training. These athletes need to perform heavy resistance training sessions to promote physiological adaptations, which consequently induce fatigue. Yet, they need to minimize fatigue to perform subsequent high-quality training sessions often within the same day. To support these training endeavours, a high-quality dietary regimen and adequate protein consumption is deemed to be an essential component of an athlete's recovery plan, as it has been shown to support muscle recovery and reduce muscle inflammation following exercise. Indeed, current sports nutrition recommendations advocate for the consumption of dietary protein and carbohydrate after exercise to promote tissue repair and replenish muscle energy stores (glycogen). Additionally, previous research has shown how water immersion therapies post-exercise may alleviate fatigue and restore performance. However, little is known about how different temperatures, as well as timing of cold-water immersion can support performance recovery in a population of athletes adhering to contemporary post-exercise nutrition recommendations. The objective of this project is to investigate the effects of timing of cold-water immersion relative to exercise on performance recovery within the same day, as well as to investigate whether cold water immersion augments blood amino acid concentrations after exercise and protein intake.",[28,29,30],"Sport Recovery","Aminoacidemia","Cold-water Immersion",[32,33,34,35,36,37,38,39,40,29,41,42],"Cold-water immersion","Protein","Performance","Athlete","Exercise physiology","Nutrition","Exercise","Resistance training","Sport recovery","cold-therapy","strength training","RECRUITING","2026-04-07",{"date":46,"type":47},"2026-04-09","ACTUAL",{"date":49,"type":47},"2024-12-20",{"date":51,"type":22},"2026-09-01",{"name":53,"class":54},"McGill University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":55},"100615152","effects-of-pulsed-electromagnetic-field-therapy-on-sport-performance-and-recovery-100615152","NCT07288892","Effects of Pulsed Electromagnetic Field Therapy on Sport Performance and Recovery","Inclusion Criteria:\n\n* Exercise at least twice a week in the past 3 months\n* Perform resistance training 1-3 times per week in the past 3 months.\n* Have competed in at least two matches \u002F events in the past one year (e.g. heat and final are counted as two events).\n\nExclusion Criteria:\n\n* History of fracture or surgery over the past year.\n* History of musculoskeletal injury in the last 3 months that required more than 7 days of rest.\n* Currently experiencing any injury, discomfort and\u002For pain at the time of study.","30 Years",{"count":64,"type":22},30,[25],"The goal of this clinical trial is to learn if pulsed electromagnetic field (PEMF) therapy works to improve sports performance and recovery in athletes. The main questions it aims to answer are:\n\n* Does PEMF therapy enhance participants' performance during exercise?\n* Does PEMF therapy enhance recovery in participants after exercise? Researchers will compare active PEMF therapy to sham PEMF therapy (using the same device for both, but without any electromagnetic fields) to see if active PEMF therapy is effective in improving sports performance and recovery.\n\nParticipants will:\n\n* Receive active pulsed electromagnetic field therapy or sham pulsed electromagnetic field therapy twice a week for 8 weeks.\n* Visit the laboratory at baseline, 8 weeks, and 12 weeks for sports performance and recovery assessments.",[68,28,35],"Sport Performance",[70,71,34,72,38],"PEMF","Sport","Recovery","2026-04-06",{"date":75,"type":47},"2026-04-08",{"date":77,"type":47},"2026-01-19",{"date":79,"type":22},"2026-08-30",{"name":81,"class":54},"Nanyang Technological University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":55},"100603009","molecular-hydrogen-inhalation-effects-on-health-exercise-capacity-and-inflammatory-response---in-vivoin-vitro-studies-100603009","NCT07130942","Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo\u002Fin Vitro Studies","The Effect of Inhalation Using a Molecular Hydrogen Generator on the Level of Exercise Capacity and Inflammatory Response, Anti-cancer Potential of Human Blood Serum in the Light of in Vivo\u002Fin Vitro Studies","Inclusion Criteria:\n\nThe study will be used purposeful selection of the following criteria:\n\n* age 18-25,\n* not taking medicines during the study,\n* negative history of cardiovascular disorders,\n* negative history of autonomic nervous system disorders,\n* negative history of mental disorders,\n* negative history of cerebrospinal traumas,\n* negative history of other diseases that may directly affect obtained results,\n* good health status (no concurrent injuries),\n* no drugs intake,\n* no supplements consumption,\n\nIn the study as a not training grope age and morphologically appropriate participation will take part. Participants will be recruited basing on a voluntary letter of intent. All representatives of the analysed group participating in the pre-qualification research will fill in the physical activity sheet - Global Health Activity Questionnaire - World Health Organization in Polish adaptation. This will allow to eliminate people who report high levels of physical activity (similar to the level of sport training individuals).\n\nExclusion Criteria:\n\n* taking medicines during the study,\n* history of cardiovascular disorders,\n* history of autonomic nervous system disorders,\n* history of mental disorders,\n* history of cerebrospinal traumas,\n* history of other diseases that may directly affect obtained results,\n* concurrent injuries,\n* drugs intake,\n* supplements consumption.","49 Years",{"count":91,"type":22},250,[25],"Summary To comprehensively address the research aims and explore the state of knowledge of the mechanisms of biochemical response to specific tissue affecting method in form of a molecular hydrogen inhalation and will allow to determine its role on the post-exercise response in form of changes in biochemical markers secretion, expression of selected trophic factors and changes in iron metabolism in this process.\n\nMoreover, this project will try to take into account the role of hepcidin, vitamin D and cfDNA. Additionally, the present project may contribute to the determination of the role of presented inhalation procedure on cells proliferation, as example of anty-tumor proprieties, regulation of the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway), muscle cell growth (e.g. myostatin gene), energy pathways (e.g. GAPDH, LDH) and the membrane transport and the hedgehog pathway ls (including Gli1), Hif-1-alpha and NF-kB.\n\n1.1. Primary Objectives\n\n1. Demonstration relationship between post-exercise oxidative stress parameters, and two weeks of daily inhalation with the use of a molecular hydrogen generator.\n2. Indicate of whether and how daily inhalation with the use of a molecular hydrogen generator will affect BDNF and hepcidin, erytropheron (ERFE) and erythropoietin (EPO).\n3. Show how daily inhalation with the use of a molecular hydrogen generator and physical activity procedures effects human serum anti-tumor potential, and is it associated with Vitamin D status and Iron metabolism.\n\n1.2. Secondary Objectives\n\n1. Examine the relationship between two weeks of daily inhalation using a molecular hydrogen generator and the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway).\n2. Show the relationship between the expression of genes related to muscle cell growth (e.g. myostatin gene), intracellular metabolism, energy pathways (e.g. GAPDH, LDH) and the effect of molecular hydrogen inhalation?\n3. Show the molecular hydrogen inhalation effects on the expression of genes responsible for membrane transport and the hedgehog pathway in muscle cells (including Gli1), expression of transcription factors: Hif-1-alpha (hypoxia-inducible factor) and NF-kB and selected genes dependent on their activity.\n\n1.3. Hypotheses\n\nIn the project on the basis of current knowledge, the following hypotheses are stated:\n\n1. Daily inhalation with the use of a molecular hydrogen will increase the concentration of BDNF, which will correlate with higher skeletal muscle resistance to damage;\n2. Two week daily inhalation with the molecular hydrogen will increase the concentration of BDNF, which will persist over a longer period compering to a single inhalation with the molecular hydrogen session;\n3. Daily inhalation with the molecular hydrogen and physical activity effects on vitamin D binding protein, megalin, cubilin concentration changes.\n4. Daily inhalation with the molecular hydrogen protects muscles and reduces oxidative stress induced by physical exercise and protects against oxidative stress induced by high Iron concentration (lower inflammation process and cfDNA concentration).\n5. Daily inhalation with the molecular hydrogen effects human serum anti-tumor potential against human LNCaP prostate cancer cells.\n\nIII. Research project methodology In order to achieve the objectives of the study 80 people will be recruited, then randomly divided into two groups: Experimental ((N=40) and Control (N=40). Furthermore, groups will be divided into subgroups to implement the assumptions of one-time and 10-time inhalation with the use of a molecular hydrogen generator on the level of induced muscle damage and the level of maximum anaerobic and aerobic capacity. The whole study will be carried out using the assumptions of the experiment - a blind test (inhalation with normal air but under the use of H2 generator (switched of), and in accordance with the principles of the experiment.\n\nIn the study an experiment based on an ex post facto research plan will be used, due to the lack of manipulation of the grouping variable. Study will be based on comparative analysis and regression analysis. In the independent variable test, the group (non-trainees), variables dependent on molecular hydrogen inhalation and the anaerobic\u002Faerobic performance characteristics, biochemical blood indicators. Minimal (40 people each) sample size was calculated according to Kirby et all (2002) and Kadam and Bhalerao (2010).\n\nIV. The study will consist of twelve parts. For anaerobic power of the lower limbs measurement of double Wingate anaerobic test (WAnT) will be conducted on a cycle ergometer,\n\n* For the measurement of Aerobic Components of Fitness and post-aerobic exercises response Bruce Treadmill Test will be performed.\n* The blood collection for diagnostic tests will be strictly dependent on the requirements of a particular designation,",[95,68,96,97,28],"Physiological Adaptations","Aerobic Capacity","Anaerobic Power",[99,100,101,102,103],"molecular hydrogen","anti-cancer potential","inflammatory response","exercise capacity","inhalation","NOT_YET_RECRUITING","2025-08-18",{"date":107,"type":47},"2025-08-19",{"date":109,"type":22},"2025-10-01",{"date":111,"type":22},"2030-12-31",{"name":113,"class":54},"Gdansk University of Physical Education and Sport"]