[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"st-segment-elevation-myocardial-infarction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:st-segment-elevation-myocardial-infarction":58},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100346209","ischemic-postconditioning-in-stemi-patients-treated-with-primary-pci-100346209",false,"NCT03787745","Ischemic Postconditioning in STEMI Patients Treated With Primary PCI","The Effect of Ischemic Postconditioning in Patients With STEMI Undergoing Primary PCI (DANAMI4-iPOST2)","iPOST2","Inclusion Criteria:\n\n* Age ≥18 years\n* Acute onset of chest pain with \\\u003C 12 hours duration\n* STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.\n* TIMI flow 0-1 in infarct related artery\n\nExclusion Criteria:\n\n* Potential pregnancy\n* Refusal to participate\n* OHCA without subsequent consciousness despite ROSC\n* Thrombectomy considered unavoidable","ALL","18 Years",{"count":20,"type":21},1800,"ESTIMATED","INTERVENTIONAL",[24],"NA","In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI patients who present with TIMI0-1 undergoing primary PCI",[27],"ST Segment Elevation Myocardial Infarction",[29,30,31],"Primary PCI","Ischemic postconditioning","Clinical outcome","RECRUITING","2026-03-24",{"date":35,"type":36},"2026-03-30","ACTUAL",{"date":38,"type":36},"2019-02-04",{"date":40,"type":21},"2033-01-31",{"name":42,"class":43},"Rigshospitalet, Denmark","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100566382","the-thrombus-aspiration-during-pci-after-thrombolysis-in-stemi-100566382","NCT06654453","The Thrombus Aspiration During PCI After Thrombolysis in STEMI","The Thrombus Aspiration During Percutaneous Coronary Intervention After Thrombolysis in ST-elevation Myocardial Infarction","Optimal","Inclusion Criteria:\n\n1. Diagnosed with STEMI.\n2. No contraindications for thrombolysis and has received thrombolytic treatment.\n3. Undergoing coronary angiography within 2 to 24 hours post-thrombolysis.\n4. Angiographic results confirm TIMI thrombus load ≥ 4 and residual stenosis \\> 50%.\n\nExclusion Criteria:\n\n1. Contraindications for thrombolysis.\n2. Cardiogenic shock.\n3. Need for coronary artery bypass grafting.\n4. Age less than 18 years.\n5. Life expectancy of less than 6 months.\n6. Unable to provide informed consent.",{"count":54,"type":21},3500,[24],"The goal of this clinical trial is to determine whether thrombus aspiration combined with percutaneous coronary intervention (PCI) improves clinical outcomes in ST-segment elevation myocardial infarction (STEMI) patients with high thrombus burden post-thrombolysis, compared to PCI alone. The study population includes 3500 STEMI patients, confirmed by diagnosis, who are transferred to PCI centers after receiving thrombolysis and have no contraindications to thrombolysis.The main questions it aims to answer are:\n\n1. Does thrombus aspiration reduce 30-day major adverse cardiovascular events (MACE), including cardiovascular death, recurrent myocardial infarction, stroke, or heart failure rehospitalization?\n2. Can thrombus aspiration improve microcirculation and clinical outcomes for high thrombus burden patients after thrombolysis? Researchers will compare patients randomly assigned to receive thrombus aspiration combined with PCI versus those who receive PCI alone to evaluate the effects on reducing MACE and improving clinical recovery.\n\nParticipants will:\n\nUndergo initial thrombolysis followed by transfer to PCI centers. Be randomly assigned in a 1:1 ratio to receive either thrombus aspiration combined with PCI or PCI alone.\n\nBe followed for 30 days post-treatment to assess MACE and other clinical outcomes.",[58],"ST-segment Elevation Myocardial Infarction",[60,61,62,63,64],"ST-segment elevation myocardial infarction","Thrombus aspiration","Percutaneous coronary intervention","High thrombus burden","Randomized controlled trial","2026-02-25",{"date":67,"type":36},"2026-02-27",{"date":69,"type":36},"2024-11-01",{"date":71,"type":21},"2028-11-01",{"name":73,"class":43},"Shenghua Zhou",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100490676","the-favor-v-ami-trial-100490676","NCT05669222","The FAVOR V AMI Trial","Functional and Angiography-Derived Strain Guided Multi-Vessel\u002FLesion Revascularization Strategy in Patients With Acute ST-Segment Elevation Myocardial Infarction (FAVOR V AMI)","Inclusion Criteria:\n\n* General inclusion\n\n  1. Age ≥18 years\n  2. STEMI ≤30d\n  3. Successful primary PCI of all culprit lesion(s) responsible for the STEMI (visually-assessed residual stenosis \\\u003C30% in stent-treated lesions or \\\u003C50% in DCB-treated or PTCA-treated lesions, with TIMI-3 flow in all treated vessels)\n  4. No MACE event between the index PCI and the staged randomized procedure\n  5. Able to understand the trial design and provide written informed consent\n* Angiographic inclusion:\n\n  1. The presence of at least 1 non-culprit lesion with DS% 50%-90% in any non-infarct related artery with RVD ≥2.5 mm by visual assessment\n  2. Non-culprit lesions are potentially eligible for PCI Note: All lesions in the infarct related arteries with DS ≥70% and RVD ≥2.5 mm by visual assessment must be successfully treated either during the index primary PCI or the staged procedure prior to randomization Note: There may also be 1 or more NCL with DS% \\>90% (including a CTO) as long as there is at least 1 NCL with DS% 50%-90% as above. Any such lesions in which PCI is intended must be treated successfully either during the index primary PCI or the staged procedure prior to randomization.\n\nExclusion Criteria:\n\n* General exclusion\n\n  1. Cardiogenic shock or refractory hypotension (Killip IV)\n  2. On pressors or use of or need for intra-aortic balloon pump or other mechanical circulatory support devices\n  3. Intubated\n  4. Prior thrombolytic therapy for this admission\n  5. Cockcroft-Gault-calculated CrCl \\\u003C30 ml\u002Fkg\n  6. Pregnant or woman of child-bearing potential\n  7. Life expectancy less than 1 year for non-cardiac causes\n  8. Allergy to iodine-containing contrast agents which cannot be adequately premedicated\n  9. Unable to tolerate DAPT for at least 6 months\n  10. Prior CABG or planned CABG\n  11. Any planned surgery within 6 months\n  12. Any condition that may interfere with any follow-up procedures (e.g. dementia, drug use)\n* Angiographic exclusion\n\n  1. Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to μQFR or RWS measurement\n  2. Unable to judge culprit lesion or infarct-related artery according to current evidence",{"count":82,"type":21},5000,[24],"The FAVOR V AMI study is a prospective, multicenter, blinded, randomized, sham-controlled trial comparing the long-term clinical outcomes of the \"Functional and Angiography-derived Strain inTegration (FAST)\" technique (next-generation quantitative flow ratio \\[μQFR\\] and radial wall strain \\[RWS\\]) guided percutaneous coronary intervention (PCI) strategy, with standard treatment strategy, in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease (MVD).",[86,87,88],"ST-Segment Elevation Myocardial Infarction","Multivessel Coronary Artery Disease","Percutaneous Coronary Intervention",[90,86,87,88,91],"Quantitative Flow Ratio","Radial Wall Strain","NOT_YET_RECRUITING","2023-09-10",{"date":95,"type":36},"2023-09-13",{"date":97,"type":21},"2023-09-30",{"date":99,"type":21},"2028-06",{"name":101,"class":102},"China National Center for Cardiovascular Diseases","OTHER_GOV"]