[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stability-of-microbiome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stability-of-microbiome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100640355","westlake-frequent-sampling-cohort-2-100640355",false,"NCT07606885","Westlake Frequent-sampling Cohort 2","WeF2","Inclusion Criteria:\n\n* Participants reside in Hangzhou\n\nExclusion Criteria:\n\n* Refusing or unable to give informed consent\n* Participants with chronic gastrointestinal diseases and take daily relevant medications\n* Participants with metabolic diseases including diabetes, hypertension and cardiovascular diseases (CVD)\n* Participants with craniocerebral trauma, cancer, liver disease, kidney disease, or other critical illness, or history of operation or medication\n* Participants with bulimia nervosa, post-traumatic stress disorder (PTSD), chronic anxiety and depression or other critical neuronal disorder or history of relevant medication\n* Being or to be pregnant or lactating.\n* Participants with history of alcohol or drug addiction, or smoke above 15 cigarettes per day\n* Concurrently participating other clinical trials.",true,"ALL","18 Years","40 Years",{"count":21,"type":22},20,"ESTIMATED","OBSERVATIONAL","This observational follow-up study extends a previously completed 15-day intensive longitudinal study (WeF) of the gut microbiome in healthy adults. The objective of WeF2 is to characterize the long-term stability and dynamics of the gut and oral microbiota in the same cohort across multiple timescales, and to determine whether the day-to-day variability patterns observed at baseline persist over months and years. Participants who completed the WeF baseline protocol will be invited to attend periodic follow-up visits for low-frequency biospecimen collection and to repeat the original 15-day high-frequency sampling protocol at planned intervals, beginning approximately six months after the WeF baseline and continuing at extended intervals thereafter. By combining sparse routine sampling with recurring high-density sampling windows, the study aims to distinguish the stable core microbiome from transient and seasonal fluctuations, to track gradual community shifts under free-living conditions, and to further explore relationships among microbiome dynamics, dietary intake, and host glycemic regulation over an extended observation period.",[26,27],"Health Adults","Stability of Microbiome",[29],"Microbiome","RECRUITING","2026-05-19",{"date":33,"type":34},"2026-05-26","ACTUAL",{"date":36,"type":22},"2026-05-08",{"date":38,"type":22},"2030-12-31",{"name":40,"class":41},"Westlake University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":50,"conditions":51,"keywords":52,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":42},"100628365","westlake-frequent-sampling-cohort-100628365","NCT07460687","Westlake Frequent-sampling Cohort","WeF",{"count":21,"type":22},"This intensive longitudinal study investigates the day-to-day stability and natural fluctuations of the gut microbiome in healthy adults over a 15-day period. While the human gut microbiome is a complex ecosystem, its baseline stability in the absence of disease or medical intervention remains insufficiently characterized due to low sampling frequency in prior research. By recruiting healthy volunteers for continuous daily sampling, this study aims to map temporal community structures and evaluate the stability of core microbiota. Additionally, the research utilizes Continuous Glucose Monitoring (CGM) to explore the potential relationships between microbiome dynamics, daily dietary intake, and host glycemic stability.",[26,27],[29],"2026-03-05",{"date":55,"type":34},"2026-03-10",{"date":57,"type":22},"2026-04-08",{"date":59,"type":22},"2027-12-31",{"name":40,"class":41}]