[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stage-iii-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stage-iii-periodontitis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,76,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644467","early-phase-1-comparison-of-the-efficacy-of-conventional-versus-minimally-invasive-non-surgical-periodontal-therapy-in-periodontitis-patients-100644467",false,"NCT07671274","Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients","Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients (Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .\n\n  * Medically free patients.\n  * Non-smokers\n  * Patients with good oral hygiene.\n\nExclusion Criteria:\n\n* Pregnant or lactating females.\n\n  * Patients with systemic diseases that might affect periodontal health\n  * previous periodontal treatment within 6 months before baseline examination.\n  * prior antibiotic regimen use within 1 month before baseline examination",true,"ALL","20 Years","40 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","the aim of this study is to investigate the clinical outcomes of Minimally Invasive Non-Surgical Therapy(MINST) compared to Conventional non-surgical periodontal therapy (CNST)",[28,29],"Periodontal Disease","Stage III Periodontitis",[31,32,33],"periodontitis","stage III","mechanical debridement","RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-26","ACTUAL",{"date":40,"type":38},"2025-08-05",{"date":42,"type":22},"2026-08-05",{"name":44,"class":45},"Mansoura University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100621290","active-oxygen-releasing-gel-with-photodynamic-therapy-in-treating-stage-iii-periodontitis-100621290","NCT07368699","Active Oxygen Releasing Gel With Photodynamic Therapy in Treating Stage III Periodontitis","Evaluation of Active Oxygen Releasing Gel Combined With Photodynamic Therapy in The Treatment of Stage III Periodontitis (A Randomized Controlled Clinical Trial)","Inclusion Criteria:\n\n* Patients with periodontal diagnosis of stage III periodontitis\n* Patients with residual periodontal pocket depth ≥4 mm ,CAL≥ 5mm with bone loss extending to middle third of root and beyond in radiography\n* Bleeding on probing at least four sites at base-line\n* Patients who didn't receive periodontal treatment for a minimum of 3 months prior to the examination.\n* Patients of both sexes aged ≥30 and ≤70 years\n\nExclusion Criteria:\n\n* Smokers or those with any other harmful habits such as pipe or vape smoking\n* Patients with any systemic condition that will possibly affect the outcome of periodontal therapy i.e. (diabetic patients)\n* Patients who have received any local or systemic anti-inflammatory medications or antibiotics within the last 6 months\n* Pregnant or lactating women\n* Patients with parafunctional habits","30 Years","70 Years",{"count":57,"type":22},42,[59],"NA","Periodontitis is a serious gum disease that can damage the tissues supporting the teeth. The standard treatment is scaling and root planing of the teeth and roots. However, in some patients, this treatment alone may not fully control inflammation and harmful bacteria.\n\nThis study aims to evaluate whether adding an active oxygen-releasing gel, with or without photodynamic therapy, improves treatment outcomes in patients with stage III periodontitis. The oxygen-releasing gel is applied to the gums and releases oxygen, which may help reduce harmful bacteria. Photodynamic therapy uses a light source together with a special dye to target and destroy bacteria and improve gingival health.\n\nIn this randomized clinical trial, 42 patients with stage III periodontitis will be divided into three groups. One group will receive standard scaling and root planing (SRP) plus the oxygen-releasing gel. A second group will receive standard scaling and root planing (SRP)plus the gel and photodynamic therapy. The third group will receive standard scaling and root planing(SRP) only.\n\nGum health will be evaluated by measuring gingival index, bleeding index, pocket depth, and supra crestal tissue attachment level at the start of the study and after one and three months. Microbiological samples from periodontal pockets will also be used to assess levels using quantitative Polymerase Chain Reaction (qPCR) for relative abundance of Treponema denticola and Porphyromonas gingivalis bacteria related to periodontal disease.",[29],[63,64,65,66],"Active oxygen releasing gel","Photodynamic therapy","Periodontitis","Scaling and Root Planing,","2026-04-26",{"date":69,"type":38},"2026-04-28",{"date":71,"type":38},"2025-01-26",{"date":73,"type":22},"2026-05",{"name":75,"class":45},"Alexandria University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100617238","phase-2-antimicrobial-photodynamic-therapy-with-icg-loaded-nanoparticles-for-periodontitis-management-100617238","NCT07316023","Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management","Efficacy of Antimicrobial Photodynamic Therapy Using Polymeric Nanoparticles Loaded With Indocyanine Green in Management of Periodontitis.(A Randomized Controlled Clinical Trial Study With Microbiological Analysis )","Inclusion Criteria:\n\n* 1- Both genders aged between 36-50 years (Wadhwa et al., 2021) 2- Generalized stage III grade B periodontitis (Papapanou et al., 2018). Posterior teeth, stage III with PD\\>6 mm and CAL ≥5 mm 3- Patients ready to comply with oral hygiene measures. 4- Patients free from any systemic disease that may affect the treatment (Glick et al., 2008)\n\nExclusion Criteria:\n\n* Exclusion criteria:\n\n  1. Smokers\n  2. Pregnant females.\n  3. Drug abusers.\n  4. Patients taking antibiotics or performed any periodontal treatment in the previous 6 months.\n\nJustification for Exclusions:\n\nTo reduce any confounding factors and bias that may affect the results of this study.","36 Years","50 Years",{"count":86,"type":22},27,[88],"PHASE2","To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable \"containers\" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth.\"",[29],[92],"periodontits\u002F stage III \u002F NSPT\u002FPDT\u002FNano particles\u002F ICG","2025-12-18",{"date":95,"type":38},"2026-01-05",{"date":97,"type":22},"2026-01-15",{"date":99,"type":22},"2026-08-30",{"name":101,"class":45},"Nada Mahmoud Soliman",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":84,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":46},"100568005","phase-2-treatment-of-periodontitis-by-tulsi-gel-100568005","NCT06675578","Treatment of Periodontitis by Tulsi Gel","Non Surgical Treatment Using Tulsi Gel Versus Chlorhexidine Gel as Adjunctive in Treatment of Advanced Periodontitis ( Stage III and Stage IV )","Inclusion Criteria:\n\n* All patients included in this study will be having advancedI Periodontitis\n* Aging from 30 to 50 years old\n* Free from any local or systemic risk factors that may affect the results of the study.\n\nExclusion Criteria:\n\n* Long-term therapy with medications within a month prior to enrollment that could affect periodontal status or healing.\n* Pregnant woman and lactating mothers.\n* Patients with previous periodontal treatment including scaling and root planning and periodontal surgery in the last 3 and 6 months, respectively.",{"count":110,"type":22},24,[88,112],"PHASE3","This study will be carried out to compare between the effect of 4%Tulsi gel and 1%Chlorohexidine gel as locally administered agents in the treatment of advanced periodontitis. Clinical parameters measurements, microbiological and radiographic assessment will be performed at base line, one month and 3 months after the intervention.",[115,29,116],"Advanced Periodontitis","Stage IV Periodontitis",[31,118,119],"clinical attachment loss","advanced periodontitis","NOT_YET_RECRUITING","2025-06-27",{"date":123,"type":38},"2025-07-01",{"date":125,"type":22},"2025-07",{"date":127,"type":22},"2025-11",{"name":129,"class":45},"Al-Azhar University"]