[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stage-iv-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stage-iv-periodontitis":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100568005","phase-2-treatment-of-periodontitis-by-tulsi-gel-100568005",false,"NCT06675578","Treatment of Periodontitis by Tulsi Gel","Non Surgical Treatment Using Tulsi Gel Versus Chlorhexidine Gel as Adjunctive in Treatment of Advanced Periodontitis ( Stage III and Stage IV )","Inclusion Criteria:\n\n* All patients included in this study will be having advancedI Periodontitis\n* Aging from 30 to 50 years old\n* Free from any local or systemic risk factors that may affect the results of the study.\n\nExclusion Criteria:\n\n* Long-term therapy with medications within a month prior to enrollment that could affect periodontal status or healing.\n* Pregnant woman and lactating mothers.\n* Patients with previous periodontal treatment including scaling and root planning and periodontal surgery in the last 3 and 6 months, respectively.","ALL","30 Years","50 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","This study will be carried out to compare between the effect of 4%Tulsi gel and 1%Chlorohexidine gel as locally administered agents in the treatment of advanced periodontitis. Clinical parameters measurements, microbiological and radiographic assessment will be performed at base line, one month and 3 months after the intervention.",[28,29,30],"Advanced Periodontitis","Stage III Periodontitis","Stage IV Periodontitis",[32,33,34],"periodontitis","clinical attachment loss","advanced periodontitis","NOT_YET_RECRUITING","2025-06-27",{"date":38,"type":39},"2025-07-01","ACTUAL",{"date":41,"type":21},"2025-07",{"date":43,"type":21},"2025-11",{"name":45,"class":46},"Al-Azhar University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100521336","effect-of-mops-during-orthodontic-movement-in-periodontitis-patients-100521336","NCT06068270","Effect of MOPs During Orthodontic Movement in Periodontitis Patients","Randomized Clinical Trial on the Effect of Micro-osteoperforations (MOPs) During Intrusion of Flared Upper Anterior Teeth in Stage IV Periodontitis Patients","MOPorthoperi","Inclusion Criteria:\n\nPatients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:\n\n* adult patients older than 18-year-old;\n* systemically healthy (see exclusion criteria);\n* diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;\n* the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \\\u003C5mm) (experimental teeth);\n* in need of orthodontic therapy.\n\nExclusion Criteria:\n\n* systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);\n* any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);\n* pregnant or lactating woman;\n* inability to respond questions or to attend follow-up visits;\n* extreme skeletal malocclusions requiring orthognathic surgery;\n* patients smoking more than 10 cigarettes\u002Fday; and\n* the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy","18 Years","80 Years",{"count":59,"type":21},28,[61],"NA","Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \\\u003C5mm)",[30,64],"Orthodontic Tooth Movement",[66,67,68],"Stage IV periodontitis","Orthodontic tooth movement","Micro-osteoperforations","RECRUITING","2025-03-24",{"date":72,"type":39},"2025-03-27",{"date":74,"type":39},"2023-12-15",{"date":76,"type":21},"2026-01",{"name":78,"class":46},"Universidad Complutense de Madrid"]