[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"staphylococcus-aureus-bloodstream-infections-bsi-bacteremia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:staphylococcus-aureus-bloodstream-infections-bsi-bacteremia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100054119","linezolid-plus-standard-of-care-100054119",false,"NCT06958835","Linezolid Plus Standard of Care","Combination Antibiotic Treatment With Linezolid for Staphylococcus Aureus Bacteraemia: a Randomised Controlled Trial","LIPS","Inclusion criteria:\n\n* Staphylococcus aureus (S. aureus) grown from at least one blood culture\n* Hospitalised at a participating centre\n* ≥18 years old\n* Written informed consent or fulfilling criteria for an emergency exception from informed consent requirements\n\nExclusion criteria:\n\n* Administration of the initial drug treatment not feasible within 72 hours since the collection of the first positive blood culture with S. aureus\n* Documented history of positive blood cultures for S. aureus occurring between 72 hours and 180 days prior to the eligibility assessment\n* Necrotising fasciitis\n* Currently receiving linezolid or clindamycin\n* Use of any monoamine oxidase A or B inhibitor within the last two weeks\n* Known hypersensitivity to linezolid or any other ingredients of the study drugs\n* Current severe thrombocytopenia (i.e. \\\u003C30 x 10\\^9\u002FL)\n* Application of study drug not possible (per mouth or per gastric tube)\n* Currently breastfeeding\n* Local treating team believes that death is imminent and inevitable\n* Patient is receiving end of life care and antibiotic treatment is not considered appropriate\n* Local treating team believes that participation in the study is not in the best interest of the patient\n* Any indication that the patient is unwilling to participate in the study including an advance directive stating such unwillingness","ALL","18 Years",{"count":20,"type":21},606,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.",[27],"Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)",[29,30,31,32,33,34,35,36,37,38],"Virulence factors","Linezolid","Bloodstream Infection","Hierarchical composite endpoint","Staphylococcus aureus","Bacteremia","Bacteraemia","Methicillin-resistant Staphylococcus aureus (MRSA)","Penicillin-susceptible Staphylococcus aureus (PSSA)","Methicillin-susceptible Staphylococcus aureus (MSSA)","RECRUITING","2026-07-09",{"date":42,"type":43},"2026-07-13","ACTUAL",{"date":45,"type":43},"2025-10-06",{"date":47,"type":21},"2028-10",{"name":49,"class":50},"University Hospital, Basel, Switzerland","OTHER",12,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100571910","phase-4-comparison-of-cloxacillin-and-benzylpenicillin-in-penicillin-susceptible-s-aureus-bacteraemia-100571910","NCT06726395","Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia","Randomized Controlled Clinical Trial Comparing Treatment With Cloxacillin Versus Benzylpenicillin in Bacteraemia Caused by Penicillin-susceptible Staphylococcus Aureus (PSSA)","COMeBAC","Inclusion Criteria:\n\nAged ≥18 with penicillin susceptible S. aureus bacteraemia (PSSA), and able to provide written informed consent.\n\nExclusion Criteria:\n\n* allergy to penicillin,\n* inability to give informed consent,\n* concomitant growth of other clinically significant bacteria in blood cultures\n* neutropenia\n\n  -≥ 96h with prior antibiotics\n* When the per oral follow up medication can not be flukloxacillin or penicillinV\u002FAmoxicillin (ie prosthetic joint infection)\n* Patients in terminal palliation, where death is expected within 7 days.\n* Where the treating physician believes cloxacillin is not a first-line treatment.",{"count":61,"type":21},420,[63],"PHASE4","The goal of this study is to investigate if benzylpenicillin is a better treatment option than cloxacillin in patients with penicillin-susceptible Staphylococcus aureus bacteraemia.",[66,67,27,68],"Staphylococcus Aureus Bacteraemia","Staphylococcal Bacteraemia","Staphylococcus (S.) Aureus Infection",[70,71,72,73,74],"Penicillin treatment","benzylpenicillin","cloxacillin","Penicillin susceptible S. aureus","Staphylococcus aureus bacteraemia","2026-04-24",{"date":77,"type":43},"2026-04-30",{"date":79,"type":43},"2025-03-10",{"date":81,"type":21},"2028-07",{"name":83,"class":50},"Region Skane",1,{"id":86,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":25,"conditions":89,"keywords":90,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":96,"locationsCount":51},"100589778",{"count":20,"type":21},[24],[27],[29,30,31,32,33,34,35,36,37,38],"2026-03-19",{"date":93,"type":43},"2026-03-24",{"date":45,"type":43},{"date":47,"type":21},{"name":49,"class":50}]