[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stent":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100513945","integration-of-telemedicine-and-home-based-cardiac-rehabilitation-feasibility-efficacy-and-adherence-100513945",false,"NCT05972070","Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence","Inclusion Criteria:\n\n1. Over the age of 18\n2. NYHA Functional Class I, II,\n3. Recent (within 60 days) status post coronary artery revascularization for atherosclerotic coronary artery disease (coronary artery bypass grafting or percutaneous coronary revascularization with stent implantation)\n4. Candidate for traditional center-based cardiac rehabilitation\n\nExclusion Criteria:\n\n1. Under the age of 18\n2. Adults lacking capacity to consent.\n3. NYHA Functional Class III, IV\n4. Acute coronary syndrome\n5. Systolic heart failure (LV EF \\\u003C40%)\n6. Status post cardiac surgery for structural heart disease or heart transplant\n7. Percutaneous coronary angioplasty\n8. Adults lacking capacity to consent.\n9. Pregnant women","ALL","18 Years",{"count":18,"type":19},500,"ESTIMATED","OBSERVATIONAL","The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine. Several components will be assessed such as quality-of-life, nutritional counseling, maximum metabolic activity (MET's), diabetic management, tobacco cessation, lipid, blood pressure, and psychosocial management. These tasks will be accomplished through concurrent conversations between patients and their therapist's utilizing telemedicine with observed exercise training.",[23,24,25,26,27,28,29,30],"Myocardial Infarction","Percutaneous Transluminal Coronary Angioplasty","Coronary Artery Bypass","Stable Angina","Heart Failure","Valve Disease, Heart","Cardiac Rehabilitation","Stent",[32,33,34],"Cardiac rehabilitation","Home based cardiac rehabilitation","Telemedicine and Home-Based Cardiac Rehabilitation","RECRUITING","2025-07-21",{"date":38,"type":39},"2025-07-24","ACTUAL",{"date":41,"type":39},"2023-06-01",{"date":43,"type":19},"2025-12-31",{"name":45,"class":46},"ROM Technologies, INC","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100575963","intracoronary-optical-coherence-tomography-guidance-vs-angiography-only-guidance-for-treatment-of-coronary-in-stent-restenosis-100575963","NCT06779110","Intracoronary Optical Coherence Tomography Guidance Vs. Angiography Only Guidance for Treatment of Coronary In-stent Restenosis","IN-Stent RestenosIs Detection and TrEtment by Optical Coherence Tomography","INSIDE OCT","Inclusion Criteria:\n\n* Informed consent signed\n* Age ≥ 18 years\n* Referred for angiography either in stable or ACS setting suitability for PCI through femoral or radial access\n* A coronary in-stent restenosis between 70% and 99% in at least two projections in a vessel with a lumen diameter ≥ 2.25 - ≤ 5.75 mm (The severity of the stenosis should be based on visual estimation, with current online state-of-the-art angiographic equipment of the participating centres and after a mandatory dose of 50-200 mcg intracoronary of nitroglycerine.\n* Stable hemodynamics\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Participation in another clinical study with an investigational product\n* OCT pullback not technically feasible in vessel site","99 Years",{"count":58,"type":19},360,"INTERVENTIONAL",[61],"NA","Although advances in drug-eluting stents (DES) have substantially reduced the risk of coronary in-stent restenosis (ISR) and the need for target lesion revascularisation (TLR), ISR persists. There are several treatment options for ISR (conventional balloon angioplasty, cutting or scoring balloons, drug-coated balloons, repeat DES implantation or bypass surgery). Coronary imaging is mandatory to perform PCI on ISR. Optimal coherence tomography (OCT) is an excellent option to guide PCI, but its role in ISR-PCI remains unclear. The INSIDE OCT Trial aims to compare the acute performance of PCI for ISR, either guided by OCT and angiography or by angiography alone.",[64,65,66],"Coronary Artery Disease","Stent Restenosis","STENT",[68,69],"Percutaneous Coronary Intervention (PCI)","Optimal Coherence Tomography (OCT)","2025-01-12",{"date":72,"type":39},"2025-01-16",{"date":74,"type":39},"2024-09-01",{"date":76,"type":19},"2028-09-01",{"name":78,"class":79},"San Luigi Gonzaga Hospital","OTHER",12,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":59,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":47},"100454805","camrelizumab-combined-with-neoadjuvant-chemotherapy-after-stent-placement-for-left-sided-obstructive-colonic-cancer-100454805","NCT05202314","Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement for Left-Sided Obstructive Colonic Cancer","Camrelizumab Combined With Neoadjuvant Chemotherapy After Stent Placement Versus Surgery Alone for Left-Sided Obstructive Colonic Cancer","NACSOC-02","Inclusion Criteria:\n\n* Radiologically proven colonic obstruction of the left colon\u002Fupper rectum presumed secondary to a carcinoma\n* Able to give written, informed consent\n* Primary tumor was resectable\n* ECOG score 0 or 1\n* Haemoglobin greater than 100 g\u002FL after transfusion before chemotherapy,\n* White blood cells greater than 3.0×10# \u002FL\n* Platelets greater than 100×10# \u002F L;\n* Glomerular filtration rate greater than 50 mL per minute as calculated by the Wright or Cockroft formula\n* Bilirubin less than 1.5×Upper Limit of Normal(ULN)\n* ALT and AST less than 2.5×ULN\n\nExclusion Criteria:\n\n* Distal rectal cancers(equal or less than 10cm from the anal verge)\n* Patients with signs of peritonitis and\u002For bowel perforation\n* Patients who did not give informed consent\n* Patients who were considered unfit for operative treatment or refuse surgery.\n* Patients with suspected or proven metastatic adenocarcinoma;\n* Patients with unresectable colorectal cancer, or planning for palliative treatment.","80 Years",{"count":91,"type":19},20,[61],"Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity rates of 30%-60% and mortality rates of 7-22%, and about two-thirds of such patients end up with a permanent stoma. Self-expanding metallic stents (SEMS) haven been used as a bridge to surgery (to relieve obstruction prior to elective surgery) in patients with potentially resectable colorectal cancer. Several clinical trials demonstrate that SEMS as a bridge to surgery may be superior to emergency surgery considering the short-term outcomes. SEMS is associated with lower morbidity and mortality rate, increased primary anastomosis rate, and decreased stoma creation rate. Although about half of patients can achieve primary anastomosis after stent placement, the primary anastomosis rate is still significantly lower compared with nonobstructing elective surgery. The interval between stent placement and surgery may be not long enough that bowel decompression is insufficient at the time of operation. Furthermore#the long-term oncologic results regarding SEMS as a bridge to surgery are still limited and contradictory. Sabbagh et al. suggest worse overall survival of patients with SEMS insertion compared with emergency surgery, the 5-year cancer-specific mortality was significantly higher in the SEMS group (48% vs 21%, respectively, P=0.02). One interpretation is that tumor cells may disseminate during the procedure of colonic stenting placement. Immunotherapy has proven to be highly effective as first-line treatment of metastatic colorectal cancer (CRC). And immunotherapy also has emerged as a neoadjuvant approach, possibly changing treatment strategy for both primary resectable and metastatic CRC. We hypothesis that, regardless of the MSI state, immunotherapy (Camrelizumab, an anti-PD-1 antibody) combined with chemotherapy after stenting may improve overall survival by eradicating micrometastasis. Moreover, immunotherapy (Camrelizumab, an anti-PD-1 antibody) combined with neoadjuvant chemotherapy prolongs the interval between stent placement and surgery, and the time for bowel decompression is more sufficient, which may increase the success rate of primary anastomosis and decrease risk of stoma formation, and furthermore, improve OS and PFS.",[95,96,30,97,98],"Colorectal Cancer","Neoadjuvant Chemotherapy","Obstruction","Immunotherapy","2023-02-19",{"date":101,"type":39},"2023-02-21",{"date":103,"type":39},"2021-12-12",{"date":105,"type":19},"2026-12-30",{"name":107,"class":79},"Beijing Chao Yang Hospital"]