[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sti\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sti":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,64,91,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":63},"100628220","healthy-expectancy-through-routine-antenatal-sti-screening-100628220",false,"NCT07458802","Healthy Expectancy Through Routine Antenatal STI Screening","Screening and Treatment for Chlamydia Trachomatis Infection to Prevent Preterm Birth","HERA","Inclusion Criteria:\n\n1. Asymptomatic for cervicovaginitis at first ANC (i.e., not syndromically treated for an STI by clinic midwives at first ANC)\n2. Age ≥ 15 years\n3. Currently pregnant\n4. ≤20 weeks gestation (based on gestational age in obstetric record or last menstrual period if gestational age missing from record)\n5. Attending first ANC visit\n6. Residence in Gaborone, Bostwana or surrounding villages through the time of delivery\n7. Mentally competent to understand study procedures or give informed consent",true,"FEMALE","15 Years",{"count":21,"type":22},2000,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and whether this approach is affordable and cost-effective for the health system.\n\nAbout 2,000 pregnant women attending their first antenatal care visit at up to 10 government clinics in Botswana will be invited to join the study. All women will first receive the usual antenatal care services provided in Botswana, including routine health checks and HIV and syphilis testing. Women who enroll in the study will be randomly assigned to one of two groups:\n\n1. Standard of care group: Women receive routine antenatal care only.\n2. Intervention group: In addition to routine antenatal care, women are screened for chlamydia and gonorrhoea using self-collected vaginal swabs at their first antenatal care visit and again in the third trimester.\n\nThe main outcome of the study is whether screening and treating chlamydia and gonorrhoeae reduces preterm birth (before 37 weeks). Other outcomes include low birth weight, very preterm birth, and maternal health conditions.",[28,29,30,31,32,33,34,35],"Antenatal Health","Antenatal Care","STI","Chlamydia Trachomatis Infection in Pregnancy","Chlamydia","Chlamydia Trachomatis","Chlamydia Trachomatis Infection","Preterm Birth",[37,38,39,40,41,42,43,30,44,45,46,47,48,49,50],"antenatal health","antenatal screening","chlamydia","chlamydia trachomatis","chlamydia screening","chlamydia treatment","pregnancy screening","STI screening","STI in pregnancy","preterm delivery","Botswana","CT infection","chlamydia in pregnancy","birth outcomes","RECRUITING","2026-06-30",{"date":54,"type":55},"2026-07-02","ACTUAL",{"date":57,"type":55},"2026-05-25",{"date":59,"type":22},"2030-07-01",{"name":61,"class":62},"Adriane Wynn","OTHER",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":17,"sex":71,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":63},"100391550","appalachian-partnership-to-reduce-disparities-aim-2-100391550","NCT04378439","Appalachian Partnership to Reduce Disparities (Aim 2)","Harnessing the Power of Peer Navigation and mHealth to Reduce Health Disparities in Appalachia","Inclusion Criteria:\n\n* reside in one of the rural Appalachian catchment countiesreside in one of the rural Appalachian catchment counties\n* be ≥18 years of age\n* report being assigned male sex at birth and having had sex with at least 1 man in past 12 months\n* provide informed consent","ALL","18 Years",{"count":74,"type":22},141,[25],"By combining two strategies (i.e., peer navigation and mHealth) into a complete, culturally compatible, bilingual intervention to increase the use of needed HIV, STI, and HCV prevention and care services among racially\u002Fethnically diverse GBMSM and transgender women in rural Appalachia.\n\nStudy Investigators anticipate that participants in the intervention group, relative to counterparts in the delayed-intervention group, will demonstrate increased HIV, STI, and HCV testing.",[78,30,79],"HIV\u002FAIDS","HCV",[81],"PrEP","2026-05-22",{"date":84,"type":55},"2026-05-26",{"date":86,"type":55},"2022-04-01",{"date":88,"type":22},"2027-05",{"name":90,"class":62},"Wake Forest University Health Sciences",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":17,"sex":18,"minAge":72,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":63},"100613284","hivstihcv-testing-and-overdose-prevention-among-survivors-of-sex-trafficking-100613284","NCT07264582","HIV\u002FSTI\u002FHCV Testing and Overdose Prevention Among Survivors of Sex Trafficking","A Citizen Science Approach to Increase HIV\u002FSTI\u002FHCV Testing and Substance Use Service Utilization Among Survivors of Sex Trafficking Living in New York City","Inclusion Criteria:\n\n* 18 years or older\n* Born biologically female or identify as a woman\n* Living in New York City\n* Used illicit substances within the past 12 months or has a history of substance use dependency\n* Would feel safe participating in the study\n* Is a survivor of sex trafficking as defined by the following criteria: 1) Has the individual ever had sex for things of value? If 'Yes', then the individual must also answer 'Yes' to the following question, 2) Was the individual pressured or forced by another person to do this?\n\nExclusion Criteria:\n\n* Not willing to provide consent or not able to understand study procedures",{"count":99,"type":22},368,[25],"This project will assess whether a digital survivor crowdsourced intervention can increase HIV\u002FSTI\u002FHCV testing and overdose prevention kit utilization among survivors of sex trafficking living in New York City. Survivors of sex trafficking have among the highest rates of HIV\u002FSTIs\u002FHCV and substance use disorder (SUD), yet they face substantial barriers to care, including lack of information about care and financial and logistical constraints. In addition, there is a lack of public health messaging tailored specifically for survivors of sex trafficking to meet their needs. Citizen science approaches, such as crowdsourcing (i.e., engaging groups of individuals to address public health challenges and share solutions), are scalable, cost-effective tools that can increase HIV\u002FSUD prevention and treatment utilization. Crowdsourcing can be used to engage survivors in developing tailored messaging to promote HIV\u002FSTI\u002FHCV testing, overdose prevention, and treatment utilization. Complementing crowdsourcing, specimen self-collection with remote HIV\u002FSTI\u002FHCV testing and online delivery of overdose prevention kits to survivors may also increase use of needed healthcare services. Study aims are: 1) develop crowdsourced digital messages to promote HIV\u002FSTI\u002FHCV testing uptake and utilization of overdose prevention services for substance use among sex trafficking survivors; 2) in a randomized controlled trial, to compare the survivor-crowdsourced HIV and substance use intervention to existing public health messaging among sex trafficking survivors (n=368) in New York City; and 3) assess the contribution of multi-level factors on reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) outcomes. This work will result in a digital crowdsourced intervention to increase HIV\u002FSTI\u002FHCV testing uptake, overdose prevention kit utilization, and linkage to care among survivors of sex trafficking. This project will also result in a crowdsourcing and messaging toolkit that can be broadly distributed to public health and other agencies across the country for their use in designing messaging campaigns for survivors. Findings from this project will lay the groundwork for citizen science-developed HIV and SUD interventions for sex trafficking survivors across the US.",[103,30,79,104],"HIV Testing","Overdose, Drug",[106,30,79,107,108,109],"HIV","overdose prevention","crowdsourcing","citizen science","NOT_YET_RECRUITING","2026-01-27",{"date":113,"type":55},"2026-01-28",{"date":115,"type":22},"2026-10-01",{"date":117,"type":22},"2028-06-30",{"name":119,"class":62},"Columbia University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":17,"sex":71,"minAge":72,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":130,"phases":4,"briefSummary":131,"conditions":132,"keywords":136,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":146},"100607260","prevention-icona-dedicated-ensemble-100607260","NCT07186244","Prevention ICONA Dedicated Ensemble","Implementation of an Italian Cohort of People on HIV-1 Pre-exposure Prophylaxis Within the ICONA Network: PrIDE (Prevention ICONA Dedicated Ensemble)","PrIDE","Inclusion Criteria:\n\n* Age \\>18 years\n* Negative HIV Ab\u002FAg test (4th generation or higher) at the enrollment visit\n* Request and\u002For willingness to take PrEP, or already on PrEP\n* Ability to understand the study procedures and to sign informed consent\n\nExclusion Criteria:\n\n* Individuals with HIV infection or with strong clinical\u002Fepidemiological suspicion of HIV infection\n* Individuals with contraindications to the use of medications included in the PrEP regimen (as per the product information)\n* Documented allergy to one or more pharmacological components of the proposed PrEP regimen\n* Lack of willingness to adhere to the required procedures and follow-up assessments",{"count":129,"type":22},5000,"OBSERVATIONAL","Despite significant advances in HIV treatment, transmission remains a public health concern. In 2022, there were 1.3 million new HIV infections worldwide and 1,888 new diagnoses in Italy, with sexual transmission being the predominant route. Many individuals are still diagnosed late, and a portion of people living with HIV are unaware of their status. Pre-Exposure Prophylaxis (PrEP) has emerged as an effective biomedical strategy to prevent new infections, especially when integrated into comprehensive prevention efforts.\n\nStudy Objectives The primary objective of this observational study is to establish a large prospective cohort of individuals using PrEP in Italy. The study aims to assess PrEP's effectiveness, tolerability, adherence, and barriers to long-term use in a real-world setting. These data will be instrumental in guiding future strategic interventions to optimize PrEP management and move toward the goal of zero new HIV infections in Italy.\n\nPrimary Objective\n\n* To assess the incidence of new HIV infections among PrEP users in Italy. Secondary Objectives\n* Incidence of other sexually transmitted infections (STIs);\n* Tolerability of PrEP;\n* Psychological and behavioral aspects related to PrEP use;\n* Adherence and persistence in care;\n* Use of therapies and prophylaxis for STIs during PrEP use. Study Design and Coordination This is a prospective observational study, promoted by Fondazione ICONA in collaboration with clinical centers and community-based organizations. The coordinating enrolling center is INMI \"L. Spallanzani\" IRCCS in Rome.\n\nParticipating Centers:\n\n* 49 university and hospital-based centers across Italy;\n* 4 non-clinical checkpoints offering PrEP screening, prescription, and follow-up.\n\nStudy Population Adults (≥18 years) who are HIV-negative, sexually active, and considered eligible for PrEP per national or international guidelines, including both new and current PrEP users.\n\nInclusion Criteria\n\n* Age ≥18 years;\n* Negative HIV test at enrollment;\n* Willingness to initiate or continue PrEP;\n* Informed consent provided. Exclusion Criteria\n* HIV infection or strong suspicion of infection;\n* Contraindications to PrEP medications; Known allergy to PrEP components; Refusal to comply with study procedures.",[81,133,106,134,30,135],"PrEP Adherence Monitoring","HIV -1 Infection","STI Prevention",[81,106,30,135],"2025-09-15",{"date":139,"type":55},"2025-09-22",{"date":141,"type":55},"2024-09-09",{"date":143,"type":22},"2033-12-31",{"name":145,"class":62},"Fondazione ICONA",53]