[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stigma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stigma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,44,70,100,125,151,171,205,241,269],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100609666","solving-stigma-through-pov-simulation-enhancing-pharmacist-empathy-based-practices-with-sickle-cell-disease-patients-100609666",false,"NCT07217548","Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients","point of view","Inclusion Criteria:\n\n* Practicing healthcare professional OR student in a healthcare professional program\n* Ability to fill opioid prescriptions\n\nExclusion Criteria:\n\n* Not currently practicing or rotating in a clinical setting that fills opioid prescriptions",true,"ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","Why This Research Matters (Significance)\n\n1 in 5 of the 50+ million people with chronic pain in the U.S. face stigma when using opioids, especially women and racial minorities. This stigma often comes from pharmacy staff treating chronic pain patients as drug seekers, who then refuse to fill the patient's script, and leave the patient in severe pain. The team has found that having pharmacists watch testimonial videos of sickle cell patients sharing their pain management struggles can help reduce these misconceptions. However, using point of view simulations could be even more effective in fostering empathy among pharmacists. The goal is to create an educational simulation that helps pharmacists better understand and manage pain in sickle cell patients, ultimately improving their care.\n\nWhat Makes This Research Unique (Innovation) Traditional methods to address biases in healthcare include watching patient testimonials or using expensive actors to play a standardized patient interaction to health professionals. This innovative point of view simulations engage participants' empathy more effectively by playing back what participants told the patient from the patient's point of view and are more accessible by having participants interact with the simulation on the computer any time and any place, rather than organizing a paid actor to visit the hospital. With advancements in artificial intelligence, we can create interactive simulations where virtual patients respond dynamically to questions, making the experience more realistic and impactful.\n\nHow Will the Researchers Conduct the Research (Approach)\n\nThe researchers will test if point of view simulations can reduce misconceptions among healthcare professionals and improve pain management for sickle cell patients. Here's the plan:\n\n1. Create and Implement the Simulation: Use it as part of the training for pharmacy and hospital staff, as well as nursing and pharmacy students.\n2. Survey Participants: Before and after the simulation, participants will take a survey to measure their misconceptions about opioid use.\n3. Follow-Up: Six months later, researchers will survey the participants' patients and their managers to see if there's been an improvement in the empathetic care the participants provided.",[27],"Stigma",[29,30],"pharmacists","PharmD students","NOT_YET_RECRUITING","2026-06-29",{"date":34,"type":35},"2026-07-01","ACTUAL",{"date":37,"type":21},"2026-09-01",{"date":39,"type":21},"2027-07-31",{"name":41,"class":42},"Ohio State University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100643593","healthy-choices-to-reduce-stigma-and-improve-self-management-of-alcohol-and-hiv-among-young-adults-100643593","NCT07638618","Healthy Choices to Reduce Stigma and Improve Self-Management of Alcohol and HIV Among Young Adults","Inclusion Criteria:\n\n* Aged 18-29 years\n* Have HIV\n* Live in the Dominican Republic\n* Speak Spanish\n* Are unsuppressed\n* Report being stigmatized in the past 6 months\n* Report problem alcohol use in the past 6 months\n* Can provide informed consent\n\nExclusion Criteria:\n\n* Doe not meet the inclusion criteria.","29 Years",{"count":52,"type":21},45,[24],"The Spanish language Healthy Choices intervention pilot study (N=45) holds direct relevance to the United States and federal priorities related to improving HIV outcomes to reduce transmission using implementation science models. If Healthy Choices is found to have a clinical signal of impact, our team is committed to testing the intervention in the United States and training Spanish speaking HIV care navigators on the intervention, specifically in the southern United States where Spanish speaking populations are concentrated, namely in Alabama, Texas, New Mexico, Arizona, Nevada, and Florida.",[56,57,27],"HIV","Alcohol Misuse",[59,60],"Behavioral Intervention","Young Adults with HIV","2026-06-04",{"date":63,"type":35},"2026-06-10",{"date":65,"type":21},"2027-10-01",{"date":67,"type":21},"2029-02-28",{"name":69,"class":42},"Florida State University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":43},"100489978","influence-of-resentment-and-forgivingness-on-quality-of-life-in-people-living-with-hiv-100489978","NCT05660148","Influence of Resentment and Forgivingness on Quality of Life in People Living With HIV","FORGHIV","Inclusion Criteria:\n\n* Belonging to the PLHIV followed at the Amiens University Hospital, not likely to move within the year\n* Possibility of follow-up in teleconsultation (usual support of the service)\n* Benefiting from a social security scheme\n* Consent to participate in the research\n\nExclusion Criteria:\n\n* Erratic follow-up (non-compliance, predictable move) or moribund patient\n* Illiterate or not speaking french",{"count":78,"type":21},206,"OBSERVATIONAL","Life stress is strongly associated with poor mental and physical health and its effects explain significant morbidity and mortality. Forgiveness is one of the factors that can influence the effects of stress on health. By definition, forgiveness is the release of negative feelings, emotions, and behaviors - and possibly the release of positive feelings - toward an offender. Numerous studies have shown that forgiveness is associated with several mental and physical health benefits. The literature argues that high levels of propensity to forgive (trait) predispose that person to experience forgiveness (state) more often. In other words, a stronger forgiving disposition is believed to increase the experience of forgiveness, which, in turn, mitigates the negative effects of stress. Forgiveness is therefore a coping style that can play a beneficial role in the stress-health relationship. Patients living with HIV (PLHIV) are patients particularly exposed to stress, not only because of their chronic pathology but also because of the stigma attached to this disease. Very few studies have studied the impact of forgiveness (state or trait) on the physical health of PLHIV and even fewer the impact of an intervention promoting the disposition to forgive. The objective of this prospective observational monocentric study is to show in a very secular country that forgiveness has an effect on well-being as well as on other health parameters.",[82,83,84,27,85],"Forgiveness","Hiv","Stress","Health",[82,87,83,84,88,89],"forgivingness","stigma","health","RECRUITING","2026-05-27",{"date":93,"type":35},"2026-05-28",{"date":95,"type":35},"2024-05-06",{"date":97,"type":21},"2026-11-06",{"name":99,"class":42},"Centre Hospitalier Universitaire, Amiens",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":43},"100639596","tb-stigma-in-the-uk-patients-experiences-and-everyday-responses-100639596","NCT07609264","TB Stigma in the UK: Patients Experiences and Everyday Responses","Making Sense of Tuberculosis (TB) Related Stigma in a Low-incidence Area of the UK: Patients Experiences and Everyday Responses","TB stigma","This study seeks participants who have been diagnosed with pulmonary TB, extrapulmonary TB, latent TB infection (LTBI), and drug sensitive or drug resistant TB within the last 10 years. Participants may have different cultural and socioeconomic backgrounds and will be resident within a pre-defined TB low-incidence coastal\u002Frural area of the UK.\n\nInclusion criteria\n\n* Aged 18 or over at start of study\n* Resident in rural or coastal areas within South or Southwest England\n* Diagnosed with either active or latent TB within the last 10 years\n\nExclusion criteria\n\n* Lacks mental capacity or is unwilling to consent to participate in the study\n* Under 18 years of age\n* Lives in an area of TB high-incidence (above 10 cases\u002F100,000 population) or outside of rural and coastal areas of South\u002FSouthwest England",{"count":109,"type":21},20,"Public understanding of tuberculosis (TB) is shaped by sociocultural norms, educational background, and personal experiences. Misconceptions about TB transmission, disease severity, and treatment side effects are widespread, contributing to stigma and fear of social rejection. Such stigma can lead individuals to conceal their diagnosis, limiting access to support, engagement with healthcare, and overall health literacy.\n\nTB-related stigma is recognised as a significant barrier to ending the global TB epidemic, affecting quality of life and access to care. Yet in high-income, low-incidence (HILI) countries like the UK, its prevalence, influence, and lived impact remain largely unexplored. Where stigma appears in research, it is often treated as an emerging theme, leaving a critical gap in understanding how individuals with TB, or those caring or supporting them, experience and respond to it.\n\nThis study adopts a Constructivist Grounded Theory (CGT) approach to examine TB-related stigma in depth. CGT allows the research to explore how people living with TB make sense of, interpret, negotiate, and resist stigma, capturing the dynamic and contextual ways it shapes their lives, identities, and interactions with healthcare systems. By investigating these meaning-making processes, the study aims to illuminate how stigma operates in the UK, providing insights to inform future stigma-reduction interventions, communication strategies, and supportive healthcare practices, ultimately benefiting patients, communities, and the NHS.",[112,113,27,114,115],"TB","Tuberculosis","TB Stigma","Low Incidence",[112,113,27,117,106],"Low incidence","2026-05-21",{"date":91,"type":35},{"date":37,"type":21},{"date":122,"type":21},"2028-03-01",{"name":124,"class":42},"Bournemouth University",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":131,"minAge":132,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":43},"100631006","adaptation-and-implementation-of-an-evidence-based-approach-to-advance-hiv-prevention-and-care-100631006","NCT07495059","Adaptation and Implementation of an Evidence-based Approach to Advance HIV Prevention and Care","Inclusion Criteria:\n\n* 16 years of age or older\n* being male at birth and currently self-identified as a TW\n* currently living in Ho Chi Minh City adjacent areas and having no plans to move out of the areas in the next 6 months - have the cognitive capacity to participate in study activities as judged by the study recruiter.\n\nExclusion Criteria:\n\n* have been involved in intervention adaptation activities previously with the study team\n* inability to give informed consent\u002Fassent","MALE","16 Years",{"count":134,"type":21},80,[24],"Transgender women in the intervention condition will attend TransAction individual risk reduction sessions; skill building and open group support sessions, and social events between baseline and 3-month assessment. Transgender women participants in the control condition will be invited to social events only.",[138,139,27],"HIV (Human Immunodeficiency Virus)","Continuum of Care",[141],"HIV, Implementation Science, Continuum of Care","2026-04-15",{"date":144,"type":35},"2026-04-21",{"date":146,"type":35},"2026-03-01",{"date":148,"type":21},"2027-01-10",{"name":150,"class":42},"University of California, Los Angeles",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":43},"100499585","ending-the-hiv-epidemic-an-all-facility-intervention-for-patient-and-healthcare-staff-well-being-100499585","NCT05785169","Ending the HIV Epidemic: An All-facility Intervention for Patient and Healthcare Staff Well-being","Inclusion Criteria:\n\n* Selected Ryan White Clinics. Selection based on the following:\n\nFirst, clinic leaders will complete a 15-min Site Characteristics Survey, assessing suitability for participation and clinic comparability. Staff and leadership at Ryan White clinics will next complete an anonymous 15-minute Eligibility Survey.\n\nWithin each clinic, both clinic staff and patients will be invited to participate.\n\nExclusion Criteria:\n\n* Non-Ryan White Clinics\n* Clinics not located in the geographical area of interest\n* Clinics that are not interested in participating",{"count":158,"type":21},1000,[24],"The scope of this study is to engage Ryan White HIV\u002FAIDS Program (RWHAP) funded organizations in the South\u002FEast US to co-develop context-responsive programs utilizing evidence-informed interventions to reduce stigma against living with HIV (PLH) who have difficulties accessing and remaining engaged in life-saving treatment. Five RWHAP clinics will be selected for this trial. Clinic members will participate in interactive trainings to raise awareness of and reduce stigma, from the clinic policy level to individual attitudes. Clinic members and select patients will complete self-administered surveys every 6 months over 24 months.",[27,56,162],"Well-Being, Psychological",{"date":164,"type":35},"2026-04-20",{"date":166,"type":35},"2025-01-27",{"date":168,"type":21},"2028-04",{"name":170,"class":42},"Columbia University",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":187,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":204},"100585320","awarehiv-europe-supporting-healthcare-professionals-to-find-undiagnosed-hiv-in-european-hospitals-an-effectiveness-implementation-trial-100585320","NCT06900829","#AWARE.HIV Europe: Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals: An Effectiveness-implementation Trial.","#aware hiv","Since this study involves screening individuals presenting to a specific hospital through a hospital-wide intervention, the inclusion and exclusion criteria are established at the hospital level.\n\nInclusion Criteria:\n\n1. Standard of care: HIV testing for HIV indicator conditions should be part of routine care in the country, and any prevailing guidelines on HIV testing and prevention policies can be integrated.\n2. Management approval: Hospital management must be willing to allocate resources and provide authorization for the proposed activities, including Surveillance, Audit \\& Feedback, Education \\& Training, Linkage to Prevention, and fostering an Enabling Environment, including stigma reduction.\n3. Resources: Assembling an HIV team led by a local HIV expert should be viable considering the available human resources.\n4. Data collection: There should be an IT specialist and IT infrastructure capable of flagging a pre-defined set of HIV indicator conditions and monitoring the project's implementation effects with feedback loops to healthcare professionals.\n5. Quality assurance: Continuous linkage for care and access to antiretroviral therapy must be assured.\n6. Ethics and Regulatory Compliance: Provision for ethical and regulatory compliance is necessary.\n\nExclusion Criteria:\n\nAny hospital that does not meet the inclusion criteria will be excluded from participation. We will not use data of patients who have objected against the use of their data for research.",{"count":179,"type":21},5200,[24],"The #aware.hiv Europe study is a real-world, multicenter, stepped-wedge cluster randomized, effectiveness-implementation trial designed to evaluate whether the introduction of dedicated HIV teams in hospitals can improve HIV testing rates among patients presenting with HIV indicator conditions across ten European countries.\n\nStudy Design:\n\nThe study employs a stepped-wedge design, whereby clusters of hospitals transition sequentially from a control phase (routine care) to an intervention phase. All patient data are collected retrospectively from routine care, while prospective data are gathered at the healthcare professional level. The project spans four years and involves hospitals from the Netherlands, Belgium, United Kingdom, Germany, Spain, France, Italy, Romania, Poland, and Ukraine. This design allows for comparison of HIV testing rates and related outcomes before and after the implementation across different settings and time points.\n\nIntervention:\n\nThe core intervention involves the establishment of hospital-based HIV teams. Each team is led by an HIV specialist and supported by nurses and data collectors. Their responsibilities include:\n\nIdentification and Surveillance: Screening routine electronic health records for HIV indicator conditions using predefined ICD-10 codes and verifying cases that warrant HIV testing.\n\nAudit \\& Feedback: Providing targeted recommendations to treating physicians when an HIV test is indicated but has not been performed, thereby prompting action.\n\nEducation \\& Training: Delivering training sessions to healthcare professionals to improve their knowledge and attitudes towards HIV testing, prevention, and care.\n\nEnabling Environment: Implementing digital solutions and other support mechanisms to streamline testing processes, reduce stigma, and enhance overall guideline adherence.\n\nLinkage to prevention: Improving linkage to the locally available preventive services.\n\nThe intervention is intended to integrate seamlessly into routine hospital care, thereby reinforcing existing guidelines while addressing the current diagnostic testing gap.\n\nEndpoints and Outcome Measures:\n\nPrimary Endpoint:\n\nThe change in HIV testing rate among patients diagnosed with HIV indicator conditions before and after the implementation of HIV teams.\n\nKey Secondary Endpoints:\n\nThe change in the incidence of new HIV diagnoses among patients with HIV indicator conditions.\n\nVariations in HIV testing rates across different countries, medical specialties, and types of indicator conditions, as well as over time.\n\nAssessment of the cascade of HIV diagnosis, including the proportion of patients identified with an indicator condition, the offer and acceptance of HIV testing, and documented reasons for non-testing.\n\nEvaluation of the cascade of HIV care and prevention, including linkage to HIV care, achievement of viral suppression, and referral and uptake of preventive services.\n\nChanges in healthcare professionals' knowledge, attitudes, and levels of stigma towards HIV.\n\nImplementation outcomes such as fidelity of HIV team activities, resource utilization, cost-effectiveness, and sustainability of the intervention.\n\nAnalysis of contextual factors, barriers, and facilitators impacting the implementation process, using established frameworks like CFIR and RE-AIM.\n\nImpact:\n\nBy introducing HIV teams and systematically monitoring their effect on HIV testing practices, the study aims to enhance early HIV diagnosis and improve patient outcomes. The findings will contribute to evidence-based guidelines and may promote the adoption of similar interventions across European healthcare settings, ultimately reducing HIV-associated morbidity, mortality, and transmission rates.\n\nThis project not only addresses a critical diagnostic gap in HIV care but also provides valuable insights into the effective implementation of complex interventions in routine clinical practice.",[183,56,27,184,185,186],"HIV Infection","Education","Prevention of Infection With HIV-1","Electronic Health Records",[188,88,189,190,191,192,193,194],"hiv","linkage to care","linkage to prevention","electronic prompts","behavioural intervention","ICD-10 code based","audit and feedback","2026-03-11",{"date":197,"type":35},"2026-03-12",{"date":199,"type":35},"2025-10-01",{"date":201,"type":21},"2030-02-01",{"name":203,"class":42},"Casper Rokx",28,{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":225,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":43},"100591839","khanya-ekhaya-a-home-based-intervention-100591839","NCT06985641","Khanya Ekhaya: A Home-Based Intervention","Home-Based Community Health Worker Support for Mental Health Among People Living With HIV in South Africa: A Hybrid Effectiveness Implementation Trial","Inclusion Criteria:\n\nCHWs:\n\n* at least 18 years old\n* must conduct home visits for people with HIV newly initiating or re-initiating ART at the approved clinic site\n\nPATIENTS:\n\n* at least 18 years old\n* seen by a CHW after newly initiating or re-initiating ART in the past three months\n* screen positive for depressive symptoms or harmful alcohol use\n\nExclusion Criteria:\n\nCHWs:\n\n-Unable or unwilling to complete informed consent and study procedures in English, isiXhosa, or Afrikaans\n\nPATIENTS:\n\n-Unable or unwilling to complete informed consent and study procedures in English, isiXhosa, or Afrikaans",{"count":213,"type":21},119,[24],"Mental health conditions, such as depression, anxiety, and harmful alcohol use are prevalent among people with chronic diseases, including HIV, and contribute to poor engagement in care. There is a need to address untreated mental health problems. Community health workers (CHWs) are frontline workers who play a central role in supporting vulnerable individuals to stay in care, including seeking people living with HIV who are newly initiating antiretroviral therapy (ART) or re-initiating after a period of care disengagement. CHW-delivered interventions are promising for improving engagement and retention in care. Yet, these programs rarely address mental health -a significant barrier to chronic disease care engagement and treatment. An approach that moves beyond providing care in the clinic setting is needed. Community-delivered home-based mental health care has been shown to be feasible and acceptable and shows promise for integration into broader community health care services for people with chronic conditions, such as HIV.",[56,217,218,219,27,220,221,222,223,224],"HIV Antiretroviral Therapy (ART) Adherence","Mental Health","Substance Use Disorders","Community Health Workers","Training","Global Health","Mental Health Recovery","Substance Use Recovery",[220,226,222,224,223,56,227,228,229,230,231,219],"Health Personnel","Health Care Seeking Behavior","Treatment Adherence and Compliance","Attitude of Health Personnel","Substance Use Stigma","Mental health Stigma","2025-05-14",{"date":234,"type":35},"2025-05-22",{"date":236,"type":21},"2025-09-01",{"date":238,"type":21},"2026-06-15",{"name":240,"class":42},"University of Maryland, College Park",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":251,"conditions":252,"keywords":254,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":43},"100578562","urban-and-insular-study-on-treatment-experiences-and-stigma-in-people-living-with-hiv-100578562","NCT06812910","Urban and Insular Study on Treatment Experiences and Stigma in People Living with HIV","Clinical Characterization and Cross-Sectional Comparison of Stigma, Mental Health, and Treatment Experience Among People Living with HIV in Urban and Insular Settings in Portugal","SUNRISE","Inclusion Criteria:\n\n* Individuals diagnosed with HIV\n* Aged 18 years or older.\n* On antiretroviral therapy (ART) for at least six months.\n* On a daily oral treatment regimen (single or multiple pills).\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Individuals under 18 years of age.\n* Individuals who have switched antiretroviral regimen in the previous six months.\n* Individuals unable to provide informed consent (e.g., due to cognitive impairment or lack of capacity).\n* Individuals with limited understanding of the study procedures or questionnaires (e.g., language barriers or cognitive limitations).\n* Individuals who are incarcerated or deprived of liberty.\n* Pregnant individuals.",{"count":250,"type":21},300,"Study Title: SUNRISE Study: Urban and Island Experiences of HIV Treatment and Stigma\n\nWhat is this study about? This study aims to understand how living in urban areas versus islands affects the experiences of people living with HIV (PLWH) in Portugal. Specifically, the investigators want to explore how stigma and mental health (such as depression and anxiety) differ between these two settings. The investigators are also interested in understanding how the number of pills a person takes daily (called \"pill burden\") impacts their mental health and satisfaction with treatment.\n\nWhy is this study important? Stigma related to HIV can make it harder for people to stick to their treatment and can negatively affect their mental health and overall well-being. By comparing urban and island settings, the investigators hope to identify unique challenges faced by PLWH in different environments. This information will help the investigators to develop better strategies to support people living with HIV, no matter where they live.\n\nWho can participate? Adults (18 years or older) who have been diagnosed with HIV. People who have been on antiretroviral therapy (HIV treatment) for at least six months.\n\nIndividuals living in urban areas or island region.\n\nWhat will happen during the study?\n\nParticipants will complete a one-time interview during their regular HIV care visit. The interview will include questions about:\n\nTheir experiences with HIV-related stigma. Their mental health (including depression and anxiety). Their satisfaction with their current HIV treatment. The number of pills they take daily and how this affects their daily life. All information will be kept confidential, and participation is voluntary.\n\nWhat are the potential benefits of participating? This study will help to understand the challenges faced by people living with HIV in different parts of Portugal. This knowledge can lead to improved support services and treatment options for PLWH in the future.\n\nWhat are the risks of participating? There are no physical risks associated with this study. However, some questions may touch on sensitive topics, such as stigma or mental health.\n\nHow will the results be used? The results of this study will be shared with the scientific community, healthcare providers, and organizations that support people living with HIV. The goal is to use this information to improve care and reduce stigma for PLWH in Portugal and beyond.\n\nWho is conducting this study? This study is led by researchers from the Faculty of Medicine of Lisbon, in collaboration with hospitals in Portugal mainland, the Azores, and Madeira.",[56,27,253],"Depression\u002FAnxiety",[56,255,256,257,258],"HIV related stigma","mental health","pill burden","treatment experience","2025-02-15",{"date":261,"type":35},"2025-02-19",{"date":263,"type":21},"2025-03-01",{"date":265,"type":21},"2026-02-27",{"name":267,"class":268},"Fábio Cota Medeiros","NETWORK",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":22,"phases":279,"briefSummary":280,"conditions":281,"keywords":284,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":296,"locationsCount":43},"100559669","a-group-based-treatment-for-self-stigma-in-people-with-mental-disorders-in-north-east-italy-100559669","NCT06567145","A Group-based Treatment for Self-stigma in People With Mental Disorders in North-east Italy","Assessing the Effectiveness and Feasibility of Group-based Treatment for Self-stigma in People With Mental Disorders: a Pragmatic Multisite Randomized Controlled Trial in Routine Mental Health Services in North-east Italy","NECT-ITA","Inclusion Criteria:\n\n1. Participants must be 18 years or older.\n2. Individuals must have a diagnosis of schizophrenia, schizoaffective disorder, schizoid disorder, schizophreniform disorder, bipolar I or II disorder, or major depressive disorder, according to DSM-5 criteria.\n3. Participants must be outpatients with clinical stability for at least 3 months, with no changes in pharmacological treatment during this period.\n4. Participants must have sufficient knowledge of written and spoken Italian.\n5. Participants must score above 1 on the ISMI (Internalized Stigma of Mental Illness) scale, indicating at least moderate levels of self-stigma.\n\nExclusion Criteria:\n\n1. Individuals unable to provide informed consent are excluded.\n2. Participants with intellectual disabilities are excluded.\n3. Individuals with primary diagnosis of personality disorder or substance dependence condition are excluded.\n4. Participants engaged in other programs that could influence self-stigma (e.g., social cognitive rehabilitation, social skills training) during the study are excluded.",{"count":278,"type":21},416,[24],"Self-stigma refers to the internalization of negative stereotypes by individuals with mental disorders, leading to beliefs that they are dangerous, aggressive, or incapable of working. This phenomenon has harmful effects on various aspects of life, such as adherence to treatment, self-esteem, quality of life, and can increase feelings of despair and suicide risk. To address these issues, the Narrative Enhancement and Cognitive Therapy (NECT) was developed. NECT is a group-based intervention consisting of 20 sessions designed to reduce self-stigma in individuals with mental disorders.\n\nThis study aims to evaluate the efficacy and feasibility of NECT in 416 patients from 26 mental health centers in Northeast Italy. It is structured as a pragmatic, multicenter, randomized controlled trial with two parallel arms. The study will assess the impact of NECT on several psychological dimensions, including levels of self-stigma, self-esteem, hope, empowerment, perception of recovery, mental well-being, and stigma-related stress. The findings of this research are expected to contribute to the understanding of effective treatments for patients with mental disorders, particularly those burdened by high levels of self-stigma, and to improve their recovery outcomes.",[27,282,283],"Mental Disorders","Self-stigma",[88,285,286,287,288,289],"narrative enhancement cognitive therapy","narrative therapy","cognitive therapy","mental disorders","self-stigma","2024-11-21",{"date":292,"type":35},"2024-11-26",{"date":294,"type":35},"2024-10-01",{"date":199,"type":21},{"name":297,"class":42},"Universita di Verona"]