[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stoma---ileostomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stoma---ileostomy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100604170","feasibility-of-a-newly-developed-ostomy-prototype-100604170",false,"NCT07146035","Feasibility of a Newly Developed Ostomy Prototype","Inclusion Criteria:\n\nHas given written informed consent Is at least 18 years old Has full legal capacity Is able (assessed by the investigator) and willing to adhere to study procedures during study duration.\n\nHas had an ileostomy for at least 30 days. Has been self-managing their own ostomy product for at least 14 days. Has experienced leakage under the baseplate at least 3 times within the past 2 weeks.\n\nIs able to fit one of the two test product sizes (Ø50mm or Ø60mm). Uses a flat baseplate Is willing to change their baseplate daily Has intact peristomal skin (assessed by the investigator) Is able to use a smartphone with camera\n\nExclusion Criteria:\n\nIs participating in any other clinical investigation during this investigation Has previously participated or completed this investigation Has a known hypersensitivity towards the prototype used in the investigation Is pregnant Is breast feeding Has more than one ostomy synchronously Has ongoing non-healed abdominal wounds Has planned MR scans during the 24-hour test recording","ALL","18 Years",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","Despite the development of better stoma products, individuals with intestinal stomas can experience leakage problems, which negatively affect their quality of life. To overcome this, Coloplast are in the process of developing a leakage measurement device. Each participant will undergo five 24-hour test periods over three weeks, wearing the prototype around the stoma (Test) and on the opposite side (Control).",[25],"Stoma - Ileostomy","NOT_YET_RECRUITING","2025-08-27",{"date":29,"type":30},"2025-08-28","ACTUAL",{"date":32,"type":19},"2025-08-25",{"date":34,"type":19},"2025-09-30",{"name":36,"class":37},"Coloplast A\u002FS","INDUSTRY",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":49,"briefSummary":50,"conditions":51,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100586637","study-of-treatment-with-intensified-omeprazole-treatment-to-prevent-high-output-stoma-1-100586637","NCT06917963","Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1","Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1: a Randomized, Non-blinded, Controlled Trial","STOP-HOS-1","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective or emergency surgery requiring end or loop ileostomy formation\n* Able and willing to provide written informed consent\n* No contraindications to omeprazole use\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Known hypersensitivity or allergy to proton pump inhibitors (including omeprazole)\n* Conditions preventing accurate measurement of daily ileostomy output",{"count":48,"type":19},80,[22],"The goal of this clinical trial is to evaluate if intensified omeprazole therapy can reduce high-output stoma (HOS) in adults undergoing ileostomy formation surgery. The main objectives of the study are:\n\n* To assess if intensified omeprazole treatment significantly reduces mean daily ileostomy output (ml\u002F24h) during the first three postoperative days compared to standard omeprazole treatment.\n* To evaluate the proportion of patients meeting the criteria for high-output stoma (HOS ≥1400 ml\u002Fday) on consecutive postoperative days.\n* To measure the time required for stabilization of ileostomy output (\\\u003C1400 ml\u002Fday maintained for three consecutive days).\n* To determine the incidence of dehydration-related complications, specifically electrolyte disturbances (hyponatremia, hypokalemia).\n* To compare the length of initial hospital stay, frequency of rehospitalizations within 30 days post-discharge, and total length of hospital stay (including rehospitalizations).\n\nResearchers will compare 10 days intensified omeprazole treatment (loading dose of 80 mg IV followed by 40 mg IV twice daily) with standard treatment (40 mg IV once daily) to determine the effectiveness of intensified dosing in reducing ileostomy output and improving postoperative outcomes.\n\nParticipants will:\n\n* Receive either standard or intensified intravenous omeprazole during their hospitalization and after discharge for 10 days combined.\n* Undergo daily measurements of ileostomy output.\n* Have routine laboratory assessments of electrolyte levels.\n* Participate in follow-up assessments up to 30 days post-discharge, conducted either through outpatient visits or telephone consultations.",[25,52,53,54,55,56],"High Output Stoma","Colon Cancer","IBD (Inflammatory Bowel Disease)","Ileus","Omeprazole",[58,59,60,61,62,63,64],"stoma","ileostomy","high output stoma","omeprazole","ipp","colon cancer","ibd","RECRUITING","2025-07-28",{"date":68,"type":30},"2025-07-31",{"date":70,"type":30},"2025-04-10",{"date":72,"type":19},"2027-07",{"name":74,"class":75},"Medical University of Gdansk","OTHER",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":83,"targetDuration":85,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":38},"100590982","implementation-of-an-efferent-loop-stimulation-protocol-prior-to-ileostomy-closure-at-la-paz-university-hospital-100590982","NCT06974500","Implementation of an Efferent Loop Stimulation Protocol Prior to Ileostomy Closure at La Paz University Hospital","IInclusion Criteria:\n\n1. Subjects must be able to understand the purpose and risks of the study, provide informed consent, and authorise the use of confidential health information.\n2. Patients over 18 years of age who, regardless of the underlying cause, have an ileostomy and a medical indication for intestinal transit reconstruction by a general surgeon.\n3. Subjects who are able and willing to participate and to comply with follow-up for the duration of the study.\n\nExclusion Criteria:\n\n1. Subjects with an ileostomy who do not wish to undergo intestinal reconstruction.\n2. Subjects who are unable to complete at least two weeks of efferent loop stimulation prior to reconstruction surgery.\n3. Subjects who do not provide consent to participate in the study.",{"count":84,"type":19},68,"2 Years","OBSERVATIONAL","Stoma creation is a common surgical procedure, employed in certain contexts within general surgery, particularly in colorectal and emergency surgery. Although stoma formation is a life-saving technique, the diversion of intestinal contents has pathophysiological, aesthetic, and psychological repercussions on patients' lives. Stomas may be either permanent or temporary. In temporary cases, a second intervention is required to perform ileostomy closure and restore normal intestinal transit.\n\nSeveral studies indicate that stimulation of the efferent loop prior to ileostomy closure yields benefits in patients' postoperative outcomes. Currently, there is no established protocol for this intervention at Hospital Universitario La Paz. However, implementing such a protocol-given that it is a simple, inexpensive, and accessible intervention-could offer significant cost-effectiveness. It may reduce complications and hospital stay, improve patients' quality of life, and represent a valuable contribution to the General Surgery Departmen",[89,90,25],"Postoperative Ileus","Colorectal Cancer Control and Prevention",[92],"Ileostomy , Stoma, Colorectal, Posoperative","2025-05-07",{"date":95,"type":30},"2025-05-16",{"date":97,"type":30},"2025-01-01",{"date":99,"type":19},"2027-04-01",{"name":101,"class":75},"Hospital Universitario La Paz"]