[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"strabismus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:strabismus":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,58,85,119,142,168,194,219,243,278,307,326,354,381,405,428,456],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100638476","clinical-validation-of-ai-based-quantitative-eye-movement-analysis-from-smartphone-9-gaze-videos-glandy-eom-100638476",false,"NCT07623837","Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)","Prospective Multicenter Observational Study for Clinical Validation of AI-Based Quantitative Eye Movement Analysis Using Smartphone-Recorded 9-Gaze Videos","GLANDY-EOM-VAL","Inclusion Criteria:\n\n* Adults who have reached the legal age of consent for research participation in the applicable jurisdiction.\n* Subjects with suspected or known ocular motility abnormalities.\n* Subjects who are able to understand and follow gaze instructions required for the 9-gaze examination, as judged by the investigator.\n* Subjects who are able to undergo facial video recording using a smartphone.\n* Subjects who provide written informed consent.\n\nExclusion Criteria:\n\n* Conditions that prevent reliable detection of ocular landmarks in video recordings (e.g., severe ptosis, corneal opacity, or significant occlusion of the eyes).\n* Ocular or facial conditions that, in the opinion of the investigator, may significantly interfere with image-based analysis.\n* Subjects who are unable to comply with study procedures.","ALL","22 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","This prospective, multicenter, multinational observational study evaluates the clinical validity of an AI-based quantitative eye movement analysis system (Glandy EOM) that analyzes smartphone-recorded 9-gaze videos. Approximately 200 adults per site with suspected or confirmed ocular motility abnormalities will undergo a single study visit consisting of a standard clinical 9-gaze examination, an assistant-aided smartphone video recording, and a patient self-recorded video acquisition using a mobile application. Because the study population is defined by clinical suspicion or diagnosis of ocular motility abnormality rather than confirmed disease at enrollment, some participants may be clinically judged to have no abnormality on formal evaluation; such subjects remain part of the study population and are not considered healthy volunteers. AI-derived quantitative eye movement metrics (corneal center displacement in millimeters and angular deviation) will be compared with rater-derived measurements obtained from the same videos using a calibrated reference approach, and with clinician-assessed 9-gaze grading. The investigational device is used solely for video acquisition and analysis and does not influence clinical decision-making.",[25,26,27,28],"Ocular Motility Disorders","Strabismus","Extraocular Muscle Dysfunction","Thyroid Eye Disease",[30,31,32,33,34,35,36,37,38,26,39,40,41,42,43,44],"Ocular motility","Eye movement","9-gaze examination","Artificial intelligence","Smartphone video","Quantitative analysis","Corneal center displacement","Angular deviation","Extraocular muscle","Diplopia","Glandy EOM","Software as a Medical Device","SaMD","Digital health","Clinical validation","NOT_YET_RECRUITING","2026-05-28",{"date":48,"type":49},"2026-06-03","ACTUAL",{"date":51,"type":21},"2026-07-01",{"date":53,"type":21},"2027-12-31",{"name":55,"class":56},"THYROSCOPE INC.","INDUSTRY",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":66,"studyType":22,"phases":4,"briefSummary":70,"conditions":71,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":57},"100635058","evaluation-of-a-county-based-eye-health-service-model-in-rural-chinese-children-100635058","NCT07547748","Evaluation of a County-Based Eye Health Service Model in Rural Chinese Children","Evaluation of a County-Based Eye Health Service Model for Preventing and Controlling Avoidable Visual Impairment in Rural Chinese Children","Inclusion Criteria:\n\n* Aged 3 to 18 years; Enrolled in schools within the study areas, including kindergartens, primary schools, junior high schools, and senior high schools, in Yangxi County, Jiexi County, Huidong County, and Yingde City of Guangdong Province, as well as Fengqing County of Yunnan Province, or are children and adolescents who are permanent residents within these jurisdictions.\n* Written informed consent has been provided by their legal guardians.\n* For children aged 8 years and older, assent from the child is also required.\n\nExclusion Criteria:\n\n* Presence of severe systemic diseases (such as severe congenital heart disease or intellectual developmental disorders) that preclude cooperation with ophthalmic examinations.\n* Refusal by the legal guardian to participate, or inability of the legal guardian to cooperate with scheduled follow-up visits.",true,"3 Years","18 Years",{"count":69,"type":21},20000,"This project proposes to conduct a prospective, multicenter registry study in rural China to evaluate, under real-world conditions, the implementation effectiveness of an integrated child eye health service model centered at the county level and coordinated across county, township, village, and school tiers. The target population will include all children and adolescents within participating counties, and the primary exposure will be the annual coverage and implementation intensity of this service model. The study will focus on its impact on clinical outcomes such as refractive error correction rates and referral rates following eye disease screening, while also examining annual trends in disparities in access to different eye care services. Through long-term and systematic observation, the project aims to clarify the sustained effects of this eye health service model on improving the management of pediatric eye diseases, enhancing visual function, and promoting health equity, thereby providing evidence-based support for optimizing the rural child eye care system in China.",[72,26,73],"Myopia","Eye Health","RECRUITING","2026-04-16",{"date":77,"type":49},"2026-04-23",{"date":79,"type":49},"2025-01-01",{"date":81,"type":21},"2028-12-31",{"name":83,"class":84},"Zhongshan Ophthalmic Center, Sun Yat-sen University","OTHER",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":57},"100627283","risk-factors-and-surgical-outcomes-of-strabismus-reoperation-100627283","NCT07446621","Risk Factors And Surgical Outcomes Of Strabismus Reoperation","Risk Factors And Surgical Outcomes Of Strabismus Reoperation: A Clinical Study","RSOR","Inclusion Criteria:\n\n* Patients diagnosed with horizontal strabismus (esotropia or exotropia).\n\n  * Patients undergoing repeat surgery for correction of residual, recurrent, undercorrected, or overcorrected horizontal strabismus.\n  * Availability of sufficient medical records documenting previous strabismus surgery.\n  * Ability to attend scheduled postoperative follow-up visits.\n  * Written informed consent obtained from the patient or legal guardian.\n\nExclusion Criteria:\n\n* Combined vertical and horizontal strabismus.\n\n  * Paralytic strabismus.\n  * Restrictive strabismus.\n  * Strabismus associated with neurological or syndromic conditions.\n  * Patients with incomplete or insufficient documentation of previous surgical procedures.\n  * Patients unwilling or unable to complete follow-up.",{"count":94,"type":21},62,"INTERVENTIONAL",[97],"NA","Horizontal strabismus, commonly known as inward or outward deviation of the eyes, is a frequent eye condition that may require surgical correction. Although the first surgery is often successful, some patients develop residual or recurrent eye misalignment and require a second operation (reoperation).\n\nThis study aims to identify the clinical and surgical factors that may increase the risk of undercorrection, overcorrection, or recurrence after the first surgery. It also evaluates the outcomes and success rate of repeat surgery in patients with horizontal strabismus.\n\nPatients undergoing reoperation will receive a complete ophthalmological examination before surgery. The surgical plan will be individualized based on previous surgical history and current eye findings. All procedures will be performed under general anesthesia by the same surgeon. Participants will be followed for three months after surgery to assess eye alignment, movement, and possible complications.\n\nThe results of this study may help improve surgical planning and predict which patients are at higher risk of requiring additional surgery in the future.",[26,100,101],"Esotropia","Exotropia",[103,104,105,106,107,108,109,30],"Horizontal strabismus","Strabismus reoperation","Recurrent strabismus","Ocular alignment","Prism diopters","Paediatric strabismus surgery","Orthotropia","2026-03-06",{"date":112,"type":49},"2026-03-09",{"date":114,"type":21},"2026-03",{"date":116,"type":21},"2027-07",{"name":118,"class":84},"Assiut University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":57},"100386323","visual-function-abnormalities-in-strabismus-and-amblyopia-and-response-to-therapy-100386323","NCT04310241","Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy","Oculomotor Disorders: Experimental and Clinical Study","Inclusion Criteria:\n\n* History of amblyopia or presence of amblyogenic risk factors.\n\nExclusion Criteria:\n\n* History of neurologic disorders","6 Months","90 Years",{"count":129,"type":21},150,"Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.",[132,26],"Amblyopia","2026-03-02",{"date":135,"type":49},"2026-03-04",{"date":137,"type":49},"2020-02-21",{"date":139,"type":21},"2027-03-12",{"name":141,"class":84},"The Cleveland Clinic",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":65,"sex":17,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":95,"phases":153,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":57},"100518839","phase-4-the-occurrence-of-emergence-agitation-in-pediatric-strabismus-surgery-100518839","NCT06035757","The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery","The Effect of Administration of Sugammadex on the Occurrence of Emergence Agitation in Pediatric Strabismus Surgery-prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients scheduled elective strabismus surgery aged 4-7 with American Society of Anesthesiologists (ASA) classification 1-3.\n\nExclusion Criteria:\n\n* ASA classification 3 or more\n* impaired liver function\n* impaired kidney function\n* myasthenia gravis or other neuromuscular disorders\n* history of drug allergy\n* cardiovascular disease or arrhythmia","4 Years","7 Years",{"count":152,"type":21},76,[154],"PHASE4","The present trial conducted to demonstrate the administration of sugammadex as reversal of neuromuscular blockade agent reduces the incidence of emergence agitation (EA) comparing to neostigmine",[157,26,158],"Emergence Delirium","Pediatric ALL","2026-03-01",{"date":161,"type":49},"2026-03-03",{"date":163,"type":49},"2023-12-01",{"date":165,"type":21},"2026-03-30",{"name":167,"class":84},"Konkuk University Medical Center",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":57},"100587464","ocular-characteristics-in-patients-with-craniosynostosis-100587464","NCT06928727","Ocular Characteristics in Patients With Craniosynostosis","COPACA","Inclusion Criteria:\n\n* Diagnosis of craniostenosis\n\nExclusion Criteria:\n\n* Posterior plagiocephalia",{"count":176,"type":21},65,"Craniosynostosis are cranial deformations due to the premature closure of one or more cranial sutures. These deformations affect approximately one in 2.500 births. In most cases, craniosynostoses are isolated with unknown (non syndrome). On the other hand, 20% of these deformations are associated with other concentration (syndrome).\n\nCraniosynostosis has morphological (associated dysmorphism) and functional (growth conflict between the skull and the brain) repercussions. Ophthalmological disorders are frequent: refractive disorders, oculomotor disorders, optic nerve damage, sensory damage.\n\nThis retrospective study aims to describe the ocular clinical characteristics associated with craniosynostosis in patients followed at the Amiens University Hospital.",[179,26,180,132],"Craniosynostosis","Intracranial Hypertension",[179,182,183,184],"strabismus","amblyopia","intracranial hypertension","2026-02-10",{"date":187,"type":49},"2026-02-12",{"date":189,"type":49},"2025-04-04",{"date":191,"type":21},"2026-11",{"name":193,"class":84},"Centre Hospitalier Universitaire, Amiens",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":149,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":95,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":4},"100616133","vision-3d-visual-skills-improvement-with-on-screen-3d-movies-100616133","NCT07301645","VISION-3D: Visual Skills Improvement With On-screen 3D Movies.","Efficacy of 3D Versus 2D Movie Viewing on Stereopsis and Visual Function in Children With Residual Ambliopia. A Randomized Controlled Trial.","VISION3D","Inclusion Criteria:\n\n* Children aged 4 to 12 years.\n* Previous diagnosis of unilateral amblyopia (anisometropic, strabismic, or mixed).\n* History of conventional treatment (optical correction, occlusion and\u002For penalization) with stable visual acuity for at least 6 months.\n* Interocular visual acuity difference ≥ 0.2 logMAR (≈ ≥2 Snellen lines).\n* Ability to understand and follow age-appropriate basic instructions.\n* Parent\u002Fguardian consent (and child assent when applicable)\n\nExclusion Criteria:\n\n* Ocular surgery within the last 6 months.\n* Manifest strabismus \\>15 prism diopters.\n* Concomitant ocular pathology that may affect vision (e.g., cataract, nystagmus, ptosis, corneal opacity, retinal disease, optic neuropathy).\n* Cognitive or neurological deficits preventing compliance with the protocol.\n* Prior intensive exposure to 3D cinema or VR\u002F3D videogames that could act as a confounder.\n* Family or child refusal to participate","14 Years",{"count":204,"type":21},40,[97],"This clinical study investigates whether watching 3D films can help improve the vision of children with residual amblyopia (lazy eye), that is, those children who, despite having undergone usual treatments such as glasses or patching, still maintain some visual deficit. The main objective is to verify whether viewing in 3D is better than viewing in 2D in improving depth vision (stereopsis), visual acuity and ocular alignment. The hypothesis is that 3D films, by providing richer binocular stimuli, will produce greater improvements than the same 2D films.\n\nChildren between 4 and 14 years of age with residual, stable and previously treated unilateral amblyopia will be included. Participants will be recruited from the pediatric ophthalmology\u002Foptometry clinics of the Mútua University Hospital\n\nThe study will be conducted in two locations: the visual examinations will be performed at the Mútua University Hospital in Terrassa, and the film sessions at the Faculty of Optics and Optometry of Terrassa (FOOT, UPC), in rooms prepared with a projector and 3D glasses.\n\nThe design is randomized and controlled. In a first phase, the children will be randomly divided into two groups: one group will watch 3 films in 3D and the other will watch the same films in 2D. Then, in a second phase, all participants will watch 3 additional sessions in 3D. Four evaluation visits will be made: before starting, after phase 1, after phase 2 and a follow-up two months later. These visits will measure stereopsis, visual acuity, and ocular deviation with standard optometric tests.\n\nWatching 3D movies is a safe and non-invasive activity; therefore, no significant risks are expected beyond some possible mild and transient discomfort such as eye strain or headache, which will be recorded if it occurs. Potential benefits include improved depth perception and other visual functions, and the results could open the door to new, fun and motivating therapeutic options for other children with amblyopia in the future.",[132,26],[132,26,209],"Cinema 3D","2025-12-10",{"date":212,"type":49},"2025-12-24",{"date":214,"type":21},"2026-01-15",{"date":216,"type":21},"2026-07",{"name":218,"class":84},"Universitat Politècnica de Catalunya",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":57},"100421647","genetic-studies-of-strabismus-nystagmus-and-associated-disorders-100421647","NCT04770519","Genetic Studies of Strabismus, Nystagmus, and Associated Disorders","Inclusion Criteria:\n\n\\- Member of a family with at least 3 biological relatives with strabismus. (Both affected and non-affected family members will be enrolled).\n\nOR\n\n\\- Member of a family with at least 1 individual with infantile esotropia. (Both affected and non-affected family members will be enrolled).\n\nOR\n\n\\- Member of a family with at least 1 individual with infantile nystagmus. (Both affected and non-affected family members will be enrolled).\n\nExclusion Criteria:\n\n* paralytic strabismus in affected family members",{"count":226,"type":21},400,"Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and\u002For whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.",[26,229],"Nystagmus, Congenital",[182,231,232,233],"esotropia","exotropia","nystagmus","2025-12-09",{"date":236,"type":49},"2025-12-12",{"date":238,"type":49},"2021-09-03",{"date":240,"type":21},"2030-12",{"name":242,"class":84},"Boston Children's Hospital",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":65,"sex":17,"minAge":251,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":254,"conditions":255,"keywords":265,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":57},"100340496","intraoperative-oct-guidance-of-intraocular-surgery-ii-100340496","NCT03713268","Intraoperative OCT Guidance of Intraocular Surgery II","Intraoperative OCT Guidance of Intraocular Surger","MIOCT","Inclusion Criteria:\n\n1. Healthy controls: Healthy eyes without known disease: refractive error including myopia and non-significant cataract is allowed. For selected testing pseudophakia is allowed.\n2. Surgeons as research subjects: Adult (≥18 years old)\n3. Surgical patients (vitreoretinal surgery): Patients undergoing examination under anesthesia or surgery for vitreoretinal diseases\n4. Surgical patients (anterior segment surgery-glaucoma, ocular surface or strabismus requiring extraocular muscle surgery): Include both adults and children. Patient undergoing primary, elective minimally invasive glaucoma surgery, ocular surface surgery, or strabismus surgery.\n\nExclusion Criteria:\n\n1. Healthy controls: Any ocular disease that restricts the ability to perform OCT scanning. Conflict of interest with investigators\u002Fstudy personnel, e.g. a student in the lab of an investigator.\n2. Surgeons as research subjects: no specific exclusion criteria.\n3. Surgical patients (vitreoretinal surgery): Neonates (\\\u003C 4 weeks of age) and patients with any ocular disease that restricts the ability to perform OCT scanning.\n4. Surgical patients (anterior segment surgery-corneal and cataract diseases): Pediatric patients: The cornea and cataract surgery studies will be restricted to adults (≥ 18 years). Children do not have cataract surgery typically by residents and therefore would not fit our study design. Similarly pediatric corneal transplants are very rare.","4 Weeks",{"count":253,"type":21},262,"The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other microsurgeries not possible due to current limitations in surgical visualization.",[256,257,258,259,260,261,262,263,26,264],"Macular Holes","Epiretinal Membrane","Diabetic Retinopathy","Retinal Detachment","Retinal Disease","Preretinal Fibrosis","Cataract","Ocular Tumor","Healthy",[266,249,267,268],"Microscope Integrated optical coherence tomography","OCT Angiography","OCTA","2025-10-02",{"date":271,"type":49},"2025-10-06",{"date":273,"type":49},"2018-09-30",{"date":275,"type":21},"2027-05-31",{"name":277,"class":84},"Duke University",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":282,"acronym":283,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":17,"minAge":285,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":95,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":57},"100606810","botulinum-toxin-for-strabismus-treatment-100606810","NCT07180394","Botulinum Toxin for Strabismus Treatment","Botox Squint","Inclusion Criteria:\n\n* Esotropia or exotropia presenting with a small-to-moderate angle deviation (\\\u003C40 PD)\n\n  * Acute onset comitant esotropia\n  * Postoperative residual or consecutive strabismus (2-8 weeks postoperatively or later)\n  * Acute paralytic strabismus to alleviate diplopia while the palsy resolves (mainly sixth nerve palsies, sometimes fourth nerve palsy)\n  * Active thyroid eye disease (Graves Disease), inflamed or pre-phthisical eyes, when surgery is not recommended\n  * Adjunct to surgery for large-angle esotropia or sixth nerve palsy or for large-angle exotropia\n  * As a muscle sparing option in patients at risk of anterior segment ischemia\n\nExclusion Criteria:\n\n* Unrealistic expectations\n\n  * Neuromuscular disorders: Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis and Eaton-Lambert syndrome\n  * Pregnancy and breastfeeding","1 Month",{"count":287,"type":21},127,[97],"The bacterial species Clostridium botulinum produces a class of neurotoxins known as botulinum toxin. At the neuromuscular junction, botulinum toxin A prevents acetylcholine from being released. Following a Botox intramuscular injection, the injected EOM becomes paralysed 2-4 days after the injection and remains so clinically for at least 5-8 weeks. Muscle function recovery takes five to fourteen weeks, depending on the injection site, volume, and concentration of the solution, as well as the innervation density.\n\nBotulinum toxin treatment results in a pharmacologic recession of the injected extraocular muscle, and the muscle lengthens while its agonist contracts, paralysing it. Improved ocular alignment or a decrease in the severity of the deviation may last for a long time, even if the pharmaceutical impact normally goes away after three months.\n\nEven after the pharmacologic effect has worn off, a number of elements, such as mechanical, proprioceptive, and binocular effects, may intervene during the period of muscle paralysis to help stabilise and improve alignment in strabismus patients over the long term.",[291,26],"Strabismic Deviation",[26,231,232,293,294,295,296,297],"hypotropia","hypertropia","Botulinum toxin","therapy","outcomes","2025-09-15",{"date":300,"type":49},"2025-09-18",{"date":302,"type":21},"2025-09-30",{"date":304,"type":21},"2030-08-30",{"name":306,"class":84},"Foundation University Islamabad",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":4},"100604703","medial-rectus-tendon-width-and-surgical-dose-response-in-commitant-esotropic-patients-100604703","NCT07152964","Medial Rectus Tendon Width and Surgical Dose Response in Commitant Esotropic Patients","Clinical Correlation Between Medial Rectus Tendon Width and Surgical Dose Response in Commitant Esotropic Patients Undergoing Medical Rectus Recession","Inclusion Criteria:\n\n\\- All patients with comitant esotropia scheduled for unilateral or bilateral medial rectus recession\n\nExclusion Criteria:\n\n* previous extraocular muscle surgery Incomitant esotropia",{"count":315,"type":21},28,"This study aims to investigate the clinical correlation between medial rectus tendon width and surgical dose response in esotropic patients undergoing medical rectus recession",[26],"2025-08-26",{"date":320,"type":49},"2025-09-03",{"date":322,"type":21},"2025-09",{"date":324,"type":21},"2026-10",{"name":118,"class":84},{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":17,"minAge":333,"maxAge":334,"enrollmentInfo":335,"targetDuration":4,"studyType":95,"phases":336,"briefSummary":338,"conditions":339,"keywords":340,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":57},"100582466","phase-3-highly-aspherical-lenslet-hal-and-binocular-vision-bv-disorders-halt-xt-study-100582466","NCT06863675","Highly Aspherical Lenslet (HAL) and Binocular Vision (BV) Disorders [HALT X(T) Study]","HALT XT","Inclusion Criteria:\n\nAge 5-12 years old Myopia of between -1D and -6D in at least 1 eye Progression of at least 0.5D within the last year Astigmatism less than 2.5D Exotropia Exophoria: horizontal deviation \\\u003C40PD Esotropia (good control), Esophoria: horizontal deviation \\\u003C40PD Any vertical strabismus: Vertical deviation \\\u003C10 PD Intermittent exotropia (good, moderate, poor) Horizontal deviation ≥15 PD, vertical deviation ≤5 PD (?)\n\nExclusion Criteria:\n\nVA poorer than logMAR 0.2 (6\u002F9.5) in either eye Any other ocular condition (e.g. lens opacity, glaucoma) other than myopia, strabismus or nystagmus) Any medical\u002Fneurological condition which would interfere with subjects ability to co-operate with tests and attend follow-up appointments.\n\nPlans of surgery for strabismus or nystagmus in the next year Constant XT). Past use of any other from of myopia control treatment (eg. atropine or myopia control glasses or contact lenses) within the last year.","5 Years","12 Years",{"count":204,"type":21},[337],"PHASE3","Assess the effect and changes of eye misalignment (strabismus) with myopia control glasses Assess the efficacy of myopia control glasses on childhood myopia progression in children with strabismus due to the uncertainty clinicians face when prescribing myopia control glasses to these strabismic children",[72,26],[72,26,341,342,343],"HALT","Stellest","Myopia Control","2025-03-03",{"date":346,"type":49},"2025-03-07",{"date":348,"type":21},"2025-06-01",{"date":350,"type":21},"2030-06-30",{"name":352,"class":353},"Singapore National Eye Centre","OTHER_GOV",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":362,"maxAge":363,"enrollmentInfo":364,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":366,"conditions":367,"keywords":368,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":57},"100572434","balance-in-the-strabismic-patient-undergoing-strabismus-surgery-100572434","NCT06733220","Balance in the Strabismic Patient Undergoing Strabismus Surgery","Assessment of Balance in the Strabismic Patient Undergoing Strabismus Surgery","BASS","Inclusion Criteria:\n\n* Age between 16 and 65 years;\n* Presence of congenital strabismus or acquired strabismus in the care of the Ophthalmology OU, the Diagnosis and Treatment of Ocular Motility Disorders OU, and the Pediatric Ophthalmology Outpatient Clinic\n* Ability to maintain balance safely for at least 180 seconds;\n* In case of adult patient, Ability to understand and sign informed consent\n* In case of minor patient, Ability to understand and sign the assent for participation in the study and consent from the parent\n\nExclusion Criteria:\n\n* Presence of diplopia associated with nystagmus;\n* Presence of psychomotor and cognitive delay, as assessed by the Mini Mental State Examination (adjusted score \\\u003C 24);\n* Noncooperation of the patient;\n* Inability to provide informed consent, in the case of adult patients.\n* Inability to provide consent in case of minor patients, or consent from parents.","16 Years","65 Years",{"count":365,"type":21},50,"Strabismus is a clinical condition characterized by the failure of the visual axes of the two eyes to align on the stared object. There are many possible causes of strabismus, but it can be divided into two main groups: concomitant strabismus, which is characterized by an almost equal angle of deviation in all positions of gaze, and incomitant or paralytic strabismus, which is characterized by a deficit of ocular motility in one or more directions of gaze. Depending on the age of onset, congenital strabismus and acquired strabismus are distinguished. Concomitant strabismus and incomitant strabismus can occur in both plastic age and adults. They are accompanied by diplopia or confusion if they arise in adulthood; there is no diplopia if they arise in plastic age due to cortical compensation mechanisms such as suppression or abnormal retinal matching. Causes of incomitant strabismus in adults can be: decompensation of a preexisting heterophoria; acute incomitant strabismus; injury to fusional centers. Paralytic incomitant strabismus is characterized by a reduction in the force developed by one or more muscles of an eye. Among incomitant strabismus, restrictive strabismus represent clinical pictures of very different etiology united by a single distinguishing feature: the existence of a mechanical obstacle to the free movement of the bulb in the orbit that prevents or reduces the excursion of the eye in one or more directions of gaze.\n\nIn about 4% of the young population, the sensory and\u002For motor pathways are not adequately developed, resulting in misalignment of the visual axes and strabismus. Eye surgery for strabismus is one of the most widely used treatment methods.\n\nOnly a few studies in the literature have analyzed changes in postural control after strabismus surgery and on a limited number of patients.\n\nA French study evaluated the effect of surgery on postural control in children with strabismus, concluding that eye surgery affects the somatosensory properties of extraocular muscles, leading to improved postural control and that binocular visual perception could affect the whole body.",[26],[26,369,370,371],"Balance","Risk of falling","Quality of life","2025-02-27",{"date":374,"type":49},"2025-03-04",{"date":376,"type":49},"2025-02-05",{"date":378,"type":21},"2027-02",{"name":380,"class":84},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":11,"sex":17,"minAge":149,"maxAge":334,"enrollmentInfo":388,"targetDuration":4,"studyType":95,"phases":390,"briefSummary":392,"conditions":393,"keywords":394,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":403,"locationsCount":57},"100569107","phase-2-pain-after-strabismus-surgery-100569107","NCT06689943","Pain After Strabismus Surgery","Pain After Strabismus Surgery: Post-Operative Outcomes Using Courses of Acetaminophen in Children","Inclusion Criteria:\n\n* Children between 4-12 years old\n* Children receiving single muscle, bilateral horizontal strabismus surgery (that is, children who are having only one horizontal eye muscle in each eye operated on) at Lurie Children's hospital in Chicago, IL\n* ASA classification 1 or 2. Note: ASA is a physical status classification system (scale of 1-6) created by the American Society of Anesthesiologists to describe patients prior to surgery. ASA 1 or 2 means the patient is either healthy or has mild systemic disease prior to surgery.\n\nExclusion Criteria:\n\n* ASA classification 3 or higher (patient has severe systemic disease or worse)\n* Contraindication to toradol (anesthesia)\n* Contraindication to acetaminophen\n* Previous strabismus surgery",{"count":389,"type":21},80,[391],"PHASE2","At Ann \\& Robert H. Lurie Children's Hospital of Chicago (Lurie Children's), the current practice is to prescribe children with oral Tylenol as needed every 4-6 hours post strabismus surgery. Prescribing Tylenol \"as needed\" leaves more room for error for parents to be under-dosing their children, which can lead to avoidable pain. This study aims to figure out if children ages 4-12 years old will feel significantly less pain and discomfort when given regimented Tylenol every 6 hours for 48 hours after strabismus surgery (eye muscle surgery) compared to controls whose parents are instructed to give Tylenol every 4-6 hours as needed for 48 hours after surgery. To date, there have been no studies comparing patient outcomes between those taking Tylenol regimen and those receiving Tylenol as needed after pediatric surgery.",[26],[395,396],"pain","strabismus surgery","2025-02-15",{"date":399,"type":49},"2025-02-19",{"date":401,"type":21},"2025-04-01",{"date":81,"type":21},{"name":404,"class":84},"Ann & Robert H Lurie Children's Hospital of Chicago",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":11,"sex":17,"minAge":333,"maxAge":412,"enrollmentInfo":413,"targetDuration":4,"studyType":95,"phases":414,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":4},"100574652","exercise-training-on-a-mirror-for-intermittent-exotropia-control-post-strabismus-surgery-100574652","NCT06762067","Exercise Training on a Mirror for Intermittent Exotropia Control Post Strabismus Surgery","Exercise Training in Front of a Mirror for Intermittent Exotropia Control Post Strabismus Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n1. 40 boys and girls with ages from 5 to 15 years\n2. History of strabismus surgery from 6 months presence of intermittent exotropia.\n3. Normal sensory and motor fusion, equal visual acuity. Good general health condition.\n4. Ability to understand and do the exercises at home\n\nExclusion Criteria:\n\n1. systemic diseases as myasthenia gravis, multiple sclerosis and diabetes\n2. Optic nerve injury, organic ocular disease, attention disorder and mental disorders\n3. Attention disorder and learning disability","15 Years",{"count":204,"type":21},[97],"The study aims to explore the impact of mirror therapy on exodeviation control, near and far strabismus angles, and quality of life in intermittent exotropia control post strabismus surgery, as well as its effects on near and far strabismus angles.",[417,418,26],"Exercise Training","Intermittent Exotropia","2025-01-04",{"date":421,"type":49},"2025-01-07",{"date":423,"type":21},"2025-02-01",{"date":425,"type":21},"2025-05-01",{"name":427,"class":84},"Cairo University",{"id":429,"slug":430,"hasResults":11,"nctId":431,"briefTitle":432,"officialTitle":433,"acronym":434,"eligibilityCriteria":435,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":436,"enrollmentInfo":437,"targetDuration":4,"studyType":95,"phases":438,"briefSummary":439,"conditions":440,"keywords":443,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":4},"100559141","phase-4-low-flow-anesthesia-in-children-undergoing-strabismus-surgery-100559141","NCT06560268","Low Flow Anesthesia in Children Undergoing Strabismus Surgery","Effects of Different Fresh Gas Flows on Emergence Agitation and Anesthetic Agent Consumption in Children Undergoing Strabismus Surgery","LFA in child","Inclusion Criteria:\n\n* 3-10 years old children with strabismus\n\nExclusion Criteria:\n\n* Mental retardation\n* Cardiovascular disease\n* Serebrovasculay disease\n* Renal disease\n* Hepatic disease\n* Pulmonary disease","10 Years",{"count":129,"type":21},[154],"Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia. Sevoflurane and desflurane have increased the incidence of EA in children. A proposed explanation for this is that sevoflurane and desflurane cause differential recovery rates in brain function, due to differences in clearance of inhalational anesthetics from the central nervous system; whereas audition and locomotion recover first, cognitive function recovers later, resulting in EA. Low-flow anaesthesia (LFA) occurs when the fresh gas flow (FGF) is significantly lower than the patient's minute volume. In a low-flow system, the recirculated fraction should amount to at least 50% after carbon dioxide (CO2) absorption.In LFA using minimal FGF (250-500 mL\u002Fmin), if the vaporizer is turned off 10-15 minutes before the end of the operation and the FGF is not changed, the inhaled anesthetic agent concentration gradually and slowly decreases to zero and the inhaled agent consumption decreases even more. In a study conducted on infants undergoing cleft lip-palate surgery, it was shown that the incidence of postoperative agitation were statistically lower in infants who administered 0.5 L\u002Fmin FGF.\n\nStrabismus surgery is one of the most frequently performed ophthalmologic operations in children and is associated with moderate postoperative pain and a high incidence of EA (40-86%). The incidence of EA after strabismus surgery is high, especially due to visual disturbances; however, the pathogenesis of this condition remains unclear. In our study, the effects of different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.",[441,442,26,157],"Low Flow Anesthesia","Sevoflurane",[444,182,445,446],"emergence agitation","children","low flow anesthesia","2024-08-23",{"date":449,"type":49},"2024-08-26",{"date":451,"type":21},"2024-11-04",{"date":453,"type":21},"2025-07-04",{"name":455,"class":84},"Cukurova University",{"id":457,"slug":458,"hasResults":11,"nctId":459,"briefTitle":460,"officialTitle":460,"acronym":461,"eligibilityCriteria":462,"healthyVolunteers":65,"sex":17,"minAge":285,"maxAge":463,"enrollmentInfo":464,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":466,"conditions":467,"keywords":469,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":57},"100389675","the-alaska-oculocardiac-reflex-study-100389675","NCT04353960","The Alaska Oculocardiac Reflex Study","AK-OCR","Inclusion Criteria:\n\n* Patient scheduled for ocular manipulation and tension on extra ocular muscles and strabismus surgery\n\nExclusion Criteria:\n\n* anophthalmia","100 Years",{"count":465,"type":21},4000,"Observation study monitoring vital signs and anesthetic variables particularly heart rate during prospective, ocular manipulation and specifically uniform tension on extra ocular muscles during strabismus surgery.\n\n\\*IRB approval from 1992 covered in letter from then IRB chair Dr. Judith Whitcomb, Anchorage, Alaska (letter 10\u002F2020).\\*",[468,26],"Bradycardia",[470],"oculocardiac reflex","2024-07-30",{"date":473,"type":49},"2024-07-31",{"date":475,"type":49},"1992-09-01",{"date":477,"type":21},"2035-12-31",{"name":479,"class":84},"Alaska Blind Child Discovery"]