[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"strains\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:strains":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,76,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100520268","predictive-value-of-right-atrial-strain-in-postoperative-atrial-fibrillation-in-patients-undergoing-cardiac-surgery-100520268",false,"NCT06054360","Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery","ODFAPO","Inclusion Criteria:\n\n* Adult patient (\\>18 years old)\n* The patient was hospitalized at the Amiens University Hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass.\n* Echocardiographic image quality enabling the measurement of RAS parameters\n* Patient affiliation to a social security scheme\n* Patient\u002Fproxy information and collection of their non-opposition.\n\nExclusion Criteria:\n\n* Patients participating in an interventional study may modify the incidence of POAF.\n* History of atrial fibrillation or flutter.\n* Valvular and ascending aorta cardiac surgery\n* Urgent cardiac surgery.\n* Presence of tricuspid insufficiency greater than grade 2.\n* Left ventricular ejection fraction lower than 50%.\n* Patient receiving circulatory mechanical assistance before surgery.\n* Dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.","ALL","18 Years",{"count":19,"type":20},334,"ESTIMATED","OBSERVATIONAL","The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. While the role of the left atrium (LAF) in the pathophysiology of POAF is now well-established, the part of the right atrium (RA) remains poorly understood. Recent studies suggest a correlation between RA function and POAF.\n\nRA function can be assessed by transthoracic echocardiography (TTE) with dedicated software for measuring the RA strain (RAS). RA function is thus divided into three phases: reservoir (RASr), conduit, and contraction. Numerous studies have demonstrated that a significant alteration in RAS predicts POAF in various clinical contexts. Therefore, it is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.\n\nIt is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.",[24,25],"Postoperative Atrial Fibrillation","Strains",[27,28,29,30,31],"coronary bypass grafting","postoperative atrial fibrillation","strain","left atrial","right atrial","RECRUITING","2026-05-27",{"date":35,"type":36},"2026-05-28","ACTUAL",{"date":38,"type":36},"2023-10-09",{"date":40,"type":20},"2026-10-09",{"name":42,"class":43},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100516838","diaphragmatic-speckle-tracking-during-spontaneous-breathing-trial-100516838","NCT06009731","Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial","DIAPHRAGMATIC SPECKLE TRACKING DURING SPONTANEOUS BREATHING TRIAL","DIAST","Inclusion Criteria:\n\n* Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation)\n* patients fulfilling criteria for an SBT\n* patients will have to be able to trigger ventilator breaths with a reasonable level of assistance,\n* patients with lack of severe impairment in gas exchange,\n* patients that not require significant hemodynamic support.\n* Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.\n\nExclusion Criteria:\n\n* Use of pressure support during the SBT.\n* Severe hemodynamic instability (\\>30% increase in vasopressors in the last 6 hours or norepinephrine \\> 0.5 µg\u002Fkg\u002Fmin).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \\\u003C 30% predicted).\n* Known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence\n* Clinical judgement of the attending physician.",{"count":54,"type":20},60,"Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. This technique is relatively invasive and its interpretation may be complex. The diaphragmatic longitudinal strain (LSdi) and strain rate (LSRdi) might provide additional information in the assessment of diaphragmatic effort and movement during SBT, allowing early detection of diaphragmatic dysfunction. Patients will be monitored during a 30-120 minutes SBT consisting of no assistance on the ventilator using CPAP with a pressure level of 0 cmH2O. Parameters to evaluate diaphragm function will include diaphragmatic strain (LSdi and LSRdi), diaphragmatic thickening fraction (TFdi), and airway occlusion pressure (ΔP0.1 and ΔPocc). These parameters will be measured immediately before ('baseline') the SBT, as well as 2 minutes ('early' assessment), 15 ('intermediate' assessment) and 30 minutes ('late' assessment) after the beginning of the SBT.",[57,58,59,60,25,61],"Weaning","Spontaneous Breathing Trial","Mechanical Ventilation","Speckle Tracking","Diaphragm",[63,64,65,66,25,67],"weaning","spontaneous breathing trial","mechanical ventilation","speckle tracking","diaphragm","2026-05-12",{"date":70,"type":36},"2026-05-15",{"date":72,"type":36},"2023-06-12",{"date":74,"type":20},"2027-07",{"name":42,"class":43},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100594312","molecular-epidemiology-strains-genotyping-of-multi-drug-resistant-tuberculosis-circulating-in-central-africa-region-100594312","NCT07017803","Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region","MESTCAR","Inclusion Criteria:\n\n* All GeneXpert positive TB patients and participants who provide written informed consent will be screened for the study. Participants aged above 8 who can provide sputum will also be screened.\n* Patients enrolled in the tuberculosis epidemiology (TB-EPI) study and eligible for MESTCAR will be enrolled without any additional consent form as the data to be collected for the two studies will be shared and no additional process is needed.\n\nExclusion Criteria:\n\n* Samples which do not meet the quality criteria.\n\n  * Samples not enough to perform all of the laboratory process\n  * Samples contaminated",true,"9 Years",{"count":86,"type":20},460,"Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens.\n\nIt is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.",[89,25,90,91,92],"Tuberculosis, Multi Drug Resistant","Molecular Epidemiology","Multi Drug Resistant Tuberculosis","Central Africa","NOT_YET_RECRUITING","2025-06-04",{"date":96,"type":36},"2025-06-12",{"date":98,"type":20},"2025-07-01",{"date":100,"type":20},"2026-01-31",{"name":102,"class":43},"Centre de Recherche Médicale de Lambaréné",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":112,"conditions":113,"keywords":119,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":44},"100430743","coronary-artery-calcification-in-type-2-diabetes-mellitus-uscac-study-100430743","NCT04889053","Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)","Prospective Cohort Study of Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Type 2 diabetes is diagnosed according to WHO diagnostic criteria\n* Low dose prospectively triggered sequential dual-source CT coronary angiography can be performed at baseline investigation\n* Those subjects are able to understand the purpose and procedure of this study and sign the informed consent voluntarily\n\nExclusion Criteria:\n\n* Those have received coronary artery stenting or coronary artery bypass grafting\n* Those with severe lung (respiratory failure), liver (ALT or AST 3 times normal value or bilirubin increase), renal dysfunction\\[GFR \\\u003C 45ml\u002F(min.1.73m2) or dialysis patients\n* Malignant tumor\n* Mental illness or mental retardation\n* Pregnant or lactating women or those with fertility planning\n* Concomitant diseases (hyperparathyroidism, sarcoidosis, amyloidosis) affecting calcium balance and soft tissue calcification\n* Contraindications of contrast agents\n* Based on the judgment of the researcher, the compliance is poor and the study could not be completed according to the requirements",{"count":111,"type":20},1400,"Coronary artery calcification (CAC) is a common complication of type 2 diabetes mellitus(T2DM), which can significantly increase all-cause mortality and the incidence of serious cardiovascular events, and increase the burden of the national economy. The epidemiological characteristics and the clinical progress of CAC are still not clear. Moreover, the pathogenesis of CAC has not yet been fully elucidated, and lack of specific diagnostic indicators. Arterial calcification is an active, reversible, and multifactorial biological process like bone formation. It is generally believed that early detection of calcification lesions and active targeted treatment may be the key to prevention and treatment of vascular calcification. In addition, statins are commonly used in patients with dyslipidemia and can stabilize CAC plaque. However, the timing, dosage and effect of statins are controversial. Moreover, our previous study found that the expression of miR-32 is significantly elevated in patients with CAC, and can promoting vascular calcification. Herein, this study is to conduct a prospective cohort study on T2DM patients with CAC in Hunan province through a multidisciplinary and multi-center cooperation model, the main research objectives include the following three parts: ① To identify the prevalence, incidence, and characteristics of CAC in T2DM patients in Hunan province, and to build a risk assessment model. ② To observe the effects of statins on the occurrence and development of CAC in patients with T2DM, and to provide clinical data for the improvement of medication guidelines; ③To observe the dynamic changes of serum miR-32 in the progression of CAC in patients with T2DM, and to explore its possibility as a serological diagnosis or prognostic bio-maker of CAC. The completion of this research project is expected to bring a new breakthrough in the field of early diagnosis, prognosis evaluation, and intervention treatment of patients with T2DM combined with CAC, and provide an important reference for the formulation of cardiovascular disease prevention and control strategy.",[114,115,116,25,117,118],"Type 2 Diabetes","Vascular Calcification","Coronary Artery Calcification","Epidemiology","microRNA",[114,120,117,121],"Vascular calcification","microRNA-32","2021-09-27",{"date":124,"type":36},"2021-09-29",{"date":126,"type":36},"2021-06-01",{"date":128,"type":20},"2030-12-31",{"name":130,"class":43},"University of South China"]