[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"strength-training-effects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:strength-training-effects":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,85,128,159,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643764","eccentric-muscle-training-in-cardiac-rehabilitation-100643764",false,"NCT07636343","Eccentric Muscle Training in Cardiac Rehabilitation","Eccentric Muscle Training in Cardiac Rehabilitation: Randomized Controlled Trial to Evaluate Effectiveness and Feasibility in Heart Failure Patients With Reduced Ejection Fraction","Inclusion Criteria:\n\n* HFrEF patients with ejection fraction \\\u003C40%\n* Exercise intolerance (\\\u003C85% of predicted VO2 peak)\n* clinically stable for \\> 6 weeks, optimal medical treatment for \\> 6 weeks\n\nExclusion Criteria:\n\n* Contra indications for cardiac exercise rehabilitation as per consensus guidelines and recommendations\n* Musculoskeletal disorders that hamper (progression in) strength training\n* Non-stabilized acute coronary syndrome\n* Current acute heart failure (decompensation)\n* Patient having sustained a recent (\\\u003C3 months) procedure that could act as a confounder to increase VO2peak (i.e., coronary artery bypass graft surgery, percutaneous coronary intervention, cardiac resynchronization therapy, valve surgery or reparation)","ALL",{"count":18,"type":19},3,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.\n\nResearchers will compare a training program of eccentric overload training and eccentric cycling training with a traditional training program of strength and cardio training in people with heart failure with reduced ejection fraction.\n\nThis study will be delivered in a cardiac rehabilitation setting.",[25,26],"Strength Training Effects","HFrEF - Heart Failure With Reduced Ejection Fraction",[28],"eccentric muscle training","RECRUITING","2026-06-03",{"date":32,"type":33},"2026-06-09","ACTUAL",{"date":35,"type":33},"2023-01-20",{"date":37,"type":19},"2027-01-01",{"name":39,"class":40},"University Hospital, Antwerp","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":68,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":41},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years",true,"35 Years","65 Years",{"count":54,"type":19},90,[22],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[58,59,60,61,62,25,63,64,65,66,67],"Pain","Pain Management","Athlete","Exercise Training","Sports Medicine","Aerobic Exercise","Strength Training","Aging","Quality of Life","Sports",[69,70,58,71,72,73,74,65,75],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","Exercise","Rehabilitation","Sport","2026-03-27",{"date":78,"type":33},"2026-03-31",{"date":80,"type":33},"2026-03-02",{"date":82,"type":19},"2028-05",{"name":84,"class":40},"Marquette University",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":50,"sex":16,"minAge":52,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":20,"phases":95,"briefSummary":96,"conditions":97,"keywords":106,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":41},"100628795","l-serine-and-strength-training-in-the-elderly-100628795","NCT07466290","L-serine and Strength Training in the Elderly","AAAging","Inclusion Criteria:\n\n* Men and women between the ages of 65 and 85\n* Mini-Mental-State \\>23\n* Independently mobile, without aids (walker, cane, etc.)\n\nExclusion Criteria:\n\n* Chronic diseases that contraindicate medical training therapy\n* Regular strength training (\\>1x\u002Fweek) in the last 6 months before confinement\n* Frailty Index ≥ 3\n* Lack of written consent to test physical performance\n* Regular use of Cortison-containing medications or Antibiotika\n* MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body\n* Non-compliance with the study protocol: \\\u003C70% of the planned L-serine administration, \\\u003C70% of the strength training","85 Years",{"count":94,"type":19},126,[22],"This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.\n\nHealthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.\n\nCognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.",[98,99,100,25,101,102,103,104,105],"Brain Health","Longevity","Cognitive Performance","Healthy Ageing","Ageing","Cognition","Memory","Muscle Strength",[101,107,108,109,110,111,112,104,113,114,115,116,117,118],"Brain ageing","Older adults","L-serine supplementation","Resistance training","Cognitive function","Cognitive ageing","Hippocampus","Magnetic resonance imaging","Electroencephalography","Brain connectivity","Muscle strength","Synaptic plasticity","2026-03-06",{"date":121,"type":33},"2026-03-12",{"date":123,"type":19},"2026-03",{"date":125,"type":19},"2028-12",{"name":127,"class":40},"University of Vienna",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":20,"phases":139,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":41},"100596359","fall-risk-assessment-and-an-exercise-intervention-for-prevention-of-falls-in-multiple-myeloma-patients-100596359","NCT07044427","Fall Risk Assessment and an Exercise Intervention for Prevention of Falls in Multiple Myeloma Patients","Investigation of Fall Risk Factors and Implementation of an Exercise Intervention for Prevention of Falls in Patients With Multiple Myeloma","Myfall","Inclusion Criteria:\n\n* Patients with multiple myeloma requiring therapy (at least 6 months of systemic therapy)\n* ECOG status ≤ 3\n* Age ≥18 years\n* Patients who state that they want to carry out the training program at least 3 times\u002Fweek and participate in the planned follow-up visits\n* Ability to give informed consent\n* Written consent to participate in the study\n* Sufficient written and spoken German to complete the questionnaire\n\nExclusion Criteria:\n\n* Any physical or mental limitations that would prevent participation in the training program or the planned follow-up checks.","18 Years",{"count":138,"type":19},60,[22],"Approximately one third of the population over the age of 65 falls at least once a year. The risk of falling is in increased in older patients with tumor diseases. In addition to high treatment and care costs for the healthcare system, falls often lead to a decrease of quality of life, a reduction in physical performance and a loss of independence. Despite the high risk, falls in cancer patients have not yet been scientifically investigated in detail. For patients with multiple myeloma in particular, very little data is available on the prevalence, risk factors and effects of falls. In this study, a fall risk assessment is carried out in patients with multiple myeloma. Furthermore, a patient-specific training intervention for fall prevention will be implemented.\n\nThe aim of the study is to identify possible fall risk factors in multiple myeloma patients and to establish a structured exercise intervention that minimizes the risk of falls and injuries.",[142,143,25,144],"Multiple Myeloma","Fall Risk Factors","Balance Training Effects",[142,146,147,148,149],"Fall risk","pertubation training","strength training","Balance","2026-01-19",{"date":152,"type":33},"2026-01-22",{"date":154,"type":33},"2024-02-02",{"date":156,"type":19},"2026-12-30",{"name":158,"class":40},"University Hospital Heidelberg",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":50,"sex":16,"minAge":166,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":20,"phases":169,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":41},"100568141","impact-of-creatine-monohydrate-micronized-supplementation-with-or-without-multicomponent-training-in-older-adults-100568141","NCT06677359","Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.","CREAGED","Inclusion Criteria:\n\n* Age: 75 years or older.\n* Able to ambulate with or without personal\u002Ftechnical assistance.\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n* Informed consent by patients, or legal representatives.\n\nExclusion Criteria:\n\n* Global Deterioration Scale (GDS 6-7).\n* Intolerance or allergy foods or drugs.\n* Deglutition problems (Dx: dysphagia)\n* Any pathological or metabolic condition incompatible with physical exercise.\n* Creatine supplementation for less than 6 weeks.\n* Consumption of more than 200 mg of caffeine daily.\n* Supervised physical training.","75 Years",{"count":168,"type":19},120,[22],"The goal of this clinical trial is to study and evaluate whether a protocol of creatine supplementation, with or without multicomponent training, improves functional and cognitive capacity in individuals over 75 years old. The results of this study will further our understanding of creatine supplementation effects in the context of older patients and in combination with multicomponent training, thereby enhancing patient care strategies. Additionally, the goal is to improve the quality of life for the elderly and the efficiency of the healthcare system.\n\nThe main questions it aims to answer are:\n\n1. Does creatine supplementation alone provide physical, functional and cognitive benefits to people over 75 years of age?\n2. Is creatine supplementation safe for people over 75 years old?\n\nResearchers will compare creatine monohydrate supplementation with or without multicomponent training intervention to placebo supplementation with or without multicomponent training intervention to see if the creatine supplementation protocol leads to significant improvements in functional and cognitive outcomes. This comparison will help determine the effectiveness of the supplementation intervention in enhancing the overall well-being of elderly patients.\n\nParticipants will:\n\n* Engage in a structured multicomponent exercise program designed specifically for elderly patients. This program will include activities focused on strength training, balance exercises, and walking to improve mobility and reduce the risk of falls.\n* Attend supervised exercise sessions several times a week, allowing for individualized attention and adjustments based on each participants abilities and health status.\n* Be monitored for changes in functional capacity using standardized assessments, which will measure improvements in mobility, strength, and overall physical functioning.\n* Undergo cognitive assessments to evaluate any changes in cognitive status throughout the intervention and during follow-up periods after discharge.\n* Participate in surveys and interviews to assess their quality of life, including physical, emotional, and social well-being, before and after the intervention.\n* Attend follow-up assessments at designated intervals to track their progress and outcomes, ensuring that any long-term benefits of the exercise program are recognized and documented.\n\nInclusion criteria will focus on individuals aged over 75 years. Participants must be capable of communication and ambulation, either independently or with assistance.\n\n* Life expectancy ≥ 6 months.\n* Barthel Index \\> 60.\n\nExclusion criteria will ensure the safety and appropriateness of the intervention. Individuals who explicitly refuse to participate or cannot provide informed consent will be excluded. Additionally, those with a life expectancy of less than three months, terminal illnesses, or significant medical contraindications for exercise will not be eligible. Participants with moderate to severe neurocognitive disorders or disabilities that severely limit mobility will also be excluded to maintain the integrity of the intervention.\n\nThis clinical trial aims to recruit a total of 120 participants from the Geriatric Department or Primary Care, providing a comprehensive dataset to analyze the effectiveness and safety of the multicomponent exercise program. By examining the outcomes related to functional capacity, cognitive status, and quality of life, the study seeks to provide valuable insights into the benefits of physical activity for elderly patients during hospitalization.",[172,103,25],"Functionality",[174,175,176,177],"creatine","supplementation","multicomponent training","older people","2025-06-09",{"date":180,"type":33},"2025-06-12",{"date":182,"type":33},"2024-11-30",{"date":184,"type":19},"2026-12-01",{"name":186,"class":40},"Fundacion Miguel Servet",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":16,"minAge":195,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":20,"phases":199,"briefSummary":200,"conditions":201,"keywords":210,"overallStatus":216,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":41},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)","12 Years","14 Years",{"count":198,"type":19},150,[22],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[202,203,204,205,206,207,66,208,25,209],"Adolescent","Pediatric Obesity","Exercise Therapy","Health Promotion","Program Evaluation","Impulse Control Disorders","Retinal Vessels","Aerobic Capacity",[211,212,213,214,215],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","NOT_YET_RECRUITING","2025-04-04",{"date":219,"type":33},"2025-04-11",{"date":221,"type":19},"2025-06-01",{"date":223,"type":19},"2029-12",{"name":225,"class":40},"University Hospital, Basel, Switzerland"]