[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stress-biomarkers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stress-biomarkers":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100544195","effects-of-walking-in-greenspace-and-the-built-environment-in-adults-with-prediabetes-a-randomized-crossover-trial-100544195",false,"NCT06365723","Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial","Inclusion Criteria:\n\n* 25-64 years old.\n* Classified as overweight or obese with BMI 20.0-39.9 kg\u002Fm2 per self-report and a BMI of 20.0- 41.9 kg\u002Fm2 upon actual measure.\n* Documentation\\* of a PreD diagnosis within one year of enrollment by physician or primary care provider based on lab tests showing a fasted blood glucose of 100-125 mg\u002FdL, a 2-hour oral glucose tolerance test of 140-199 mg\u002FdL, or an HbA1c level of 5.7%-6.49%271; OR a study screening lab value of HbA1C within the aforementioned range.\n* Currently engaged in ≤100 min\u002Fweek of moderate to vigorous exercise -confirmed via a 7-day activity recall.\n* No exercise contraindications as assessed by the Physical Activity Readiness Questionnaire (PAR-Q) -this Questionnaire involves seven \"yes\" or \"no\" questions regarding an individual's health status. Answering \"yes\" to any one of these questions may require a prospective participant to acquire a written doctor's note stating they can safely participate in the trial's exercise intervention. The participant would not be enrolled until this doctor's note is received.\n* Stable weight over the last 3 months (less than 10% change).\n* Not currently pregnant, planning to become pregnant, or currently breastfeeding.\n* Willing to maintain current dietary and exercise habits, aside from any changes to be made per the study exercise protocol.\n* Must own a smartphone and be willing and able to download the Garmin Connect app\n* Ability to speak and understand English.\n* Any level of income\n* Any race\u002Fethnicity\n\nExclusion Criteria:\n\n* Individuals \\\u003C25 or \\>64: younger individuals may have not yet reached physiological maturity and in whom PreD prevalence is low; older individuals are more likely to have contraindications to PA and other comorbidities.\n* BMI \\\u003C20 or ≥42.\n* Individuals with an HbA1c level \\\u003C5.7% or \\>6.4%.\n* Currently engaged in \\>100 min\u002Fwk of PA.\n* Individuals with contraindications to exercise participation as indicated by the PAR-Q.\n* A self-reported physical\u002Fmental disability that would prevent them from being able to adhere to the intervention.\n* Past or current diagnosis of Diabetes (Type 1, 1.5 or 2) or use of diabetic medications (e.g. medications to control blood sugar)\n* Any history of a cardiovascular disease event (e.g. heart attack, ablation, pacemaker, stroke)\n* Current treatment for cancer or heart disease (lipid and hypertensive medications acceptable but will be tracked closely).\n* Any change within the last 3 months, or anticipated changes, of any medications that would affect study outcomes (e.g. medications for lipids, blood pressure, anxiety, depression)\n* The use of any medication that significantly interferes with the autonomic nervous system\n* Current tobacco or nicotine users, or those who have quit within the last six months\n* Excessive alcohol (on average\\>1 drinks\u002Fday for women and \\>2 drinks\u002Fday for men) or excessive recreational drug use (reported usage of once a week or more).\n* Unstable weight over the last three months (\\>10% change).\n* Those with major surgery planned or recent history of bariatric surgery (within last 2 years) or a history of other medical interventions that would interfere with study outcomes\n* Currently within one-year postpartum, currently pregnant, or planning to become pregnant during the study period.\n* Currently breastfeeding.\n* Unwilling to comply with study randomization procedures.\n* Unwilling to maintain current dietary and exercise habits, aside from any changes to be made per the study exercise protocol.\n* Current participation in another interventional clinical trial.\n* Previous randomization in this study.","ALL","25 Years","64 Years",{"count":19,"type":20},216,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban\u002Fsuburban commercial environments vs. urban\u002Fsuburban nature areas\u002Fpreserves) in adults with prediabetes. The main questions it aims to answer are:\n\n* Do psychological measures of stress, anxiety, and affect improve more in one type of outdoor environment over the other?\n* Do physiological measures of stress improve more in one type of outdoor environment over the other?\n\nAs this is a crossover trial, participants will serve as their own controls. Researchers will compare both the psychological and physiological effects walking in the two types of outdoor environments.\n\nParticipants will:\n\n* Walk 150-minutes per week for six weeks in each of the two outdoor conditions.\n* Visit the clinic four times, including before and after each six-week walking period.\n* Collect saliva samples immediately proceeding or following the four clinic visits.\n* Return to their pre-study level of physical activity for a 5-week washout period between each of the two walking interventions.",[26,27,28,29],"PreDiabetes","Heart Rate Variability (HRV)","Stress and Anxiety","Stress Biomarkers",[31,32,33,34,35,36],"walking intervention","built environment","outdoor environment","prediabetes","stress","urban","RECRUITING","2026-06-16",{"date":40,"type":41},"2026-06-18","ACTUAL",{"date":43,"type":41},"2024-06-06",{"date":45,"type":20},"2028-11-30",{"name":47,"class":48},"University of Minnesota","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":15,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100633645","breathwork-and-stress-investigating-the-mechanisms-of-action-and-effectiveness-of-breathing-interventions-in-modulating-the-psychophysiological-response-to-acute-stress-test-100633645","NCT07529379","Breathwork and Stress: Investigating the Mechanisms of Action and Effectiveness of Breathing Interventions in Modulating the Psychophysiological Response to Acute Stress Test","Inclusion Criteria:\n\n* Healthy adults\n* Aged 18 to 60 years\n* Willingness to participate in all study phases, including preparation and laboratory session.\n* Professionally active individuals or university students.\n\nExclusion Criteria:\n\n* Severe chronic diseases, including metabolic disorders (e.g., diabetes) and mental disorders.\n* Cardiac arrhythmia, history of heart attacks, strokes, or heart surgery.\n* Regular use of medications such as anxiolytics or beta-blockers (excluding hormonal contraception)\n* Pregnancy.\n* Current participation in other scientific experiments.\n* Significant previous experience with breathing techniques or current independent breathwork\u002Fmeditation practice (defined as regular practice for more than 7 days in total within the last 12 months).\n* Professional sports practice.\n* Raynaud's disease\n* Inability to abstain from alcohol, caffeine, and nicotine for the required periods before the experiment",true,"18 Years","60 Years",{"count":59,"type":20},120,[23],"This study investigates whether the psychophysiological benefits of breathing exercises are driven by a specific physiological rhythm (6 breaths per minute) or by the general psychological experience of performing a structured, mindful activity. Researchers aim to determine if \"coherent breathing\", which is hypothesized to synchronize heart and respiratory rhythms, offers unique physiological protection against stress compared to breathing at a natural pace or simple resting. The main questions it aims to answer are:\n\n* Does slow, steady breathing at 6 breaths per minute lower physical stress markers (like heart rate variability and cortisol) better than faster, but structured breathing or just sitting still?\n* Is the calming effect caused by the specific breathing rhythm or simply by performing a structured, relaxing activity?\n\nResearchers will compare three groups to see if the specific rhythm of \"coherent breathing\" offers unique benefits:\n\n1. Group (Interventional): Coherent Breathing: Slow breathing at 6 breaths per minute.\n2. Group (Sham Breathing): Regular breathing at 15 breaths per minute (matching a natural pace).\n3. Spontaneous Breathing (Control Group): Natural, unguided breathing.\n\nParticipants will:\n\n* Complete a one-day preparation phase to become familiar with the breathing technique.\n* Visit the research center for one experimental session.\n* Perform their assigned breathing method before and after a stress test.\n* Take the Maastricht Acute Stress Test (MAST), which involves putting a hand in cold water and doing mental math.\n* Provide saliva samples and have their heart rate variability, and mood measured multiple times.",[63,64,29,65],"Healthy Adult Participants","Acute Stress Reaction","Healthy",[67,68,69,70,71,72],"Breathwork","Coherent Breathing","Resonance Breathing","Heart Rate Variability","Maastricht Acute Stress Test (MAST)","Cortisol","2026-04-16",{"date":75,"type":41},"2026-04-21",{"date":77,"type":20},"2026-04",{"date":79,"type":20},"2026-11",{"name":81,"class":48},"Medical University of Bialystok",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":55,"sex":15,"minAge":56,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100629134","deep-relaxation-using-virtual-reality-intervention-before-surgery-for-healthcare-professionals-working-in-the-operating-room-100629134","NCT07470697","Deep Relaxation Using Virtual Reality Intervention Before Surgery for Healthcare Professionals Working in the Operating Room","DEEP_VR","Inclusion Criteria:\n\n* Volunteering and consented healthcare professionals ( ≥ 18 years) working in the operating room\n* Circulatory-, scrub-, and anesthesia nurses, anesthesiologists, surgical specialists, residents, medical students, or persons in training for the above mentioned.\n\nExclusion Criteria:\n\n* history of epilepsy.\n* claustrophobia or nyctophobia.\n* experienced VR scenery via a headset including headphones a trigger for headache, migraine, dizziness, drowsiness, nausea or other physical or mental discomfort.\n* vestibular nystagmus, otosclerosis, ear infections,\n* impaired hearing or deafness of either ear.\n* glaucoma, active eye infections or damage to orbital, cornea or lens.\n* diagnosed with chronic insomnia .\n* latex allergy as VR goggles may contain latex in the lens surround.\n* arrythmia, bradycardia or tachycardia, or those using cardiac medication against dysrhythmias.\n* All medication that may potentially induce dysrhythmias or of influence on blood pressure levels.\n* not able to wear a VR headset and\u002For noise canceling headphones for any other reason as indicated by themselves.",{"count":91,"type":20},80,[23],"The goal of this clinical trials is to primary learn if deep relaxation using Virtual Reality (VR) compared to a low stimulus environment can lower perceived and measured stress in healthcare professionals working in the operating room.\n\nWe aim to determine:\n\n* whether the use of a low-stimulus environment significantly lowers the stress response in OR health care workers just before entering the OR;\n* whether the use of a responsive VR system environment significantly lowers the stress response in OR health care workers just before entering the OR;\n* Whether the use of a responsive VR environment is both an effective and cost-effective solution compared to the low-stimulus environment, in terms of significantly mitigating stress in OR team members as measured by their biometrics, just before they enter the OR to do their job.\n\nHypothesis\n\n* The use of a 10-minute real-time adaptive VR intervention or a low-stimulus environment intervention administered at least 15 minutes before entering the operating room (OR), significantly reduces stress in OR staff, as measured by a within-person reduction in heart rate of at least 10 beats per minute (BPM) over the 10-minute intervention period\n* The reduction in heart rate over a 10-minute intervention period is significantly greater for the real-time adaptive VR intervention compared to the low-stimulus environment intervention, with an expected mean difference (delta) of 5 BPM, indicating superior stress-reducing effects of the VR intervention.\n* The use of a real-time adaptive VR intervention and the use of a low stimulus environment intervention of 10 minutes at least 15 minutes before entering the OR significantly reduces perceived stress for OR staff, as measured by Numeric Rating Scale (NRS) stress scores within person.",[95,96,29],"Stress","Stress and Burnout",[98,99,95,100,101,102,103,104,105,106,107,108,109,110,111,112],"VR","Virtual Reality","Non-invasice biomarkers","Heart rate variabillity","Heart rate","Burnout","Resilience","hospital","operating room","healthcare professionals","doctor","operating room nurse","anesthesia nurse","surgeon","low stimulus environment","NOT_YET_RECRUITING","2026-03-12",{"date":116,"type":41},"2026-03-13",{"date":118,"type":20},"2026-06-01",{"date":120,"type":20},"2026-07-01",{"name":122,"class":48},"Amsterdam UMC, location VUmc",2]