[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stress-reaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stress-reaction":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,54,85,124,157,191],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100491917","phase-1-acceptance-and-commitment-therapy-for-adolescents-and-young-adults-with-sickle-cell-disease-100491917",false,"NCT05685368","Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease","Using Acceptance and Commitment Therapy (ACT) to Promote Mental Health and Transition Readiness in Youth With Sickle Cell Disease: A Community-Based Participatory Action Research (CBPAR) Approach","ACT for SCD","Youth Participant Inclusion and Exclusion Criteria The inclusion criteria for study participation are Be an adolescent and\u002For young adult (age 14-21) who has Sickle Cell Disease Willing to enroll in the ACT group jointly provided by the Division of Adolescent and Young Adult Medicine\u002FDepartment of Hematology and Oncology Participants can be active, waitlisted, or new patients at CHLA Participants must be able to understand and speak English, as the therapy will only be delivered in English Participants must have an English-speaking parent\u002Fguardian Able to provide consent\u002Fassent An adolescent or young adult that is pregnant is eligible to participate if consent can be obtained Participants must be developmentally typical Have a stable internet connection (via computer, tablet, or phone) with access to a webcam and a private space to engage in a group therapy sessions; Must consent to audio and video recording of initial interview. Must agree to attend 6 weekly ACT group session Youth participants will be asked to become a member of the CAB. To become a CAB member, the youth participant must consent\u002Fassent to participation in the ACT intervention. If a CAB member, they must be willing to engage in CAB interviews and meetings.\n\nThe exclusion criteria are:\n\nPrisoners or youth in detention centers Unable to understand or speak English Does not have SCD Clients who are at significant risk for suicide and self-injury will be excluded due to the intense levels of support required to support these individuals which would interfere with study procedures.\n\nAdolescents with families that require frequent intervention from the Department of Children and Family Services, are currently experiencing psychosis, or have severe health concerns that will impact study participation or attendance will be excluded.","ALL","14 Years","21 Years",{"count":21,"type":22},66,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical care at the Division of Adolescent and Young Adult Medicine. Three consecutive groups will be run with approximately 8-10 participants in each group over the next year.",[29,30,31,32],"Race-related Stress","Depression, Anxiety","Quality of Life","Stress Reaction",[34,35,36,37,38,39,40],"Black","African American","Adolescents","Acceptance and Commitment Therapy","race-related stress","racial trauma","coping","RECRUITING","2026-04-30",{"date":44,"type":45},"2026-05-06","ACTUAL",{"date":47,"type":45},"2025-04-01",{"date":49,"type":22},"2029-06-30",{"name":51,"class":52},"Children's Hospital Los Angeles","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":53},"100518995","self-management-interventions-after-an-icd-shock-100518995","NCT06037785","Self-Management Interventions After an ICD Shock","Biobehavioral Intervention to Reduce PTSD After ICD Shock","Inclusion Criteria:\n\n1. ICD implant for primary or secondary prevention of sudden cardiac arrest (SCA),\n2. receipt of at least 1 ICD shock, appropriate or inappropriate, one week prior to enrollment;\n3. able to read, speak and write English;\n4. access to online resources and telephone for study duration.\n\nExclusion Criteria:\n\n1. current diagnosis of PTSD, schizophrenia or bipolar disorder;\n2. Short BLESSED score \\>6 indicating cognitive dysfunction \\[73\\];\n3. age \\\u003C18 years;\n4. AUDIT-C score ≥4 for alcohol use;\n5. regular non-medical use of illicit drugs","18 Years",{"count":63,"type":22},60,[65],"NA","This study, \"Biobehavioral Intervention to Reduce PTSD Symptoms After an ICD Shock,\" addresses a critical need in cardiology care by describing the feasibility and acceptability of a timely, highly promising, electronically-delivered intervention for patients who have recently received an ICD delivered shock. The study intervention and outcomes are designed to reduce anxiety, enhance return to activities of daily living (ADLs), and prevent the development of severe distress and post-traumatic stress disorder (PTSD), and ultimately promote quality of life. The study is a two-arm, embedded mixed methods, randomized trial (N=60, 30\u002Fgroup). The purpose is to determine feasibility and potential effects of a self-management intervention (SPSM) plus usual care (UC) compared to UC alone, delivered during the critical 1 month period after an ICD shock when distress is high. The intervention will be delivered over 1 month following an ICD shock; a 6-month follow-up will be used to assess the sustainability of intervention effects and determine if the incidence of PTSD is reduced. SPSM includes: 1) training in heart rate (HR) self-monitoring; and 2) individualized learning through 4 self-paced, web-based modules. The study interventions are delivered at a crucial time, closely after an ICD shock when stress is high, but PTSD has not yet developed. The specific aims are to: 1) examine the effects of the SPSM intervention plus UC vs. UC alone on the primary outcome of ICD shock anxiety at 1 and 6 months post-shock event, 2) describe the impact of SPSM plus UC compared to UC alone on the secondary outcomes of total daily physical activity, depression, PTSD symptoms, QOL, salivary cortisol levels, and self-efficacy and outcome expectations at 1 and 6 months post-shock event, and 3) assess feasibility, acceptability, and safety of the SPSM intervention, SDOH will be used to describe differential responses to the SPSM intervention. This study fills a significant gap in the care of patients with an ICD, through the systematic testing of a brief, novel and cost-effective intervention that provides the knowledge and skills to improve quality of life. Study findings will be used to design future larger RCTs to test intervention effectiveness for more diverse samples and settings.",[68,32,69,70,71],"Implantable Defibrillator User","Ptsd","Stress Management","Social Cognitive Theory",[73,74,75],"implantable cardioverter defibrillator","ptsd","stress management","2025-09-22",{"date":78,"type":45},"2025-09-24",{"date":80,"type":45},"2024-10-01",{"date":82,"type":22},"2026-07-31",{"name":84,"class":52},"University of Washington",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":105,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100524217","neurobehavioral-profiles-of-adaptive-stress-responses-in-individuals-with-alcohol-use-disorder-100524217","NCT06105853","Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder","Towards Neurobehavioral Profiles and Models of Adaptive Stress Responses and Resilience in Individuals With Alcohol Use Disorder","A03","Inclusion criteria are:\n\n* age between 16 and 65 years\n* meeting at least 2 criteria of an alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), yet without the need for a therapeutic intervention\n* fluency in German\n* able to understand the study procedures and give informed consent\n* willingness to use a study smartphone\n\nExclusion criteria are:\n\n* current use of drugs or medications that interact with the central nervous system or the glucocorticoid system\n* contraindications for magnetic resonance imaging\n* medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis\n* medical history of severe head injury or other severe central nervous system disorders or other severe somatic disorders (e.g. liver cirrhosis)\n* pregnancy","65 Years",{"count":95,"type":22},100,[65],"The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are:\n\nWhat are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to:\n\n* alcohol craving?\n* alcohol use?\n* their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior?\n\nParticipants will:\n\n* be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test\n* be exposed to their favorite drink in a bar lab environment\n* be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing\n* conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.",[99,32,100,101,102,103,104],"Alcohol Use Disorder","Social Stress","Craving","Relapse","Addiction, Alcohol","Risk Behavior",[106,107,108,109,110,111,112,113],"stress","resilience","craving","sensitization","habituation","cortisol","ecological momentary assessment","alcohol use disorder","2025-04-28",{"date":116,"type":45},"2025-04-29",{"date":118,"type":45},"2023-12-01",{"date":120,"type":22},"2027-06-30",{"name":122,"class":52},"Central Institute of Mental Health, Mannheim",2,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":17,"minAge":61,"maxAge":93,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":149,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":155,"locationsCount":53},"100535832","effect-of-social-isolation-on-the-role-of-pavlovian-mechanisms-for-control-over-alcohol-use-100535832","NCT06256952","Effect of Social Isolation on the Role of Pavlovian Mechanisms for Control Over Alcohol Use","SFB TRR 265: Losing and Regaining Control Over Drug Intake B03: Role of Pavlovian Mechanisms for Control Over Substance Use WP2: Effects of Social Isolation on PIT in AUD","ReCoDe","Inclusion Criteria:\n\n* Males and females between 18-65 years of age,\n* AUD subjects: meet 4 or more criteria for DSM-5 alcohol-use disorder (not requiring withdrawal as assessed by an independent psychiatrist),\n* Currently using alcohol without a desire for abstinence,\n* Ability to consent to the study and complete the questionnaires.\n* Sufficient language skills: German\n* Availability between 3pm-6pm on 2 consecutive days,\n* existing health insurance\n\nExclusion Criteria:\n\n* Lifetime diagnosis according to DMS-5 for a: Bipolar disorder, schizophrenia, schizophrenia spectrum disorder, substance dependence except for alcohol, nicotine, cannabis, and\u002For methamphetamine\n* Currently meeting DSM-5 diagnostic criteria for depressive episode, suicidal ideation,\n* History of traumatic brain injury or severe neurological disease (such as dementia, Parkinson's disease, multiple sclerosis)\n* Pregnancy or breastfeeding,\n* Ingestion of medications known to interact with the CNS in the 10-day period prior to study participation or less than 4 half-lives after last ingestion (rapid urine test),\n* Color vision deficiency",true,{"count":95,"type":22},[65],"During the first funding period (1st FP) we investigated the impact of acute and chronic stress (Trier Social Stress Test, TSST) on Pavlovian-to-instrumental transfer (PIT). Moreover, we developed a novel full transfer task that allows assessing both general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects. We found that our online version of TSST induced stress and thereby amplified PIT effects in participants. Preliminary analyses of the full transfer task indicate that AUD participants exhibit a stronger specific PIT effect compared to controls. Based on these findings, we want to assess the following aim for this study:\n\nInvestigate the effect of experimentally induced social exclusion on alcohol-specific and general PIT effects in AUD and control participants.",[99,137,32,138,139],"Alcoholism","Ostracism","Substance Use Disorders",[141,142,143,144,145,146,147,148],"Substance use disorder (SUD)","Alcohol use disorder (AUD)","General and outcome-specific Pavlovian to instrumental transfer","Social exclusion","Humans","Surveys and Questionnaires","Reward","Cues","NOT_YET_RECRUITING","2024-08-27",{"date":152,"type":45},"2024-08-28",{"date":80,"type":22},{"date":120,"type":22},{"name":156,"class":52},"Charite University, Berlin, Germany",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":130,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":163,"maxAge":93,"enrollmentInfo":164,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":123},"100515497","cue-effects-in-human-addiction-pavlovian-to-instrumental-transfer-100515497","NCT05992272","Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer","Inclusion Criteria:\n\n* males and females between 16-65 years of age\n* AUD subjects only: meet a minimum of 2 criteria for DSM-5 alcohol-related disorder (AUD) (not requiring withdrawal as assessed by an independent psychiatrist) and AUDIT \\> 4\n* Smokers: Daily smokers only: smoke 7 days\u002Fweek during the last three months\n* Non-daily smokers only: smoke at least once but less than 7 days\u002Fweek during the last three months\n* Ability to consent to the study and complete the questionnaires\n* Sufficient language skills: German\n* Availability between 3pm-6pm on 2 consecutive days (Experiment 1, acute stress question)\n* Females only: luteal phase (Experiment 1, acute stress question)\n\nExclusion Criteria:\n\n* Lifetime diagnosis according to DMS-5 for: Bipolar disorder, schizophrenia, schizophrenia spectrum disorder, substance dependence except for alcohol, nicotine, or cannabis\n* Currently meeting DSM-5 diagnostic criteria for a depressive episode, suicidal ideation\n* Past traumatic brain injury or severe neurological disease (such as dementia, Parkinson's disease, multiple sclerosis)\n* Pregnancy or breastfeeding\n* Ingestion of medications known to interact with the CNS in the 10-day period prior to study participation or less than 4 half-lives after last ingestion (rapid urine test)\n* MR contraindications (e.g., pacemakers, metallic or electronic implants, metallic splinters, surgical staples)\n* Color vision deficiency\n* Sensorineural hearing loss of 30 dB or greater,\n* Tinnitus\n* Presence of claustrophobia\n* Acute alcohol intoxication at MRI appointments verified by breath alcohol testing or drug intoxication verified by rapid urine testing\n* For women only: not peri- or postmenopausal, not taking contraceptives (Experiment 1, acute stress question)","16 Years",{"count":165,"type":22},300,"OBSERVATIONAL","Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans. The investigators aimed to investigate the impact of acute and chronic stress on Pavlovian-to-instrumental transfer (PIT), how PIT it is associated with cognitive control abilities and whether such effects predict losing vs. regaining control in subjects with AUD. Moreover, the investigators aimed to develop a novel full transfer task that assesses both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects.",[169,137,139,170,32,171],"Alcohol Use Disorder (AUD)","Smoking, Tobacco","Stress",[173,174,175,176,177,178,179,180,181,145,146,147,182,148],"substance use disorder (SUD), cognitive control\u002Finterference","alcohol use disorder (AUD)","Smokers","general and outcome-specific Pavlovian to instrumental transfer","chronic and acute stress","Amygdala","Stroop Test","Ventral Striatum","Neuroimaging","Fractals","2024-08-20",{"date":185,"type":45},"2024-08-21",{"date":187,"type":45},"2020-11-24",{"date":189,"type":22},"2024-12-31",{"name":156,"class":52},{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":132,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":53},"100520423","phase-1-biological-and-behavioral-outcomes-of-community-nature-walks-100520423","NCT06056375","Biological and Behavioral Outcomes of Community Nature Walks","Examining Anti-Racist Healing in Nature to Protect Telomeres of Transitional Age BIPOC for Health Equity","Inclusion critieria:\n\n* 18 years or older\n* able to commit to a 9-month Nature Intervention (6-month walks; 3-month chosen nature activity)\n* spoken languages: English, Spanish, or Tagalog\n* able-bodied as in must be able to walk.\n\nExclusion criteria:\n\n* pregnant women (and other gender identities who are pregnant)\n* prisoners\n* cognitively impaired",{"count":199,"type":22},200,[25],"The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial\u002Fethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities found in these communities. The intervention is comprised of two phases. The first consists of community nature walks in a pristine redwood forest for six months. This is followed by chosen nature activities with family and\u002For friends for three months. The investigators will test the ability of these activities in nature to reduce chronic stress that underpins many health disparities using validated biological, behavioral, and sociocultural measures. The use of these measures is in alignment with the National Institute of Minority Health and Health Disparities (NIMHD) Research Framework, and will increase understanding of individual, interpersonal, community, and social level factors that lead to, and that can eliminate health disparities.",[203,204,32],"Stress, Psychological","Telomere Shortening","2023-09-20",{"date":207,"type":45},"2023-09-28",{"date":209,"type":45},"2023-02-01",{"date":211,"type":22},"2026-09-01",{"name":213,"class":52},"Charlotte Tate"]