[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stress-response\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stress-response":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,85,112,134,157,180,205,248],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100627815","cranberry-polyphenols-and-stress-resilience-during-multitasking-in-healthy-adults-100627815",false,"NCT07453537","Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults","Cranberry Polyphenols and Human Stress Resilience: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Integrating Cognitive, Physiological, and Microbiome Adaptations Underlying Nutritional Neuroprotection and Multitasking Performance in Healthy Adults.","CRAN-MULTI","Inclusion Criteria:\n\n* At least 110 pounds\n* Between 30 and 55 years\n* BMI between 18.9 and 29.9 kg\u002Fm²\n* A minimum education level of high school or above\n\nExclusion Criteria:\n\n* Heavy caffeine users (consuming more than 300 mg\u002Fday or more than two cups of coffee per day)\n* Alcohol consumption exceeding three drinks per week\n* A smoking history of 10 years or more, or current use of cannabis products\n* Uncontrolled hypertension\n* Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions\n* Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly those related to blood and fecal sample analysis\n* Individuals who regularly take vitamin or mineral supplements and are unwilling to discontinue them for the duration of the study will not qualify.\n* Participants must be willing to maintain their current daily routine and lifestyle, undergo body weight and height measurements, and notify study coordinators of any illnesses or significant adverse life events during the study period\n* Those with specific dietary restrictions that prevent them from consuming the standardized breakfast sandwich required in the study protocol\n* Participants must successfully complete the on-site multitasking task as a screening measure prior to signing consent.\n* Beck's Depression Inventory score of 21 or higher\n* Beck's Anxiety Inventory score of 21 or higher\n* A history of severe suicidal tendencies, or seasonal depression\n* Pregnancy and breastfeeding (Female participants must complete four pregnancy tests throughout the study and track their menstrual cycle. Those unwilling to comply with these requirements will not be eligible.)\n* Potential participants must not have taken any anti-inflammatory medications, antibiotics, or antidepressants within the past three months prior to the start of the study\n* Individuals who were previously enrolled in IRB#202300950 will be excluded due to the learning effect of cognitive tests, ensuring accurate data collection for this study",true,"ALL","30 Years","55 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2\u002FHypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3\u002FHypothesis 3).",[29,30,31,32,33,34],"Stress Response","Mental Stress","Multitasking Behavior and Multitasking Ability","Physiological Stress","Cognitive Symptoms","Motor Activity","RECRUITING","2026-06-29",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":23},"2026-08-01",{"date":43,"type":23},"2029-08-01",{"name":45,"class":46},"University of Florida","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":47},"100643009","video-versus-verbal-preoperative-education-in-elective-cesarean-delivery-100643009","NCT07647601","Video Versus Verbal Preoperative Education in Elective Cesarean Delivery","Effects of Verbal and Video-Based Preoperative Education on Anxiety and Serum Cortisol Response in Women Scheduled for Elective Cesarean Delivery: A Prospective Randomized Controlled Trial","VIDEO-CS","Inclusion Criteria:\n\n* Female participants aged 18 years or older\n* Scheduled for elective cesarean delivery\n* Planned to undergo spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean delivery\n* History of psychiatric disease\n* Current use of anxiolytic or antidepressant medications\n* Endocrine disorders, including adrenal or thyroid disease\n* Current corticosteroid therapy\n* Previous surgery performed under spinal anesthesia\n* Cognitive impairment or communication difficulties that may interfere with completion of anxiety assessments\n* ASA physical status III, IV, or V","FEMALE","18 Years",{"count":59,"type":23},140,[26],"This prospective randomized controlled trial aims to evaluate the effects of verbal and video-based preoperative education on anxiety levels and serum cortisol response in women scheduled for elective cesarean delivery under spinal anesthesia.\n\nEligible participants will be randomly assigned to receive either standard verbal education or a standardized video-based educational intervention before surgery. Anxiety levels will be assessed using the State-Trait Anxiety Inventory (STAI-S), and serum cortisol levels will be measured before and after the educational intervention.\n\nThe primary objective is to compare the effectiveness of the two educational methods in reducing preoperative anxiety and physiological stress response.",[63,64,29],"Preoperative Anxiety","Cesarean Delivery",[66,67,68,69,70,71,72,73,74],"Preoperative Education","Video-Based Education","Verbal Education","Cesarean Section","Spinal Anesthesia","Anxiety","Serum Cortisol","STAI","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-13",{"date":78,"type":39},"2026-06-16",{"date":80,"type":23},"2026-06-10",{"date":82,"type":23},"2026-07-20",{"name":84,"class":46},"Elazıg Fethi Sekin Sehir Hastanesi",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":24,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":47},"100632196","comparison-of-stress-response-evoked-by-conventional-versus-videolaryngoscope-100632196","NCT07510542","Comparison of Stress Response Evoked by Conventional Versus Videolaryngoscope","Comparison of the Efficacy of Non-channelled Video Laryngoscopy Versus Direct Laryngoscopy in Terms of Stress Response and Intubation Time: a Single-blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I \\& II\n* Age 18-60 years.\n* Preoperatively nonhypertensive and hemodynamically stable patients\n* Patients scheduled for elective procedures not involving airway surgeries\n* Patients with informed consent\n* Mallampati score I and II\n* Interincisor gap \\> 3 cms\n* BMI less than 30 kg\u002Fm²\n\nExclusion Criteria\n\n* Patient refusal\n* ASA III, IV \\& V\n* Hemodynamically unstable patients\n* Patients with Hypertension and Ischemic Heart Disease (whether controlled or uncontrolled)\n* Airway abnormalities, including congenital airway malformations \\& maxillofacial abnormalities\n* Head, neck or any facial traumas or history of prior head, neck or airway surgeries\n* Emergency procedures\n* Pregnancy","60 Years",{"count":94,"type":23},124,[26],"Impact of using video laryngoscopy versus direct laryngoscopy technique in terms of improved hemodynamics post intubation and time taken for intubation.",[98,29,99],"Laryngoscopy","Duration",[98,101,102],"Stress response","Video laryngoscope","2026-04-01",{"date":105,"type":39},"2026-04-03",{"date":107,"type":39},"2026-03-05",{"date":109,"type":23},"2026-09-05",{"name":111,"class":46},"Sindh Institute of Urology and Transplantation",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":47},"100629098","transcutaneous-vagus-nerve-stimulation-tvns-and-stress-regulation-during-performance-tasks-100629098","NCT07470229","Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks","Inclusion Criteria:\n\n\\- Adults aged 18 to 65 years\n\nFluent in English\n\nAble to provide informed consent\n\nAble to complete study procedures during a single laboratory session\n\nExclusion Criteria:\n\n\\- History of neurological or psychiatric disorders\n\nCardiovascular disease or uncontrolled hypertension\n\nImplanted electrical devices (e.g., pacemaker)\n\nCurrent pregnancy\n\nContraindications to transcutaneous vagus nerve stimulation (tVNS)\n\nCurrent use of medications that significantly affect autonomic nervous system functioning","65 Years",{"count":120,"type":23},200,[26],"This study examines how individuals respond to performance-related tasks and whether a non-invasive ear stimulation device influences stress responses during those tasks. Participants will be randomly assigned to use either an active or inactive (placebo) version of a transcutaneous vagus nerve stimulation (tVNS) device during a laboratory session.\n\nThe study includes two task conditions. In one condition, participants will prepare a brief speech under evaluative conditions designed to induce stress. In the other condition, participants will complete a non-evaluative writing task. During the session, participants will wear a heart rate monitor and complete short questionnaires assessing their current feelings, including state anxiety.\n\nThe primary objective is to determine whether active tVNS is associated with lower state anxiety during a performance-related stress task compared to placebo stimulation. Secondary outcomes include heart rate and task-related responses. The study will also examine whether individual differences in stress reactivity influence responses to stimulation.\n\nParticipation involves one laboratory session lasting approximately 45 minutes.",[29],[125],"transcutaneous vagus nerve stimulation tVNS, stress regulation state anxiety , Trier Social Stress Test, performance","2026-03-10",{"date":128,"type":39},"2026-03-13",{"date":130,"type":23},"2026-03-15",{"date":132,"type":23},"2026-04-15",{"name":45,"class":46},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":118,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":155,"locationsCount":47},"100605666","do-increasing-preoperative-timing-of-single-dexmedetomidine-dose-have-an-effect-on-stress-response-of-laryngoscopy-and-intubation-100605666","NCT07165483","Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?","Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n\nExclusion Criteria:\n\n* Severe cardiovascular problems.\n* Respiratory disorders.\n* Diabetes.\n* Hypertension.\n* Obesity.\n* Allergic reaction to study drugs.\n* Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)\n* Medications that affect heart rate (HR) or blood pressure (BP).\n* Pregnant.\n* Currently breast-feeding women.\n* History of sleep apnea.\n* Those for emergency procedures.",{"count":142,"type":23},45,[26],"This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.",[146,147,29,98,148],"Time","Dexmedetomidine","Intubation","2025-09-11",{"date":151,"type":39},"2025-09-12",{"date":149,"type":39},{"date":154,"type":23},"2026-03-01",{"name":156,"class":46},"Tanta University",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":17,"sex":18,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":24,"phases":168,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":4},"100603685","effect-of-nebulized-lignocaine-on-the-stress-response-of-endotracheal-intubation-in-pediatrics-undergoing-tonsillectomy-operation-monitored-by-rise-in-serum-cortisol-level-post-intubation-100603685","NCT07139730","Effect of Nebulized Lignocaine on the Stress Response of Endotracheal Intubation in Pediatrics Undergoing Tonsillectomy Operation Monitored by Rise in Serum Cortisol Level Post Intubation","Effect of Nebulized Lignocaine on the Stress Response of Endotracheal Intubation in Pediatrics Undergoing Tonsillectomy Operation ; A Randomized Controlled Clinical Trial","Inclusion Criteria: 1. Elective tonsillectomy operation 2- pediaterics below 9 years old 3- ASA I OR II\n\n\\-\n\nExclusion Criteria: 1- emergency cases as bleeding tonsills 2- ASA III OR IV","1 Year","9 Years",{"count":167,"type":23},70,[26],"This randomized clinical trial aims to is examining the effect of preoperative nebulized lidocaine on the stress response to intubation, monitored by rise in serum cortisol level post intubation",[29],"2025-08-22",{"date":173,"type":39},"2025-08-24",{"date":175,"type":23},"2025-09-01",{"date":177,"type":23},"2026-10",{"name":179,"class":46},"Assiut University",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":17,"sex":18,"minAge":187,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":47},"100596053","stress-trajectories-and-anhedonia-in-adolescence-research-study-100596053","NCT07040449","Stress Trajectories and Anhedonia in Adolescence Research Study","STAARS","Inclusion Criteria:\n\n* Age 13-15 years old at study entry\n* Ability to understand and sign an assent form\n* Meets study hearing and vision requirements\n\nExclusion Criteria:\n\n* Current use of antipsychotic medication\n* Current use of medications that would interfere with cardiovascular or endocrine assessments\n* Metal in the body or other MRI exclusion\n* Central nervous system disorder or brain injury that could confound brain imaging evaluations\n* Presence of a medical condition that would interfere with cardiovascular or endocrine assessments\n* Impaired intellectual functioning\n* Diagnosed with a neurodevelopmental disability","13 Years","15 Years",{"count":190,"type":23},192,[26],"This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress.\n\nThe main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time.\n\nThis study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.",[194,29,195],"Anhedonia","Adolescent Development","2025-06-18",{"date":198,"type":39},"2025-06-27",{"date":200,"type":39},"2025-03-12",{"date":202,"type":23},"2030-02",{"name":204,"class":46},"University of North Carolina, Chapel Hill",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":213,"targetDuration":215,"studyType":216,"phases":4,"briefSummary":217,"conditions":218,"keywords":231,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":4},"100587057","survey-of-psychological-well-being-of-health-care-workers-in-the-hospital-setting-100587057","NCT06923436","Survey of Psychological Well-being of Health Care Workers in the Hospital Setting","FROM THE INVISIBLE TO THE VISIBLE: Survey on the Psychological Well-being of Hospital Healthcare Workers","IN-VISIBLE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Work activity carried out in departments classified as at risk for work-related stress (emergency care, oncology...)\n* Willingness to participate in the study and the ability to understand and sign the informed consent form.\n\nExclusion Criteria:\n\n* Psychological\u002Fpsychiatric comorbidities\n* Inability to sign the informed consent form",{"count":214,"type":23},500,"4 Months","OBSERVATIONAL","The psychological well-being of healthcare workers in hospital settings is a topic of growing interest in the scientific literature, given the crucial importance of their role in ensuring high-quality care. In addition, the Covid-19 pandemic health emergency has further accentuated the relevance of this issue, increasing anxiety and stress levels, testing the resilience and resistance of those working in care settings, revealing and highlighting how the accumulation of work-related stress can result in disabling pathologies for the caregiver, with an inevitable impact on the facility and care in general. Recent studies show that health care workers are particularly vulnerable to work-related stress, which can result from various factors such as high work demands, emotional pressure, irregular shifts, and interactions with critically ill patients. Burnout syndrome, characterized by emotional exhaustion, depersonalization and reduced personal accomplishment, is widely documented among hospital staff. Research indicates that burnout not only compromises the psychological health of healthcare workers, but also negatively affects the quality of care provided by increasing the risk of medical errors.\n\nIn light of these factors, it is crucial to deepen our understanding of the dynamics that influence psychological well-being and work-related stress in health care workers in order to develop effective interventions that can improve their quality of life and consequently the quality of care provided to patients.\n\nPreliminary assessment of the emotional burden and motivational aspects of health care workers (showing what very often eludes a first glance, making visible something that is often invisible), along with effective stress management, would allow for greater ability to remain calm under pressure, reduced frustration, increased ability to make informed decisions, and to communicate effectively with patients and colleagues. These aspects translate into an image of a safer and more caring health care system in promoting better quality of care.\n\nThe aim of this project is to highlight the importance of psychological wellbeing for those working in health care settings and to promote attention to this area, also with a view to identifying possible interventions aimed at identifying preventive and protective factors in relation to health care workers.\n\nThe aim, therefore, is to show what is very often invisible at first sight, to make visible what is invisible: to explore, accommodate and contain areas of criticality and fragility in the context of work in health care settings, working on interventions aimed at the psychological well-being of workers.",[219,220,29,221,222,223,224,225,226,227,228,229,230],"Healthy","Psychological Well Being","Professional Quality of Life","Resilience","Alexithymia","Spirituality","Coping Skills","Job-related Affective Well-being","Burnout, Healthcare Workers","Empathy Skills","Quality of Life Outcomes","Technostress",[232,233,234,235,236,237,238],"Psychological well-being of health care workers in the hospital setting","work-related stress","emotional burden","Motivational aspects of health professionals","occupational well-being","Perceived Stress","Perceived stress from the intensive use of digital technology in work settings","2025-04-23",{"date":241,"type":39},"2025-04-27",{"date":243,"type":23},"2025-04",{"date":245,"type":23},"2026-04",{"name":247,"class":46},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":18,"minAge":254,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":24,"phases":258,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":47},"100564619","phase-4-effect-of-dexmedetomidine-supplementation-to-general-anaesthesia-in-paediatric-transcatheter-closure-of-atrial-septal-defect-100564619","NCT06631534","Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect","Inclusion Criteria:\n\n* Pediatric Patients 3-12 years of age admitted for device closure of ASD secundum\n\nExclusion Criteria:\n\n* ASA IV, V\n* Neurological problems (cerebral palsy, mental retardation, etc.,)\n* Children with chromosomal abnormalities or other multiple congenital anomalies or other complex cardiac anomalies\n* Hepatic or renal insufficiency\n* History of allergy to the drugs used\n* Previous Cardiac Surgery","3 Years","12 Years",{"count":257,"type":23},30,[259],"PHASE4","The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters. Additionally he stress reducing effects of dexmedetomidine will be investigated in this population .\n\nThe main questions it aims to answer are:\n\nDoes Dexmedetomidine maintain stable hemodynamics in pediatric patients undergoing transcatheter ASD Closure while improving their quality of recovery?\n\nDoes dexmedetomidine prolong duration of recovery and time to extubation in pediatric patients ?\n\nDoes dexmedetomidine exert stress reducing properties in this population?\n\nParticipants will:\n\nEither be administered Dexmedetomidine in a loading\u002Fmaintenance regimen or a placebo, with hemodynamics being monitored at the baseline, intraoperatively and postoperatively, with recovery time and quality of recovery especially emergence delirium being monitored. Stress hormone levels will be sampled at baseline and postoperatively.",[262,147,263,29],"Atrial Septal Defect (ASD)","Delirium - Postoperative",[265,266,147,267,268,269,270,271,272],"Atrial septal Defect","ASD","Echocardiography","Cardiac index","PAED","VTI","Norepinephrine","Corisol","2024-10-10",{"date":275,"type":39},"2024-10-15",{"date":277,"type":39},"2024-04-03",{"date":279,"type":23},"2024-12",{"name":281,"class":46},"Alexandria University"]