[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-cerebrovascular\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-cerebrovascular":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,79,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100630952","effects-of-dual-task-oriented-circuit-training-on-walking-recovery-in-sub-acute-stroke-100630952",false,"NCT07494357","Effects of Dual Task-Oriented Circuit Training on Walking Recovery in Sub-acute Stroke","The Effect of Dual Task-Oriented Circuit Training on Neuroplasticity and Walking Adaptability in Subacute Stroke Patients: A Pilot and Feasibility Study","DTOCT-Stroke","Inclusion Criteria\n\n1. Diagnosed with a first-ever subacute stroke (defined as 2 weeks to 5 months post-onset) with anterior circulation involvement.\n2. Diagnosis confirmed via neuroimaging (CT or MRI).\n3. Men and women aged 40 to 65 years.\n4. Motor recovery in the lower limbs corresponding to Brunnstrom stages 4 to\n5. Functional Ambulation Category (FAC) score of at least grade 3.\n6. Ability to walk independently, with or without walking aids.\n7. Montreal Cognitive Assessment Indonesian version (MoCA-INA) score of ≥20, demonstrating the capacity to collaborate and follow multi-step instructions.\n8. Medically stable with controlled comorbidities.\n\nExclusion Criteria\n\n1. Expressive or receptive aphasia that impedes task comprehension\n2. Unstable cardiovascular or medical conditions (e.g., severe hypertension, congestive heart failure) for which moderate exercise is contraindicated.\n3. Moderate to severe depression, indicated by a Patient Health Questionnaire-9 (PHQ-9) score of ≥ 15.","ALL","40 Years","65 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","This pilot study aims to assess the feasibility, safety, and initial efficacy of an integrated Dual Task-Oriented Circuit Training (DTOCT) program for individuals in the subacute phase of stroke recovery. Although numerous patients recover the capacity to walk in a regulated hospital environment, they frequently encounter difficulties with \"community ambulation,\" the capability to traverse real-world settings while multitasking (e.g., walking while conversing or circumventing barriers). This study will examine if the integration of high-intensity circuit training with cognitive difficulties can promote neuroplasticity and enhance the patient's capacity to safely traverse intricate daily settings.",[28],"Stroke, Cerebrovascular","NOT_YET_RECRUITING","2026-05-23",{"date":32,"type":33},"2026-05-28","ACTUAL",{"date":35,"type":22},"2026-06-01",{"date":37,"type":22},"2026-08-30",{"name":39,"class":40},"Universitas Padjadjaran","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":41},"100525889","the-reactplusnmes-trial-a-double-blinded-rct-100525889","NCT06127602","The REACTplusNMES Trial: A Double-blinded RCT","NeuroMuscular Electrical Stimulation to Facilitate Perturbation-based REACtive Balance Training for Fall Risk Reduction Post-stroke: The REACTplusNMES Trial","REACT+NMES","Inclusion Criteria:\n\n* Age group: 18-90 years.\n* Presence of hemiparesis.\n* Onset of stroke (\\> 6 months).\n* Ability to walk at least for 2 minutes on the treadmill with or without ankle foot orthosis.\n* Can understand and communicate in English.\n* Cognitively and behaviorally capable of complying with the regimen (Mini-Mental State Examination \\> 25\u002F30).\n* No history or recent use (i.e., past 6 weeks) of any Neuromuscular electrical stimulation device to leg muscles during walking (e.g., Bioness, Walkaide).\n\nExclusion Criteria:\n\n* Subjects will not proceed with the test if any of the following occurs at baseline measurement: 1) HR \\> 85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \\> 165 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg during rest, or 3) oxygen saturation (measured by pulse oximeter) \\\u003C 95% during rest.\n* Body weight of more than 250 lbs.\n* Spasticity (Ashworth scale \\> 2).\n* Loss of protective sensations on the paretic leg (indicated by inability to perceive the 5.07\u002F10 g on Semmes-Weinstein Monofilament) or inability to feel the NMES.\n* Severe osteoporosis (indicated by T score \\\u003C -2)\n* Cognitive impairment (indicated by Mini-Mental State Exam score\\\u003C25)\n* Global Aphasia (indicated by \\\u003C71% on the Mississippi Aphasia Screening Test).\n* Subjects with Chedoke McMaster Leg Assessment Scale score (\\> 4).","18 Years","90 Years",{"count":53,"type":22},46,[25],"The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical, neuromuscular and neuroplastic outcomes of reactive balance control. This project is a Phase-I study and incorporates a double-blinded, randomized controlled trial design.\n\nMethods: Forty-six individuals with chronic stroke will be recruited and screened for determining their eligibility for the study. Once enrolled, they will be randomized into either of the two groups: intervention group (23 participants) and control group (23 participants). Both groups will undergo series of pre-training assessments which includes a postural disturbance in the form of a slip- or trip-like perturbations and walking tests in laboratory environment. After the pre-training assessment, individuals will undergo 6-weeks of training (2 hour per session, 2 sessions per week). The intervention group will receive NMES with the REACT training and the control group will receive ShamNMES. NMES will be applied to the different muscle groups of the paretic lower limb using an advanced software which is able to synchronize muscle activation with the time of perturbation onset and according to the phases of gait. After training, both groups will again be tested on all the assessments performed pre training.\n\nThis study will help us understand the immediate therapeutic and mechanistic effects of REACT+NMES and inform stroke rehabilitation research and clinical practice. Our study will provide foundational evidence for future use of NMES to implement clinically applicable neuromodulation adjuvants to reactive balance training, which could be leveraged for designing more effective future interventions for fall-risk reduction.",[57,58,28],"Stroke, Ischemic","Stroke Hemorrhagic",[60,61,62,63,64,65,66,67,68],"Reactive balance","Falls","Perturbation training","NMES","FES","Stroke","Fall prevention","Neuroplastic","Neuromuscular","RECRUITING","2025-07-31",{"date":72,"type":33},"2025-08-06",{"date":74,"type":33},"2024-03-01",{"date":76,"type":22},"2026-05-31",{"name":78,"class":40},"University of Illinois at Chicago",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":41},"100473341","enhancing-language-function-in-aphasia-100473341","NCT05443633","Enhancing Language Function in Aphasia","Enhancing Language Function in Aphasia Using Behavioral Language Intervention","Inclusion Criteria:\n\n1. Present with speech-language impairment (aphasia) caused by stroke or dementia\n2. A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician\n3. Are native speakers of English\n4. Present with no contraindications for MRI\n5. Have adequate (normal or corrected to normal) vision and hearing\n\nExclusion Criteria:\n\n1. Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.\n2. Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.\n3. Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)\n4. Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.\n5. Individuals suffering from clinically significant claustrophobia\n6. Severe systemic disease (e.g., renal failure)\n7. Poor overall health\n8. Individuals who are pregnant\n9. Individuals with a history of epileptic activity in the past 12 months\n10. Individuals with a personal or family history of epilepsy or other seizure disorders will not be included in the study.\n11. Individuals who have had a brain surgery in the past\n12. Individuals with implanted metallic skull plates or intracranial implants\n13. Individuals with skin lesions or skull damage\n14. Individuals who have a history of excessive use of alcohol or drugs\n15. Individuals with premorbid psychiatric disease affecting communication\n16. Individuals with severe non-linguistic cognitive disturbances impeding language therapy",true,"21 Years","80 Years",{"count":90,"type":22},30,[25],"Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans acquire aphasia every year (National Aphasia Association, 2020). Aphasia poses significant impact on the affected individuals and their families. Behavioral treatments that target language deficits have been shown to enhance overall communication skills and life satisfaction among individuals with aphasia. Although there is evidence that suggests that treatment is efficacious for individuals with aphasia, the extent of improvement long-term coupled with the neural patterns among those individuals are largely unknown. The current study aims to investigate the efficacy of language-based treatment and its corresponding neural patterns.",[94,95,96,28],"Aphasia, Acquired","Language Disorders","Primary Progressive Aphasia","2024-12-04",{"date":99,"type":33},"2024-12-09",{"date":101,"type":33},"2022-10-30",{"date":103,"type":22},"2028-12-15",{"name":105,"class":40},"University of Arizona",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":41},"100512999","clinical-development-of-a-tool-for-optimized-self--and-hetero-diagnosis-of-stroke-using-artificial-intelligence-stage1--collection-of-video-clinical-data-in-a-pragmatic-situation-100512999","NCT05959746","Clinical Development of a Tool for Optimized Self- and Hetero-diagnosis of Stroke Using Artificial Intelligence: Stage1- Collection of Video-clinical Data in a Pragmatic Situation.","PREDISTROKE","Inclusion Criteria:\n\n* Patients treated in the emergency department or hospitalized in the NICU at the CHU de Nîmes for suspected stroke or transient ischemic attack in the acute phase (\\\u003C72h), with or without motor deficit\n* Patient to be seen again in consultation within 4 months\n* Patient has given free and informed consent and signed the consent form. If the patient is not in a position to give consent, it must be obtained, prior to filming the first video, from the designated trusted support person or relatives present. In this case, data will not be used until the patient is able to sign the consent (CNIL).\n* Patient affiliated or beneficiary of a health insurance scheme\n\nExclusion Criteria:\n\n* Patients who do not speak or read French.\n* Patient in a period of exclusion determined by another study.\n* Patient under court protection, guardianship or curatorship.\n* Pregnant, parturient or breast-feeding patients.",{"count":114,"type":22},300,[25],"The study authors aim to form a collection of video-clinical data in a pragmatic situation to enable the development of relevant AI algorithms (for both hetero- and self-diagnosis modes). The aim is to optimize management through early diagnosis (self- and hetero-diagnosis) and thus to reduce sequelae disability.\n\nThe study authors hypothesize that some stroke patients will be able to successfully perform a self-test consisting of a few exercises dictated by an application on a smartphone or tablet and recorded on video.",[28],[119,120,121],"Artificial Intelligence","Data bank","Video recording","2024-11-25",{"date":124,"type":33},"2024-11-27",{"date":126,"type":33},"2023-08-28",{"date":128,"type":22},"2024-12",{"name":130,"class":40},"Centre Hospitalier Universitaire de Nīmes"]