[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-chronic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100589103","amplifi-adaptive-modulation-of-plasticity-through-lactate-and-fitness-interventions-100589103",false,"NCT06950060","AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions","AMPLIFI","Inclusion Criteria:\n\nFor All Participants:\n\n* Able to provide informed consent\n* Right-handed (for TMS consistency)\n* English-speaking\n* Clearance for moderate-intensity aerobic exercise\n* Able to safely sit and pedal a stationary cycle ergometer\n* No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history)\n\nYounger Adults (18-35):\n\n* No history of neurological or psychiatric conditions\n* Not currently on medications that affect the central nervous system\n\nOlder Adults (60-85):\n\n* No diagnosis of dementia\n* Independent in activities of daily living\n* No stroke history\n\nStroke Survivors (40-85):\n\n* At least 6 months post-stroke (chronic phase)\n* Medically stable and cleared for aerobic exercise\n* Able to engage in motor learning task (with or without hemiparetic adaptations)\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* Current substance abuse or uncontrolled psychiatric disorder\n* Severe cardiovascular disease or unstable medical condition\n* Pregnancy\n* Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension)\n* Participation in another interventional trial within the past 30 days",true,"ALL","18 Years","85 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"NA","The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity that elevates lactate levels, one performing low-intensity exercise, and one receiving health education without exercise.\n\nAll participants will complete motor learning tasks and undergo brain-stimulation testing using transcranial magnetic stimulation (TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, and how the body's response to exercise (like lactate levels) might support brain health.\n\nThis research may help identify low-cost, non-invasive interventions-such as targeted exercise-that improve motor and cognitive outcomes in aging and stroke recovery.",[28,29,30,31,32],"Stroke, Chronic","Aging","Cognitive Decline","Motor Dysfunction","Neuroplasticity",[34,35,32,36,37,29,38,39,40],"Transcranial Magnetic Stimulation (TMS)","Cortical Inhibition","Aerobic Exercise","Motor Learning","Stroke Rehabilitation","Cortical Excitability","GABAergic Inhibition","NOT_YET_RECRUITING","2026-04-16",{"date":44,"type":45},"2026-04-17","ACTUAL",{"date":47,"type":22},"2026-05-14",{"date":49,"type":22},"2030-01-01",{"name":51,"class":52},"University of Alabama at Birmingham","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":53},"100484137","phase-2-repetitive-transcranial-magnetic-stimulation-a-form-of-non-invasive-brain-stimulation-as-a-possible-treatment-for-post-stroke-fatigue-100484137","NCT05584124","Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue.","Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study","Inclusion Criteria:\n\n* 34 - 80 years of age\n* more than 6 months post-stroke\n* Clinically present fatigue\n\nExclusion Criteria:\n\n* Contraindications to MRI\u002FTMS\u002FrTMS (e.g. implanted metal within the head, history of seizures)\n* Inability to follow simple three-step instructions\n* Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate\u002Fsevere TBI)\n* Pregnancy\n* strokes within stimulation sites\n* Pregnancy\n* Severe hypertension (resting SBP \\> 200, DBP \\> 120)","34 Years","80 Years",{"count":64,"type":22},60,[66],"PHASE2","This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive transcranial magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue and other clinical characteristics related to mood and cognition before and after participants receive rTMS.",[69,28,70],"Stroke","Fatigue",[72,73,74,75,76],"non-invasive brain stimulation","post-stroke fatigue","perception of fatigue","repetitive transcranial magnetic stimulation","rTMS","RECRUITING","2026-04-15",{"date":80,"type":45},"2026-04-21",{"date":82,"type":45},"2023-04-10",{"date":84,"type":22},"2027-10-29",{"name":86,"class":87},"VA Office of Research and Development","FED"]