[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-hemorrhagic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-hemorrhagic":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,51,84,111,133,161,189,216,256,286,315,344,370,403,433,457,479,500,530,557,591,614,641,669],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100524838","phase-4-prevention-of-infection-of-the-respiratory-tract-through-application-of-non-invasive-methods-of-secretion-suctioning-100524838",false,"NCT06113939","Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning","Prevention of Infection of the Respiratory Tract by Applying Methods That Are Non-Invasive for Extraction of Secretions. An Open Label, Randomized, Assessor-blinded, Pilot Trial.","PIRAMIDES","Inclusion criteria\n\n1. Endotracheal intubation with an anticipated duration \\> 48 hours.\n2. High risk of early respiratory infection associated with a diagnosis of:\n\n   1. Severe trauma.\n   2. Severe traumatic brain injury.\n   3. Ischaemic or haemorrhagic stroke.\n   4. Other causes of impaired consciousness: post-resuscitated cardiac arrest status, intoxications, acute infections or diseases of the central nervous system, seizures.\n3. Informed consent signed by the patient or, when impossible due to clinical status, by their legal representative, with re-consent by the patients themselves upon regaining capacity (section 15).\n\nExclusion criteria\n\n1. Intubation with an anticipated duration \\\u003C 48 hours.\n2. Foreseeable ominous prognosis within \\\u003C 7 days.\n3. Already established indication for systemic antibiotic therapy, either for suspected aspiration pneumonia with radiological pulmonary infiltrate or for suspected non-respiratory source infection.\n4. Active haemoptysis or pulmonary haemorrhage.\n5. Unstable chest.\n6. Undrained pneumothorax (inclusion may be considered once drained).\n7. Known allergy or intolerance to beta-lactam antibiotics.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Adults who are unconscious or severely ill and need a breathing tube connected to a ventilator are at high risk of developing a lung infection (pneumonia) within the first few days in the intensive care unit. This early pneumonia affects up to 30 to 50 % of certain high-risk patients, prolongs the time on the ventilator and in hospital, and increases the use of antibiotics.\n\nTwo strategies are commonly used today to try to prevent this infection: a short, three-day course of an intravenous antibiotic, and removal of secretions from the airway with a sterile suction catheter. Both have limitations - antibiotics can favour the growth of resistant bacteria, and catheter suctioning is uncomfortable and may injure the airway.\n\nPIRÁMIDES is a small (60-patient) pilot study that compares the current practice with two non-invasive, mechanical alternatives for keeping the airway clear: a continuous low-pressure suction system built into a special breathing tube, and a device that produces a gentle, programmed \"artificial cough\" through the ventilator. Adult patients who are intubated for severe trauma, severe brain injury, stroke, resuscitated cardiac arrest or other causes of decreased consciousness are randomly assigned, in equal numbers, to one of the three approaches and followed for 14 days, with a final visit at day 90.\n\nThe main goal is to find out which of the three strategies best prevents early pneumonia, and which provides the best overall result for patients when survival, severity of infection, need for additional antibiotics and side effects are considered together. To make these comparisons as fair as possible in an open-label study, an independent committee of doctors not involved in patient care reviews each suspected pneumonia case without knowing which strategy the patient received. The results will help design a larger trial to confirm which approach is safest and most effective for preventing early pneumonia in critically ill patients on a ventilator.",[27,28,29,30,31,32,33],"Intubation Complication","Stroke, Ischemic","Stroke Hemorrhagic","Head Trauma","Cardiac Arrest","Ventilator Associated Pneumonia","Airway Clearance Impairment",[35,36,37],"ventilator-associated pneumonia","prevention","airway clearance","NOT_YET_RECRUITING","2026-06-25",{"date":41,"type":42},"2026-06-29","ACTUAL",{"date":44,"type":21},"2026-09-15",{"date":46,"type":21},"2029-06-30",{"name":48,"class":49},"Hospital San Carlos, Madrid","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":50},"100641203","virtual-stroke-units-versus-conventional-stroke-unit-care-in-non-thrombectomy-candidate-patients-100641203","NCT07635498","Virtual Stroke Units Versus Conventional Stroke Unit Care in Non-Thrombectomy-Candidate Patients.","Virtual Stroke Units Versus Conventional Stroke Unit Care in Non-Thrombectomy-Candidate Patients: A Non-Inferiority Prospective Cohort Study","VSU","Inclusion Criteria\n\n* Age ≥ 18 years.\n* Diagnosis of acute stroke (ischemic or hemorrhagic) confirmed by clinical assessment and neuroimaging (CT and\u002For MRI) within 24 hours of symptom onset or last-seen-well.\n* Not a candidate for mechanical thrombectomy according to current clinical guidelines.\n* Admission to a participating hospital (Hospital de Riotinto, Hospital San Juan de Dios del Aljarafe, or Hospital Universitario Virgen Macarena).\n* Signed informed consent by the participant or legal representative. Exclusion Criteria\n* Pre-stroke modified Rankin Scale (mRS) ≥ 4.\n* Life expectancy \\\u003C 6 months due to non-stroke comorbid conditions.\n* Inability to complete protocolized follow-up (geographical, social, or clinical reasons).\n* Concurrent participation in another interventional clinical trial that may affect study endpoints.\n* Refusal to provide informed consent.",{"count":60,"type":21},726,"OBSERVATIONAL","Stroke is the leading cause of acquired disability in adults and a major cause of mortality worldwide; in Spain, Andalusia shows the highest stroke-related mortality rate. Comprehensive Stroke Units (SU) are the gold-standard organizational model for acute stroke care; however, only a fraction of patients have direct access to an SU, particularly those not eligible for mechanical thrombectomy who are admitted to regional or district hospitals without on-site SU capacity.\n\nThe Virtual Stroke Unit (VSU) concept extends specialized stroke care to non-SU hospitals by combining standardized in-hospital monitoring boxes with synchronous remote multidisciplinary assessment by a stroke neurologist and stroke nurse from a reference center, via the regional telemedicine platform (CATI).\n\nThis prospective, multicenter, non-inferiority cohort study compares effectiveness, safety, and feasibility of VSU care versus conventional SU care in patients with acute ischemic or hemorrhagic stroke who are not candidates for mechanical thrombectomy. Recruitment targets 363 patients per arm (726 total). The primary outcome is death or dependency at 3 months (modified Rankin Scale 3-6) - the canonical measure of stroke-unit effectiveness - with functional independence (mRS 0-2), adherence to the stroke-unit care quality bundle, safety, mortality, recurrence, length of stay, satisfaction (TUQ\u002FTSQ\u002FTMPQ) and cost-effectiveness as secondary outcomes.",[64,29,65],"Stroke","Ischemic Stroke",[67,68,69,70,71,72,73],"Virtual Stroke Unit","Telemedicine","Telestroke","Stroke Unit","Healthcare delivery system","Non-inferiority","Modified Rankin Scale","RECRUITING","2026-06-16",{"date":77,"type":42},"2026-06-18",{"date":79,"type":42},"2026-04-01",{"date":81,"type":21},"2028-03-31",{"name":83,"class":49},"Hospital Universitario Virgen Macarena",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":50},"100368519","urinary-disorders-in-subacute-patients-after-stroke-100368519","NCT04078373","Urinary Disorders in Subacute Patients After Stroke","Assessment and Treatment of Urinary Disorders in Patients in the Subacute Phase After Stroke","UIMK","Inclusion Criteria:\n\n* subacute patients after ischaemic or hemorrhagic stroke;\n* direct transfer from acute hospital to complex inpatient rehabilitation at our Institute.\n\nExclusion Criteria:\n\n* incontinence before stroke;\n* previous brain injury or other brain disease;\n* previous bladder or prostate surgery;\n* inability to ambulate before stroke;\n* terminal disease with expected survival less than three months.",{"count":93,"type":21},250,"This observational study will address urinary disorders in subacute stroke patients. Patients without and with urinary disorders will be compared, and treatment outcome will be assessed among the latter.",[28,29,96],"Urinary Incontinence",[98,99,100,101],"stroke","inpatient rehabilitation","urinary disorders","treatment","2026-06-11",{"date":104,"type":42},"2026-06-15",{"date":106,"type":42},"2019-06-01",{"date":108,"type":21},"2026-10",{"name":110,"class":49},"University Rehabilitation Institute, Republic of Slovenia",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":50},"100450027","phase-2-promoting-recovery-after-stroke-with-amantadine-100450027","NCT05140148","Promoting Recovery After STroke With Amantadine","PRESTA","Inclusion Criteria:\n\n1. 18 to 85 years old, male and female\n2. Modified Rankin Score (mRS)\\\u003C=2 prior to stroke\n3. Ischemic or hemorrhagic stroke as diagnosed by vascular neurologist or as proven on magnetic resonance imaging (MRI) or non-contrast head computed tomography NCHCT)\n4. 24 hours to 3 weeks after stroke onset or time last known well prior to detection of symptoms\n5. National Institute of Health Stroke Scale (NIHSS)\\>=3 and NIHSS\\\u003C=15\n6. Creatinine Clearance of greater than or equal to 60 mL\u002Fmin using the Cockroft- Gault equation.\n7. Have passed a swallow evaluation prior to drug administration\n8. The patient is an acute rehabilitation candidate or candidate for the Homeward Stroke Program\n9. Able to participate in administered tests\n\nExclusion Criteria:\n\n1. Any degree of receptive aphasia\n2. Moderate or severe expressive aphasia\n3. Currently pregnant or plans to get pregnant\n4. Currently breastfeeding\n5. Any patient admitted with primary SubarachnoidH emorrhage (SAH )on either non-contrast head CT or MRI brain\n6. Diagnosis of dementia or mild cognitive impairment prior to index stroke\n7. Prior limb amputation\n8. Currently prescribed or taking a primary anticholinergic medication\n9. Currently enrolled in any other investigational pharmacologic or procedural clinical trial\n10. Malignancy with active treatment\n11. History of prior stroke with residual impairment\n12. Current or prior neuroleptic use\n13. History of suicidality or psychosis (The Columbia Suicide Severity Ratings Scale (C-SSRS) will be administered at the screening visit to assess depression and suicidal thoughts for subject eligibility. Any subjects who indicate severe depression or suicidal thoughts and\u002For attempts within the last year will not be eligible)\n14. Prior history of seizures\n15. Prior treatment with amantadine\n16. Parkinson's disease\n17. Amantadine allergy\n18. Elevated liver function tests (aspartate aminotransferase and alanine aminotransferase above the upper limit of normal) -","85 Years",{"count":20,"type":21},[121],"PHASE2","The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. Patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. At various time points patients will be examined and fill out questionnaires to determine level of stroke recovery.",[28,29],"2026-03-25",{"date":126,"type":42},"2026-03-30",{"date":128,"type":42},"2022-02-01",{"date":130,"type":21},"2028-06-30",{"name":132,"class":49},"University of Pennsylvania",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":145,"conditions":146,"keywords":147,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":160},"100583014","rapid-evacuation-and-access-of-cerebral-hemorrhage-trial-100583014","NCT06870812","Rapid Evacuation and Access of Cerebral Hemorrhage Trial","REACH","Inclusion Criteria:\n\n* Age 18-70 years\n* Pre-randomization head CT demonstrating an acute, spontaneous, anterior basal ganglia primary intracerebral hemorrhage (ICH) (the anterior basal ganglia include the caudate, putamen, and pallidum to the capsula externa and excludes the thalamus)\n* ICH volume between 20 - 80 mL as calculated by an approved and standardized volumetric measurement\n* Study intervention can reasonably be initiated within 24 hours after the onset of stroke symptoms. If the onset is unclear, then the onset will be considered the time that the subject was last known to be well.\n* Glasgow Coma Score (GCS) 5 - 14\n* Historical Modified Rankin Score 0 or 1\n\nExclusion Criteria:\n\n* Ruptured aneurysm, arteriovenous malformation (AVM), vascular anomaly, Moyamoya disease, venous sinus thrombosis, mass or tumor, hemorrhagic conversion of an ischemic infarct, recurrence of a recent (less than 1 year) ICH, as diagnosed with radiographic imaging\n* NIH Stroke Scale (NIHSS) less than or equal to 5\n* Bilateral fixed dilated pupils\n* Extensor motor posturing\n* Intraventricular extension of the hemorrhage is visually estimated to involve greater than 50% of either of the lateral ventricles\n* Primary thalamic ICH or basal ganglia hemorrhage with involvement \\> 25% of thalamus\n* Infratentorial intraparenchymal hemorrhage including midbrain, pontine, or cerebellar\n* Use of anticoagulants that cannot be rapidly reversed (i.e., criteria is met if investigators are confident that clinically significant coagulopathy is not present after targeted correction)\n* Evidence of active bleeding involving a retroperitoneal, gastrointestinal, genitourinary, or respiratory tract site\n* Uncorrected coagulopathy or known clotting disorder\n* Known platelet count less than 75,000 or known international normalized ratio (INR) greater than 1.4 after correction\n* Patients requiring long-term anti-coagulation that needs to be initiated less than or equal to 5 days from initial ICH\n* End-stage renal disease\n* Patients with a mechanical heart valve\n* End-stage liver disease\n* History of drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements\n* Positive urine or serum pregnancy test in female subjects without documented history of surgical sterilization or post-menopausal\n* Known life expectancy of less than 6 months before ICH\n* No reasonable expectation of recovery, do-not-resuscitate (DNR), or comfort measures only before randomization\n* Participation in a concurrent interventional medical investigation or clinical trial. Patients in non-interventional\u002Fobservational studies are eligible\n* Inability or unwillingness of the subject or legal guardian\u002Frepresentative to give written informed consent\n* Homelessness or inability to meet follow-up requirements","70 Years",{"count":142,"type":21},600,[144],"NA","The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, doctors will recommend surgery to remove the blood if medical treatment alone is not successful.\n\nThere is evidence that doing minimally invasive surgery early-using a small opening in the skull to remove blood-may help some patients. Researchers aim to understand whether this surgery is better than current medical treatment, which may include surgeries to relieve pressure on the brain in some cases. This study, called REACH, is comparing usual medical care to early minimally invasive surgery so doctors can know which is better for patients.",[29],[148,149,150],"Intracerebral hemorrhage","minimally invasive surgery","Blood clot","2026-03-17",{"date":153,"type":42},"2026-03-19",{"date":155,"type":42},"2025-05-27",{"date":157,"type":21},"2030-03",{"name":159,"class":49},"Emory University",21,{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":50},"100507236","early-upper-limb-rehabilitation-with-eeg-neurofeedback-after-stroke-100507236","NCT05884762","earlY Upper Limb Rehabilitation WIth EEG-Neurofeedback After Stroke","YUWIN-Stroke","Inclusion Criteria:\n\n* Unilateral ischaemic or haemorrhagic stroke\n* Adult (18-80 years), both sexes\n* Stroke \\\u003C 3 weeks\n* Upper limb deficit defined by Shoulder Abduction Finger Extension score \\\u003C5 measured during the 7 days following stroke; i.e., patients predicted to have incomplete recovery\n* No participation-limiting comprehension problems\n* With or without homonymous lateral hemianopia; with or without visuospatial hemineglect\n* Free, informed and written consent signed by the patient or a member of the patient's family (in the case of a patient who is able to understand the information and give consent but has motor difficulties resulting in an invalid signature).\n* Affiliated to french social security\n\nExclusion Criteria:\n\n* Ischemic or hemorrhagic brain stem and\u002For cerebellum involvement\n* Multiple strokes\n* Stroke \\\u003C 1 week; in order not to be deleterious by starting active rehabilitation too early after immediate stroke\n* Aphasia with major comprehension impairment\n* Contraindication to MRI\n\n  * pacemaker or implantable defibrillator,\n  * neurosurgical clips,\n  * cochlear implants,\n  * intra-orbital or encephalic metallic foreign bodies,\n  * stents placed less than 4 weeks ago and osteosynthesis devices placed less than 6 weeks ago,\n  * claustrophobia. (Patients who have undergone thrombolysis or thrombectomy may be included in the study.)","80 Years",{"count":170,"type":21},40,[144],"The aim of this study is to evaluate the effect of early rehabilitation treatment by electroencephalographic neurofeedback on upper limb motor function after stroke.\n\nResearchers will compare :\n\nInterventional group: electroencephalographic neurofeedback + traditional reference rehabilitation programme Control group: SHAM electroencephalographic neurofeedback + traditional reference rehabilitation programme",[64,29,28,174,175],"Stroke Rehabilitation","Brain Infarction",[64,177,178,179],"Rehabilitation","neurofeedback","Upper Limb","2026-02-26",{"date":182,"type":42},"2026-03-03",{"date":184,"type":42},"2024-02-20",{"date":186,"type":21},"2027-11",{"name":188,"class":49},"Rennes University Hospital",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":50},"100516224","utility-of-cc7-transfer-in-stroke-subtypes-100516224","NCT06001736","Utility of CC7 Transfer in Stroke Subtypes","Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke","Inclusion Criteria:\n\n* History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.\n* baseline Fugl-Meyer score below 33\n\nExclusion Criteria:\n\n* pregnancy","65 Years",{"count":198,"type":21},95,[144],"The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.",[28,29,202],"Spastic Hemiparesis",[204,205,206],"Ischemic stroke","Hemorrhagic stroke","Spastic hemiparesis","2026-02-25",{"date":209,"type":42},"2026-02-27",{"date":211,"type":42},"2022-03-13",{"date":213,"type":21},"2027-03-01",{"name":215,"class":49},"Dartmouth-Hitchcock Medical Center",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":223,"sex":17,"minAge":224,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":239,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":50},"100519758","vision-loss-impact-on-navigation-in-virtual-reality-100519758","NCT06047717","Vision Loss Impact on Navigation in Virtual Reality","The Impact of Vision Loss on Naturalistic Behavior and Navigation in Virtual Reality","Cortically Blind Group:\n\nInclusion Criteria:\n\n* Residents of the United States or Canada\n* Presence of one-sided stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and\u002For CT scans)\n* Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey or equivalent perimetry.\n* Willing, able, and competent to provide their own informed consent\n* Cognitively able, responsible to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Those who have never driven or earned a drivers' license\n* Past or present ocular disease interfering with visual acuity\n* Best corrected visual acuity (BCVA) worse than 20\u002F40 in either eye\n* Sustained damage to the dorsal lateral geniculate nucleus\n* Presence of diffuse, whole-brain degenerative processes\n* Presence of brain damage deemed by study staff to potentially interfere with outcome measures\n* History of traumatic brain injury\n* Documented history of drug\u002Falcohol abuse\n* Diagnosis of cognitive or seizure disorders\n* Diagnosis of one-sided attentional neglect\n\nControl Group:\n\nInclusion Criteria:\n\n* Normal or corrected-to-normal vision, who are between the ages of 21 and 75 years of age, roughly matched to the age of CB subjects enrolled above\n* Competent and responsible, as determined by the Principal Investigator\n* Willing, able, and competent to provide their own informed consent\n* Normal cognitive abilities, be able to understand written and oral instructions in English\n* Emmetropic or else wear corrective contact lenses inside the virtual reality headset\n\nExclusion Criteria:\n\n* Subjects who have never driven or earned a drivers' license\n* BCVA worse than 20\u002F40 in either eye\n* Presence of vision loss from ocular diseases or disorders\n* Presence of a visual field defect\n* Inability to wear corrective contact lenses inside the virtual reality helmet if required to see clearly\n* Subjects with a history of neurological disorders\n* Subjects with a history of TBI\n* Persons who lack the competence or are otherwise unable to perform the visual testing as directed.",true,"21 Years","75 Years",{"count":170,"type":21},[144],"The purpose of this research is to better understand the impact of cortically-induced blindness (CB) and the compensatory strategies subjects with this condition may develop on naturalistic behaviors, specifically, driving. Using a novel Virtual Reality (VR) program, the researchers will gather data on steering behavior in a variety of simulated naturalistic environments. Through the combined use of computer vision, deep learning, and gaze-contingent manipulations of the visual field, this work will test the central hypothesis that changes to visually guided steering behaviors in CB are a consequence of changes to the visual sampling and processing of task-related motion information (i.e., optic flow).",[28,230,231,232,233,234,235,236,237,238,29],"Quadrantanopia","Hemianopsia, Homonymous","Hemianopia, Homonymous","Hemianopia","Hemianopsia","Occipital Lobe Infarct","Visual Field Defect, Peripheral","Vision Loss Partial","Quadrantanopsia",[240,241,242,243,244,245,246,98],"Occipital stroke","Vision loss after stroke","Vision recovery","Vision restoration","Partial vision loss","Homonymous quadrantanopsia","Homonymous quadrantanopia","2026-01-07",{"date":249,"type":42},"2026-01-09",{"date":251,"type":42},"2023-11-28",{"date":253,"type":21},"2028-10",{"name":255,"class":49},"University of Rochester",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":263,"targetDuration":265,"studyType":61,"phases":4,"briefSummary":266,"conditions":267,"keywords":270,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":285},"100609113","non-invasive-intracranial-pressure-monitoring-to-improve-emergency-care-in-brazils-public-health-system-100609113","NCT07210333","Non-invasive Intracranial Pressure Monitoring to Improve Emergency Care in Brazil's Public Health System","Evaluation and Enhancement of the Effectiveness of Non-invasive Intracranial Pressure Monitoring for Screening in Neurological Emergencies Within the Brazilian Unified Health System","Inclusion Criteria\n\nPatients of both sexes.\n\nAge ≥ 18 years.\n\nClinical signs and symptoms of traumatic brain injury (mild, moderate, or severe) or stroke (ischemic or hemorrhagic).\n\nSigned informed consent form by the patient or by a legally authorized representative in cases where the patient is unable to consent due to the severity of the clinical condition. If the legal representative is not present at the time of admission or initial care, consent may be obtained retrospectively.\n\nExclusion Criteria\n\nIndividuals with brain lesions of other etiologies, such as previous TBI and\u002For stroke, neoplasms, infections, sepsis, arteriovenous malformation, intoxication, or illicit drug use.\n\nIndividuals with scalp or skin lacerations that prevent proper placement of the brain4care sensor.\n\nIndividuals with craniectomy or skull fractures.\n\nIndividuals with severe debilitating mental health disorders and\u002For severe debilitating neurological diseases.\n\nIndividuals who are agitated, aggressive, or uncooperative, preventing follow-up and outcome assessment.\n\nPregnant women.",{"count":264,"type":21},300,"14 Days","The goal of this observational study is to evaluate the diagnostic accuracy of non-invasive intracranial pressure (ICP) and intracranial compliance (ICC) pulse morphology and associated parameters (such as the P2\u002FP1 ratio and nTTP) obtained with the brain4care system for the screening of intracranial hypertension (ICH) in patients with traumatic brain injury (TBI) and stroke treated in Brazil's public health system (SUS).\n\nThe main questions it aims to answer are:\n\nCan non-invasive ICP and ICC pulse morphology reliably identify or exclude intracranial hypertension, cerebral edema, and hemorrhage compared to CT findings and clinical\u002Fneurological evaluations?\n\nCan this approach differentiate ischemic stroke from hemorrhagic stroke with sufficient accuracy?\n\nDoes the use of brain4care contribute to earlier detection, improved clinical decision-making, and cost reduction in emergency settings?",[268,29,269],"Traumatic Brain Injury (TBI) Patients","Stroke Ischemic",[64,271,272,273,274],"Traumatic Brain Injury","Intracranial Pressure","Intracranial Compliance","Medical Devices","2025-09-30",{"date":277,"type":42},"2025-10-07",{"date":279,"type":21},"2025-12-16",{"date":281,"type":21},"2028-01-28",{"name":283,"class":284},"Braincare USA Corp","INDUSTRY",3,{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":293,"targetDuration":4,"studyType":22,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":314},"100608266","clinical-validation-of-an-ai-based-decision-support-system-for-robotic-upper-limb-rehabilitation-in-patients-with-stroke-a-co-aider-study-100608266","NCT07199322","Clinical validatiOn of an AI-based DEcision Support System for Robotic Upper Limb Rehabilitation in Patients With Stroke. A CO-AIDER Study.","COAIDER","Inclusion Criteria:\n\n* Diagnosis of ischemic or hemorrhagic stroke confirmed by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI);\n* Age between 18 and 85 years;\n* Time since stroke less than six months;\n* Mild to severe upper limb impairment (Fugl-Meyer Assessment for Upper Extremity (FMA-UE) ≤ 58).\n\nExclusion Criteria:\n\n* Behavioral or cognitive disorders and\u002For reduced compliance;\n* Severe spasticity or hypertonia in the affected limb (Modified Ashworth Scale (MAS) \\> 3);\n* Severe visual impairments;\n* Concurrent participation in another clinical trial for upper limb rehabilitation following stroke;\n* Refusal to provide written informed consent.",{"count":294,"type":21},100,[144],"The goal of this clinical trial is to validate an artificial intelligence-based decision support system (AI-DSS) for robotic rehabilitation in participants with stroke.\n\nThe study aims to answer the following questions:\n\n* Can the AI-DSS support therapists in setting therapy parameters and adapting personalized robotic rehabilitation programs effectively?\n* Can AI-supported robotic rehabilitation improve upper limb function, activities of daily living (ADL), cognitive function, and quality of life compared with standard therapist-guided robotic rehabilitation?\n\nResearchers will compare two groups:\n\n* Robotic rehabilitation supported by the AI-DSS (CO-AIDER);\n* Robotic rehabilitation with parameters set by therapists (control group).\n\nParticipants will:\n\n* Receive robotic rehabilitation for the upper limb, either guided by the AI-DSS or by therapists;\n* Be monitored throughout the program, with therapy parameters adjusted according to their progress;\n* Complete assessments to evaluate changes in upper limb function, activities of daily living, cognitive function, and quality of life.\n\nThe study will also evaluate the usability and acceptability of the AI-supported robotic system as perceived by participants and clinical staff, and will include a cost-effectiveness analysis of the two interventions.",[64,269,29,298],"Upper Limb Rehabilitation",[64,300,301,302,303,304,305],"Upper limb rehabilitation","Artificial Intelligence","Robot-assisted therapy","AI-supported robotic system","AI-based decision support system","rehabilitation","2025-09-26",{"date":275,"type":42},{"date":309,"type":21},"2025-09",{"date":311,"type":21},"2026-12",{"name":313,"class":49},"Fondazione Don Carlo Gnocchi Onlus",10,{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":330,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":4},"100608168","can-listening-to-music-improve-attention-and-language-after-post-stroke-aphasia-100608168","NCT07198048","Can Listening to Music Improve Attention and Language After Post-Stroke Aphasia?","Treating Attention and Language in Post-stroke Aphasia Using a Music-based Intervention.","Inclusion Criteria:\n\nAdults at least 18 years of age Individuals who have had a stroke and are at least 6 month post stroke Individuals are able to answer 4 questions to determine ability to consent (What is your name, what is the day\u002Fdate, where are you , and why are we having this conversation).\n\nHave normal or corrected to normal hearing Have normal or corrected to normal vision Have no issues with color blindness Individuals who have at least mild aphasia on the Western Aphasia Battery Revised Speaks American English\n\nExclusion Criteria:\n\nIndividuals who meet the inclusion criteria, but are unwilling to travel to the ABC Lab at Purdue University for in person testing and do not have a laptop or desktop with a web camera that they could participate online with, will be excluded.\n\nIndividuals who have had a dementia diagnosis or attention disorder pre stroke will be excluded.",{"count":323,"type":21},45,[144],"The goal of this clinical trial is to learn if a music-based intervention can acutely improve three types of attention (alerting, orientating, executive control) in people with aphasia following a stroke.\n\nThe main questions it aims to answer are:\n\n1. Is a music based intervention effective at improving attention with someone who has aphasia?\n2. Does music-induced changes in attention improve language abilities and quality of life with someone who has aphasia? Researchers will compare a group that listening to music, to listing to an audiobook group, to a group that serves as a control to see if there are changes in attention over time.\n\nParticipants will:\n\n1. Listen to music or an audiobook for 30 minutes a day for 8 weeks\n2. Complete a daily journal about each day's listening experience\n3. Complete three testing sessions where attention, language, and quality of life are assessed.",[327,64,328,29,269,329],"Aphasia","Stroke and Aphasia","Music Intervention",[98,331,332,333,334,335],"aphasia","attention","language","music","music intervention","2025-09-25",{"date":275,"type":42},{"date":339,"type":21},"2025-10",{"date":341,"type":21},"2028-07-01",{"name":343,"class":49},"Purdue University",{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":350,"enrollmentInfo":351,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":352,"conditions":353,"keywords":356,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":366,"leadSponsor":368,"locationsCount":50},"100603663","use-of-physical-therapy-outcome-measures-to-predict-discharge-destination-in-people-with-stroke-from-acute-care-hospital-100603663","NCT07139444","Use of Physical Therapy Outcome Measures to Predict Discharge Destination in People With Stroke From Acute Care Hospital","Inclusion Criteria:\n\n1. Individuals who have a confirmed diagnosis of a first acute, single or multiple infarct, ischemic or hemorrhagic in nature by imaging.\n2. Individuals who are 18 years of age or older.\n3. Individuals must be non-institutionalized prior to hospital admission.\n4. Individuals whose primary spoken and written language is English.\n5. Individuals who are referred for physical therapy in acute care.\n\nExclusion Criteria:\n\n1. Individuals who are non-ambulatory prior to hospital admission.\n2. Individuals having a diagnosis of secondary major trauma or subarachnoid hemorrhage.\n3. Individuals with any comorbidity that prevents him\u002Fher from completing the tests such as a previous neurological injury or recent orthopedic diagnoses.","100 Years",{"count":93,"type":21},"Physical therapy assessments assist in discharge planning along with demographic and social factors for patients with stroke in acute care. Understanding where a patient can be discharged to, based on the patient's functional status post stroke is important to be able to use resources effectively, decrease length of stay, and facilitate early initiation of rehabilitation services if needed. Standardized outcome measures can help quantify functional deficits and the scores on the standardized outcome measures can in turn guide the discharge planning process. The Activity Measure for Post Acute Care \"6-Clicks\" (AM-PAC \"6-Clicks\") has been used in the acute care setting to guide discharge planning. Based on its cutoff scores, it also can assist in predicting discharge destination. The Mobility Scale for Acute Stroke (MSAS) has been used to determine discharge to home versus not home in patients with stroke. Understanding the validity of the MSAS in comparison with the Postural Assessment Scale for Stroke (PASS) and the AM-PAC \"6-Clicks\" can be beneficial as the MSAS is a stroke specific outcome measure which is mainly used in acute care and is easy to administer. It can be administered in a short duration and consists of mobility and balance assessments which can help determine functional deficits.",[354,355,64,29],"Stroke, Acute","Cerebrovascular Accident",[98,357,358,359,360,361],"PASS","AM-PAC \"6-Clicks\"","MSAS","acute care hospital","physical therapy outcome measures","2025-08-17",{"date":364,"type":42},"2025-08-24",{"date":309,"type":21},{"date":367,"type":21},"2026-03",{"name":369,"class":49},"New York Presbyterian Brooklyn Methodist Hospital",{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":378,"enrollmentInfo":379,"targetDuration":4,"studyType":22,"phases":381,"briefSummary":382,"conditions":383,"keywords":385,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":50},"100525889","the-reactplusnmes-trial-a-double-blinded-rct-100525889","NCT06127602","The REACTplusNMES Trial: A Double-blinded RCT","NeuroMuscular Electrical Stimulation to Facilitate Perturbation-based REACtive Balance Training for Fall Risk Reduction Post-stroke: The REACTplusNMES Trial","REACT+NMES","Inclusion Criteria:\n\n* Age group: 18-90 years.\n* Presence of hemiparesis.\n* Onset of stroke (\\> 6 months).\n* Ability to walk at least for 2 minutes on the treadmill with or without ankle foot orthosis.\n* Can understand and communicate in English.\n* Cognitively and behaviorally capable of complying with the regimen (Mini-Mental State Examination \\> 25\u002F30).\n* No history or recent use (i.e., past 6 weeks) of any Neuromuscular electrical stimulation device to leg muscles during walking (e.g., Bioness, Walkaide).\n\nExclusion Criteria:\n\n* Subjects will not proceed with the test if any of the following occurs at baseline measurement: 1) HR \\> 85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \\> 165 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg during rest, or 3) oxygen saturation (measured by pulse oximeter) \\\u003C 95% during rest.\n* Body weight of more than 250 lbs.\n* Spasticity (Ashworth scale \\> 2).\n* Loss of protective sensations on the paretic leg (indicated by inability to perceive the 5.07\u002F10 g on Semmes-Weinstein Monofilament) or inability to feel the NMES.\n* Severe osteoporosis (indicated by T score \\\u003C -2)\n* Cognitive impairment (indicated by Mini-Mental State Exam score\\\u003C25)\n* Global Aphasia (indicated by \\\u003C71% on the Mississippi Aphasia Screening Test).\n* Subjects with Chedoke McMaster Leg Assessment Scale score (\\> 4).","90 Years",{"count":380,"type":21},46,[144],"The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical, neuromuscular and neuroplastic outcomes of reactive balance control. This project is a Phase-I study and incorporates a double-blinded, randomized controlled trial design.\n\nMethods: Forty-six individuals with chronic stroke will be recruited and screened for determining their eligibility for the study. Once enrolled, they will be randomized into either of the two groups: intervention group (23 participants) and control group (23 participants). Both groups will undergo series of pre-training assessments which includes a postural disturbance in the form of a slip- or trip-like perturbations and walking tests in laboratory environment. After the pre-training assessment, individuals will undergo 6-weeks of training (2 hour per session, 2 sessions per week). The intervention group will receive NMES with the REACT training and the control group will receive ShamNMES. NMES will be applied to the different muscle groups of the paretic lower limb using an advanced software which is able to synchronize muscle activation with the time of perturbation onset and according to the phases of gait. After training, both groups will again be tested on all the assessments performed pre training.\n\nThis study will help us understand the immediate therapeutic and mechanistic effects of REACT+NMES and inform stroke rehabilitation research and clinical practice. Our study will provide foundational evidence for future use of NMES to implement clinically applicable neuromodulation adjuvants to reactive balance training, which could be leveraged for designing more effective future interventions for fall-risk reduction.",[28,29,384],"Stroke, Cerebrovascular",[386,387,388,389,390,64,391,392,393],"Reactive balance","Falls","Perturbation training","NMES","FES","Fall prevention","Neuroplastic","Neuromuscular","2025-07-31",{"date":396,"type":42},"2025-08-06",{"date":398,"type":42},"2024-03-01",{"date":400,"type":21},"2026-05-31",{"name":402,"class":49},"University of Illinois at Chicago",{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":11,"sex":17,"minAge":410,"maxAge":225,"enrollmentInfo":411,"targetDuration":4,"studyType":22,"phases":412,"briefSummary":413,"conditions":414,"keywords":416,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":50},"100459918","the-role-of-cognition-in-motor-learning-after-stroke-100459918","NCT05268861","The Role of Cognition in Motor Learning After Stroke","The Role of Cognition in the Use of Enhanced Intrinsic Feedback for Motor Learning After Stroke","Inclusion Criteria:\n\n* Sustained a first cortical\u002Fsub-cortical ischemic\u002Fhemorrhagic stroke less than 3 years previously and are medically stable.\n* Are no longer receiving treatment.\n* Normal or corrected-to-normal vision.\n* Have arm paresis (Chedoke-McMaster Arm Scale 2-6\u002F7) and spasticity (Modified Ashworth Scale ≥ 1\u002F4) but can voluntarily flex\u002Fextend the elbow to approximately 30 degrees in each direction.\n\nExclusion Criteria:\n\n* Other major neurological or musculoskeletal problems that may interfere with task performance.\n* Marked elbow proprioceptive deficits (\\\u003C6\u002F12 Fugl-Meyer UL sensation scale) that may interfere with elbow position perception.\n* Visuospatial neglect (Line Bisection Test deviation \\> 6 mm).\n* Uncorrected vision.\n* Depression (≥ 14 Beck Depression Inventory II).","40 Years",{"count":5,"type":21},[144],"Stroke leads to lasting problems in using the upper limb (UL) for everyday life activities. While rehabilitation programs depend on motor learning, UL recovery is less than ideal. Implicit learning is thought to lead to better outcomes than explicit learning. Cognitive factors (e.g., memory, attention, perception), essential to implicit motor learning, are often impaired in people with stroke. The objective of this study is to investigate the role of cognitive deficits on implicit motor learning in people with stroke. The investigators hypothesize that 1) subjects with stroke will achieve better motor learning when training with additional intrinsic feedback compared to those who train without additional intrinsic feedback, and 2) individuals with stroke who have cognitive deficits will have impairments in their ability to use feedback to learn a motor skill compared to individuals with stroke who do not have cognitive deficits.\n\nA recent feedback modality, called error augmentation (EA), can be used to enhance motor learning by providing subjects with magnified motor errors that the nervous system can use to adapt performance. The investigators will use a custom-made training program that includes EA feedback in a virtual reality (VR) environment in which the range of the UL movement is related to the patient's specific deficit in the production of active elbow extension. An avatar depiction of the arm will include a 15 deg elbow flexion error to encourage subjects to increase elbow extension beyond the current limitations. Thus, the subject will receive feedback that the elbow has extended less than it actually has and will compensate by extending the elbow further. Subjects will train for 30 minutes with the EA program 3 times a week for 9 weeks. Kinematic and clinical measures will be recorded before, after 3 weeks, after 6 weeks, and after 9 weeks. Four weeks after the end of training, there will be a follow-up evaluation. Imaging scans will be done to determine lesion size and extent, and descending tract integrity with diffusion tensor imaging (DTI).\n\nThis study will identify if subjects with cognitive deficits benefit from individualized training programs using enhanced intrinsic feedback. The development of treatments based on mechanisms of motor learning can move rehabilitation therapy in a promising direction by allowing therapists to design more effective interventions for people with problems using their upper limb following a stroke.",[29,28,415],"Cognitive Impairment",[417,418,419,420,421,422,423],"virtual reality","motor learning","cognition","intrinsic feedback","cognitive impairment","imaging","error augmentation","2025-05-30",{"date":426,"type":42},"2025-06-04",{"date":428,"type":42},"2022-04-01",{"date":430,"type":21},"2026-07",{"name":432,"class":49},"McGill University",{"id":434,"slug":435,"hasResults":11,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":440,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":442,"conditions":443,"keywords":445,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":451,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":50},"100453050","prognosis-and-diagnosis-of-spasticity-in-acute-post-stroke-patients-100453050","NCT05179473","Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients","Changing Practice: Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients: a Pilot Study","Inclusion Criteria:\n\n* Acute stroke in Middle Cerebral Artery area resulting in hemiparesis.\n* Hemorrhagic or ischemic\n* Medically stable\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Severe cognitive disorders\n* Ataxia",{"count":441,"type":21},12,"Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle muscles. However, despite its clinical relevance, the natural development of spasticity over the first 3 months after stroke is not clearly understood. Indeed, common clinical measures of spasticity such as the Modified Ashworth Scale (MAS) do not take into account the neurophysiological origin of spasticity and lack reliability and objectivity.\n\nThe objective of this study is to examine the natural history of the development of spasticity among patients with stroke over the first 3 months using a new neurophysiological measure (TSRT, the tonic stretch reflex threshold angle) and its velocity sensitivity (mu) in comparison to MAS and other common clinical tests. In addition, detailed brain imaging will be used to understand the relationship between damage to brain regions relevant to the development of spasticity and TSRT\u002Fmu values.\n\nIt is hypothesized that 1) TSRT\u002Fmu will indicate the presence of spasticity earlier than MAS\u002Fclinical tests; 2) TSRT\u002Fmu measures will be more closely related to motor impairments and activity limitations than MAS; 3) the lesion severity (identified by imaging) will be related to the change in TSRT\u002Fmu values.\n\nOutcomes will be measured in a pilot cohort of 12 patients hospitalized for first-ever stroke. Measurements will be taken at the bedside within the 1st week of the patient's admission and will be done once per week for 12 weeks with a follow-up at week 16. Brain Imaging will be done around the 6th week post-stroke.",[354,28,29,444],"Spasticity as Sequela of Stroke",[98,446,422,447,448,449,450],"spasticity","prognosis","diagnosis","upper limb","lower limb",{"date":426,"type":42},{"date":453,"type":42},"2021-06-17",{"date":455,"type":21},"2025-12-30",{"name":432,"class":49},{"id":458,"slug":459,"hasResults":11,"nctId":460,"briefTitle":461,"officialTitle":461,"acronym":462,"eligibilityCriteria":463,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":350,"enrollmentInfo":464,"targetDuration":4,"studyType":22,"phases":465,"briefSummary":466,"conditions":467,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":50},"100572078","emergency-stroke-unit-for-acute-cerebrovascular-events-a-prospective-single-arm-trial-with-a-historical-control-group-100572078","NCT06728592","Emergency Stroke Unit for Acute Cerebrovascular Events: A Prospective, Single-arm Trial With a Historical Control Group","ESU-ACE-E","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Diagnosed as ischemic stroke;\n3. Potentially eligible for IVT and\u002For EVT and can be treated within 6 hours of symptom onset (time of symptom onset is defined as the last known normal time);\n4. Presenting to AED during working hours (8AM to 6PM, weekdays);\n5. Written informed consent from patients or representatives, who understand Cantonese, to participate in this study.\n\nExclusion Criteria:\n\n1. Patients with unstable vital signs who need urgent medical interventions\u002Fcare;\n2. Confirmed contraindications for IVT or EVT by initial assessment (e.g., unstable vital signs, history of severe head trauma within 3 months, known bleeding tendency), before starting brain imaging exams;\n3. Claustrophobia or other conditions that are contraindicated for MRI;\n4. Patients with pacemakers, brain stimulators or insulin pumps;\n5. Patients with medical or other conditions that prevent cooperation with the procedures;\n6. Pregnant or breastfeeding women;\n7. Participation in other clinical trials within 3 months before screening.",{"count":294,"type":21},[144],"Background Reperfusion therapies, i.e., intravenous thrombolysis (IVT) and\u002For endovascular thrombectomy (EVT), are most effective treatments in the management of acute ischemic stroke (AIS) patients. The benefits of reperfusion therapies, however, may be reduced by treatment delays due to tests and examinations and logistic issues. Emergency Stroke Unit (ESU), a new concept of stroke unit locating at the Accident and Emergency Department (AED), equipped with a mobile, low-field MR imaging (lfMRI) scanner for fast diagnosis of ischemic stroke, differentiation of intracranial hemorrhage and identification of large vessel occlusion (LVO), is being tested in Mainland China. It may shorten the door-to-needle time (DNT) for IVT and door-to-groin puncture time (DPT) for EVT, which may hance associate with improved functional outcomes of AIS patients.\n\nThis is a prospective, single-center, open-label, non-randomized, single-arm study aims to evaluate the safety and efficacy of the ESU workflow using lfMRI in shortening the DNT\u002FDPT and improving functional outcomes in AIS patients, who are potentially eligible for IVT and\u002For EVT and can be treated within 6 hours after onset, compared with standard practice in Hong Kong; to reveal the changes in the ischemic lesions over a few days after IVT\u002FEVT in these patients, with serial follow-up lfMRI exams.",[65,468,64,354,28,29,469,470],"Intracerebral Hemorrhage","Stroke (CVA) or TIA","Brain Diseases","2025-05-25",{"date":424,"type":42},{"date":474,"type":42},"2024-12-02",{"date":476,"type":21},"2027-06-30",{"name":478,"class":49},"Chinese University of Hong Kong",{"id":480,"slug":481,"hasResults":11,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":486,"targetDuration":4,"studyType":22,"phases":488,"briefSummary":489,"conditions":490,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":498,"locationsCount":50},"100563489","at-home-tavns---stroke-rehab-100563489","NCT06616831","At-Home taVNS - Stroke Rehab","Development of At-Home Transcutaneous Auricular Vagus Nerve Stimulation for Post-Stroke Rehabilitation","Inclusion Criteria:\n\n* 18-80 years old with an ischemic or hemorrhagic stroke that occurred ≥6 months prior;\n* Ability to give consent;\n* Unilateral limb (left or right) weakness with Fugl Meyer-Upper Extremity Scale score of 19-53\u002F60 points which indicates adequate arm\u002Fhand use for rehabilitation tasks;\n* active wrist flexion\u002Fextension ≥10° with active abduction\u002Fextension of thumb and at least 1 digit ≥10° to further assure ability to participate in rehabilitation tasks;\n* Passive range of motion in affected shoulder, elbow and wrist within 20 degrees of normal values.\n\nExclusion Criteria:\n\n* Other concomitant neurological disorders affecting upper extremity motor function;\n* Presence of Dysphagia or aspiration difficulties;\n* Prior injury to vagus nerve;\n* Pregnancy;\n* Documented history of dementia before or after stroke;\n* Documented history of uncontrolled depression or psychiatric disorder either before or after stroke which could affect their ability to participate in the experiment;\n* Uncontrolled hypertension;\n* Botox injections within 4 weeks of the first day of rehabilitation therapy.",{"count":487,"type":21},5,[144],"Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear. This study aims to test the new approach of pairing ear stimulation with motor rehabilitation in the home setting in stroke survivors with upper limb motor function deficits.",[64,28,29],"2025-05-15",{"date":493,"type":42},"2025-05-20",{"date":495,"type":42},"2024-10-28",{"date":497,"type":21},"2026-09-30",{"name":499,"class":49},"Medical University of South Carolina",{"id":501,"slug":502,"hasResults":11,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":506,"eligibilityCriteria":507,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":508,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":509,"conditions":510,"keywords":512,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":50},"100493719","find-stroke-recovery---a-longitudinal-study-100493719","NCT05708807","FIND Stroke Recovery - A Longitudinal Study","FIND Stroke Recovery: A Longitudinal Frequent Evaluation Long-term Follow-up Study","FIND","Investigators enrol patients presenting with first-ever ischemic stroke or intracerebral haemorrhage admitted to the stroke units at the Sahlgrenska University Hospital in Gothenburg, Sweden.\n\nThe inclusion criteria are:\n\n• first-ever acute ischemic stroke; or intracerebral hemorrhage.\n\nThe exclusion criteria are:\n\n* pre-stroke mRS score of ≥3;\n* severe neurodegenerative disease, cerebral neoplasm or terminal illness; and\n* patients considered unlikely to be able to participate in or to understand and\u002For comply with study procedures during follow-up visits at the hospital.",{"count":142,"type":21},"Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. Some will recover fully after stroke and others will have permanent impairments. Few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. Also, the whole range of mechanisms leading to recovery are not precisely known (1). To monitor those mechanisms one can utilize biomarkers.\n\nIn parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke.",[64,29,28,511,415],"Risk Factor, Cardiovascular",[513,305,514,515,516,517,518,519,520],"recovery","stroke severity","plasticity","modified Rankin Scale","National Institutes of Health Stroke Scale","Fugl-Meyer assessment","blood sampling","stroke subtype","2025-03-27",{"date":523,"type":42},"2025-04-02",{"date":525,"type":42},"2018-02-01",{"date":527,"type":21},"2030-12-31",{"name":529,"class":49},"Göteborg University",{"id":531,"slug":532,"hasResults":11,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":536,"eligibilityCriteria":537,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":538,"targetDuration":4,"studyType":22,"phases":539,"briefSummary":540,"conditions":541,"keywords":543,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":555,"locationsCount":487},"100494949","virtual-physical-activity-seated-exercise---phase-2-100494949","NCT05724823","Virtual Physical Activity Seated Exercise - Phase 2","Assessing a Telehealth Seated Exercise Program on Post-stroke Balance and Mobility: a Mixed-method Design","V-PASE","Inclusion Criteria:\n\nParticipants must meet the following inclusion criteria:\n\n* Adult (as defined by Province)\n* Chronic stroke (more than 6 months post-stroke)\n* Ability to stand up from a chair\n* Mobility impairment of lower extremity (requires a walking aid, with or without close supervision)\n* Able to safely engage in exercise and tolerate 60 minutes of exercises\n* Able to communicate in English\n* Have access to a tablet, computer, or laptop with internet and email access\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following criteria:\n\n* Participating in formal exercise or rehabilitation activities\n* Participating in \\> 30 minutes\u002Fday of physical activity (moderate intensity)\n* Participating in another study that may affect outcomes to this study\n* Severe loss of vision, hearing, speech (including aphasia) or cognition that would preclude use of a computer\u002Ftablet and communication over videoconference software\n* A serious comorbid condition (eg., amputation, Parkinson's disease, active cancer)\n* Clinically diagnosed with acute\u002Fchronic illness or other condition which has known physical activity contraindications or limits their ability to complete each experimental condition (i.e., chronic low back pain aggravated by prolonged sitting)",{"count":294,"type":21},[144],"This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility impairment.\n\nParticipants will be allocated to either a 10-week seated exercise program or a delayed 2-week Boot Camp program. All seated exercises sessions and assessments will be conducted virtually.",[64,542,28,29],"Chronic Stroke",[64,544,545,546,547,548],"Seated Exercise","Balance","Mobility","Cardiometabolic health","Randomized Controlled Trial","2025-03-05",{"date":551,"type":42},"2025-03-10",{"date":553,"type":42},"2023-10-11",{"date":311,"type":21},{"name":556,"class":49},"University of British Columbia",{"id":558,"slug":559,"hasResults":11,"nctId":560,"briefTitle":561,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":564,"targetDuration":4,"studyType":22,"phases":566,"briefSummary":567,"conditions":568,"keywords":574,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":589,"locationsCount":487},"100524306","effects-of-atalante-exoskeleton-on-gait-recovery-in-non--or-poorly-ambulatory-patients-with-hemiparesis-in-the-acutesubacute-phase-month-1-to-4-100524306","NCT06107010","Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute\u002FSubacute Phase (Month 1 to 4)","EarlyExo","Inclusion Criteria:\n\n* \\>18 years old\n* First clinically significant disability due to stroke\n* Hemiparesis in acute-subacute phase (1 to 4 months since lesion) due to a stroke\n* Functional Ambulation Category score (FAC) \\\u003C2\n* Patient with health insurance\n* Informed and willing to sign an informed consent form approved by the Ethics Committee. For clarity, if a motor impairment prevents the subject from signing by himself, he\u002Fshe can still be included if the signature can be done by an impartial witness.\n\nExclusion Criteria:\n\n* Muscle overactivity in hip adductors, hamstrings, quadriceps and plantar flexors, which interferes with exoskeleton use, based on clinician investigator's opinion\n* Recent fracture (\\\u003C 3 months) or any therapy inducing secondary osteoporosis\n* Excessive joint mechanical pain in the lower limbs based on clinician investigator's opinion\n* Pressure sore grade I or more over contact zones with Atalante system, according to the International Pressure Ulcer Classification System NPUAP - EPUA\n* Medical contra-indication to medium intensity physical strain\n* Orthostatic hypotension (loss of \\> 20 mmHg systolic BP after 3 minutes in standing position)\n* Uncontrolled seizures\n* Morphological contra-indications to the use of Atalante (as per user's manual)\n* Pregnant woman\n* Adults who lack the capacity to provide informed consent, and all those persons deprived of their liberty in prisons or other places of detention\n* Concurrent participation in another interventional trial",{"count":565,"type":21},66,[144],"The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.\n\nThis clinical investigation is designed to test the hypothesis that early and intense introduction of walking sessions assisted by the Atalante exoskeleton, in a sample of hemiparetic patients with still non or poor ambulatory capacities (FAC 0 or 1) between one- and four-months post stroke, would result in a better recovery of functional walking compared to a control group only receiving conventional therapy. Improved recovery will be measured through the proportion of patients reaching a FAC score of 4 or higher at the end of the intervention period. The tested hypothesis is that this proportion will be higher in the Exo group.\n\nThe duration of the intervention period in both groups is 6 weeks.\n\n* For the Exo group: 3 sessions per week (i.e., 18 one-hour sessions) with the Atalante device and 2 sessions per week (i.e., 12 one-hour sessions) of conventional therapy.\n* For the Control group: 5 sessions per week of conventional therapy (i.e., 30 one-hour sessions).\n\nThe study will include 66 patients (33 in each arm) and takes place in two French centers, two German centers and one Spanish center.",[354,28,569,29,570,355,571,572,573],"Stroke, Subacute","Cerebrovascular Disorders","Hemiparesis","Hemiparesis;Poststroke\u002FCVA","Hemiparesis\u002FHemiplegia (One Sided Weakness\u002FParalysis)",[575,177,576,577,64,578,579,580,581],"Robotics","Powered Exoskeleton","Walking recovery","Acute stroke","Subacute stroke","Functional Ambulation Category","Randomized controlled study","2025-01-30",{"date":584,"type":42},"2025-02-04",{"date":586,"type":42},"2023-06-12",{"date":588,"type":21},"2026-02-28",{"name":590,"class":284},"Wandercraft",{"id":592,"slug":593,"hasResults":11,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":597,"eligibilityCriteria":598,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":599,"targetDuration":601,"studyType":61,"phases":4,"briefSummary":602,"conditions":603,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":50},"100435896","data-collection-of-patients-admitted-to-the-stroke-unit-100435896","NCT04956185","Data Collection of Patients Admitted to the Stroke Unit","Prospective Data Collection of Patients Admitted to the Stroke Unit At University Hospital Ghent","PRODA-STROKE","Inclusion Criteria:\n\n* Patients admitted to the Stroke unit with a cerebrovascular disease\n* Patients admitted to the regular neurological ward or any other department in the University Hospital Ghent with a cerebrovascular disease who are actively followed by the department of Neurology during hospitalisation\n* Patients who have given their explicit informed consent for data collection\n\nExclusion Criteria:\n\n* Patients who have not given informed consent for data collection\n* Patients who are not able to give informed consent and whose legal representative has not given informed consent",{"count":600,"type":21},5000,"12 Months","The purpose of this prospective observational study is to create a database in which data will be collected from every patient admitted to the Stroke unit and who has explicitly given his or her informed consent for this data collection. The data that will be collected are part of the standard clinical data. No additional investigations, blood tests or any other tests will be performed. The purpose of this database is to conduct retrospective observational research in the future and will allow the hospital to keep track of some important quality indicators in stroke care.",[64,354,28,29,604],"Stroke Sequelae","2025-01-13",{"date":607,"type":42},"2025-01-15",{"date":609,"type":42},"2021-04-29",{"date":611,"type":21},"2031-02-01",{"name":613,"class":49},"University Hospital, Ghent",{"id":615,"slug":616,"hasResults":11,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":11,"sex":17,"minAge":622,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":22,"phases":625,"briefSummary":626,"conditions":627,"keywords":629,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":50},"100298062","rehabilitation-of-visual-function-after-brain-injury-100298062","NCT03160131","Rehabilitation of Visual Function After Brain Injury","Rehabilitation of Visual Function After Brain Injury - Effect of Neuro Vision Technology (NVT)","IBOS-NVT","Inclusion criteria:\n\n* 14 years or older with brain injury.\n* Persons who experience significant vision impairment.\n* Eye sight 6\u002F18 or better.\n* The time from symptoms onset to study inclusion is between 6 weeks and 9 months.\n\nExclusion criteria:\n\n* Cognitive dysfunction.\n* Persons with anosognosia or severe neglect.\n* Inability to move independently at least 35 meters with or without assistance, including wheelchairs.\n* Inability to understand Danish or with communication disorders that prevent participation in tests.\n* Terminal disorder, other progressive disorder.\n* Significant abuse of alcohol or euphoric or narcotic drugs.\n* Serious disorders such as mental illness, especially severe depression.\n* New brain injury or other significant disorders emerging after study inclusion.\n* Impaired vision not due to brain damage, where the disorder is not considered to be permanent or where the field of vision does not cause significant disability.","14 Years",{"count":624,"type":21},56,[144],"In Denmark, about 120,000 people suffer from brain damage, of whom approx. 75,000 with brain damage after stroke. Serious and often lasting vision impairments affect 20% to 35% of people after stroke. Vision is the most important sense in humans, and even smaller permanent injuries can drastically reduce quality of life.\n\nVision impairments after brain damage inhibits rehabilitation and enhances other invalidating effects. Reduced vision results in impaired balance, increased risk of serious falls, increased support needs, reduced quality of life, and impaired ability to perform activities of daily living. Restoration of visual field impairments occur only to a small extent during the first month after brain damage, and therefore the time window for spontaneous improvements is very limited. Hence, brain-impaired persons with visual impairment will most likely experience chronically impaired vision already 4 weeks after brain injury and the need for visual compensatory rehabilitation is substantial.\n\nNeuro Vision Technology (NVT) is an supervised training course where people with visual impairments are trained in compensatory techniques using special equipment. Through the NVT process, the individual's vision problems are carefully investigated and personal data is used to organize individual training sessions that practice the individual in coping with situations that cause problems in everyday life.\n\nThe purpose of this study is to investigate whether rehabilitation with NVT can cause significant and lasting improvement in functional capacity in persons with chronic visual impairments after brain injury. Improving eyesight is expected to increase both physical and mental functioning, thus improving the quality of life. Participants included in the project will be investigated in terms of both visual and mental functions, including quality of life, cognition and depression. Such an investigation has not been performed previously and can have a significant impact on vision rehabilitation both nationally and internationally.",[28,628,29,271],"Brain Injuries",[64,630,233,631,177],"Visual impairment","Neuro Vision Technology","2024-12-04",{"date":634,"type":42},"2024-12-09",{"date":636,"type":42},"2017-08-01",{"date":638,"type":21},"2027-07-31",{"name":640,"class":49},"University Hospital, Gentofte, Copenhagen",{"id":642,"slug":643,"hasResults":11,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":649,"enrollmentInfo":650,"targetDuration":4,"studyType":22,"phases":652,"briefSummary":653,"conditions":654,"keywords":658,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":660,"lastUpdatePostDateStruct":661,"startDateStruct":663,"completionDateStruct":665,"leadSponsor":667,"locationsCount":285},"100560284","associative-peripheral-stimulation-for-reduction-of-motor-impairment-during-acute-period-of-stroke-recovery-100560284","NCT06575140","Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery","Pilot Randomized Controlled Trial Assessing Associative Peripheral Stimulation (APS) for Reduction of Motor Impairment During Acute Period of Stroke Recovery","APS-PILOT","Inclusion Criteria:\n\n1. Confirmed ischemic or hemorrhagic stroke no earlier than 7 days prior to enrollment;\n2. Presentation of hemiparesis or paralysis of the upper extremity due to stroke;\n3. Ability to comprehend and follow study instructions;\n4. Ability to initiate finger extension (≥3°) at least three times per minute;\n5. Fugl-Meyer Assessment (Upper Extremity) score of \\\u003C47.\n\nExclusion Criteria:\n\n1. Contraindications, intolerance, or high sensitivity to the experimental protocol;\n2. History of upper-extremity disability prior to the index stroke;\n3. Neurological conditions (other than stroke) affecting motor function;\n4. Treatment of spasticity\u002Fincreased tone in the affected upper extremity (e.g., with Botox injection);\n5. Lack of access to a safe and suitable place of discharge for experimental sessions and follow-up visits.","79 Years",{"count":651,"type":21},20,[144],"Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement. This pilot study investigates whether APS applied during the acute phase of stroke recovery may reduce impairment and improve function in the affected upper extremity.",[64,354,28,655,571,572,656,604,657],"Stroke, Hemorrhagic","Weakness of Extremities as Sequela of Stroke","Upper Extremity Paresis",[174,659],"Associative Peripheral Stimulation","2024-08-28",{"date":662,"type":42},"2024-08-30",{"date":664,"type":42},"2021-12-18",{"date":666,"type":21},"2024-12",{"name":668,"class":49},"Ahmed A. Rahim",{"id":670,"slug":671,"hasResults":11,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":675,"eligibilityCriteria":676,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":168,"enrollmentInfo":677,"targetDuration":4,"studyType":22,"phases":678,"briefSummary":679,"conditions":680,"keywords":681,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":684,"lastUpdatePostDateStruct":685,"startDateStruct":687,"completionDateStruct":689,"leadSponsor":691,"locationsCount":50},"100507755","dti-guided-minimally-invasive-hematoma-evacuation-for-intracerebral-hemorrhage-100507755","NCT05891509","DTI-guided Minimally Invasive Hematoma Evacuation for Intracerebral Hemorrhage","Efficacy and Safety of DTI-guided Minimally Invasive Hematoma Evacuation Versus Best Medical Therapy for Acute Spontaneous Intracerebral Hemorrhage: a Randomized Controlled Trial","GLAMOR","Inclusion Criteria:\n\n1. Age 18-80 years old;\n2. Intracerebral hemorrhage in the basal ganglia was diagnosed by CT examination;\n3. The amount of bleeding is 20-40ml, and the midline structure is displaced horizontally by \\\u003C 3mm in the pineal gland;\n4. The degree of integrity and continuity of the corticospinal tract on the lesion side of magnetic resonance diffusion tensor imaging was graded as grade 2\\~4;\n5. The time from onset to randomization is within 24 hours;\n6. GCS score ≥ 4 points at randomization;\n7. Muscle strength level 3 in the affected limb;\n8. Written informed consent are provided by the patients or their legal representatives.\n\nExclusion Criteria:\n\n1. Bleeding in other parts (e.g., bleeding in subtentorial areas such as thalamus, brainstem or cerebellum);\n2. Bleeding caused by other causes (such as aneurysm, arteriovenous malformation, brain trauma, brain tumor, bleeding transformation of large cerebral infarction, bleeding caused by β amyloidosis, bleeding caused by coagulation dysfunction) or combined with aneurysm, arteriovenous malformation, brain trauma, brain tumor, large-scale cerebral infarction, β amyloidosis, severe coagulation dysfunction;\n3. Multiple intracranial hemorrhage;\n4. Patients with ventricular hemorrhage or ICH rupture into the ventricles should consider the need for ventricular drainage;\n5. Any history of brain parenchymal or other intracranial subarachnoid, subdural or epidural hemorrhage and surgical history in the past 30 days;\n6. Myocardial infarction within the past 30 days;\n7. Previous history of bleeding, such as gastrointestinal bleeding, genitourinary bleeding, respiratory bleeding that has not been completely controlled;\n8. Hemoglobin \\\u003C 100g\u002FL, hematocrit \\\u003C25%, platelet count \\\u003C 100\\*109\u002FL;\n9. Receiving anticoagulant drugs such as warfarin, dabigatran or rivaroxaban within 1 week prior to enrollment, with an INR \\> 1.4;\n10. Long-term anticoagulation and antiplatelet therapy are expected to be required;\n11. Allergy to alpeplase, urokinase or surgery-related drugs and instruments;\n12. Pregnant or lactating women;\n13. Known high risk of embolism, including patients with mechanical heart valves implanted in the body, history of left heart thrombosis, mitral stenosis with atrial fibrillation, acute pericarditis, or subacute bacterial endocarditis. Atrial fibrillation without mitral stenosis is appropriate;\n14. hypertension (systolic blood pressure is still greater than 180mmHg) that cannot be effectively controlled by aggressive antihypertensive therapy before randomization;\n15. Life expectancy \\\u003C 12 months in the advanced stage of any disease;\n16. Participating in other interventional clinical studies.",{"count":294,"type":21},[144],"Intracerebral hemorrhage (ICH) is a devastating disease with high early mortality, unfavorable neurological outcomes, and high cost of care. To date, the role of DTI-guided minimally invasive hematoma evacuation in ICH is still uncertain.\n\nThe investigators will conduct a multicenter randomized controlled trial, as well as a concurrent prospective observational study including all ICH patients who decline participation in the trial and will therefore receive minimally invasive hematoma evacuation or best medical therapy and consent to be followed up. All participants will be followed up at the same time using the same outcomes measures. The primary outcome will be collected by a blinded assessor.",[29],[682,468,548,683],"Minimally Invasive Hematoma Evacuation","Magnetic Resonance Imaging","2023-09-08",{"date":686,"type":42},"2023-09-13",{"date":688,"type":42},"2023-08-03",{"date":690,"type":21},"2027-08-31",{"name":692,"class":49},"Zhongming Qiu"]