[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-prevention":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100575082","urgent-carotid-endarterectomy-cea-versus-delayed-cea-in-symptomatic-carotid-stenosis-spread-staci-ii-100575082",false,"NCT06767657","Urgent Carotid Endarterectomy (CEA) Versus Delayed CEA in Symptomatic Carotid Stenosis (SPREAD-STACI II)","Multicenter, Open-label Randomized Study Comparing Urgent Carotid Endarterectomy (CEA) (Within 72 Hours) Versus Delayed CEA (After 72 Hours) in Patients With Symptomatic Carotid Stenosis (SPREAD-STACI II)","Time_to_sCEA","Eligibility Criteria\n\nInclusion Criteria:\n\nPatients presenting with the following characteristics:\n\nDe novo stenosis of the carotid bifurcation and\u002For internal carotid artery origin, equal to or greater than 50% (NASCET method), diagnosed by color Doppler ultrasound, MR angiography (MRA), CT angiography (CTA), or catheter angiography.\n\nTIA or minor ischemic stroke (NIHSS ≤ 5) ipsilateral to the carotid stenosis, occurring within the previous 24 hours.\n\nPreserved consciousness and neurologically stable symptoms. No evidence of ongoing cerebral ischemia, or evidence of cerebral ischemia with a diameter \\\u003C25 mm.\n\nAge between 45 and 90 years. ASA score \\\u003C 4. Ability to comply with follow-up requirements as specified. Willingness to provide informed consent for participation in the study.\n\nA patient with an NIHSS ≤ 5 who is aphasic may be unable to provide consent. In these cases:\n\nThe attending physician assesses the feasibility of including the patient. Family members are informed but, under Italian law, cannot provide consent. A third-party physician certifies that the patient meets the inclusion criteria.\n\nThe attending physician signs the appropriate form, and randomization proceeds. If and when the patient regains the ability to provide or refuse consent, the informed consent form will be presented to them. Should they decline, their data will be removed from the study database.\n\nAdditionally, the study includes patients who underwent thrombolysis and\u002For mechanical thrombectomy after the onset of the index symptom, followed by a brain CT\u002FMRI without secondary cerebral hemorrhage (PH1, PH2, or PHr).\n\nExclusion Criteria:\n\nStenosis \\\u003C 50% (NASCET method) at the bifurcation and\u002For internal carotid artery origin, diagnosed by ECD, CTA, or MRA.\n\nCarotid thrombosis or dissection. NIHSS \\> 5. Cerebral hemorrhage. Impaired consciousness or neurologically unstable condition. Cancer, any condition with a poor prognosis, major cardiopathy, or any severe neurological disorder.\n\nCT or MRI evidence of cerebral ischemia \\> 25 mm in diameter. CT or MRI evidence of cerebral lesions of uncertain origin. Recurrent TIA or stroke-in-evolution. Age \\\u003C 45 years or \\> 90 years. ASA risk score = 4. Lack of informed consent. Inability to undergo CEA within 72 hours of the initial ischemic symptom. Inability to participate in a 90-day follow-up after the initial ischemic symptom.\n\nPrevious CEA or stenting of the examined carotid artery.","ALL","45 Years","90 Years",{"count":21,"type":22},456,"ESTIMATED","INTERVENTIONAL",[25],"NA","In patients with internal carotid artery (ICA) stenosis of 50% or greater (measured according to the criteria of the North American Symptomatic Carotid Endarterectomy Trial (NASCET)) who have experienced a transient ischemic attack (TIA) or minor ipsilateral stroke, carotid endarterectomy (CEA) offers maximum benefit if performed within 15 days of the initial ischemic symptom. National and international guidelines recommend surgical treatment (CEA) within this timeframe; however, no studies have specifically evaluated the optimal timing for CEA after a TIA or minor stroke.\n\nIt is well established that the risk of a major stroke is highest in the first few days following a transient ischemic attack or minor stroke and then decreases over the subsequent days and weeks.\n\nThis raises the hypothesis that performing an urgent carotid endarterectomy (within 3 days) may provide greater benefit compared to a delayed procedure (between 4 and 15 days).",[28,29,30,31],"Stroke, Ischemic","Transient Ischemic Accident","Endarterectomy, Carotid","Stroke Prevention",[33,34,35,36],"stroke","endarterectomy","transient ischemic accident","stroke prevention","RECRUITING","2026-03-02",{"date":40,"type":41},"2026-03-04","ACTUAL",{"date":43,"type":41},"2025-07-03",{"date":45,"type":22},"2028-01-01",{"name":47,"class":48},"Italian Society of Vascular and Endovascular Surgery","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100602531","syntrillo-telehealth-stroke-risk-reduction-study-100602531","NCT07124728","Syntrillo Telehealth Stroke Risk Reduction Study","Impact of Syntrillo's Telehealth Service on Stroke Risk Factor Reduction in At-risk Patients","Inclusion Criteria:\n\n* Age greater than or equal to 30\n* Diagnosis of hypertension\n* One or more of the following:\n* Dtrial fibrillation\n* Diabetes\n* Chronic kidney disease (stage 2+)\n* Obesity (class 2+)\n* Obstructive sleep apnea\n* Coronary artery disease\n* Hyperlipidemia\n* Carotid stenosis (greater than or equal to 50%)\n* Congestive heart failure\n\nExclusion Criteria:\n\n* History of stroke or TIA\n* Inability to consent or understand study\n* Residence in long-term acute care facility\n* Inability to ambulate independently\n* Non-English speaking\n* No internet access\n* Not residing in Virginia\n* Pregnancy or suspected pregnancy","30 Years",{"count":59,"type":22},68,[25],"A prospective, single-arm, open-label study evaluating the impact of Syntrillo's telehealth program on stroke risk factors, particularly blood pressure, among 68 high-risk patients. The 6-month intervention includes personalized remote care with blood pressure monitoring, wearable tracking, and multidisciplinary telehealth visits.",[63,64,31,65],"Hypertension","Hypertension (HTN)","Cardiovascular Risk Factor",[36,67,68,69,70,71,72,73,74],"telehealth","telemedicine","blood pressure","remote patient monitoring","digital health","heart rate variability","inflammation","hypertension","NOT_YET_RECRUITING","2025-08-08",{"date":78,"type":41},"2025-08-15",{"date":80,"type":22},"2025-08",{"date":82,"type":22},"2026-05",{"name":84,"class":48},"Syntrillo, Inc",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":92,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":102,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100559429","wearable-cardiac-monitor-to-enhance-detection-of-arrhythmia-recurrence-after-catheter-ablation-of-atrial-fibrillation-100559429","NCT06564012","Wearable Cardiac Monitor to Enhance Detection of Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation","WEAR-AF","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Diagnosed with paroxysmal or persistent atrial fibrillation.\n* Scheduled to undergo catheter ablation for atrial fibrillation.\n* Able to provide informed consent.\n* Willing to wear the Skiin garments (chest band or bralette) for the duration of the study (approximately 1 month pre and 6 months post-ablation).\n* Have a smartphone with an Operating System compatible with the Skiin Connected Life App (Android 9+ or iOS 13+)\n\nExclusion Criteria:\n\n* Adverse reaction to Skiin garments (e.g. skin allergy)\n\nThe relevant Skiin Underwear contraindications acting as exclusion criteria for this study are:\n\n* Pacemaker and\u002For (ICD) implantable cardioverter defibrillator users.\n* Pregnancy","18 Years",{"count":94,"type":22},100,"OBSERVATIONAL","The WEAR-AF study is a prospective, multicenter clinical trial designed to evaluate the efficacy of wearable technology in the detection, monitoring, and management of atrial fibrillation (AF). This study aims to assess how wearable devices, such as smartwatches equipped with electrocardiogram (ECG) capabilities, can be used to identify AF episodes, guide treatment decisions, and ultimately improve patient outcomes.\n\nParticipants will be individuals diagnosed with or at high risk for atrial fibrillation. The study will track the accuracy of AF detection, patient adherence to monitoring, and the impact on clinical outcomes, including stroke prevention, symptom management, and quality of life.\n\nThe findings from WEAR-AF are expected to contribute to the growing body of evidence supporting the integration of wearable technology into routine clinical practice for AF management, offering insights into its potential to enhance patient care and reduce healthcare costs.",[98,99,100,101,31],"Atrial Fibrillation","Arrhythmias, Cardiac","Heart Diseases","Cardiovascular Diseases",[71,103,104,105,106],"wearable technology","electrocardiography","remote monitoring","patient adherence","2025-05-20",{"date":109,"type":41},"2025-05-25",{"date":111,"type":22},"2025-07-01",{"date":113,"type":22},"2026-12",{"name":115,"class":48},"Sunnybrook Health Sciences Centre"]