[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-rehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-rehabilitation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,52,80,105,136,165,194,224,253,277,299,326,362,388,419,446,465,487,507],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641665","efficacy-of-tele-cpass-compared-to-in-person-cpass-therapy-for-upper-extremity-motor-recovery-100641665",false,"NCT07661849","Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery","Efficacy of Tele-CPASS, a Telerehabilitation Intervention Using Critical Periods After Stroke Study (CPASS) Compared to In-person CPASS for Upper Extremity Motor Recovery","Inclusion Criteria:\n\n* Age 21 years or older\n* Neuroimaging-confirmed stroke within 40 days prior to enrollment\n* Persistent hemiparesis resulting in impaired upper extremity function, defined by a score of 0 to 3 on the NIH Stroke Scale motor arm item\n* Able to participate in all study-related activities, including 1-year follow-up\n* Short Blessed Memory Orientation and Concentration Scale score less than 8\n* Able to follow 2-step commands\n* Montreal Cognitive Assessment (MoCA) score greater than 25\n* No upper extremity injury or condition that limited upper extremity use prior to the stroke\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Persistent disabling neurologic condition, such as multiple sclerosis, Parkinsonism, amyotrophic lateral sclerosis, or dementia requiring medication\n* Clinically significant fluctuations in mental status within 72 hours prior to randomization\n* Active psychosis, psychosis within the prior 2 years, active substance abuse, or prior substance abuse\n* Dense sensory loss, defined by a score of 3 or 4 on the NIH Stroke Scale sensory item\n* Ataxia out of proportion to weakness in the affected arm, defined by a score greater than 1 on the NIH Stroke Scale ataxia item\n* Not expected to survive 12 months because of other illnesses\n* Pregnancy\n* Severe aphasia\n* Receipt of botulinum toxin or expectation of receiving botulinum toxin during the study period","ALL","21 Years",{"count":19,"type":20},42,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke. Stroke often leads to long-term difficulty using the affected arm in daily activities, and access to in-person therapy can be limited. This study aims to determine whether therapy delivered remotely can provide similar benefits to standard in-clinic care.\n\nParticipants who recently experienced a stroke will be randomly assigned to receive 20 hours of upper extremity rehabilitation therapy either in person or through a telehealth platform. Both groups will receive the same type and amount of therapy focused on practicing meaningful, patient-selected daily activities. Participants will complete assessments before treatment, immediately after treatment, and at 6 and 12 months to measure recovery of arm function, real-world arm use, and participation in daily life.\n\nThe results of this study will help determine whether telerehabilitation can improve access to effective stroke recovery interventions while maintaining clinical effectiveness comparable to in-person therapy.",[26,27,28,29],"Stroke","Hemiparesis","Upper Extremity Impairments","Stroke Rehabilitation",[31,32,33,34,35,36,37,38],"Telerehabilitation","Telehealth","Stroke rehabilitation","Upper extremity recovery","Motor recovery","Critical period plasticity","Wearable sensors","Accelerometry","RECRUITING","2026-06-16",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":43},"2025-09-01",{"date":47,"type":20},"2029-08-31",{"name":49,"class":50},"University of Texas, El Paso","OTHER",3,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100643603","comparison-between-ll-sesorimotor-training-and-wbb-therapy-on-ps-db-and-fof-in-post-stroke-patients-100643603","NCT07642154","Comparison Between LL Sesorimotor Training and WBB Therapy on PS, DB and FOF in Post Stroke Patients","Comparison Between Lower Limb Sensorimotor Training and Whole-Body Vibration Therapy on Postural Stability, Dynamic Balance and Fear of Fall in Post Stroke Patients.","Inclusion Criteria:\n\n* Both male and female ranging from 50-65 years.\n* Definitive diagnosis of stroke .\n* Having sensory issues due to stroke in lower extremities.\n* Those who did not have a problem with walking due to other diseases other than stroke.\n* Having score less than 45 on berg balance scale.\n* Having no wounds, infections, and skin diseases in the feet, not taking medications such as nitroglycerin, dopamine, and dobutamine.\n* Having no history of mental illness, no suffering from osteoporosis, and not having neurological diseases. (7)\n\nExclusion Criteria:\n\n* Vestibular problems.\n* Severe cognitive decline and aphasia\n* Systemic diseases.\n* Cerebellar-related diseases.\n* Having acute and critical conditions during the intervention. (14)","50 Years","65 Years",{"count":62,"type":20},52,[23],"Stroke is a neurological disorder causing 70-80 percent deaths in the low income and developing countries. Patients commonly present with common impairments associated with balance, proprioception, poor gait, speech impairment and posture which affect the activities of daily living along with increased risk and fear of fall. This negatively impacts patients' mobility, confidence and role in the society. Lower limb sensorimotor training targets the integration of sensory and motor systems enhancing tactile stimulation, balance and proprioception; whereas whole body vibration stimulates muscle spindles and mechanoreceptors via mechanical oscillations that may promote reflexive muscle contractions, improve muscle tone, and enhance postural responses. The aim of this study is to find the comparative effects of lower limb sensorimotor training and whole-body vibration therapy on balance, posture and fear of fall in post stroke patients.\n\nThis study will be a randomized clinical trial. Non probability convenience sampling will be used to recruit 42 patients of either gender, aged 50-65 years, and diagnosed with stroke. This study will be carried out in Saira Memorial Hospital, Lahore. The participants will be randomly allocated to Group A and Group B through computerized table generator method. Each group will be given conventional physical therapy treatment as a baseline which includes range of motion exercises, balance and gait training. Group A will receive lower limb sensorimotor training, whereas group B will receive whole body vibration therapy. Each group will perform their respective exercises 45 minutes, three times a week for 8 weeks. The participants will be evaluated at the start and end of the exercise program through Berg Balance scale for dynamic balance, falls efficacy scale for risk of fall and Nottingham sensory assessment scale for sensory assessment. Data will be analyzed by SPSS version 26.",[26,29],[26,67,68,69],"Sensorimotor training","Whole body vibration therapy","Berg balance scale","2026-06-08",{"date":72,"type":43},"2026-06-11",{"date":74,"type":43},"2026-04-07",{"date":76,"type":20},"2026-07-01",{"name":78,"class":50},"Riphah International University",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":79},"100636413","the-effect-of-motor-imagery-on-upper-extremity-function-in-stroke-rehabilitation-100636413","NCT07565363","The Effect of Motor Imagery on Upper Extremity Function in Stroke Rehabilitation","The Effect of Motor Imagery on Upper Extremity Function in Stroke Rehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Being aged 18 years or older\n* Having a diagnosis of ischemic or hemorrhagic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI)\n* Being in the late subacute phase (more than 3 months post-stroke) or chronic phase (more than 6 months post-stroke) following stroke onset\n* Presence of unilateral extremity hemiparesis\n* Upper extremity stage between II and V for both proximal and distal segments according to the Modified Brunnstrom Classification\n* A score of 21 or higher on the Mini-Mental State Examination (MMSE)\n\nExclusion Criteria:\n\n* Severe spasticity in the affected upper extremity, defined as a Modified Ashworth Scale score \\> 2\n* Presence of impaired consciousness, or severe hearing, visual impairment or global aphasia.\n* Musculoskeletal disorders affecting upper extremity motor function, such as fracture or arthritis in the affected upper limb","18 Years",{"count":89,"type":20},51,[23],"Stroke is one of the leading causes of mortality and disability worldwide. A proportion of individuals who experience a stroke fail to achieve the desired level of motor recovery in the affected upper extremity following rehabilitation, resulting in significant limitations in activities of daily living. After stroke, rehabilitation programs are essential to reduce disability and enhance functional outcomes.\n\nThis study aims to evaluate whether the addition of Motor Imagery (MI) to a standard rehabilitation program contributes to improvements in upper extremity motor function in individuals with stroke. MI is a mental practice technique in which individuals cognitively rehearse movements without physically performing them. Although the movement is not executed, the brain regions involved in the movement are activated.\n\nEligible participants will be randomly assigned to three groups. All groups will receive a standard physical therapy and rehabilitation program. The first group will receive only standard physical therapy and rehabilitation. The second group will receive, in addition to conventional therapy, 15 minutes of MI training three days per week, while the third group will receive 15 minutes of MI training five days per week. The total treatment duration for all groups is planned as 30 sessions.\n\nAssessments will be conducted at baseline, at the end of the treatment period, and again at the 12th week. This study is based on the hypothesis that adding MI practice to a conventional upper extremity rehabilitation program after stroke will contribute to improvements in activities of daily living and functional recovery, and that these effects may be associated with the frequency of the intervention.",[29],[94,95,26,96],"Motor Imagery (MI)","Upper Extremity","Rehabilitation","2026-06-03",{"date":70,"type":43},{"date":100,"type":43},"2026-05-01",{"date":102,"type":20},"2026-12-15",{"name":104,"class":50},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100640038","volunteer-facilitated-discharge-assistance-and-supports-at-home-dash-for-people-with-stroke-100640038","NCT07590076","Volunteer Facilitated Discharge Assistance and Supports at Home (DASH) for People With Stroke","Volunteer Facilitated Discharge Assistance and Supports at Home (DASH) for People With Stroke: An Effectiveness-implementation Hybrid Trial.","DASH","Inclusion Criteria:\n\n* Confirmed diagnosis of stroke\n* Either undergoing or recently completed in-patient rehabilitation within the last 3 weeks\n* Lived at home pre-stroke\n* Discharged directly home (to own residence or that of a family member)\n* Live in one of the program implementation areas (i.e., Toronto, Ottawa)\n\nExclusion Criteria:\n\n* Discharged to additional hospital inpatient care, nursing home, or other long-term care\n* Inability to communicate in English\n* Inability to provide informed consent due to cognitive deficits",{"count":114,"type":20},840,[23],"The goal of this clinical trial is to learn if a home visit by a trained volunteer can improve stroke recovery after a stroke survivor is discharged home from the hospital. The main questions it aims to answer are:\n\n1. After 3 months of being discharged from the hospital, does this additional volunteer support at home improve coping skills for stroke survivors?\n2. Does the effects of the volunteer support last over 3 to 6 months after being discharged home?\n\nResearchers will compare between a group who will receive the volunteer support and a group who will not to see if the additional support can improve stroke recovery.\n\nParticipants will:\n\n* Either receive volunteer support over an 8-week time period OR receive no additional volunteer support\n* Continue with their usual care plan and receive educational resources from the research team during the study\n* Complete online surveys during study enrollment, at 3 months, and at 6 months after hospital discharge",[26,29,118],"Transitional Care",[120,121,122,123,33,124],"Patient Oriented Research","Community-Based Services","Intersectoral Partnership","Volunteers","Transitional care","NOT_YET_RECRUITING","2026-05-15",{"date":128,"type":43},"2026-05-18",{"date":130,"type":20},"2026-06",{"date":132,"type":20},"2028-04",{"name":134,"class":50},"Bruyère Health Research Institute.",6,{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":79},"100414869","telerehabilitation-for-aphasia-terra-100414869","NCT04682223","Telerehabilitation for Aphasia (TERRA)","Center for the Study of Aphasia Recovery (C-STAR): Telerehabilitation for Aphasia (TERRA)","TERRA","Inclusion Criteria:\n\n1. Participants must have sustained a left hemisphere ischemic or hemorrhagic stroke at least 12 months prior to enrollment.\n2. Participants must primarily speak English for at least the past 20 years.\n3. Participants must be capable of giving informed consent or indicating another to provide informed consent.\n4. Participants must be between 21-80 years of age.\n5. Participants must be magnetic resonance imaging (MRI) compatible (e.g., no metal implants, not claustrophobic) on a 3-Tesla (3T) scanner.\n\nExclusion Criteria:\n\n1. Participants must not have previous neurological disease affecting the brain (e.g. history of traumatic brain injury).\n2. Participants must not have severely limited speech production (severe unintelligibility) and\u002For auditory comprehension that interferes with adequate participation in the therapy provided (i.e., WAB-R Spontaneous Speech rating scale score of 0-1 or WAB-R Comprehension score of 0-1).\n3. Participants must not have a history of stroke to the right hemisphere of the brain.\n4. Participants must not have a bilateral, cerebellar or brainstem stroke.\n5. Participants must not have anything that makes them be 3T MRI incompatible\n6. Insufficient intelligible speech to provide accurate responses with discourse\u002Fnaming.","80 Years",{"count":146,"type":20},100,[23],"Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) to the more traditional In-Clinic Therapy (I-CT).",[150,26,29],"Aphasia",[152,153,154,155],"aphasia","stroke","telerehabilitation","speech-language therapy","2026-04-01",{"date":158,"type":43},"2026-04-02",{"date":160,"type":43},"2021-05-05",{"date":162,"type":20},"2027-03",{"name":164,"class":50},"University of South Carolina",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":182,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":79},"100576378","stroke-cerebral-reorganization-pathways-spectre-100576378","NCT06784518","Stroke Cerebral Reorganization Pathways (SPECTRE)","Stroke Cerebral Reorganization Pathways Longitudinal Study After Stroke of the Clinical Motor Pattern and the Cerebral Reorganization According to the Different Damaged Motor Pathways (Main and Accessory) (SPECTRE)","SPECTRE","Inclusion Criteria:\n\n* Adult (age greater than or equal to 18 years) less than 75 years of age, both sexes;\n* single supratentorial ischemic stroke confirmed by brain imaging\n* Upper limb deficit defined by a SAFE score \\\u003C5 (SAFE Stinear protocol, prognosis of post-stroke upper limb recovery) on D3 of stroke. This corresponds to the sum of shoulder abduction and finger extension according to the MRC (Medical Research Council) scale for each of these movements out of 5.\n* Absence of comprehension disorders limiting participation;\n* Patient covered by french social security;\n* Free, informed and written consent signed by the patient or a member of the patient's family (in the case of a patient who is able to understand the information and give consent but has motor difficulties resulting in an invalid signature).\n\nNon-Inclusion Criteria:\n\n* Multiple ischemic strokes or history of clinically significant stroke ;\n* Posterior fossa stroke ;\n* Hemorrhagic stroke;\n* Patient who have undergone thrombolysis or mechanical thrombectomy;\n* Extensive Fazekas grade 3 vascular leukopathy;\n* Pre-existing neurodegenerative pathology;\n* Patient with severe dyspnea or swallowing disorders who cannot undergo brain MRI;\n* Adults under legal protection (safeguard of justice, curatorship, guardianship, family habilitation), persons deprived of liberty;\n* Women declaring that they are pregnant or breast-feeding;\n* Patient participating in another therapeutic or drug intervention study that may have an impact on the effect of cerebral neuroplasticity on the SPECTRE study;\n* Patients with contraindications to MRI pacemaker or implantable defibrillator, neurosurgical clips, cochlear implants, intra-orbital or encephalic metallic foreign bodies, stents placed less than 4 weeks ago and osteosynthesis devices placed less than 6 weeks ago, claustrophobia.\n\nExclusion Criteria:\n\n* If the prognostic group according to the PREP2 algorithm (good, limited and poor) has already been reached during motor evoked potential assessment the patient is excluded.\n* Recurrence of clinically significant stroke (with worsening NIHSS score \\> 4) during study.","75 Years",{"count":175,"type":20},30,[23],"SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases. This study allows close longitudinal follow-up of patients with severe clinical motor impairment using functional MRI to study cerebral neuroplasticity after ischemic stroke in the acute and sub-acute phase in patients with upper limb motor impairement, taking into account prognostic criteria used in current practice.",[179,180,26,181,29],"Brain Diseases","Ischemic Stroke","Brain Infarction",[153,96,183,184,185],"Upper Limb","Neuroplasticity","Connectivity","2026-03-27",{"date":158,"type":43},{"date":189,"type":20},"2026-09-01",{"date":191,"type":20},"2029-03",{"name":193,"class":50},"Rennes University Hospital",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":210,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":79},"100520692","biomarkers-of-reaction-to-hiit-exercise-100520692","NCT06059872","Biomarkers of Reaction To HIIT Exercise","What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke","BReaTHE","Inclusion Criteria:\n\n* chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident\n* lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m\u002Fs during a 10m walk\n* Veteran status\n\nExclusion Criteria:\n\n* MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia\n* any neurodegenerative condition other than stroke that may lead to lower extremity impairment\n* a visual or auditory impairment that may hinder study procedures\n* any medical condition that would preclude participation in a physical exercise intervention program","89 Years",{"count":204,"type":20},55,[23],"Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.",[26,29,208,209],"Lower Extremity Weakness, Spastic","Walking, Difficulty",[211,212,213,214],"Predictors of Stroke Rehabilitation","Biomarkers of Stroke Rehabilitation","Exercise Intervention","Neuroimaging","2026-03-23",{"date":186,"type":43},{"date":218,"type":43},"2024-01-01",{"date":220,"type":20},"2027-12-01",{"name":222,"class":223},"VA Office of Research and Development","FED",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":21,"phases":234,"briefSummary":235,"conditions":236,"keywords":238,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":79},"100592826","substrates-for-post-stroke-arm-rehabilitation-100592826","NCT06998485","Substrates for Post-Stroke Arm Rehabilitation","Defining the Neurological Substrates of Proximal Upper Extremity Motor Control and Recovery After Stroke","SPARk","Inclusion Criteria:\n\n* first time unilateral ischemic or hemorrhagic stroke occurring within the 3-6 months\n* upper extremity motor impairment as measured by the Upper Extremity Fugl-Meyer Assessment (UE-FMA) Score \\\u003C= 44\n* ability to participate in a 6-week intensive upper extremity intervention in English as determined by a licensed occupational therapist.\n\nExclusion Criteria:\n\n* bilateral stroke\n* unstable medical status affecting functional status\n* pre-stroke upper extremity injury or conditions that limited use\n* visual or auditory impairment limiting ability to participate in study procedures\n* significant aphasia (NIHSS sub-item 9 \\> 1) or cognitive (NIHSS 1a or 1b or\n\n  1c \\> 1) deficits\n* known or expected inability to maintain follow-up through the study intervention and post- assessment\n* contraindications to MRI\n* contraindications to TMS\n* known history of uncontrolled seizure disorder.",{"count":233,"type":20},50,[23],"Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used to improve arm motor function, it remains unknown how therapy actually changes brain pathways after stroke. This project seeks to generate fundamental knowledge about brain pathways that allow people to move their arm after stroke and how these pathways change with rehabilitation; we expect this knowledge to translate to new therapies to reduce stroke-related disability.\n\nWe plan to enroll N = 50 patients with moderate to severe difficulty moving their arm after ischemic or hemorrhage stroke during the subacute period (3 to 6 months post stroke) into either 30 hours over 6 weeks of Arm Basis Training (a protocolized form of occupational therapy targeting motor control) or usual care. We will perform kinematic motor assessments, neuroimaging, and neurophysiology before and after therapy in order to test the hypothesis that intensive, target training improves arm motor control and induces corresponding anatomical and physiological changes of associated brain pathways.",[29,26,237],"Neurorecovery",[239,240,241,242,243],"stroke rehabilitation","motor control","neurorecovery","upper limb kinematics","corticospinal tract","2026-03-08",{"date":246,"type":43},"2026-03-11",{"date":248,"type":43},"2025-10-07",{"date":250,"type":20},"2030-04-30",{"name":252,"class":50},"Massachusetts General Hospital",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":144,"enrollmentInfo":260,"targetDuration":4,"studyType":21,"phases":262,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":79},"100507236","early-upper-limb-rehabilitation-with-eeg-neurofeedback-after-stroke-100507236","NCT05884762","earlY Upper Limb Rehabilitation WIth EEG-Neurofeedback After Stroke","YUWIN-Stroke","Inclusion Criteria:\n\n* Unilateral ischaemic or haemorrhagic stroke\n* Adult (18-80 years), both sexes\n* Stroke \\\u003C 3 weeks\n* Upper limb deficit defined by Shoulder Abduction Finger Extension score \\\u003C5 measured during the 7 days following stroke; i.e., patients predicted to have incomplete recovery\n* No participation-limiting comprehension problems\n* With or without homonymous lateral hemianopia; with or without visuospatial hemineglect\n* Free, informed and written consent signed by the patient or a member of the patient's family (in the case of a patient who is able to understand the information and give consent but has motor difficulties resulting in an invalid signature).\n* Affiliated to french social security\n\nExclusion Criteria:\n\n* Ischemic or hemorrhagic brain stem and\u002For cerebellum involvement\n* Multiple strokes\n* Stroke \\\u003C 1 week; in order not to be deleterious by starting active rehabilitation too early after immediate stroke\n* Aphasia with major comprehension impairment\n* Contraindication to MRI\n\n  * pacemaker or implantable defibrillator,\n  * neurosurgical clips,\n  * cochlear implants,\n  * intra-orbital or encephalic metallic foreign bodies,\n  * stents placed less than 4 weeks ago and osteosynthesis devices placed less than 6 weeks ago,\n  * claustrophobia. (Patients who have undergone thrombolysis or thrombectomy may be included in the study.)",{"count":261,"type":20},40,[23],"The aim of this study is to evaluate the effect of early rehabilitation treatment by electroencephalographic neurofeedback on upper limb motor function after stroke.\n\nResearchers will compare :\n\nInterventional group: electroencephalographic neurofeedback + traditional reference rehabilitation programme Control group: SHAM electroencephalographic neurofeedback + traditional reference rehabilitation programme",[26,265,266,29,181],"Stroke Hemorrhagic","Stroke, Ischemic",[26,96,268,183],"neurofeedback","2026-02-26",{"date":271,"type":43},"2026-03-03",{"date":273,"type":43},"2024-02-20",{"date":275,"type":20},"2027-11",{"name":193,"class":50},{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":173,"enrollmentInfo":284,"targetDuration":4,"studyType":286,"phases":4,"briefSummary":287,"conditions":288,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":296,"locationsCount":79},"100610528","how-realistic-are-caregivers-expectations-in-patients-with-subacute-stroke-100610528","NCT07228754","How Realistic Are Caregivers' Expectations in Patients With Subacute Stroke?","How Realistic Are Caregivers' Expectations in Determining Rehabilitation Goals for Subacute Stroke Patients?","Inclusion Criteria:\n\n1. Followed by ischemic or hemorrhagic stroke\n2. No more than 6 months have passed since the date of the event\n3. Being between the ages of 18 and 75\n4. The caregiver being between the ages of 18 and 75\n\nExclusion Criteria:\n\n1. The patient has additional neurological conditions besides stroke\n2. The patient has a psychiatric condition\n3. The patient is not willing to participate in the study",{"count":285,"type":20},58,"OBSERVATIONAL","The aim of this study is to evaluate the extent to which the patient's goals and the physical therapist's goals can be achieved after stroke rehabilitation and to compare their expectations in terms of rehabilitation outcomes. Thus, the expected benefit of the study is to contribute to goal setting in post-stroke rehabilitation. There are no expected risks from the study.",[29,289],"Stroke Rehabilitation and Caregivers","2026-02-22",{"date":292,"type":43},"2026-02-24",{"date":294,"type":43},"2025-12-06",{"date":100,"type":20},{"name":297,"class":298},"Ankara Etlik City Hospital","OTHER_GOV",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":16,"minAge":306,"maxAge":144,"enrollmentInfo":307,"targetDuration":4,"studyType":21,"phases":309,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":325},"100515560","mirror-therapy-and-augmented-reality-in-stroke-rehabilitation-100515560","NCT05993091","Mirror Therapy and Augmented Reality in Stroke Rehabilitation","Outcomes of Mirror Therapy Preceding Augmented Reality in Stroke Rehabilitation","Inclusion Criteria:\n\n1. a first-ever unilateral stroke ≥3 months and ≤3 years\n2. age between 30 and 80 years (Kwakkel et al., 1999)\n3. baseline Fugl-Meyer Assessment Upper Extremity (FMA-UE) score \\>10 (Fugl-Meyer et al., 1975)\n4. no severe spasticity in any joints of the affected arm (modified Ashworth scale \\\u003C3) (Charalambous, 2014)\n5. ability to follow the instructions of the evaluator and therapists\n6. the ability to maintain a step-standing position for at least 30 seconds (Lloréns et al., 2015)\n7. ability to walk a minimum of 10 meters, with or without a device (Park et al., 2017)\n8. no severe vision impairments or other major neurologic diseases\n9. no participation in other studies during the study period\n10. willingness to provide informed written consent.\n\nExclusion Criteria:\n\n1. acute inflammation\n2. serious medical problems or poor physical conditions that might be detrimental to study participation.","30 Years",{"count":308,"type":20},75,[23],"This research is in line with the National Health Research Institutes (NHRI) Innovative Research Grant priority to address innovative treatment strategies for neurological disorders that are in desperate need of scientific scrutiny. Stroke is one of the major medical conditions that leads to long-term disability and causes a heavy health care and financial burden. To meet multidimensional needs of patients with stroke, hybrid interventions that combine different approaches are needed due to the complexity of stroke. Our previous research funded by the NHRI has been published and translated to stroke rehabilitation, particularly in the priming and synergic effects of robotic-assisted training and\u002For mirror therapy (MT). To extend from our previous research, the investigators will combine MT with augmented reality (AR), an emerging adjunct therapy in stroke rehabilitation. An AR-based intervention provides an intensive, repetitive, and context-rich training program, leading to an interesting environment with real-time feedback to increase motivation and participation.",[29],[153,313,314,315],"rehabilitation","mirror therapy","augemnted reality","2026-02-03",{"date":318,"type":43},"2026-02-05",{"date":320,"type":43},"2023-05-05",{"date":322,"type":20},"2026-12-31",{"name":324,"class":50},"National Taiwan University Hospital",5,{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":21,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":361},"100584143","personalised-health-motor-and-cognitive-assistance-system-for-rehabilitation-phrase-100584143","NCT06885502","Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE)","Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE): A Randomized Clinical Trial","PHRASE-2024","Inclusion Criteria:\n\n* Patients presenting an ischemic or intracerebral haemorrhagic stroke, ≥ 3 months post-stroke.\n* Age \\> 18 years old\n* Moderate to mild proximal upper limb motor impairment Medical Research Council Scale (MRC \\>2).\n* ARAT: \\\u003C50, inclusive, to avoid ceiling effects while allowing room for improvement.\n* Able to sit on a chair or a wheelchair to interact with the RGS system.\n* Minimal experience with smartphone technology based on the clinician's opinion\n* Willing to participate and agree to comply with the trial scheme and procedures\n* Must sign an Informed Consent Form (ICF) indicating that they understand the purpose and the procedures of the study.\n\nExclusion Criteria:\n\n* Presence of a condition or abnormality that, in the opinion of the investigator, would compromise the safety of the patient or the quality of the data.\n* Severe cognitive capabilities that prevent the execution of the study, evaluated by the MoCA \\\u003C 19 or based on the clinician's opinion.\n* Pre-stroke history of upper limb motor disability.\n* Unable to use the RGS independently, according to the clinician's observations, and needing more support from a caregiver to use the RGS.",{"count":335,"type":20},70,[23],"This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke. The study focuses on combined motor and cognitive training for patients in the late subacute and chronic phases post-stroke. The intervention is provided through the Rehabilitation Gaming System application RGSapp, a goal-oriented, first-person virtual reality (VR) and augmented reality (AR) mobile application for upper limb rehabilitation. A total of seventy participants will be randomly assigned (1:1 ratio) to either the RGSapp intervention or conventional therapy\u002Fstandard of care for six weeks. The primary outcome is motor function improvement (upper limb), assessed using the Action Research Arm Test (ARAT). Secondary outcomes include changes in cognitive function, depression, usability, adherence, validity of remote assessments, and healthcare costs.",[26,29,339,340],"Chronic Stroke Patients","Post Stroke Recovery",[26,342,343,33,344,345,346,347,348,349,350],"ARAT","Motor rehabilitation","Telemedicine","Virtual Reality (VR)","Augmented Reality (AR)","Cognitive rehabilitation","Rehabilitation at home","eHealth technology","upper limbs","2025-12-31",{"date":353,"type":43},"2026-01-06",{"date":355,"type":43},"2025-02-21",{"date":357,"type":20},"2026-06-30",{"name":359,"class":360},"Eodyne Systems SL","INDUSTRY",2,{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":368,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":144,"enrollmentInfo":370,"targetDuration":4,"studyType":21,"phases":371,"briefSummary":372,"conditions":373,"keywords":374,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":387},"100511881","effects-of-local-vibrations-program-of-dorsiflexor-muscles-on-neuromotor-recovery-in-subacute-stroke-patients-100511881","NCT05945212","Effects of Local Vibrations Program of Dorsiflexor Muscles on Neuromotor Recovery in Subacute Stroke Patients.","Effects of Local Vibrations Program of Dorsiflexor Muscles on Neuromotor Recovery in Subacute Stroke Patients - a Multicentric Randomized Controlled Study","NEUROVIB-AVC","Inclusion Criteria:\n\n* Stroke patients in subacute rehabilitation phase (between 14 days and 3 months post-stroke)\n* Presenting with a stroke, ischemic or hemorrhagic\n* Lower-limb deficiency with an initial motor testing \\\u003C 4 according to the MRC scale\n* No neurological history with functional impact other than stroke\n* Having received informed information about the study and having signed the written consent\n* Affiliated or entitled to a social security scheme.\n* Patients under guardianship may be included; they may give their consent with the assistance of their guardian.\n\nIf the participant is unable to write, their consent may be given and documented by other appropriate means in the presence of at least one impartial witness. In this case, the witness will sign and date the informed consent document.\n\nExclusion Criteria:\n\n* Multiple stroke\n* Other neurological, cognitive or psychiatric conditions\n* Orthopedic ankle history compromising measurements\n* Botulinum toxin injected in the lower limb prior the study protocol\n* Patient with phlebitis or risk of thrombosis in the lower limb\n* Patient under tutorship",{"count":335,"type":20},[23],"The aim of the vibration intervention proposed in the current study is to allow a better neuromotor recovery in subacute stroke patients when compared with standard rehabilitation alone. These last years, it has been proven that the solicitation of a muscle using vibrations may lead to positive effects on the neuromuscular function. Thus, the aim of the current study is to assess if the addition to a standard rehabilitation program of local vibrations sessions of the dorsiflexor muscles of the paretic limb of stroke patients may allow a better recovery of walking speed (primary outcome). One group using vibrations (i.e. experimental group) and one group with sham vibration (i.e. control group) will take part to this study.",[29],[375,26,35,376,377],"Local vibration","Walking speed","Gait","2025-11-26",{"date":380,"type":43},"2025-12-04",{"date":382,"type":43},"2024-03-12",{"date":384,"type":20},"2027-05-15",{"name":386,"class":50},"Centre Hospitalier Universitaire de Saint Etienne",7,{"id":389,"slug":390,"hasResults":11,"nctId":391,"briefTitle":392,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":395,"targetDuration":4,"studyType":21,"phases":396,"briefSummary":397,"conditions":398,"keywords":400,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":79},"100611648","evaluating-functional-outcomes-of-3d-printed-splints-in-post-stroke-upper-limb-recovery-100611648","NCT07243314","Evaluating Functional Outcomes of 3D-Printed Splints in Post-Stroke Upper Limb Recovery","3D-splint","Inclusion Criteria:\n\n1. Over 18 years old.\n2. Chronic stroke\n3. Upper limb hemiparalysis\n4. Ability to understand and follow orders and able to provide informed consent (Mini-Mental State Exam (MMSE) \\> 24)\n5. Upper-limb mild to moderate spasticity (Modified Ashworth Scale 1+ to 3 at the wrist).\n6. Not participating in other clinical or research studies at the same time\n\nExclusion Criteria:\n\n1. Had deficits in language or cognitive impairments that were likely to interfere with their cooperation in the study\n2. Deformity or presented with severe upper-limb contractures\n3. Inability to commit to the time requirement of the protocol.\n4. Unilateral neglect",{"count":146,"type":20},[23],"This study aims to evaluate the upper limb motor recovery using a 3D-printed dynamic orthosis compared to a conventional one as part of a rehabilitation program in individuals with chronic stroke.\n\nThe main question it seeks to answer:\n\nWhich type of dynamic splint (3D-printed or traditional), combined with the task-oriented therapy program, leads to greater improvement in affected upper-limb function, patient satisfaction, and usability in stroke patients? Researchers will compare these two types of dynamic splints.\n\nParticipants will:\n\nReceive 20 sessions of task-oriented therapy combined with either a 3D-printed dynamic splint or a traditional dynamic splint.\n\nVisit the clinic five times a week for a period of four weeks. Undergo assessments before and after the 4-week program.",[26,29,399],"Hemiparesis of the Upper Limb Following Stroke",[153,180,401,27,402,403,404,405,406,407,408,409],"Hemorrhagic Stroke","Splint","Dynamic Splint","Three-Dimensional Printing","3D-Printed Splint","Orthosis","Task-Oriented","Traditional Dynamic Splint","Motor Function","2025-11-17",{"date":412,"type":43},"2025-11-21",{"date":414,"type":20},"2025-11",{"date":416,"type":20},"2027-09-30",{"name":418,"class":50},"King Saud University",{"id":420,"slug":421,"hasResults":11,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":173,"enrollmentInfo":426,"targetDuration":4,"studyType":21,"phases":427,"briefSummary":429,"conditions":430,"keywords":433,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":51},"100598576","phase-2-efficacy-of-cerebello-spinal-direct-current-stimulation-csdcs-on-functional-mobility-in-chronic-stroke-patients-100598576","NCT07073287","Efficacy of Cerebello-spinal Direct Current Stimulation (csDCS) on Functional Mobility in Chronic Stroke Patients","Efficacy of Cerebello-spinal Direct Current Stimulation on Functional Mobility in Chronic Stroke Patients","Inclusion Criteria:\n\n* Confirmation of Stroke by digital or physical imaging or medical report\n* Gait impairment\n* Stroke with at least 6 months after ictus\n\nExclusion Criteria:\n\n* Metallic implants in spinal cord\n* Major orthopedic\u002Frheumatological disorders\n* Inability of verbal or non-verbal communication",{"count":175,"type":20},[428],"PHASE2","The aim of this clinical trial is to determine if cerebello-spinal direct current stimulation (csDCS) is effective in treating gait disorders in individuals with chronic stroke. Additionally, the trial seeks to evaluate the safety of this technique.\n\nThe primary objectives include:\n\nInvestigating whether cerebello-spinal direct current stimulation improves gait and functional mobility in participants with chronic stroke.\n\nAssessing any potential side effects associated with the method.\n\nResearchers will conduct a comparative analysis between cerebello-spinal direct current stimulation and a sham procedure (which mimics the stimulation without any actual effect) to assess its effectiveness in addressing gait disorders and enhancing mobility.\n\nParticipants in the trial will:\n\nUndergo cerebello-spinal direct current stimulation combined with treadmill training or a sham procedure with treadmill training daily over a two-week period.",[29,431,432],"Gait Disorders, Neurologic","tDCS",[434,153,435,313,436],"spinal cord","gait","direct current stimulation","2025-07-09",{"date":439,"type":43},"2025-07-18",{"date":441,"type":43},"2024-05-01",{"date":443,"type":20},"2026-08-01",{"name":445,"class":50},"Universidade Federal de Pernambuco",{"id":447,"slug":448,"hasResults":11,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":16,"minAge":453,"maxAge":144,"enrollmentInfo":454,"targetDuration":4,"studyType":21,"phases":455,"briefSummary":456,"conditions":457,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":464,"locationsCount":325},"100475199","mirror-therapy-preceding-augmented-reality-in-stroke-rehabilitation-100475199","NCT05467813","Mirror Therapy Preceding Augmented Reality in Stroke Rehabilitation","Mirror Therapy Preceding Augmented Reality in Stroke Rehabilitation: A Cross-Setting Study","Inclusion Criteria:\n\n1. a first-ever unilateral stroke ≥3 months\n2. age between 20 and 80 years\n3. baseline FMA-UE \\>10\n4. no severe spasticity in any joints of the affected arm MAS \\\u003C 3)\n5. ability to follow the instructions of the evaluator and therapists (Mini-Mental State Examination Score ≥22)\n6. ability to stand in a step-standing position for at least 30 seconds\n7. ability to walk a minimum of 10 meters with or without a device\n8. no severe vision impairments and other major neurologic diseases\n9. ability to take part in a rehabilitation intervention program for 9 weeks\n10. not participating in other studies over the study period and willingness to provide informed written consent.\n\nExclusion Criteria:\n\n1. acute inflammation\n2. serious medical problems or poor physical conditions that might be detrimental to study participation","20 Years",{"count":233,"type":20},[23],"This proposed research is in line with the National Health Research Institutes (NHRI) Innovative Research Grant priority to address innovative treatment strategies for neurological disorders that are in desperate need of scientific scrutiny. Stroke is one of the major medical conditions that leads to long-term disability and causes a heavy health care and financial burden. To meet multiple needs of patients with stroke, hybrid interventions that combine different approaches and practices in different settings are needed based on the complexity of stroke. Our previous research funded by the NHRI has been published and translated to stroke rehabilitation. Extending our previous research, the investigators will study the benefits of novel rehabilitation regimens of mirror therapy preceding augmented reality as well as the effects of practice setting (i.e., clinic- vs. home-based settings). In line with the current trend for the development of mirror therapy, mirror therapy will be implemented based on the bilateral and unilateral approach. Augmented reality will be implemented as a means of exergaming with real-time feedback to motivate the patients with stroke for active participation. In addition, telehealth techniques will be used to monitor home practice. This research is innovative in the use of telehealth techniques that will meet the call for therapy outside of the clinical settings in the era of COVID-19 pandemic.",[29],"2025-06-15",{"date":460,"type":43},"2025-06-18",{"date":462,"type":43},"2022-07-23",{"date":351,"type":20},{"name":324,"class":50},{"id":466,"slug":467,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":11,"sex":16,"minAge":472,"maxAge":144,"enrollmentInfo":473,"targetDuration":4,"studyType":21,"phases":475,"briefSummary":476,"conditions":477,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":79},"100585108","dual-task-training-during-curved-walking-in-stroke-patients-100585108","NCT06898073","Dual-task Training During Curved Walking in Stroke Patients","Effects of Dual-task Training During Curved Walking for Cognitive Function in Stroke Patients","Inclusion Criteria:\n\n1. First-time unilateral stroke\n2. Age between 40 and 80 years\n3. Able to walk 10 meters continuously with or without the use of assistive devices\n4. Capable of following instructions and performing simple arithmetic\n5. Brunnstrom stage 3 or higher\n\nExclusion Criteria:\n\n1. Other neurological disease or unstable medical conditions\n2. Visual field defect\n3. Mini-Mental State Examination (MMSE) \\\u003C24 points\n4. Pusher syndrome\n5. Half-sided neglect\n6. Expressive aphasia\n7. Poorly controlled hypertension or cardiovascular disease","40 Years",{"count":474,"type":20},60,[23],"The purpose of this study is to explore the effects of curved walking training under dual-task conditions on the cognitive function and walking ability of stroke patients.",[29],"2025-06-05",{"date":480,"type":43},"2025-06-10",{"date":482,"type":43},"2025-03-12",{"date":484,"type":20},"2026-07-31",{"name":486,"class":50},"Fooyin University",{"id":488,"slug":489,"hasResults":11,"nctId":490,"briefTitle":491,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":11,"sex":16,"minAge":453,"maxAge":144,"enrollmentInfo":493,"targetDuration":4,"studyType":21,"phases":495,"briefSummary":496,"conditions":497,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":504,"locationsCount":506},"100477070","proximal--versus-distal-prioritized-robotic-practice-plus-kinetic-exergaming-in-stroke-rehabilitation-100477070","NCT05492175","Proximal- Versus Distal-Prioritized Robotic Practice Plus Kinetic Exergaming in Stroke Rehabilitation","Inclusion Criteria:\n\n1. a first ever-stroke≧3 months\n2. age range between 20 to 80 years\n3. baseline Fugl-Meyer assessment of upper extremity scale (FMA-UE) between 18 to 56\n4. no excessive muscle spasticity of the affected extremities (Modified Ashworth Scale \\\u003C 3 at any joints)\n5. able to follow examiners' commands and study instructions (Mini-Mental State Examination score≧22)\n6. can maintain a step-standing position for at least 30 seconds\n7. can walk for at least 10 meters with or without device\n8. no participation in further experimental rehabilitation or drug studies during the duration of the project\n\nExclusion Criteria:\n\n1. acute inflammation and pain\n2. concomitant neurologic, neuromuscular or orthopedic conditions that may impede participation in this research.",{"count":494,"type":20},72,[23],"This research program aims at investigating the effects of upper-limb robotic therapy primed with interactive exergaming as an innovative hybrid regimen in stroke rehabilitation.",[29],"2025-02-18",{"date":500,"type":43},"2025-02-19",{"date":502,"type":43},"2022-02-17",{"date":322,"type":20},{"name":505,"class":50},"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation",4,{"id":508,"slug":509,"hasResults":11,"nctId":510,"briefTitle":511,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":513,"enrollmentInfo":514,"targetDuration":4,"studyType":21,"phases":515,"briefSummary":516,"conditions":517,"keywords":519,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":51},"100540936","music-therapy-for-rehabilitation-in-post-stroke-non-fluent-aphasia-the-indian-adaptation-100540936","NCT06323330","Music Therapy for Rehabilitation in Post-stroke Non-fluent Aphasia: the Indian Adaptation","Inclusion Criteria:\n\nAll of the following\n\n1. Age ≥18 years of age\n2. Stroke with non-fluent aphasia, within one year of ictus\n3. Imaging evidence suggestive of ischemic or hemorrhagic stroke of dominant hemisphere\n4. Patient is alert and able to follow simple commands (should not have global aphasia)\n5. Motivated caregiver\n6. Informed and signed consent\n\nExclusion Criteria:\n\nAny of the following:\n\n1. Patients with a history of a previous stroke other than the index event, which can explain the aphasia.\n2. Any clinical condition (e.g., short life expectancy, coexisting disease) or other characteristics that preclude appropriate follow-up in the study (e.g., distant residence, no family support)\n3. Patients participating in any therapeutic intervention clinical trials evaluating poststroke recovery\n4. Use of psychotropic drugs that interfere with patient evaluation","99 Years",{"count":474,"type":20},[23],"The goal of this Interventional Study is to develop and test the Indian Adaptation of Melodic Intonation Therapy (MIT) for Indian patients in with post-stroke Non-Fluent Aphasia (PSNFA). The main question\\[s\\] it aims to answer are: • To develop the MIT Indian Adaptation tool and check its feasibility • To compare the MIT with standard speech rehabilitation in patient with PSNFA. Participants will undergo Speech Rehabilitation according to the developed module and the standard treatment will be given in the comparator arm. The speech recovery at 12 weeks will be compared in both treatment arms.",[29,518],"Aphasia, Broca",[520,521,522],"Post stroke non-fluent aphasia","Melodic Intonation Therapy","Indian Adaptation","2024-11-28",{"date":525,"type":43},"2024-12-03",{"date":527,"type":43},"2024-06-01",{"date":529,"type":20},"2026-11-30",{"name":531,"class":50},"All India Institute of Medical Sciences"]