[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stroke-with-hemiparesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stroke-with-hemiparesis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,80,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100604228","home-based-graded-repetitive-arm-supplementary-program-for-quality-of-life-and-functional-upper-limb-recovery-100604228",false,"NCT07146789","Home-based Graded Repetitive Arm Supplementary Program for Quality of Life and Functional Upper Limb Recovery","Effectiveness of the Home-Based Graded Repetitive Arm Supplementary Program Combined With Occupational Therapy Versus Conventional Occupational Therapy Alone on Quality of Life and Upper Limb Function After Stroke: A Randomized Controlled Trial","REC-HOMEGRASP","Inclusion Criteria:\n\n* Be of legal age.\n* Have suffered only one stroke and be clinically stable.\n* At least 3 months must have passed since the stroke and less than 12 months.\n* Signing of informed consent\n* Be able to communicate any adverse effects (e.g. shoulder pain)\n* Be able to follow instructions and perform the exercises independently for one hour. If they are not able to do so, have the help of a caregiver to ensure that the exercises are performed.\n* Perform at least 10º of active wrist or finger extension.\n* Ability to raise the scapula of the affected upper limb against gravity.\n\nExclusion Criteria:\n\n* Having neurological conditions other than stroke.\n* Experiencing excessive pain in the affected upper limb that prevents the patient from correctly performing the exercises proposed in the programme. Visual Analogue Scale (VAS \\> 7).\n* Having a visual perception deficit that prevents the patient from correctly performing the exercises proposed in the programme.\n* Excessive muscle tone (spasticity or hypertonia) that prevents the person from correctly performing the exercises proposed in the programme. Asworth \\> 2.\n* A Folstein Mini-Mental State Examination (MMSE) score of ≥22 is required.","ALL","18 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","In post-stroke rehabilitation of the affected upper limb, increasing treatment intensity has been shown to lead to better outcomes compared to conventional approaches with fewer hours of therapy per day and week. However, logistical, human, and material constraints in neurorehabilitation centres often limit the feasibility of increasing treatment intensity.\n\nThe GRASP programme (Graded Repetitive Arm Supplementary Program) is a home-based exercise intervention grounded in motor learning principles and conducted weekly under the supervision of an occupational therapist. This strategy enables the intensity of upper limb rehabilitation to be increased by up to seven additional hours per week.\n\nThis project aims to evaluate the effectiveness of the Spanish version of the HomeGRASP programme, implemented as an adjunct to conventional occupational therapy, in improving quality of life, autonomy, and upper limb functionality in people after stroke. To this end, a single-blind, randomised controlled clinical trial will be conducted. Participants in the experimental group will receive conventional occupational therapy in addition to the HomeGRASP programme performed at home, while those in the control group will receive only conventional therapy. The treatment period for both groups will last eight weeks.\n\nParticipants will be assessed at baseline and after the 8-week intervention period by a blinded evaluator. The primary outcomes will include changes in quality of life and upper limb functionality, measured using the CAVIDACE scale and the Wolf Motor Function Test. Secondary outcomes will include upper limb dexterity and personal autonomy, assessed using the Box and Block Test, Purdue Pegboard Test, Motor Activity Log-30, Duruöz Hand Index, and the Functional Independence Measure (FIM).",[27],"Stroke With Hemiparesis",[29,30,31,32,33],"stroke","hemiparesis","upper limb","upper extremity","recovery","RECRUITING","2025-08-25",{"date":37,"type":38},"2025-08-28","ACTUAL",{"date":40,"type":38},"2025-04-01",{"date":42,"type":21},"2027-02-28",{"name":44,"class":45},"Universidad Miguel Hernandez de Elche","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100578061","study-of-hemodynamic-markers-of-upper-extremity-motor-dysfunction-in-stroke-patients-using-functional-near-infrared-spectroscopy-fnirs-100578061","NCT06806397","Study of Hemodynamic Markers of Upper Extremity Motor Dysfunction in Stroke Patients Using Functional Near Infrared Spectroscopy (fNIRS)","Studying the Mechanisms of Visual-motor Transformation to Find Neurophysiological Markers of Altered Functions of Cortical Motor Circuits in Patients with Neurological Disorders and Developing Technologies for Their Rehabilitation.","For Healthy Volunteers:\n\nInclusion Criteria:\n\n1\\. Availability of signed written informed consent. 3. Absence of somatic and psychiatric diseases (more details in the exclusion criteria) 4. Ability and willingness to comply with the requirements of this protocol.\n\nExclusion Criteria:\n\n1. The presence of superficial injury of head (S00-S09 International Classification of Diseases 10 (ICD-10).\n2. The presence of mental, behavioural disorders (F00-F99 ICD-10).\n3. Drug addiction in the past or at the moment.\n4. The presence of diseases of the nervous system (G00-G99 ICD-10).\n5. . History of intracranial injury (S06 ICD-10) or stroke (I64 ICD-10).\n6. The presence of somatoform disorders (F45 ICD-10).\n7. Any conditions that, in the opinion of the Investigator, meet the exclusion criteria\n8. Presence of electrical and\u002For metallic implants or stimulants in the body (eg, implanted deep brain stimulation devices, pacemakers, hearing aids and cochlear implants, intracranial metal implants).\n9. Pregnancy\n10. The presence of malignant neoplasms (C00-C97 ICD-10).\n\nFor stroke patients:\n\nInclusion Criteria:\n\n1. Signed written informed consent.\n2. People after the first acute cerebrovascular accident (CVA), early or late rehabilitation period.\n3. The level of severity of paresis of the upper limb from 3 points to 0 (according to a 6-point neurological scale)\n4. The minimum visual acuity is not lower than 0.2 on the Sivtsev scale.\n5. The ability and willingness of the patient to comply with the requirements of this protocol.\n6. Expressed patient motivation for rehabilitation.\n\nExclusion Criteria:\n\n1. Severe cognitive impairment (\\\u003C10 points according to the Montreal Cognitive Assessment Scale).\n2. Hamilton score above 18 points.\n3. The score on the Rankin scale is above 4 points.\n4. Associated neurological disorders that cause decreased muscle strength or increased muscle tone in the upper limbs (eg, cerebral palsy, brain damage from trauma) or stiffness (eg, Parkinson's disease, contracture).\n5. Late stages of arthritis or clinically significant limitation of passive range of motion in any of the joints studied in the study due to other reasons.\n6. The absence of a part of the upper limb due to amputation caused by various reasons.\n7. Any medical condition, including mental illness or epilepsy, that may affect the interpretation of study results, study conduct, or patient safety.\n8. Alcohol abuse, medical marijuana use, or recreational drug use in the 12 months prior to Visit 1.\n9. Use of experimental drugs or medical devices within 30 days prior to Visit 1.\n10. Lack of ability to follow study procedures, in the opinion of the investigator.\n11. The severity of the patient's condition according to the neurological or somatic status, which does not allow full rehabilitation.\n12. Severe visual disturbances, minimal visual acuity less than 0.2 Sivtsev visual acuity table.\n13. Unstable angina and\u002For heart attack within the previous month\n14. Repeated stroke.\n15. Severe unilateral spatial neglect.\n16. Uncontrolled arterial hypertension\n17. Ataxia\n18. All forms of epilepsy",true,"35 Years","70 Years",{"count":58,"type":21},40,"OBSERVATIONAL","The aim of the study was to explore potential pathways for recovery and adaptation of the motor cortex by examining cerebral blood flow characteristics and hemodynamic markers analyzed by functional near-infrared spectroscopy (fNIRS) in patients with hemiparesis after stroke. Participants in the study performed a simple stimulus-response task several times with one healthy and one paralyzed limb at different stages of basic rehabilitation. A group of healthy, age-matched volunteers participated in the same experiment to verify the stroke-related changes. The researchers recorded fNIRS signals, muscle activity using electromyography, and heart activity using electrocardiography.",[62,63,64],"Stroke","Stroke with Hemiparesis","Stroke, Ischemic",[29,30,66,67,68,69],"hemodynamics","fNIRS","restoration of motor function","Neurovascular coupling","2025-01-28",{"date":72,"type":38},"2025-02-04",{"date":74,"type":38},"2024-06-26",{"date":76,"type":21},"2025-04",{"name":78,"class":45},"Skolkovo Institute of Science and Technology",2,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100573955","research-on-the-effectiveness-of-neurorehabilitation-after-stroke-100573955","NCT06753006","Research on the Effectiveness of Neurorehabilitation After Stroke","A Study of Neurorehabilitation Based on Robotics, Brain-Computer Interface (BCI) and Virtual Reality (VR) in Patients with Upper Limb Paresis Due to Stroke in the Early Rehabilitation Period","Inclusion Criteria:\n\n* Signed written informed consent.\n* Age 18 to 80 years at the time of stroke onset.\n* Early rehabilitation period (up to 6 months post-stroke).\n* Diagnosis of acute cerebrovascular accident confirmed by MRI or CT.\n* Upper limb paresis severity between 0 and 3 on the 6-point Medical Research Council (MRC) muscle strength scale.\n* Ability and willingness to comply with the study protocol.\n* Demonstrated motivation for rehabilitation.\n\nExclusion Criteria:\n\n* Montreal Cognitive Assessment scale (MoCA) score less than 10 points.\n* Hamilton Depression Rating Scale (Ham-D) score greater than 18 points.\n* Modified Rankin Scale (mRS) score greater than 4 points.\n* Pre-existing conditions that cause decreased muscle strength or increased muscle tone in the upper limbs (e.g., cerebral palsy, traumatic brain injury) or rigidity (e.g., Parkinson's disease, contractures).\n* Advanced arthritis or significant limitation of upper limb range of motion.\n* Absence of part of the upper limb due to amputation for any reason.\n* Any medical condition that may affect the conduct of the study or patient safety (e.g., mental illness).\n* Alcohol abuse or recreational drug use within the 12 months preceding the study.\n* Use of experimental medications or medical devices within the 30 days preceding the study.\n* Inability to comply with research procedures, as determined by the researcher.\n* The severity of the patient's condition, based on neurological or physical status, does not permit full rehabilitation.\n* Visual acuity less than 0.2 in the weakest eye according to the Sivtsev visual acuity chart.\n* Unstable angina and\u002For heart attack within the 30 days preceding the study.\n* Recurrent stroke.\n* Uncontrolled arterial hypertension.\n* Ataxia.\n* Presence of a pacemaker and\u002For other implanted electronic devices.\n* Use of muscle relaxants.\n* Peripheral neuropathy.\n* Coexisting diseases in an exacerbation or decompensated stage requiring active treatment.\n* Allergic reactions or other skin lesions at the EEG electrode application sites at the time of the study.\n* Acute urinary tract infections.\n* Acute thrombophlebitis.\n* Any form of epilepsy.\n* Benign and malignant neoplasms.","80 Years",{"count":89,"type":21},44,[24],"This clinical trial aims to investigate the effectiveness of a novel neurorehabilitation technology for treating stroke in adults. The study will evaluate a simulator that combines robotic orthosis, a non-invasive brain-computer interface (BCI), and a virtual reality (VR) display. The goal of this trial is to advance stroke rehabilitation by exploring the potential benefits of these cutting-edge technologies.\n\nKey Research Questions:\n\nEfficacy: Does the new simulator significantly improve arm function compared to standard rehabilitation techniques?\n\nBCI Technology: Which approach - motor imagery of only the paretic arm or both the paretic and healthy arm - yields greater functional improvements?\n\nVR Contribution: How does the integration of VR enhance rehabilitation outcomes?\n\nSafety and Tolerability: What potential side effects or adverse events may arise from using the new simulator?\n\nParticipants who have suffered a stroke will undergo a standard rehabilitation course, during which 10-12 sessions will take place using the innovative simulator: a robotic device moves a patient's paralyzed arm at the command of a non-invasive brain-computer interface to perform a game task resembling real-life activities, augmented by a virtual reality display.\n\nResearchers will assess the impact of the new technology on arm function to determine its efficacy in promoting recovery.",[62,93,63,94,95,64],"Stroke Acute","Stroke, Acute","Stroke, Acute, Ischemic",[62,97,98,99,100,101,102],"Rehabilitation","Brain-Computer Interface","Motor Imagery","Robotics","Virtual Reality","Neurofeedback","2024-12-31",{"date":105,"type":38},"2025-01-01",{"date":107,"type":38},"2024-08-27",{"date":109,"type":21},"2025-07",{"name":111,"class":112},"Neurotechnika","INDUSTRY",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":140,"locationsCount":46},"100563145","phase-1-impact-of-the-boost-gait-program-on-gait-recovery-and-functional-mobility-after-stroke-100563145","NCT06612359","Impact of the BOOST GAIT Program on Gait Recovery and Functional Mobility After Stroke","Impact of the BOOST GAIT Program on Gait Recovery and Functional Mobility After Stroke - a Pilot Study Impact Van Het BOOST GAIT Programma Op Het Herstel Van Het Gangbeeld En Functionele Mobiliteit Na Een Beroerte - Een Pilootstudie","BOOST GAIT","Inclusion Criteria:\n\n* A first-ever unilateral stroke, infarction or bleeding\n* Undergoing inpatient rehabilitation in the Jessa hospital, Herk-de-Stad\n* Less than 3 months after stroke onset at the moment of inclusion\n* 18 years of older\n* Berg Balance Scale score 24 or higher (out of 56) at moment of inclusion\n* Timed Up-and-Go score 14 s or higher at moment of inclusion\n* Functional Ambulation Category 3 or higher at moment of inclusion\n* Understanding the goals and procedures of this study and giving informed consent\n\nExclusion Criteria:\n\n* Significant cognitive and\u002For speech impairments that markedly affect the comprehension and execution of instructions",{"count":122,"type":21},12,[124],"PHASE1","The overarching goal is to determine if the BOOST GAIT program can improve functional mobility in patients with stroke who are undergoing inpatient rehabilitation and have some walking function, through the application of augmented therapeutic exercises designed to achieve a normative gait pattern. The evaluation will be conducted using a combination of clinical scales and objective motion sensors that map walking quality and performance during activities of daily living, such as rising from a chair and standing.\n\nIt is acknowledged that this single-group pilot study, which aims to include 12 participants, is insufficiently powered to address the primary objective. A larger parallel-design study is required to definitively address this issue. To help design a larger study, the current objectives are: first, to have realistic expectations regarding recruitment and dropout rates; second, to identify potential barriers to therapy adherence and data collection that may impede the success of a larger study; third, assess the test-retest reliability of sensor-based motion capture of movement quality during walking and related tasks in hemiparetic stroke patients. For the latter objective, the sensor measurements at the end of the intervention will be repeated on two consecutive days.\n\nIn addition to their usual care, participants will undergo additional therapy over a four-week period, with sessions occurring five times per week for one hour as part of the BOOST GAIT program. The BOOST GAIT sessions will be conducted as group-based therapy with four patients and two physiotherapists present to oversee the performance of mobility-specific exercises, including sit-to-stand transfers, standing and stepping, and eventually walking. The rationale for this approach is that the combined effects of augmenting the amount of therapeutic exercises and specifically targeting motor control of the paretic leg will facilitate symmetry during tasks, which in turn will have carry-over effects on safe performance of walking and other mobility tasks.",[63,62],[128,129,130,131,62,132,133],"Recovery","Gait","Physical exercise","Pilot study","Hemiparesis","Walking","2024-09-21",{"date":136,"type":38},"2024-09-25",{"date":138,"type":38},"2024-09-02",{"date":103,"type":21},{"name":141,"class":45},"Hasselt University"]