[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"strokebrain-attack\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:strokebrain-attack":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100376976","imaging-post-stroke-recovery-using-meg-to-evaluate-cognition-100376976",false,"NCT04188522","Imaging Post-Stroke Recovery: Using MEG to Evaluate Cognition","Imaging the Network: Using MEG to Determine the Pathophysiology Underlying Post-Stroke Cognitive Impairment","Inclusion Criteria:\n\n1. Adults (≥18 years) admitted to Bayview Medical Center Neurology.\n2. Evidence of acute ischemic stroke (CT or MRI)- lacunar stroke or branch occlusion (M3\u002FA3\u002FP3 or smaller) OR NIHSS ≤ 8 on admission.\n3. Competent speaker of English (by self or family report) prior to stroke.\n4. Return for follow-up 4-6 weeks post event (+\u002F- 4 wks).\n5. Cognitive deficits present on initial testing.\\*\\* unique to MEG study\n6. Willing to travel to the University of Maryland twice for MEG.\\*\\* unique to MEG study\n7. Fully independent functionally and able to travel to the University of Maryland unassisted.\\*\\* unique to MEG study\n\nExclusion Criteria:\n\n1. Primary intracerebral hemorrhage- as evidenced by blood on head CT or MRI.\n2. Previous neurological disease (e.g., dementia, multiple sclerosis, prior symptomatic stroke). Incidental asymptomatic lacunar strokes found on imaging will not be excluded as prior disease.\n3. Uncorrected hearing or visual loss.\n4. Large vessel occlusion.\n5. Presence of any of the following that would lead to significant artifact on MEG: cardiac pacemaker, intracranial clips, metal implants, or external clips within 10mm of the head, metal in the eyes.\\*\\* unique to MEG study\n6. Claustrophobia, obesity, and\u002For any other reason leading to difficulty staying in the MEG for up to 1 hour.\\*\\* unique to MEG study\n7. For controls- clinical history of stroke or other neurological dysfunction (seizure, multiple sclerosis, etc.); psychiatric disease","ALL","18 Years","100 Years",{"count":20,"type":21},55,"ESTIMATED","OBSERVATIONAL","This is a study using magnetoencephalography (MEG) to look at recovery in those with minor stroke. The investigators know that these individuals report difficulties in attention, concentration, multi-tasking, energy level, and processing speed that appear to be independent of lesion size or location. The underlying pathophysiology is unclear; however, anecdotally, many individuals are significantly improved by 6 months post-stroke. One hypothesis is that a single lesion, regardless of size, may disrupt the classic neural networks required for cognitive function. The investigators are currently collecting data to better characterize these difficulties and stroke patients' recovery as part of a previously approved recovery study. In this sub-study, the investigators propose to add MEG at 1 and 6 months in a subset of individuals with small: 1) subcortical, and 2) cortical lesions. The investigators will partner with colleagues at the University of Maryland (College Park), who are well experienced with MEG to conduct this research. In addition a control population of age-similar individuals will be recruited for comparison. Cerebral activation patterns of individuals with stroke versus controls will be compared, both across patients with stroke at a given time point, and within subjects from 1 to 6 months to determine the association of abnormal activation with cognitive dysfunction and recovery.\n\n\\*\\*The investigators have recently extended follow-up by adding an additional assessment at 12 months and will enroll additional participants (up to 40 patients with minor stroke, 15 age-similar controls).",[25,26,27],"Stroke","Stroke Sequelae","Stroke\u002FBrain Attack","RECRUITING","2026-06-03",{"date":31,"type":32},"2026-06-05","ACTUAL",{"date":34,"type":32},"2018-07-01",{"date":36,"type":21},"2027-06-30",{"name":38,"class":39},"Johns Hopkins University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100559821","efficacy-of-a-telehealth-delivered-group-lifestyle-balance-for-people-post-stroke-tglb-cva-100559821","NCT06569121","Efficacy of a Telehealth Delivered Group Lifestyle Balance for People Post Stroke (tGLB-CVA)","Efficacy of an Evidence-based Telehealth-delivered Weight-loss Intervention to Enhance Access and Reach Underserved Groups After Stroke","tGLB-CVA","Inclusion Criteria:\n\n* Body Mass Index ≥25\n* All types of stroke\n* Able to Participate in Physical Activity\n* ≥12 months post first stroke\n* Have internet, phone, or computer access, or be willing to use one provided by the study team\n\nExclusion Criteria:\n\n* Contraindications for physical activity\n* Low Cognitive Function\n* Residing in hospital, acute rehab, skilled nursing facility\n* Not fluent in the English language\n* Pre-existing eating disorder\n* Pregnancy","85 Years",{"count":51,"type":21},94,"INTERVENTIONAL",[54],"NA","Investigators will conduct a randomized controlled trial (RCT) to assess intervention efficacy of telehealth delivery of the GLB-CVA (tGLB-CVA) compared to a 6-month wait-list control (WLC) in partnership with a diverse group of patient partners and peer mentors.",[57,25,58,59,27],"Stroke, Acute","Stroke, Cardiovascular","Stroke (CVA) or TIA","2026-01-19",{"date":62,"type":32},"2026-01-21",{"date":64,"type":32},"2024-12-07",{"date":66,"type":21},"2029-12-31",{"name":68,"class":39},"Baylor Research Institute",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":52,"phases":79,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":99,"locationsCount":40},"100601636","phase-1-accelerated-rtms-vs-sham-for-stroke-apathy-100601636","NCT07113067","Accelerated rTMS vs. Sham for Stroke Apathy","Accelerated rTMS for Post-stroke Apathy: A Double-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* 40 years old or greater\n* Right- or left-hemisphere ischemic or hemorrhagic stroke with at least 6 months chronicity\n* Symptomatic apathy as confirmed by (A) total score on the Apathy Evaluation Scale by the participant or the caregiver\u002Fco-participant (AES) of ≥39\n* Ability to participate in psychometric testing and cognitive tasks\n* Intact cortex at the TMS target site as confirmed by pre-treatment MRI\n* Ability to have a co-participant\u002Fcaregiver who meets the criteria as detailed below.\n\nExclusion Criteria:\n\n* Primary extra-axial hemorrhage (subdural or subarachnoid) without ischemic stroke or intraparenchymal hemorrhage\n* Concomitant neurological disorders affecting motor or cognitive function (e.g. dementia)\n* Moderate or severe global aphasia\n* Visual impairment precluding completion of cognitive tasks\n* Presence of contraindications to MRI or TMS including electrically, magnetically or mechanically activated metal or nonmetal implants such as cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system;\n* Pregnancy (to be later confirmed by UPT in any premenopausal female participants)\n* History of a seizure disorder\n* Preexisting scalp lesion, wound, bone defect, or hemicraniectomy\n* Claustrophobia precluding ability to undergo an MRI\n* Active substance use disorder\n* Psychotic disorders\n* Bipolar 1 Disorder\n* Acute suicidality as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)30 or suicide attempt in the previous year\n\nFor CO-PARTICIPANT\u002FCAREGIVER:\n\nInclusion Criteria:\n\n* Age 18 years or older\n* Is a reliable informant who has at least weekly contact with the participant and can speak to the participant's cognitive and everyday functioning.\n\nExclusion Criteria:\n\n\\- Unable to engage with study procedures in which Co-Participant input is needed.","40 Years",{"count":78,"type":21},40,[80,81],"PHASE1","PHASE2","Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them. Apathy has a large negative impact on a person's quality of life, and can also have a large impact the people who take care of them. There are currently no FDA-approved treatments to help with apathy, and other services like therapy may be difficult to access for people who have had a stroke. To address this problem, investigators are conducting a study to find out if a form of treatment called repetitive transcranial magnetic stimulation (rTMS) can be safe and helpful for people struggling with apathy after a stroke. This study will apply a new form of rTMS which can be delivered quickly to a part of the brain called the medial prefrontal cortex (mPFC). This study will help establish whether this treatment is safe, comfortable, and effective for people with apathy after a stroke, and will help researchers develop new forms of treatment.",[84,25,26,27,85,86,87],"Apathy","Stroke\u002F Cerebrovascular Accident (Ischemic or Hemorrhagic)","Motivation","Abulia",[89,25,90,84,91,86,87,92],"Depression","Stroke Recovery","TMS","Amotivation","2025-10-21",{"date":95,"type":32},"2025-10-22",{"date":97,"type":32},"2025-08-08",{"date":36,"type":21},{"name":100,"class":39},"Medical University of South Carolina"]