[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stunting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stunting":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,94,132,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100543973","evaluation-of-reacts-in-an-intervention-to-improve-nutrition-hygiene-and-sexual-and-reproductive-health-services-100543973",false,"NCT06362837","Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services","Realizing Gender Equality, Attitudinal Change & Transformative Systems in Nutrition (REACTS-IN)","REACTS-IN","Inclusion Criteria:\n\n(i)Women:\n\n* 15-49 y of age\n* biological mother of child in the home who is 0-5.9, 6-23.9, or 24-59.9 months\n* has lived in the community for at 12 months\n\n(ii) Husbands\u002Fpartners:\n\n* no age limit\n* lives in the home with index woman\n* has lived in community for at least 12 months\n\n(iii) Adolescents:\n\n* 10-19 years\n* male or female\n* has been in target school for at least 6 months\n* lives in the target community\n\n(iv) Children:\n\n* 0-5.9, 6-23.9, or 24-59.9 months\n\nExclusion Criteria:\n\n(i) Children:\n\n* no limitation on normal diet or growth (birth defects, illnesses)","ALL",{"count":19,"type":20},13500,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is an independent evaluation of World VIsion's 7-year quasi-experimental intervention to improve nutrition, nutrition-related rights and gender equality for women, adolescent girls, and children under five years of age in rural Bangladesh, Kenya, and Tanzania. The evaluation will collect baseline, midline, and end-line data from intervention communities, schools, and health facilities. Only baseline and endline will be collected on the comparison communities. The evaluation objectives are to test if the intervention improved indicators for (i) child anthropometry, (ii) maternal and child dietary practices, (iii) women's empowerment, and (iv) equitable health service access for nutrition and sexual and reproductive needs. The evaluation analysis will take into account gender differences in the indicators.",[26,27,28,29,30],"Stunting","Gender Equality","Acceptability of Health Care","Diet; Deficiency","Empowerment",[32,33,34,35,36,37,38,39],"nutrition","gender equity","health services","sexual and reproductive rights","dietary diversity","anthropometry","sexual and reproductive health services","WASH","RECRUITING","2026-04-27",{"date":43,"type":44},"2026-04-29","ACTUAL",{"date":46,"type":44},"2024-09-01",{"date":48,"type":20},"2029-12-31",{"name":50,"class":51},"McGill University","OTHER",3,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":75,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100517522","impact-of-diet-and-nutrition-on-growth-and-development-in-young-children-100517522","NCT06018636","Impact of Diet and Nutrition on Growth and Development in Young Children","Dietary Intake\u002FPatterns, Nutritional Status and Their Association With Growth and Development of Children From Remote, Agropastoral Communities of District Swat, Pakistan","DIGEST","Inclusion Criteria:\n\n* Households living in the area from the last two 2 years.\n* Households having infants or young children ≤ years.\n* Households planning to reside in the same area for the next 1 year.\n\nExclusion Criteria:\n\n* Children with any co-existent systemic diseases, confirmed from medical records.\n* Children on continuous medications for any medical issue.\n* Physically or mentally handicapped children",true,"1 Day","24 Months",{"count":65,"type":20},832,"OBSERVATIONAL","The association between nutrition in early life and its long-term health consequences has long been known. However, there is a scarcity of scientific evidence on how nutritional status affects child growth and development in remote, rural agro-pastoral communities with distinct dietary intake habits, geographical location, socio-economic status, and cultures.",[69,70,71,26,72,73,74],"Nutrition","Growth","Development","Wasting","Obesity","Child Development",[76,77,70,78,79,80,81,82,83],"Nutritional status","Malnutrition","Cognitive Development","Anthropometry","Agropastoral","remote","rural","Urban","2026-01-06",{"date":86,"type":44},"2026-01-08",{"date":88,"type":44},"2023-06-28",{"date":90,"type":20},"2028-09-30",{"name":92,"class":51},"Khyber Medical University Peshawar",1,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":102,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":93},"100608890","phase-2-maternal-probiotic-intervention-to-improve-gut-health-trial-ii-pakistan-100608890","NCT07207434","Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan","Ability of VE818 to Reduce Enteropathogen Colonization and Improve Environmental Enteropathy in Pregnant Women: a Proof of Concept and Phase II Randomized Placebo-controlled Trial in Bangladesh, Pakistan, Zambia and Burkina Faso","MPIGH-II","Inclusion criteria\n\n* Women aged 18 years or older in their first or early second trimester of pregnancy (13-17 weeks of gestational age \\[GA\\]), living in defined geographical areas of Bangladesh (Matlab), Pakistan, Zambia, and Burkina Faso, where it can be assumed that environmental enteropathy is prevalent\n* Presence of any 2 out of 11 selected bacterial pathogen targets (Aeromonas, Campylobacter coli, Campylobacter jejuni, Campylobacter Pan, Enteroaggregative Escherichia coli, Enteropathogenic Escherichia coli, Enterotoxigenic Escherichia coli, Plesiomonas, Shigella\\_EIEC, Salmonella and Klebsiella pneumoniae in fecal samples measured by TAC-qPCR.\n* Presence of any of the following WASH conditions -\n\n  1. use surface water, unimproved water, or limited water for drinking; OR\n  2. use surface water, unimproved water, or limited water for cooking; OR\n  3. use surface water, unimproved water, or limited water for washing utensils; OR\n  4. practice open defecation, use unimproved sanitation (toilet facility), or limited sanitation (toilet facility); OR\n  5. lack facility or have limited facility for handwashing\n\nExclusion criteria\n\nPotential participants will not be enrolled if they:\n\n* have MUAC ≥30 cm\n* are carrying more than one fetus (i.e., multiple pregnancy)\n* have diarrhea, defined as the passage of three or more loose stools per 24 hours, or have had diarrhea in the preceding 14 days\n* have fever or an active infection\n* have taken antibiotics or probiotics in the preceding 14 days\n* have taken steroids or non-steroidal anti-inflammatory drugs in the preceding 14 days\n* have severe anemia as determined using finger stick Hb \\\u003C 8 g\u002Fdl\n* have a history of chronic digestive disease\n* have any gastrointestinal contraindication to ingestion of a capsule (known or suspected gastrointestinal obstruction, stricture, fistula, gastroparesis, or any swallowing disorder)\n* have known immunocompromised status (known history of HIV infection, autoimmune disease, diabetes mellitus, etc.)\n* have known drug hypersensitivity\u002Fallergy\u002Fintolerance\n* have chronic disease or any other illness or condition which in the opinion of the investigator will complicate the assessment of safety or efficacy\n* are medically disqualified: Any potential participant who is deemed medically unfit for trial enrollment by a non-study healthcare provider, due to the presence of severe or unstable health conditions that could compromise safety or interfere with the study outcomes, will be excluded from participation\n* have a plan to observe fast any time during the intervention period\n* have a plan to leave the study area within the follow-up period\n* are participating in any other interventional trial\n* belong to a household from which another woman is already enrolled in the study\n* but may be enrolled if\u002Fwhen these disqualifiers have expired.","FEMALE","18 Years","49 Years",{"count":106,"type":20},144,[108],"PHASE2","Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterised by altered gut permeability, infiltration of immune cells, and changes in villous architecture and cell differentiation. EED is a major reason of malnourishment, poor neurological development, stunting, oral vaccine failure, and infection. It is believed that EED is responsible for 40% of all childhood stunting.\n\nRelevance: This trial aims to investigate the concept that a probiotic or live biotherapeutic product, capable of improving gut microbiota composition, can also displace enteropathogens and reduce biomarkers of intestinal inflammation, thereby promoting gut health. This will restore healthy microbial signalling to the host epithelium, ameliorate barrier function through secretion of mucus and antimicrobial factors, and improve nutrient availability.\n\nObjectives: The primary objective is to assess if administration of oral vancomycin followed by VE818 to pregnant women colonised with at least 2 out of 11 selected bacterial enteropathogens results in a significant change in the mean count of these organisms between the baseline and 2 weeks after completion of the intervention (Study Day 35d +2), compared to oral vancomycin followed by placebo.\n\nMethods: Pregnant women will be recruited from the community of Matiari in Pakistan. The study population will be women aged 18 years or older in the first trimester or early second trimester of pregnancy. Study procedures will be explained in detail, and written consent will be taken before enrollment. Those women who give consent to participation will undergo a screening process, which will check if any exclusion criteria are fulfilled. After consent and screening, they will be randomised into one of the three arms: intervention arm (oral vancomycin followed by VE818), placebo-control arm (oral vancomycin followed by placebo), or observation-only arm. The allocation sequence will be generated by the trial statistician using a code with block permutation. The participant will remain free to withdraw at any time from the trial without giving reasons and without prejudicing her further treatment. Biological samples, including blood, saliva, urine, stool, vaginal swab, and intestinal luminal contents through CapScan. CapScan is a non-invasive device (capsule) that collects gastrointestinal samples along the gastrointestinal tract following ingestion and passes into the stool.\n\nOutcome measures\u002Fvariables: The primary endpoint is the change in the mean count in the number of 11 selected fecal bacterial pathogen groups present between baseline and 2 weeks after completion of the 14-day course with Placebo or VE818 (Study arms 2 and 3), which corresponds to the 35th day, +2 from the first dose of oral vancomycin.\n\nThe 11 enteropathogen targets will be detected by customized real-time quantitative PCR-based TaqMan Array Cards (TAC-qPCR) and include the following organisms: Aeromonas, Campylobacter coli, Campylobacter jejuni, Campylobacter Pan, Enteroaggregative Escherichia coli (E. coli), Enteropathogenic E. coli, Enterotoxigenic E. coli, Plesiomonas, Shigella\\_Enteroinvasive E. coli (EIEC), Salmonella, and Klebsiella pneumoniae",[111,26],"Environmental Enteric Dysfunction (EED)",[113,114,115,116,117,118,119,120,121,122],"probiotic","microbiome","pregnant women","capscan device","urine LR","VE818","Pakistan","malnourished children","biomarkers","EED","2025-09-26",{"date":125,"type":44},"2025-10-06",{"date":127,"type":44},"2025-08-30",{"date":129,"type":20},"2026-12-31",{"name":131,"class":51},"Aga Khan University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":61,"sex":17,"minAge":62,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":93},"100518072","impact-evaluation-of-benazir-nashonuma-program-bnp-on-stunting-among-under-five-children-100518072","NCT06025786","Impact Evaluation of Benazir Nashonuma Program (BNP) on Stunting Among Under-five Children","Impact Assessment of Benazir Nashonuma Program (BNP) on Stunting Prevention Among Children 0-59 Months of Age in Pakistan","All those households are eligible to be included in the study who have:\n\n* An under-five child with a mother registered with Benazir Income Support Program (BISP)\n* Both available at the time of interview\n\nExclusion criteria includes:\n\n• Mother of the child who is not a woman of reproductive age, i.e., less than 15 years or greater than 49 years","59 Months",{"count":141,"type":20},13200,[23],"The aim of the study is to evaluate the impact of Benazir Nashonuma Program (BNP) on prevalence of stunting among under-five children in low income setting of Pakistan. The research question that the study aims to answer is:\n\nIs there any change in the prevalence of stunting among under-five children in districts where Benazir Nashonuma Program (BNP) is established compared to districts where BNP is not established?\n\nDistricts where BNP is functional, and women and children are receiving the intervention will be compared at baseline and end line with control districts where conventional reproductive care services are given. Prevalence of stunting among under-five children will be compared along with other nutritional and growth status indicators over a period of 4 years.",[26,72,145,146],"Anemia","Nutrient Deficiency",[148,149,26,72,150,151],"Quasi experimental study","Maternal and child nutrition","Under-five malnutrition","Specialized Nutritious Food (SNF)","2023-09-08",{"date":154,"type":44},"2023-09-11",{"date":156,"type":44},"2021-12-01",{"date":158,"type":20},"2026-06-30",{"name":131,"class":51},{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":61,"sex":102,"minAge":103,"maxAge":104,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":176,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":93},"100503569","impact-of-benazir-nashonuma-program-bnp-on-maternal-and-child-nutritional-status-100503569","NCT05836961","Impact of Benazir Nashonuma Program (BNP) on Maternal and Child Nutritional Status","Evaluating Effectiveness of Benazir Nashonuma Program (BNP) on Maternal and Infant Outcomes: A Non-randomized Intervention Study in Sindh and Punjab","Inclusion Criteria:\n\nIntervention arm: All pregnant women in their first or second trimester, who are enrolled in Benazir Nashonuma Program (BNP).\n\nNon-intervention arm: All pregnant women in their first or second trimester, who are not enrolled in Benazir Nashonuma Program (BNP).\n\nExclusion Criteria:\n\n* Women who intend to migrate or relocate for more than 3 months during the study period will be excluded from the study.\n* Women in the non intervention group who are consuming specialized nutritious food (SNF) from any source at the time of enrollment will be excluded from the study.",{"count":168,"type":20},5500,[23],"The purpose of this study is to evaluate the impact of Benazir Nashonuma Program (BNP) which includes specialized nutritious food (SNF) augmented with specific reproductive health interventions during pregnancy on proportion of low birthweight babies and stunting among children, in low income setting of Pakistan. The study aims to answer if:\n\n1. Utilization of Benazir Nashonuma Program (BNP) among pregnant women is effective in reducing the proportion of low birthweight babies, compared to pregnant women who are not utilizing the program, among low income setting population.\n2. Utilization of Benazir Nashonuma Program (BNP) is effective in reducing the proportion of stunting among children, compared to those not utilizing the program, among low income setting population.\n\nParticipants who are enrolled in the Benazir Nashonuma Program (receiving intervention) and those who are not enrolled (not receiving intervention) will be followed throughout pregnancy till delivery. After delivery mother-baby dyad will be followed for a period of 12 months. Compliance of supplementation will be measured, and outcomes (low birthweight and stunting) observed throughout the follow up.",[172,26,72,173,174,175],"Low Birthweight","Malnutrition, Child","Iron Deficiency Anemia","Dietary Habits",[177,149,178,179,26],"Intervention study","Benazir Nashonuma Program (BNP)","Low birthweight","2023-04-28",{"date":182,"type":44},"2023-05-01",{"date":184,"type":44},"2023-02-01",{"date":186,"type":20},"2026-09",{"name":131,"class":51}]