[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"stuttering-developmental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:stuttering-developmental":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,77,100,126,153,176],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100472843","investigating-speech-sequencing-in-neurotypical-speakers-and-persons-with-disordered-speech-100472843",false,"NCT05437159","Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech","Sequencing and Initiation in Speech Production: Investigating Speech Sequencing in Neurotypical Speakers, Persons Who Stutter, and Persons With Primary Progressive Aphasia","Inclusion Criteria\n\n* Healthy individuals with no history of neurological, speech, or hearing disorders (other than stuttering in studies that involve adults who stutter).\n* To maximize the uniformity of prior exposure to the speech stimuli that will be used, only native speakers of American English will be recruited, and only those with limited exposure to a second language will be enrolled.\n* All adult participants will also pass a standard pure-tone hearing screening at a 25dB hearing level threshold at 500, 1k, 2k, and 4kHz frequencies.\n* All participating children will pass a hearing screening at a 20 dB threshold at 500, 1k, 2k, and 4k Hz.\n* Participants in experiments that require them to read orthographic stimuli must have normal or corrected-to-normal vision (MRI-safe corrective glasses are available at the Boston University Cognitive Neuroimaging Center for use during neuroimaging).\n* Participating children will complete additional speech, language, hearing, and cognitive tests to ensure that they are within normal performance ranges for their age with the exception of stuttering for children in the children who stutter (CWS) group.\n* Persons who stutter will be evaluated formally by a speech-language pathologist to assess stuttering severity and to ensure the absence of other speech or language disorders. PWS will have no history of neurological disorder other than stuttering, and will demonstrate very mild to severe stuttering according to the Stuttering Severity Instrument for Children and Adults - 4th Edition (SSI-4: PRO-ED, Inc.), that is confirmed by clinical reports and expressed concern by the subject and\u002For guardian.\n* Participants with primary progressive aphasia (PPA) will have been diagnosed through the Massachusetts General Hospital Frontotemporal Disorders Unit (MGH-FTD) by an experienced neurologist in coordination with a speech-language pathologist.\n* Participants with PPA will have a score of 1.0 or lower on the Clinical Dementia Rating scale (i.e., mild cognitive impairment or mild dementia) to ensure cognitive levels are sufficient to complete the task.\n* All participants with PPA must have a recent clinical assessment and T1 structural neuroimaging scan through the MGH-FTD Unit for eligibility for this study.\n\nExclusion Criteria\n\n* Participants in studies that involve tDCS or MRI scanning will have no contraindications specific to those procedures. For the tDCS study, this includes individuals who have a metallic implant in the head or electrically sensitive devices implanted in the body, a history of seizures, significant scalp lesions, or pregnancy.\n* For MRI studies, this includes a history of seizures, severe claustrophobia, the presence of magnetically or mechanically active implant, ferromagnetic material embedded in any part of the body, or pregnancy).\n* All participants will perform a standardized nonword repetition pre-test (the Dollaghan and Campbell Nonword Repetition Task) to assess working memory performance. Participants who perform more than 2 standard deviations below the norm for their age range will be deemed to be unable to perform the experimental task and released from further participation.\n* Participating children will have no history of neurological disorder other than stuttering, and will demonstrate very mild to severe stuttering according to the Stuttering Severity Instrument for Children and Adults, 4th Edition, that is confirmed by clinical reports and expressed concern by the subject and\u002For guardian.\n* Children under the age of 6 and over the age of 8 will not enrolled in this study.\n* Participants with PPA will not be eligible for this study if they are taking any medications that would be expected to affect speech or language.",true,"ALL","6 Years",{"count":20,"type":21},2,"ESTIMATED","INTERVENTIONAL",[24],"NA","Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life. Despite its prevalence and negative impact, stuttering has resisted explanation and effective treatment, due in large part to a poor understanding of the neural processing impairments underlying the disorder. The overall goal of this study is to improve understanding of the brain mechanisms involved in speech motor planning and how these are disrupted in neurogenic speech disorders, like stuttering. The investigators will do this through an integrated combination of experiments that involve speech production, functional MRI, and non-invasive brain stimulation. The study is designed to test hypotheses regarding the brain processes involved in learning and initiating new speech sound sequences and how those processes compare in persons with persistent developmental stuttering and those with typical speech development. These processes will be studied in both adults and children. Additionally, these processes will be investigated in patients with neurodegenerative speech disorders (primary progressive aphasia) to further inform the investigators understanding of the neural mechanisms that support speech motor sequence learning. Together these experiments will result in an improved account of the brain mechanisms underlying speech production in fluent speakers and individuals who stutter, thereby paving the way for the development of new therapies and technologies for addressing this disorder.",[27,28],"Stuttering, Developmental","Aphasia, Primary Progressive",[27,30,31,32,33,34],"Magnetic Resonance Imaging","Transcranial Direct Current Stimulation","Speech Motor Learning","Speech Disorders","Neurocomputational Modeling","RECRUITING","2026-04-28",{"date":38,"type":39},"2026-05-04","ACTUAL",{"date":41,"type":39},"2023-04-03",{"date":43,"type":21},"2026-05",{"name":45,"class":46},"Boston University Charles River Campus","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100606828","organization-and-development-of-motor-cortical-circuits-for-speech-production-in-stuttering-100606828","NCT07180628","Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering","Inclusion Criteria:\n\n* Are between the ages of 18-65 years\n* Have otherwise normal speech, language, hearing and cognition\n* Speak English as their primary language\n* Currently stutter\n\nExclusion Criteria:\n\n* Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.)\n* Have had a closed head injury (e.g., concussion)\n* Have a reading disorder (e.g., dyslexia)\n* Have hearing loss\n* Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.)\n* Are currently pregnant","18 Years","65 Years",{"count":57,"type":21},50,[24],"The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.",[61,62,63,27],"Stutter","Stuttering, Adult","Stuttering",[65,66],"Magnetic Resonance Imaging (MRI) scans","Behavioral assessments","2026-04-27",{"date":69,"type":39},"2026-04-29",{"date":71,"type":39},"2026-04-24",{"date":73,"type":21},"2029-03",{"name":75,"class":46},"University of Michigan",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":16,"sex":17,"minAge":84,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":76},"100560535","the-development-of-stuttering-in-young-children-100560535","NCT06578416","The Development of Stuttering in Young Children","Developmental Trajectories to Stuttering Persistence and Recovery","Inclusion Criteria for controls:\n\n* English as first\u002Fprimary language\n* No history of neurological disease\n* Normal or corrected visual acuity\n* No medications expected to affect performance\n* No intellectual impairment, autism spectrum disorder, ADHD\n* Age-appropriate scores on speech and language assessment battery\n* Pass hearing screening at 20 dB at 500, 1000, 2000, and 4000, bilaterally\n\nInclusion Criteria for children who stutter:\n\n* English as first\u002Fprimary language\n* No history of neurological disease\n* Normal or corrected visual acuity\n* No medications expected to affect performance\n* No intellectual impairment or ASD Scores on speech and language assessments indicating stuttering, phonological (speech sound), or language disorders\n* Pass hearing screening at 20 dB at 500, 1000, 2000, and 4000, bilaterally","3 Years",{"count":86,"type":21},120,"OBSERVATIONAL","The goal of this longitudinal research is to learn why some children \"grow out\" of stuttering, while others persist. Children who do and do not stutter aged 3-6 years are eligible to participate in our study. During the study, children's speech and language abilities will be assessed with standardized assessments, and they complete several child-friendly experiments. During these experiments, brain activity will be recorded using specialized caps while children describe pictures, children will speak in two virtual-reality scenarios, and produce speech while keeping to a beat.",[63,90,27],"Stuttering, Childhood","2026-04-13",{"date":93,"type":39},"2026-04-16",{"date":95,"type":39},"2023-06-01",{"date":97,"type":21},"2027-06",{"name":99,"class":46},"Michigan State University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":76},"100628297","investigating-individual-differences-in-speech-motor-skills-in-neurotypical-speakers-and-persons-with-disordered-speech-100628297","NCT07459803","Investigating Individual Differences in Speech Motor Skills in Neurotypical Speakers and Persons With Disordered Speech","Brain Mechanisms Underlying Neurotypical and Disordered Speech","Inclusion Criteria:\n\n* Native speakers of American English\n* Adults age 18-50\n* Age-appropriate cognitive and receptive vocabulary skills\n* Age-appropriate hearing\n* Adults with dyslexia will have a history of dyslexia or report of ongoing reading difficulties that will be confirmed at the first screening visit\n* Adults who stutter will have a history of stuttering that will be confirmed at the first screening visit\n\nExclusion Criteria:\n\n* History of neurological disorder, including a history of seizures\n* Major brain injury, brain surgery, or stroke\n* Orthodontia or atypical oral structure (e.g., cleft palate) that interferes with speech\n* Fluency disorder (except those in the persons who stutter cohort), apraxia of speech, or dysarthria\n* Language or reading disorder (except those in persons with dyslexia cohort)\n* Standardized score below 80 on the Kaufman Brief Intelligence Test\n* Standardized score below 1 standard deviation on the NIH Toolbox Picture Vocabulary Test\n* Pregnancy\n* Severe claustrophobia\n* Presence of magnetically or mechanically active implant, or other ferromagnetic material embedded in any part of the body\n* Significant scalp lesions that would prevent transcranial direct stimulation","50 Years",{"count":109,"type":21},90,[24],"This study aims to understand how people use different types of feedback to control their speech. When an individual speaks, the brain relies on several systems at the same time, such as sensory systems that monitor an individuals own voice and the movements of their speech muscles, and a motor system that builds and reads out learned motor patterns. The investigators are studying how these systems work together and how they differ across individuals.\n\nInvestigators will test 90 adults between 18 and 50 years old, including people who stutter, people with dyslexia, and people with typical speech and reading development. Participants will complete several short speech tasks in which the sounds they hear or the movements of their jaw or larynx are briefly changed. These responses will be used to measure each person's speech motor skills and to estimate the settings of a computer model called \"SimpleDIVA,\" which simulates how the brain controls speech.\n\nParticipants will also complete an MRI scan so investigators can measure the structure and connectivity of different brain regions. These measures will help investigators understand how individual differences in the brain relate to the speech motor control skills we observe. Participants will also complete sessions with noninvasive brain stimulation (transcranial current stimulation, or tCS) to examine how stimulation of specific areas of the brain affects responses during the speech tasks.\n\nThe knowledge gained from this study will help researchers understand why speech motor skills vary across people and how differences in neural function may contribute to conditions such as stuttering and dyslexia.",[27,113,114],"Dyslexia","Healthy Participants",[116,30,32,33,34,113],"Stuttering Developmental","NOT_YET_RECRUITING","2026-03-10",{"date":120,"type":39},"2026-03-12",{"date":122,"type":21},"2026-04",{"date":124,"type":21},"2030-03",{"name":45,"class":46},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":138,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":76},"100573030","transcranial-alternating-current-stimulation-tacs-in-stuttering-100573030","NCT06740968","Transcranial Alternating Current Stimulation (tACS) in Stuttering","Improving Neural Oscillation and Synchrony Between Motor and Auditory Regions in Stuttering Using Personalized Transcranial Alternating Current Stimulation (tACS)","Inclusion Criteria for stutterers:\n\n* Have normal language, hearing, and cognition\n* Speak English as the primary language\n* Currently stutter\n* Score (per protocol) a certain value on the Stuttering Severity Instrument (SSI-4).\n* Have not received any treatment for stuttering within the past year\n\nExclusion Criteria for stutterers:\n\n* History of seizures\n* Major medical or neurological illness (e.g., stroke, serious head trauma, brain infection, Parkinson's disease, etc.)\n* History of closed head injury with loss of consciousness (e.g., concussion)\n* Metal or electronic implants such as cochlear implants and pacemakers anywhere in the body\n* Braids or other hair styling that prevents direct access to the scalp (if removal not possible)\n* Currently pregnant",{"count":134,"type":21},80,[24],"The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that stutter. The long-term goal of this study is to test the therapeutic potential of transcranial alternating current stimulation (tACS) for the treatment of stuttering.\n\nThe study team hypothesizes that if stuttering involves impaired initiation of motor programs, delta-tuned tACS will strengthen communication between brain regions and decrease stuttering. Therefore, delta-tuned sensorimotor tACS will be paired with fluency-induced speech (choral reading), which is hypothesized to decrease stuttering via improved auditory motor integration.",[62,90,27],[139,140,141,142,143,144],"tACS","Magnetic resonance imaging","Electroencephalogram","Auditory perturbation","Neural oscillations","Brain stimulation","2025-09-05",{"date":147,"type":39},"2025-09-12",{"date":149,"type":39},"2025-08-05",{"date":151,"type":21},"2029-12",{"name":75,"class":46},{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":16,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":165,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":20},"100530005","auditory-prediction-and-error-evaluation-in-the-speech-of-individuals-who-stutter-100530005","NCT06181149","Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter","Inclusion Criteria:\n\n* being a monolingual, native speaker of American English\n* absence of developmental, psychological, neurological, or communication disorders (other than developmental stuttering) as confirmed by a certified research SLP\n* normal (age-appropriate) binaural pure-tone hearing threshold (0.5-4k Hz; ≤25 dB HL for younger than 70 years, and ≤35 dB HL for older than 70 years)\n* not taking any medications that affect the central nervous system\n* absence of safety contra-indication for tDCS, TMS and MRI (for adults)\n* scoring at the 20th percentile or higher on standardized speech-language tests (for children)\n\nExclusion Criteria:\n\n\\-",{"count":160,"type":21},300,[24],"Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words\u002Fsentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.",[164,27],"Healthy Subjects",[166],"stuttering","2025-08-19",{"date":169,"type":39},"2025-08-21",{"date":171,"type":39},"2024-01-01",{"date":173,"type":21},"2027-12-30",{"name":175,"class":46},"Arizona State University",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":16,"sex":17,"minAge":183,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":76},"100509030","exploring-the-nature-assessment-and-treatment-of-stuttering-100509030","NCT05908123","Exploring the Nature, Assessment and Treatment of Stuttering","The Blank Center CARE Model™: An Anti-Ableist Approach to Treatment","Inclusion Criteria:\n\nA participant will be considered a child who stutters (ages 2-17 years) if\n\n* their parent\u002Fcaregiver reports concern that their child is a person who stutters,\n* they exhibit three of more stuttering-like disfluencies (e.g., sound\u002Fsyllable repetitions, (in)audible sound prolongations, whole-word repetitions) per 300-word speech sample, or\n* they present with an overall score of 11 or higher on the Stuttering Severity Instrument - 4th Edition (SSI-4).\n\nA participant will be considered an adult who stutters (18+ years) if\n\n* they report they are a person who stutters,\n* they have received a formal diagnosis of stuttering from a certified speech-language pathologist,\n* they exhibit three of more stuttering-like disfluencies (e.g., sound\u002Fsyllable repetitions, (in)audible sound prolongations, whole-word repetitions) per 300-word speech sample, or\n* they present with an overall score of 11 or higher on the Stuttering Severity Instrument - 4th Edition (SSI-4).\n\nExclusion Criteria:\n\n• There are no exclusion criteria for persons who stutter.","2 Years","85 Years",{"count":186,"type":21},3000,[24],"The purposes of this study are to 1) investigate potential speech, language, and psychosocial contributions to the experience of stuttering in monolingual and multilingual speakers, and to 2) evaluate interdisciplinary, telehealth, and speech-language pathology treatment methods and clinical training specific to fluency disorders.",[63,62,90,27],[191],"stuttering, communication competence, adult, treatment","2023-06-20",{"date":194,"type":39},"2023-06-22",{"date":196,"type":39},"2015-05-22",{"date":198,"type":21},"2035-05-22",{"name":200,"class":46},"University of Texas at Austin"]