[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subarachnoid-haemorrhage-from-cerebral-aneurism-rupture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subarachnoid-haemorrhage-from-cerebral-aneurism-rupture":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100544884","investigating-the-tolerability-and-feasibility-of-tvns-following-asah-100544884",false,"NCT06374693","Investigating the Tolerability and Feasibility of tVNS Following aSAH","Investigating the Tolerability and Feasibility of Transcutaneous Vagus Nerve Stimulation Following Aneurysmal Subarachnoid Haemorrhage","tVNS in aSAH","Inclusion Criteria:\n\n* Age \\>18\n* Admitted to STH (Sheffield Teaching Hospital) neurosurgery department\n* Confirmed aneurysmal SAH on vascular imaging\n* Within 5 days of 'Securing' aneurysm (i.e., successfully coiled or surgically following rupture)\n\nExclusion Criteria:\n\n* Current or prior use of a vagus nerve stimulation\n* Symptomatic bradycardia or PPM insertion\n* Complete heart block\n* Implantation of any other electrical stimulator (e.g. DBS)","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","After a subarachnoid haemorrhage, complications are common and increase the overall rate of disability and death from the condition. Despite some advances in preventing, detecting and treating these complications, the rates of complications and associated risks remain high. Further research into ways to reduce complications of subarachnoid haemorrhage.\n\nTranscutaneous vagus nerve stimulation (tVNS) is a technique where a small handheld device is attached to an earpiece which stimulates the nerves to the ear. This is given for short periods and may help improve blood flow and reduce inflammation in the brain. The intervention has been safely used and licensed in seizures, headache and severe depression.\n\nThis study will look to see if it is feasible and tolerable to have tVNS twice daily for 5 days after subarachnoid haemorrhage, and whether it can help reduce the risk of complications from subarachnoid haemorrhage.\n\nThe participant will be randomly allocated to receive either tVNS or a dummy intervention, known as sham.\n\nThe researchers will collect some personal and clinical details such as diagnosis, medications, age, blood test results, as well as some details about the subarachnoid haemorrhage.\n\nThe researchers will also complete brief questionnaires with the participant to assess symptoms. They will take measurements of heart rate, pupil response, and brain activity using a cap. The participant will then be randomly allocated to either receive the tVNS or sham intervention.\n\nNext, the research team will apply the earpiece to their ear twice a day for 45 minutes, for a total of 5 days.\n\nAt the end of the 5-day study period, the intervention will be complete. The researchers will arrange a follow-up meeting on discharge and at 6 weeks, to assess the participants symptoms and recovery.\n\nPrevious studies have shown that tVNS is safe and well tolerated, including a recent review of tVNS studies which evaluated the side effects experienced by 1322 patients receiving tVNS.\n\nThe main side effects include localised tingling\u002Fnumbness\u002Fpain\u002Fredness around the ear (17%), headaches (3%), dizziness (1%), facial droop (1%), nausea (1%), nasal discharge (2%). Rarely, palpitations or a slow heart rate may occur.\n\nThey will continue to receive full medical treatment and observation alongside the study. They are free to withdraw from this study if they find it too demanding on top of their other activities.",[27],"Subarachnoid Haemorrhage From Cerebral Aneurism Rupture",[29,30,31,32],"subarachnoid haemorrhage","vagus nerve stimulation","transcutaneous vagus nerve stimulation","aneurysmal subarachnoid haemorrhage","RECRUITING","2026-03-17",{"date":36,"type":37},"2026-03-20","ACTUAL",{"date":39,"type":37},"2024-04-17",{"date":41,"type":21},"2026-07-31",{"name":43,"class":44},"Sheffield Teaching Hospitals NHS Foundation Trust","OTHER"]