[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subarachnoid-haemorrhage-sah\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subarachnoid-haemorrhage-sah":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100564388","ali--pulmonary-ha-deposition-after-sah-100564388",false,"NCT06628531","ALI & Pulmonary HA Deposition After SAH","Relationship Between Acute Lung Injury and Pulmonary Hyaluronic Acid Deposition After Subarachnoid Hemorrhage","Inclusion Criteria:\n\n* Age between 18 and 80 years old with independent behavior ability or authorized legal representative.\n* A documented diagnosis of SAH within 5 days.\n* A Hunt-Hess scale of Ⅳ or Ⅴ.\n* Absence of clinical and etiological evidence of pulmonary infection.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* Present history of traumatic brain injury or intracranial hemorrhage.\n* Past history of neurological disorders, lung infection within the past six months, cancer, chronic cardiopulmonary diseases, hematological diseases or renal failure.\n* Have participated in clinical trials in the past 4 weeks.\n* The investigator considers that not appropriate for inclusion.","ALL","18 Years","80 Years",{"count":20,"type":21},24,"ESTIMATED","OBSERVATIONAL","Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH. Unlike neurogenic pulmonary edema and pneumonia following brain injury, the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection. Its occurrence is influenced by the release of catecholamines, the regulatory function of the hypothalamic-pituitary-adrenal (HPA) axis and systemic inflammatory response, but the specific mechanisms are still unclear. Therefore, delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients.\n\nAbnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases, such as chest trauma, pulmonary infection and chronic obstructive pulmonary disease. From this, the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH, and to analyze its correlation with the prognosis of pulmonary complications, thereby providing assistance for the clinical diagnosis and treatment of SAH.",[25],"Subarachnoid Haemorrhage (SAH)",[27,28,29,30,31],"Subarachnoid haemorrhage","SAH","acute lung injury","ALI","hyaluronic acid","RECRUITING","2026-03-16",{"date":35,"type":36},"2026-03-18","ACTUAL",{"date":38,"type":36},"2024-12-01",{"date":40,"type":21},"2026-09-30",{"name":42,"class":43},"Tianjin Medical University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100587458","stratifying-critically-ill-patients-for-novel-ferroptosis-or-pyroptosis-intervention-strategies-100587458","NCT06928649","Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies","Innovative Cell Death Diagnostics Allowing Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies","ICU-FERRO","Inclusion Criteria:\n\n* Admitted to the ICU of UZA\n* Critically ill and predicted to be hospitalised in the ICU for \\> 48 hours (i.e. mostly patients admitted for sepsis, trauma, haemorrhagic shock, neurological catastrophe … which means at risk to develop mono-or multiple organ failure)\n* With arterial line in place (for blood sampling)\n\nExclusion Criteria:\n\n* Refusal of consent by patient or closest relative\n* Postoperative patients after major surgery in whom prolonged ICU stay is not foreseen (i.e. elective cardiac surgery",{"count":54,"type":21},600,"INTERVENTIONAL",[57],"NA","In order to better determine which therapy is best for patiënts which present with organ falure during the course of their stay in the intesive care unit (ICU) , one has to determine which underlying mechanism is causing this organ falure. We will determine levels of so called \"biomarkers\" for ferroptosis (a mechan ism of iron-related cell death) in the peripheral blood and biological fluids of criticaly ill patients admitted to the ICU with a catastrrophy (severe infection, trauma ...) . Why ? If it turns out that this ferroptosis plays a role in the ocurrence of organ failure in the critially ill, this will lead to new therapies in the future as drugs become more and more available which can influene this biochemical \"pahway\". of iron-relatd death.",[60,61,25],"Sepsis","Trauma Related Injuries","2025-04-07",{"date":64,"type":36},"2025-04-15",{"date":66,"type":36},"2024-03-13",{"date":68,"type":21},"2026-08",{"name":70,"class":43},"University Hospital, Antwerp",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100572321","the-planetary-outcomes-after-intracranial-haemorrhage-study-100572321","NCT06731751","The Planetary Outcomes After Intracranial Haemorrhage Study","A Prospective, International Observational Study Assessing the Global Variation in Patient Characteristics, Management and Outcomes of Spontaneous Intracranial Haemorrhage.","PLOT-ICH","Inclusion Criteria:\n\n* Patients of any age with the presence of spontaneous intracranial haemorrhage (parenchymal, intraventricular and \u002F or subarachnoid haemorrhage) on intracranial imaging (and absence of a history of trauma).\n\nAND:\n\n• Admission to hospital for sICH management. This includes admission for observation, conservative or interventional management to both ward-based and critical care settings.\n\nExclusion Criteria:\n\n* Patients who have a clear history of trauma as the primary cause of the haemorrhage and therefore are diagnosed with traumatic intracranial haemorrhage.\n* Patients with subdural or extradural haematomas but no clear history of trauma.\n* Patients with intracranial haemorrhage occurring as a complication of a procedure or intervention (e.g. post-operative haematoma) or iatrogenic (e.g. after thrombolysis for ischaemic stroke).\n* Patients who undergo elective (planned admission to hospital) or semi-elective (where a patient was initially admitted to hospital, then discharged from hospital and re-admitted for surgery) procedures.\n* Patients re-admitted to hospital within 30 days of the initial admission with sICH (including those re-admitted for acute management of sICH-related complications).\n* Patient presenting to the emergency department (ED) but discharged home from the ED immediately without a period of observation or admission to a ward.",{"count":80,"type":21},1000,"Over twelve million strokes occur worldwide every year, and stroke is the second most common cause of death globally. Strokes happen because blood supply to the brain is damaged. This can be due to a blockage (ischaemic stroke) or a bleed (haemorrhagic stroke - or intracranial haemorrhage). Intracranial haemorrhage can be life-threatening and patients with this type of stroke can be very sick, requiring urgent medical care including medications, close monitoring, and sometimes surgery.\n\nStrokes happen worldwide, but over 80% of stroke cases and associated death and disability occur in low- and middle- income countries (LMICs), where resources to manage them can be limited. However, the differences in how patients present, the hospital care they receive, and their overall outcomes when compared to high-income countries (HICs) patients are not fully understood. There are many stroke-related deaths occurring each year around the world, especially among those who have presented with an intracranial haemorrhage, and if survival rates are to be improved, high-quality data is needed to help us better understand where the improvements in care are required in different health settings.\n\nRun and funded by the University of Cambridge, this study will collect data on all patients across all ages during a one-month period who undergo treatment for spontaneous intracranial haemorrhage, both medical and surgical. We will include patients from any hospital across the world that treats patients with this condition, collecting data from their admission to hospital until their discharge, death or up to 30 days from their presentation.\n\nThis is an observational study, so we are only observing patients care and management, not making any direct changes to their treatment. We will also be asking each centre to complete a written survey, to better understand some of the more complex areas which are important for the care of intracranial haemorrhage patients such as hospital resources available, and the potential barriers they face in accessing appropriate healthcare.",[83,84,25],"Stroke","Intracerebral Haemorrhage",[86,87,88],"brain haemorrhage","intracerebral haemorrhage","subarachnoid haemorrhage","NOT_YET_RECRUITING","2024-12-09",{"date":92,"type":36},"2024-12-12",{"date":94,"type":21},"2025-01-01",{"date":96,"type":21},"2026-12-31",{"name":98,"class":43},"University of Cambridge"]