[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subarachnoid-haemorrhagic-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subarachnoid-haemorrhagic-stroke":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100612133","a-biopsychosocial-based-multimodal-approach-to-reducing-the-risk-of-delirium-in-icu-100612133",false,"NCT07249619","A Biopsychosocial-Based Multimodal Approach to Reducing the Risk of Delirium in ICU","A Biopsychosocial-Based Multimodal Approach to Reducing the Risk of Delirium in Patients With Subarachnoid Hemorrhage in the Intensive Care Unit (ICU.Delibma)","Inclusion Criteria:\n\n* Aged 18-85,\n* Patients scheduled for intensive care for at least 15 days due to SAH, unruptured intracranial aneurysm, and\u002For Arterovenous Malformation,\n* Those with a Mini Mental State Examination score of \\> 24,\n* Those with a Glasgow Coma Score of 15,\n* Those with motor function in at least one extremity,\n* Those with pain \\\u003C 5\u002F10 (according to the NRS)\n\nExclusion Criteria:\n\n* Patients whose GCS fell to 14 or below for any reason during the study period;\n* Patients who developed septic shock and MODS;\n* Patients requiring endotrachial intubation and mechanical ventilation due to ARDS;\n* Those requiring vasopressors such as NE at a rate of \\>0.25 mcg\u002Fkg\u002Fmin;\n* Terminal cancer cases;\n* Patients with advanced chronic heart and lung failure and COPD;\n* Those with a METS (exercise capacity) of \\\u003C4;\n* Those with a history of dementia, Alzheimer's disease, or psychiatric illness;\n* Those with vision, hearing, or speech problems that would interfere with communication;\n* Those with a history of epilepsy;","ALL","18 Years","85 Years",{"count":20,"type":21},34,"ESTIMATED","INTERVENTIONAL",[24],"NA","As part of this study, an intervention program aimed at preventing delirium in patients with subarachnoid hemorrhage treated in the intensive care unit will be implemented. Routine medical treatments, environmental adjustments, and a video-based communication program will be implemented to prevent delirium. In addition, basic body awareness training will be administered.\n\nPatients will be divided into two groups. One group will receive only the routine treatment program recommended by international guidelines (medical, enviromental adjustment and face-to-face interview etc.), while the other group will receive body awareness therapy addition to routine interventions.",[27],"Subarachnoid Haemorrhagic Stroke",[29,30,31],"Body Awareness Therapy","Communication","Delirium","NOT_YET_RECRUITING","2025-11-18",{"date":35,"type":36},"2025-11-25","ACTUAL",{"date":38,"type":21},"2026-01-02",{"date":40,"type":21},"2028-01-02",{"name":42,"class":43},"Emre Şenocak","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100417200","the-ebc-recovery-study-100417200","NCT04712591","The EBC Recovery Study","Electrophysiologic Biomarkers of Consciousness (EBC) Recovery After Brain Injury","Inclusion Criteria:\n\nFor ABI Participants\n\n* ABI adult (18 years and older) patients who are admitted to the intensive care unit\n* Unconscious with Glasgow Coma Scale (GCS) \\<8 on presentation and unable to follow bedside commands.\n* A negative COVID-19 test on arrival\n\nFor Healthy Volunteers:\n\n* 18 years and older\n\nExclusion Criteria:\n\nFor All Participants:\n\n* \\<18 years of age\n* Pregnant woman\n* Patients with cardiac arrest on presentation",true,{"count":54,"type":21},300,"OBSERVATIONAL","The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.",[58,59,27],"Traumatic Brain Injury","Intracerebral Haemorrhage",[61,62,63,64],"Consciousness","Coma","Recovery","Electroencephalogram","RECRUITING","2025-09-02",{"date":68,"type":36},"2025-09-04",{"date":70,"type":36},"2020-06-18",{"date":72,"type":21},"2030-01-01",{"name":74,"class":43},"University of Miami",2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":44},"100602906","investigation-of-the-role-of-inflammatory-markers-in-the-early-detection-of-cerebral-vasospasm-delayed-cerebral-ischemia-and-meningitis-associated-with-external-cerebrospinal-fluid-drainage-after-non-traumatic-subarachnoid-hemorrhage---a-prospective-case-control-study-100602906","NCT07129603","Investigation of the Role of Inflammatory Markers in the Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage - A Prospective Case-Control Study","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Angiography-identifiable non-traumatic SAH (regardless of source).\n* Requires lumbar or ventricular drain as part of treatment.\n\nExclusion Criteria:\n\n* Traumatic SAH.\n* Patient\u002Flegal representative does not consent.\n* Meningitis within 6 months prior to ictus.\n* Immunosuppressed state (disease or medications affecting WBC number\u002Ffunction).",{"count":83,"type":21},100,"Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis\u002Fmeningitis when external CSF drains are used; bedside TCCD has limited accuracy for vasospasm detection, creating a need for early biomarkers.\n\nObjective To assess the predictive and diagnostic performance of IL-6, IL-1β, TNFα, procalcitonin (PCT), C-reactive protein (CRP) and adrenomedullin (ADM) measured in CSF and serum for vasospasm, DCI, and drain-associated ventriculitis\u002Fmeningitis after SAH; to test whether combining biomarkers improves accuracy versus routine parameters; and to explore associations with admission and day-14 serum 25-hydroxy-vitamin D.\n\nMethods Prospective case-control study at the University of Debrecen (planned n≈100; enrolment 01-Nov-2024-31-Dec-2029). Adults with angiography-verified SAH requiring lumbar\u002Fventricular drainage are included; traumatic SAH, prior 6-month meningitis, and immunosuppression are excluded. TCCD is performed daily for 14 days; suspected vasospasm is defined by mean flow velocity \\>120 cm\u002Fs, severe by \\>200 cm\u002Fs, with monitoring extended to day 21 if severe. Sampling: daily CSF IL-6\u002FPCT\u002FCRP until drain removal; IL-1β\u002FTNFα\u002FADM at 0-2, 3-5, 6-8, 9-11, 12-14 days and at meningitis detection; serum 25-OH-D on drain insertion day and day 14. Outcomes at days 30\u002F90\u002F180: mortality, GOSE, Barthel, Karnofsky, mRS. Statistics: normality testing; t-test or non-parametric equivalents; χ² with Yates' correction; Bonferroni for multiplicity; ROC analysis for diagnostic\u002Fpredictive performance.\n\nEndpoints DCI: new unexplained CT ischaemia or a new unexplained neurological deficit \\>1 h. Drain-associated infection: infectologist-adjudicated ventriculitis\u002Fmeningitis. Vasospasm: TCCD-suggested or DSA-confirmed.\n\nExpected impact An accessible CSF\u002Fserum biomarker panel may enable earlier risk stratification and treatment for vasospasm, DCI, and drain-associated infections, and inform future randomized trials of vitamin-D supplementation in SAH.",[27],"2025-08-11",{"date":88,"type":36},"2025-08-19",{"date":90,"type":36},"2025-08-01",{"date":92,"type":21},"2029-12-31",{"name":94,"class":43},"Tamas Vegh, MD"]