[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subfertility-female\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subfertility-female":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100491295","the-cost-effectiveness-of-surgical-excision-of-colorectal-endometriosis-compared-to-art-treatment-trajectory-100491295",false,"NCT05677269","The (Cost-)Effectiveness of Surgical Excision of Colorectal Endometriosis Compared to ART Treatment Trajectory","TOSCA","Inclusion Criteria:\n\n* Colorectal endometriosis defined as endometriosis involving the (colo)rectum:\n\n  #Enzian classification score C1,C2,C3 (C=rectum) or FI (F=far locations, I=sigmoid colon) detected with ultrasound or MRI;\n* Women in a heterosexual or in a same-sex relationship;\n* The patient has an active wish to conceive and experiences at least one of the following criteria:\n\n  * At least one year of non-conception (either spontaneous of after intra uterine inseminations)\n  * Inability to have timed intercourse because of pain (dyspareunia and\u002For chronic pelvic pain)\n  * Severe complaints (expectant management is not acceptable (anymore)\n* The patients has an indication for IVF\u002FICSI according to Dutch guidelines (Werkgroep netwerkrichtlijn, december 2010);\n\n  * failed intra uterine insemination\n  * male factor subfertility (oligoasthenoteratozoospermia defined as VCM \\\u003C1 million)\n  * bilateral tubal pathology (e.g. bilateral hydrosalpinx, bilateral tubal occlusion)\n  * age \\> 38 years and (unexplained) subfertility\n  * severe endometriosis in case of subfertility\n* The patient is faces the choice between IVF\u002FICSI or laparoscopic (colorectal) endometriosis or is on the waiting list for a respective treatment at T=0 (at the beginning of the treatment trajectory), T=1 (after one unsuccessful IVF\u002FICSI cycle) or T=2 (after 2 unsuccessful IVF\u002FICSI cycles)\n\nExclusion Criteria:\n\n* Patients with deep endometriosis without colorectal involvement;\n* Patients who conceive spontaneously prior to intervention;\n* Patients requiring surgery on short notice and therefore unable to opt for IVF\u002FICSI (e.g. in case of unilateral or bilateral hydronephrosis, severe bowel stenosis and suspicion of an impending ileus);\n* Patients with a contra-indication for IVF\u002FICSI (e.g. diminished ovarian reserve (premature ovarian failure) (AMH (when available) \\\u003Cp10 adjusted for age), untreated congenital uterine abnormalities, maltreated\u002Funtreated systemic or malignant disease or severe risk factors for oocyte aspiration);\n* Patients diagnosed with other diseases causing infertility (e.g. recurrent miscarriages, antiphospholipid syndrome);\n* Not able to read and understand Dutch or English.","FEMALE","21 Years","40 Years",{"count":20,"type":21},339,"ESTIMATED","40 Months","OBSERVATIONAL","To goal of this study is to determine whether laparoscopic resection of colorectal endometriosis results in an increased cumulative live birth rate (CLBR) both spontaneous and after ART (including in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), and better patient reported outcome measures (PROMs) compared to an IVF\u002FICSI treatment trajectory.",[26,27,28],"Endometriosis, Rectum","Endometriosis of Colon","Subfertility, Female",[30,31,32,33,34,35,36],"Colorectal endometriosis","Subfertility","Surgery","In vitro fertilisation","Live birth rate","Quality of life","Cost-effectiveness","RECRUITING","2024-11-19",{"date":40,"type":41},"2024-11-21","ACTUAL",{"date":43,"type":41},"2023-02-17",{"date":45,"type":21},"2029-01-01",{"name":47,"class":48},"Leiden University Medical Center","OTHER",10,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100520026","innovation-for-small-scale-experiments-receptivfity-test-100520026","NCT06051201","Innovation for Small-scale Experiments: ReceptIVFity Test","ReceptIVFity","Inclusion Criteria:\n\n1. Naïve IVF or IVF\u002FICSI patients\n2. Indication for an IVF or IVF-ICSI procedure.\n3. 18 years \\\u003C age \\\u003C 43 years.\n4. Willing to provide a vaginal swab with the ReceptIVFity test.\n5. Willing to provide informed consent.\n\nExclusion Criteria:\n\n1. The use of hormonal contraceptives at the time of taking the test.\n2. The use of antibiotic treatment at the time of taking the test.\n3. Emergency IVF for cancer or other reasons.\n4. Women with endometriosis pre-treated with an Gn-RH analogue.\n5. Women having IVF for egg preservation reasons.","18 Years","42 Years",{"count":60,"type":21},683,"INTERVENTIONAL",[63],"NA","The ReceptIVFity acts as a timing-tool for prediction of optimal pregnancy chances and provides insight into the patient's current (two months after sampling) success rate of an IVF\u002FIVF-ICSI treatment. Benefits of physician decision treatment in case of an unfavorable vaginal profile and a low chance of achieving a pregnancy include reducing unnecessary morbidity and treatment cycles, stress and disappointment, while increasing efficacy of the treatment and lowering the costs needed to achieve a pregnancy.\n\nThe goal of this prospective, clinical non-invasive randomized controlled study, with an additional observational study arm (for women of non-European origin) in naïve IVF or IVF\u002FICSI patients is to evaluate the efficiency of Shared Decision Making compared to Physician Decision in terms of\n\n1. the success probability of an IVF cycle,\n2. the proportion of women with a successful pregnancy\n3. the number of unsuccessful IVF cycles.\n\nRandomization component Women of European origin will be randomized 1:1 to either the shared decision group or the physician decision group. All women of European origin may undergo one to three cycles of IVF\u002FIVF-ICSI reimbursed by the health insurance. The follow-up ends after the outcome of the last of these cycles has been determined. The desired outcome of the IVF or IVF\u002FICSI treatment is a successful pregnancy, i.e., a pregnancy with a heart-beat at 12 weeks of gestation.\n\nObservational component Women of non-European origin are invited to take part in an observational component of this study. Without further evaluation of the results of their vaginal microbiome, they will continue with the IVF\u002FIVF-ICSI cycle. Women eligible for participation are naïve patients and the follow-up ends after the outcome of the first IVF\u002FIVF-ICSI cycle has been determined.",[66,67,28],"Pregnancy Related","Infertility, Female",[69,70,71,72],"vaginal microbiome","IVF","IVF\u002FICSI","pregnancy","2024-09-12",{"date":75,"type":41},"2024-09-19",{"date":77,"type":41},"2023-09-04",{"date":79,"type":21},"2027-09",{"name":81,"class":48},"Erasmus Medical Center",1]