[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subfertility\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subfertility":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,73,112,132,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100367481","phase-3-gnrh-agonist-for-dual-trigger-in-ivf-and-for-luteal-phase-support-in-fet-100367481",false,"NCT04064840","GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET","Gonadotrophin Releasing Hormone Agonist for Dual Trigger in in Vitro Fertilization and for Luteal Phase Support in Frozen-thawed Embryo Transfer","IVF\n\nInclusion criteria:\n\n\\- Women aged \\\u003C43 years at the time of IVF treatment\n\nExclusion criteria:\n\n* Preimplantation genetic diagnosis treatment\n* Use of donor oocytes or donor embryos\n* Hydrosalpinx shown on pelvic scanning and not surgically treated\n* Women at risk of OHSS\n\nFET\n\nInclusion criteria:\n\n* Women aged \\\u003C43 years at the time of IVF treatment\n* Replacing early cleavage embryos or blastocysts after thawing\n* FET in natural cycles\n\nExclusion criteria:\n\n* Frozen early cleavage embryos thawed and cultured to blastocysts prior to transfer as requested by the patient\n* Preimplantation genetic diagnosis treatment\n* Use of donor oocytes or donor embryos\n* Hydrosalpinx shown on pelvic scanning and not surgically treated","FEMALE","18 Years","42 Years",{"count":20,"type":21},784,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The objectives of this study are to compare the efficacy of the dual trigger group vs the hCG trigger group on the live birth rate in women undergoing IVF and the efficacy of the agonist in LP group vs the placebo group on the live birth rate in women undergoing FET.",[27],"Subfertility",[29,30,31,32,33,34,35],"subfertility","IVF","FET","dual trigger","luteal phase support","Gonadotrophin releasing hormone agonist","live birth rate","RECRUITING","2026-05-14",{"date":39,"type":40},"2026-05-15","ACTUAL",{"date":42,"type":40},"2019-09-01",{"date":44,"type":21},"2026-05-30",{"name":46,"class":47},"The University of Hong Kong","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100465159","the-flora-project-in-search-for-the-microbial-cause-of-chronic-endometritis-and-the-most-appropriate-treatment-to-obtain-a-successful-pregnancy-ivficsi-100465159","NCT05337072","The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF\u002FICSI","FLORA","Inclusion Criteria:\n\n* Women planned for IVF\u002FICSI treatment at Brussels IVF (UZ Brussel)\n* Women who undergo a diagnostic hysteroscopy in preparation of their treatment\n\nExclusion criteria:\n\n* If an interventional instead of a diagnostic hysteroscopy in planned\n* In the occurence If a previous history of chronic endometritis and the use of antibiotics in the last 3 months.",true,{"count":58,"type":21},1000,"OBSERVATIONAL","Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems. Today, diagnosis of chronic endometritis is not evident, since no well-validated classification scales are available. In the UZ Brussel the pathology department applies its own in-house scoring system, based on the presence and position of plasma cells within the histological images.\n\nDespite limited research so far, it recently became clear that the endometrium is colonized by micro-organisms (the microbiome). However, it is still unclear what role these microorganisms play in chronic endometritis and fertility problems. Chronic endometritis is often diagnosed in the context of fertility problems, and the patient is treated 'blindly' with broad-spectrum antibiotics such as doxycycline. Broad-spectrum antibiotics unnecessarily eradicate many microorganisms in our body, including the ones that positively influence implantation. The exact cause of chronic endometritis is unknown, so treatment remains empirical. The research and knowledge in the endometrial microbiome is constantly expanding, mainly due to the rise of research into the links between pathologies and human microbiota. It is becoming increasingly clear that the composition of the microbiome can play a vital role in health and disease. Regarding the influence of the endometrial microbiome on different pathologies, such as chronic endometritis and implantation failure or miscarriage, there is still no consensus. Despite multiple studies on the endometrial microbiome, we are not yet able to define a normal or healthy endometrial microbiome.\n\nIn this project, we want to gain insight into the microorganisms that are present in the female reproductive tract based on various techniques. The analyses will performed on a transvaginal ultrasound, endometrial biopsies which will be harvested during (guided biopsy) and after (blind pipelle biopsy) the hysteroscopy and a vaginal swab. The biopsy is routinely taken at Brussels IVF for the detection of plasma cells in the anatomopathology lab for the diagnosis of chronic endometritis. In the microbiology lab we will investigate which microorganisms are present in the female reproductive tract with and without the histological diagnosis of chronic endometritis. This will be done based on the state-of-the-art analytical techniques metagenomics (sequencing) and culturomics (culture).",[62,27],"Endometritis; Chronic",[64],"Microbiome","2026-05-12",{"date":39,"type":40},{"date":68,"type":40},"2023-07-01",{"date":70,"type":21},"2026-12-31",{"name":72,"class":47},"Universitair Ziekenhuis Brussel",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":81,"minAge":17,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":87,"conditions":88,"keywords":94,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100621793","effect-of-daily-intake-of-gazpacho-on-semen-quality-and-oxidative-stress-100621793","NCT07375238","Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress","Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress in Men With Altered Semen Parameters: A Randomized Controlled Study","G-OXSEM","Inclusion Criteria:\n\n* Men aged 18 to 45 years\n* Andrological profile including altered semen parameters such as oligozoospermia, asthenozoospermia and\u002For teratozoospermia (O±A±T)\n* No clinical indication for sperm DNA fragmentation testing or advanced sperm selection techniques\n* Willingness and ability to comply with the study protocol, including adherence to a standardized Mediterranean diet\n* Signed and dated written informed consent form\n\nExclusion Criteria:\n\n* Use of antioxidant supplements during the three months prior to study start.\n* Active smokers or men who have stopped smoking within the last three months.\n* Diagnosis of azoospermia, leucocytospermia or necrozoospermia.\n* Presence of severe systemic diseases or chronic conditions that could interfere with semen quality or adherence to the study.\n* Known allergy or intolerance to any ingredient of the gazpacho used in the study.\n* Any medical, psychological or social condition that, in the investigator's judgement, could compromise the subject's ability to participate fully or comply with the protocol requirements.\n* Simultaneous participation in another clinical study.","MALE","45 Years",{"count":84,"type":21},80,[86],"NA","The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality. The study will also examine how this dietary intervention affects oxidative stress and whether it is well tolerated.\n\nThe main questions this study aims to answer are:\n\n* Does daily consumption of gazpacho improve semen quality in men with altered semen parameters?\n* Does this dietary intervention affect levels of oxidative stress in semen?\n* Is daily gazpacho intake feasible and well tolerated as part of a Mediterranean diet?\n\nResearchers will compare a Mediterranean diet plus daily gazpacho intake with a Mediterranean diet alone to determine whether adding gazpacho provides additional benefits for male reproductive health.\n\nParticipants will:\n\n* Follow a standardized Mediterranean diet for 12 weeks\n* Drink 330 mL of gazpacho every day or follow the diet without gazpacho\n* Provide semen samples at the start of the study and after 12 weeks\n* Complete a short diary to record adherence to the dietary intervention\n* Be followed for up to 18 months to record reproductive outcomes",[89,90,27,91,92,93],"Male Infertility","Oxidative Stress","Oligozoospermia","Asthenozoospermia","Teratozoospermia",[95,96,97,98,99,100,101,102],"Mediterranean diet","Gazpacho","sperm quality","Male infertility","Altered semen parameters","oxidative stress","OxiSperm II","Randomized trial","2026-03-11",{"date":105,"type":40},"2026-03-13",{"date":107,"type":40},"2026-03-02",{"date":109,"type":21},"2029-09-01",{"name":111,"class":47},"Ginefiv",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":48},"100351750","phase-3-oral-dydrogesterone-as-luteal-phase-support-in-natural-cycle-fet-100351750","NCT03859921","Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET","A Randomized Double Blind Controlled Comparison of Oral Dydrogesterone as Luteal Phase Support in Natural Cycle Frozen-thawed Embryo Transfer","Inclusion Criteria:\n\n* Age of women \\\u003C43 years at the time of stimulated IVF\n* Replacing early cleavage embryos or blastocysts after thawing\n\nExclusion Criteria:\n\n* Requiring hormonal replacement cycles\n* Use of donor oocytes or embryos\n* Undergoing preimplantation genetic testing\n* Presence of hydrosalpinx not corrected surgically prior to FET\n* Refusal to join the study",{"count":120,"type":21},716,[24],"This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support. The hypothesis is that the use of oral dydrogesterone will increase the live birth rate of natural cycle FET.",[27],"2025-06-09",{"date":126,"type":40},"2025-06-12",{"date":128,"type":40},"2021-07-01",{"date":130,"type":21},"2026-11-30",{"name":46,"class":47},{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":139,"minAge":4,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":48},"100508153","a-novel-integrative-non-invasive-embryo-selection-approach-for-ivf-based-on-mk-rs-analysis-100508153","NCT05896709","A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis","A Novel Integrative Non-invasive Embryo Selection Approach for in Vitro Fertilization Based on Artificial Intelligence Enhanced Morphokinetic Analysis and Raman Spectra in Spent Culture Media","Inclusion Criteria:\n\n1. Patients undergoing IVF\u002F ICSI treatment\n2. Patients receiving the first, second or third IVF\u002FICSI treatment cycle\n3. Patients and their partners willing to sign the informed consent agreement\n4. Patients having at least three normal fertilised embryos on the day of the fertilization check\n5. Consecutive women undergoing IVF treatment\n6. Patients planning to use a time-lapse incubator for embryo culture\n\nExclusion Criteria:\n\n1. Day one human embryos with blur imaging\n2. Large obstructions in the embryo area\n3. More than half of the embryo area is blocked by the well or degeneration\n4. Patients with more than half of the embryos without sufficient spent culture medium for RS analysis\n5. Patients with known genetic diseases","ALL",{"count":141,"type":21},176,[86],"During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate. Many assisted reproductive technology units over the world have tried different approaches to increase the clinical pregnancy rate. Conventionally, the morphology of the embryo is assessed by the embryologist with naked eyes only. Nowadays, artificial intelligence (AI) has been used to assist in morphological assessment of the embryo. Our pilot study showed that the AI-enhanced morphokinetic (MK) analysis increased the accuracy in embryo selection by \\~9%, while the detection rate for abnormal chromosomes in embryo has also been increased by Raman spectroscopy (RS) analysis. The combined MK-RS analysis will be able to complete embryo assessment within 5-6 days after fertilization. This method needs shorter time and is at lower cost when compared to invasive preimplantation genetic testing for aneuploidies (PGT-A).\n\nIn this study, we have combined the following non-invasive techniques to assist in embryo screening.\n\n1. Using time-lapse imaging (i.e. images of embryo being taken every 10 minutes inside the incubator) with AI)-enhanced MK analysis to assess the entire morphological changes of the embryo.\n2. As the embryo releases metabolites during its growth, the spent culture medium will be collected after culture of the embryo and then be used for RS analysis, which is a kind of metabolomics-based non-invasive PGT-A, for screening chromosomal abnormalities of the embryo.\n\nThis study will include two phases. In Phase I, it is a retrospective part. We will collect data to train the convolutional neural network (CNN)-enhanced MK with RS method on embryo selection, leading to the integrated approach (MK-RS). In Phase II, it is a randomized controlled trial and participants will be randomised into 2 groups. For the experimental group, embryo selection will be based on the MK-RS method, whereas embryo selection for the control group will rely on the traditional embryo assessment results alone. Then we will assess the clinical pregnancy rate and evaluate the efficacy of our approach finally. Patients who receive in vitro fertilisation (IVF)\u002F intracytoplasmic sperm injection (ICSI) treatment from The Assisted Reproductive Technology (ART) Unit of The Chinese University of Hong Kong, Prince of Wales Hospital will be recruited.",[145,27,30],"Reproductive Issues",[147,148,149,150,151,152,153],"non-invasive","in vitro fertilization","time-lapse imaging","artificial intelligence","morphokinetic analysis","Raman spectroscopy","embryo selection","2025-03-18",{"date":156,"type":40},"2025-03-21",{"date":158,"type":40},"2023-07-17",{"date":160,"type":21},"2026-12",{"name":162,"class":47},"Chinese University of Hong Kong",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":139,"minAge":17,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":48},"100464538","fertility-and-the-microbiome-100464538","NCT05328999","Fertility and the Microbiome","Fertility and the Microbiome: an Observational Study and Randomized Placebo Controlled Double-blind Pilot Trial","Inclusion Criteria:\n\n* Couples (Males and females) with subfertility, primary or secondary infertility, or recurrent pregnancy loss.\n\nExclusion Criteria:\n\n* unable to consent\n* diseases or conditions that might impact investigation\n* intake of probiotics, antibiotics within last 3 months\n* intake of nutritional supplements\n* chemo therapy or radiation therapy\n* excess alcohol intake\n* smoking","50 Years",{"count":172,"type":21},300,"With this study, the investigators want to investigate the microbiome and human papilloma virus (HPV) status of couples with subfertility. The investigators want to gain information about association of female and male microbiome and its impact on fertility. HPV prevalence is high, and its impact on fertility has not been studied intensively. The investigators want to find out whether there is an association between HPV status and subfertility, vaginal and seminal microbiome and HPV status and the prevalence among our subfertile couples.\n\nAs part of this study, the investigators will perform a randomized placebo controlled double blind pilot study to investigate the association between altered sperm quality (impaired motility and elevated DNA fragmentation index), the seminal microbiome and whether intake of probiotics alters these parameters.",[27,92],"2024-07-23",{"date":177,"type":40},"2024-07-24",{"date":179,"type":40},"2022-08-10",{"date":70,"type":21},{"name":182,"class":47},"Medical University of Graz"]