[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"substance-abuse\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:substance-abuse":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,51,103,134,164,186,213,244,293,323,354,385,431,463,490,510,530,563,586,620,646],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100638259","brief-intervention-addressing-stigma-among-parents-of-children-with-mental-health-problems-100638259",false,"NCT07594730","Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems","RCT of Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems","Inclusion Criteria:\n\n* Self-identify as English Speaking\n* Live in the US\n* Ages 25-50\n* Have a child 6-18 years old with either depression, ADHD, or a substance use problem\n\nExclusion Criteria:\n\n* Do not speak English\n* Do not live in the US\n* \\\u003C25 or \\>50\n* Do not have a child between ages 6-18 with depression, ADHD, or a substance use problem",true,"ALL","25 Years","50 Years",{"count":21,"type":22},1600,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to test the efficacy of brief video interventions parental internalized stigma and stigma-related outcomes (e.g., treatment intentions, caregiver burden, secrecy) among parents (ages 25-50) of children ages 6-18 with depression, ADHD, or substance use problems.\n\nTimely identification and treatment of mental health problems in youth is a public health priority. However, many youth do not receive treatment, and stigma has been identified as the primary barrier to help-seeking. Parents experience stigma related to their children having mental health problems, which has been associated with reduced help-seeking and increased parental distress. Prior experiments have found brief video-based interventions (BVIs), 1-2 minute videos similar to those viewed by youth on social media platforms, based on the principle of \"social contact\" with individuals affected by a stigmatized condition, effective in reducing mental health stigma and increasing help-seeking.\n\nIn this 4-arm RCT, the investigators will recruit parents aged 25-50 using an online crowdsourcing platform, to test the efficacy of BVIs featuring a personal parent narrative of their experience with their child's a) depression, b) ADHD, or c) substance use, or d) a control condition that provides general written psychoeducational information without social contact.",[28,29,30,31,32,33],"Depression Disorders","ADHD","Substance Abuse","Social Stigma","Help-Seeking Behavior","Caregiver Burden",[35,36,37],"social stigma","help-seeking behavior","caregiver burden","NOT_YET_RECRUITING","2026-06-26",{"date":41,"type":42},"2026-06-30","ACTUAL",{"date":44,"type":22},"2026-07-06",{"date":46,"type":22},"2026-09-06",{"name":48,"class":49},"New York State Psychiatric Institute","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":91,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":50},"100619125","neuroimaging-of-adolescent-cannabis-use-treatment-100619125","NCT07340554","Neuroimaging of Adolescent Cannabis Use Treatment","Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment","ACT","Inclusion Criteria:\n\n* 14-17 year old youth\n* Guardian 18 years or older\n* Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and\u002For hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant\n* Youth must endorse having used cannabis at least once per week over the past month OR youth must have been diagnosed with cannabis use disorder within the past three months\n\nExclusion Criteria:\n\n* Youth has a history of Fetal Alcohol Spectrum Disorder, intellectual disorders, pervasive development disorder or autism spectrum disorder, psychotic disorders, history of neurological problems (epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease) by parent\u002Fguardian report\n* Youth or caretaker who is monolingual non-English speaker\n* Youth who is currently experiencing active psychosis symptoms or suicidal\u002Fhomicidal ideation or who has been hospitalized within the past 6 months for psychosis or suicidality\u002Fhomicidality\n* Youth who is currently undergoing contingency management treatment for cannabis use disorder","14 Years","17 Years",{"count":62,"type":22},80,[25],"This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.",[66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,30,89,90],"Cannabis Use","Cannabis Dependence","Cannabis Use Disorder","Cannabis Abuse","Cannabis Intoxication","Cannabis Smoking","Cannabis Withdrawal","Cannabis-Related Disorder","Cannabis Abuse, in Remission","Cannabis Abuse, Episodic Use","Marijuana","Marijuana Abuse","Marijuana Use","Marijuana Smoking","Marijuana Dependence","Marijuana User","Marijuana-Related Disorder","Marijuana Use Disorder","Addiction","Addiction, Substance","Substance Use","Substance Use Disorders","Substance Dependence","Substance Related Problem","Substance Abuse Drug Chronic",[92,76,84],"Cannabis","RECRUITING","2026-06-18",{"date":96,"type":42},"2026-06-22",{"date":98,"type":42},"2026-06-15",{"date":100,"type":22},"2030-05-01",{"name":102,"class":49},"Indiana University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":50},"100641392","hybrid-dialectical-behavior-therapy-for-veterans-to-further-reduce-emotion-regulation-problems-and-trauma-symptoms-100641392","NCT07652645","Hybrid Dialectical Behavior Therapy for Veterans to Further Reduce Emotion Regulation Problems and Trauma Symptoms","REfreshment of Dialectical Behaviour Therapy for Veterans to Further Reduce Symptoms and Prevent Relapse of Post-traumatic Stress Disorder and Emotion Regulation Symptoms by Guided Self-Help","REFRESH","Inclusion Criteria:\n\n* Adult veteran (18 years or older), treated at Sinai Center, with knowledge of DBT\n* Primairy diagnosis of PTSD, determined with CAPS-5, resulting from war-related traumas\n* Stable for four weeks on their medication (type and doses)\n* Able to to do online homework assignments and communicate with their therapist via an eHealth platform\n* Dutch speaking\n\nExclusion Criteria:\n\n* Chronic psychosis (psychotic features as comorbidity from PTSD is allowed) or bipolar disorder type 1\n* IQ below 80 or cognitive disorders\n* Severe self-harming behaviour, such as auto-mutilation or suicidal ideations as main problem\n* Following day treatments or other intensive treatment for residual symptoms","18 Years",{"count":113,"type":22},24,[25],"Around 10% of post-active veterans experience post-traumatic stress disorder (PTSD) many years post-mission. PTSD in veterans is frequently associated with challenges in emotion regulation, aggression, suicidality, and financial and psychosocial stress. In 2018, a 12-week clinical treatment programme, the Veterans Intensive Treatment Unit (VIBU), was developed for veterans experiencing these psychiatric symptoms, for whom conventional treatments had proven ineffective. The VIBU provides patients with trauma-focused and dialectical behaviour therapy (DBT). A recent study revealed that the VIBU was effective in reducing psychiatric symptoms. However, a recurrence of symptoms was observed in patients a few months after discharge. Consequently, an aftercare programme consisting of hybrid DBT is offered to consolidate and repeat the DBT skills and apply them in daily life.",[117,118,30],"PTSD","Emotion Regulation Disorders",[120,117,121,122,123],"Emotional dysregulation","DBT","Hybrid DBT","Veterans","2026-06-11",{"date":126,"type":42},"2026-06-17",{"date":128,"type":42},"2026-06-01",{"date":130,"type":22},"2028-10",{"name":132,"class":133},"Arkin","INDUSTRY",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":142,"minAge":111,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":50},"100626201","testing-a-mobile-health-application-to-improve-hiv-prevention-and-substance-use-treatment-among-women-involved-in-the-carceral-system-100626201","NCT07432555","Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System","Development and Pilot Testing of a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Service Access Among Women Involved in the Carceral System","PA-Links","Inclusion Criteria:\n\n* 18 of years of age or older\n* Self-identified woman\n* Previous experience (past six months) with the carceral system (jail, prison, on parole or under supervision)\n* Speaks and reads English\n* Self-reported negative HIV status\n* Indicates at least one HIV risk (i.e. any of the following in the past 6 months or in the six months prior to the most recent incarceration that call for consideration of PrEP as per the CDC risk indices: have engaged in condomless sex; have an HIV-positive sex partner; have had an STI; have had multiple \\[\\>6\\] partners; have engaged in transactional sex; have injected drugs, shared injection or drug use preparation equipment, or have been enrolled in opiate substitution therapy because of IDU; previous overdose)\n* Self-report using opioids in the past six months or six months prior to the most recent incarceration (prescription or not) OR self-report using medications for opioid use disorder in the past year.\n* Have access to the internet through some device - smart phone, computer or tablet (personal or at community location such as library or organization)\n\nExclusion Criteria:\n\n* Under 18 years old\n* Does not read or speak English\n* Does not identify as a woman\n* Has been diagnosed with HIV\n* Does not have previous experience with the criminal legal system within the last 6 months\n* Does not have HIV risk in last six months or six months prior to being incarcerated\n* Has not used opioids in past six months or six months prior to being incarcerated or MOUD in last year\n* Does not have access to internet\n* Cannot provide informed consent","FEMALE",{"count":144,"type":22},74,[25],"Women involved in the carceral system (WICS) are at higher risk for both HIV and substance use than the general public. WICS are also more likely to engage in behaviors both before and after release that put them at risk for HIV and for overdose, due to opioid use. Despite these risk factors, WICS are less likely to be aware of, use, or adhere to pre-exposure prophylaxis (PrEP) and have less access to medications for opioid use disorder (MOUD). The primary goal of the proposed research is to pilot test a systematically developed PrEP and MOUD uptake intervention for WICS using contextually relevant messages developed through novel formative research methods and embedded in a web-based application in a rigorous research design. The investigators will then test this approach (called PA-LINKS) in a pilot randomized trial with women who have recently been incarcerated in Philadelphia in partnership with Philadelphia FIGHT, a federally qualified health center, for promise of efficacy, and to assess feasibility and acceptability.",[30,148],"HIV",[30,150,151,152,153,154],"HIV prevention","PreEP","Medications for Opioid Use Disorder","Re-entry","Women Involved in the Carceral System (WICS)","2026-05-12",{"date":157,"type":42},"2026-05-13",{"date":159,"type":22},"2026-08-01",{"date":161,"type":22},"2026-08-30",{"name":163,"class":49},"Temple University",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":16,"sex":17,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":50},"100456118","testing-alert-with-gto-in-middle-schools-100456118","NCT05219422","Testing ALERT With GTO in Middle Schools","Improving the Implementation of Evidence-based Drug Prevention Programs in Schools","GTO-ALERT","Inclusion Criteria:\n\n* Eligibility for student participants: all students in 7th grade, primarily aged 12-14, attending school at one of the enrolled schools in the study.\n* Eligibility for school staff participants: all educators interested in enrolling in the study at each of the enrolled schools.\n\nExclusion Criteria:\n\n* Not meeting eligibility criteria\n\nNote: the age range is from 11 to 70 to account for both the student AND teacher populations.","11 Years","70 Years",{"count":175,"type":22},42,[25],"To test the efficacy of Project ALERT with the support enhancement tool, Getting To Outcomes.",[30],{"date":157,"type":42},{"date":181,"type":42},"2022-08-30",{"date":183,"type":22},"2027-03-31",{"name":185,"class":49},"RAND",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":193,"enrollmentInfo":194,"targetDuration":196,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":209,"leadSponsor":211,"locationsCount":4},"100639324","comparison-of-the-italian-and-us-forensic-models-for-dual-diagnosis-offenders-a-3-year-longitudinal-study-100639324","NCT07585656","Comparison of the Italian and U.S. Forensic Models for Dual-diagnosis Offenders: a 3-year Longitudinal Study","Comparison of the Italian and US Forensic Models Regarding Dual Diagnosis Offenders: a 3-year Longitudinal Study","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Individuals admitted to forensic psychiatric care in Italy or California.\n* Presence of a diagnosed mental disorder according to DSM-5 \u002F ICD criteria.\n* Presence of a current or lifetime Substance Use Disorder, consistent with a dual-diagnosis condition.\n* Placement in one of the study settings:\n\nItaly: REMS or other forensic\u002Fcommunity facilities under custodial or non-custodial security measures; California: Department of State Hospitals forensic facilities.\n\n* Ability to provide written informed consent, or consent provided through a legal guardian when applicable.\n* Availability for longitudinal follow-up at 12, 24, and 36 months.\n\nExclusion Criteria:\n\n* Absence of a confirmed psychiatric disorder.\n* Absence of current or lifetime Substance Use Disorder.\n* Non-forensic psychiatric patients without criminal justice involvement.\n* Severe cognitive impairment or neurological condition preventing valid assessment.\n* Acute medical or psychiatric instability that makes participation temporarily impossible.\n* Inability to complete the assessment procedures, even with support or adapted administration.\n* Refusal to participate or withdrawal of informed consent. Insufficient clinical, forensic, or follow-up data for longitudinal analysis.","75 Years",{"count":195,"type":22},600,"3 Years","OBSERVATIONAL","This study aims to compare the Italian and U.S. forensic models in the treatment of offenders with dual diagnosis through a three-year longitudinal design. In Italy, the closure of Judicial Psychiatric Hospitals following Law 81\u002F2014 led to the establishment of a community-based forensic system centered on REMS (Residences for the Execution of Security Measures), integrated within the National Health Service. This model seeks to limit institutionalization and promote rehabilitative pathways in community settings. However, it continues to face challenges related to limited bed availability, waiting lists, and the complex management of social dangerousness. In contrast, the U.S. system, particularly in California, is characterized by high-security forensic psychiatric hospitals with large capacities, but also presents issues such as prolonged hospitalizations, an aging patient population, and a high prevalence of substance use disorders.\n\nDual diagnosis, defined as the co-occurrence of psychiatric disorders and substance use disorders, is highly prevalent in forensic populations and is associated with increased clinical complexity, higher risk of recidivism, and poorer treatment outcomes. Neurobiological and psychological mechanisms underlying addiction-including dysfunctions in the dopaminergic reward system, craving processes, and impairments in executive functioning-contribute to reduced behavioral control and increased impulsivity. Theoretical models such as the self-medication hypothesis and multifactorial frameworks suggest that substance use may both exacerbate psychiatric symptoms and represent an attempt to regulate them.\n\nGiven these complexities, integrated treatment approaches that combine psychiatric care and addiction interventions are essential, particularly in forensic settings. The present study includes offenders with mental illness in forensic care systems in Italy and California, encompassing both custodial and non-custodial settings. Participants will be followed over a three-year period, with assessments conducted at 12, 24, and 36 months. The methodology involves the use of standardized instruments to evaluate psychopathological severity, global functioning, risk of violent recidivism, protective factors, treatment adherence, impulsivity, and substance use. Data on clinical outcomes, antisocial behaviors, and discharge conditions will also be collected.\n\nThe primary objectives of the study are to describe and compare the clinical, demographic, and criminological profiles of forensic populations with dual diagnosis; to examine treatment pathways and outcomes; to identify indicators of treatment effectiveness; and to evaluate both risk and protective prognostic factors, as well as their predictive value for recidivism and clinical trajectories.\n\nThe expected impact of the study lies in improving the understanding of differences between community-based and hospital-based forensic models, with the goal of identifying integrated strategies capable of enhancing rehabilitation, reducing recidivism, and improving long-term outcomes. Findings may contribute to the development of more effective and individualized treatment approaches, as well as inform health and judicial policies aimed at better integrating clinical care and risk management in dual diagnosis forensic populations.",[200,30],"SCHIZOPHRENIA 1 (Disorder)",[202,203,204],"forensic treatment","SUD","forensic psychiatry","2026-05-06",{"date":207,"type":42},"2026-05-14",{"date":128,"type":22},{"date":210,"type":22},"2029-06-01",{"name":212,"class":49},"University of Bari",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":16,"sex":17,"minAge":220,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":23,"phases":224,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":50},"100636483","early-phase-1-micropractices-for-unhoused-lgbtq-youth-100636483","NCT07566273","Micropractices for Unhoused LGBTQ Youth","Developing and Evaluating Collaboratively Designed Mindfulness and Identity-Affirming Practices for Unhoused LGBTQ Youth","Inclusion Criteria:\n\n* Aged 16 to 26 years\n* Self-identify as LGBTQ\n* Currently or recently experiencing housing instability (within the past six months)\n* Have access to a mobile device with internet capability to complete study activities\n\nExclusion Criteria:\n\n* Unable to complete study procedures (e.g., lack of device access)","16 Years","26 Years",{"count":223,"type":22},200,[225],"EARLY_PHASE1","In the present study, the investigators will conduct a pilot randomized controlled trial to evaluate the feasibility, acceptability, and preliminary efficacy of brief, co-designed mindfulness and identity-affirming micropractices for LGBTQ youth and young adults experiencing housing instability. Participants (n = 200, accounting for anticipated attrition) will be randomly assigned to one of two conditions: (1) a mindfulness and identity-based micropractice condition or (2) a structurally equivalent neutral control condition. The intervention content will be developed using a participatory co-design process with members of the target population and standardized prior to trial implementation. The mindfulness and identity condition integrates brief practices targeting present-moment awareness and identity affirmation, whereas the control condition accounts for time and attention without including these components. Assessments will be conducted at baseline, post-intervention, and three-month follow-up. Primary outcomes include feasibility and acceptability, assessed using standardized implementation outcome measures and indicators of intervention adherence. Secondary outcomes include changes in mental health symptoms, psychological and emotional well-being, and substance use. The investigators will evaluate whether the mindfulness and identity-based condition demonstrates greater improvements in outcomes compared to the control condition and will estimate effect sizes to inform the design of future fully powered trials. The intervention will be delivered via a mobile-accessible platform.",[228,229,30],"Well-Being (Psychological Flourishing)","Internalizing Mental Health Symptoms",[231,232,233,30,234,229],"Micropractice","Unhoused","Well-Being","LGBTQ","2026-04-29",{"date":237,"type":42},"2026-05-05",{"date":239,"type":22},"2026-10",{"date":241,"type":22},"2027-01",{"name":243,"class":49},"Cornell University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":16,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":254,"conditions":255,"keywords":268,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":292},"100585203","health-surveillance-at-constructor-university-bremen-cub-and-among-haw-hamburg-employees-100585203","NCT06899308","Health Surveillance at Constructor University Bremen (CUB) and Among HAW-Hamburg Employees","Health Surveillance at Constructor University Bremen (CUB) to Assess Students' and HAW-Hamburg Employees' Health and Wellbeing - Explanatory Sequential Mixed-Methods Approach","CUB-HS2025","Inclusion Criteria:\n\n* English language skills\n* Reading and writing skills\n* Internet access\n* Student status\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Illiteracy\n* Massively limited cognitive abilities ( i.e. linguistic components of the digital offerings must be able to be used, and questionnaires completed, or interviews participated in) and severe psychiatric disorders (e.g., severe depression)",{"count":253,"type":22},363,"The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.",[256,257,258,259,260,261,262,263,264,265,266,30,267,88,86],"Social Isolation or Loneliness","Anxiety","Anxiety Depression (Mild or Not Persistent)","Health Behavior","Observational Study","Stress, Psychological","Emotional Stress","Life Stress","Psychological Stress","Stress, Emotional","Stress (Psychology)","Substance Addiction",[269,270,271,272,273,274,275,276,277,278,279,280,281,282],"Healthy students","Health literacy","Disability","Age","Gender","Study characteristics","PHQ-4","Self-efficacy","Satisfaction with Life Scale (SWLS)","Subjective health status","Student satisfaction","UCLA-LS","HEI-Stress","Mixed Method","2026-04-25",{"date":285,"type":42},"2026-05-01",{"date":287,"type":42},"2025-03-17",{"date":289,"type":22},"2026-12-31",{"name":291,"class":49},"Jacobs University Bremen gGmbH",2,{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":16,"sex":17,"minAge":300,"maxAge":301,"enrollmentInfo":302,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":310,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":50},"100564329","ser-familia-a-family-based-intervention-addressing-syndemic-conditions-among-latino-immigrant-families-100564329","NCT06627764","SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families","SER Familia","Inclusion Criteria:\n\n* Eligible participants must identify as Hispanic\u002FLatino\u002Fa\u002Fx\u002Fe,\n* be a first generation immigrant parent or parental figure (Parent)\n* have a child (Youth) aged 12-17\n* speak English and\u002For Spanish\n\nExclusion Criteria:\n\n* Families planning to move within two years will be excluded","12 Years","100 Years",{"count":303,"type":22},400,[25],"This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias\u002F Health, Stress, and Resilience in Families), a family-based intervention. SER Familia is a six-session intervention co-developed and delivered by community health workers (CHWs) that uses strategies to reduce acculturative stress, promote resilience, improve parent-child and family level health, while simultaneously helping families maintain strong social networks and better navigate community resources to address social determinants of health (SDOH). More specifically, investigators aim to: 1) Examine the efficacy of SER Familia to prevent or reduce the syndemic comprised of substance abuse, IPV, HIV risk, depression, and anxiety among Parents and Youth; and 2) Identify how individual, family, and community mechanisms of change related to acculturative stress and resilience mediates the effect of SER Familia.",[30,307,308,309,257],"Intimate Partner Violence (IPV)","HIV Infections","Depression",[311,312,313],"Family","Stress","Resilience","2026-04-07",{"date":316,"type":42},"2026-04-09",{"date":318,"type":42},"2025-06-30",{"date":320,"type":22},"2029-01-31",{"name":322,"class":49},"Duke University",{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":333,"briefSummary":334,"conditions":335,"keywords":339,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":50},"100583774","the-trans-led-care-study-100583774","NCT06880705","The Trans-Led Care Study","A Gender-Affirming Stigma Intervention to Improve Substance Misuse and HIV Risk Among Transgender Women","TLC","Inclusion Criteria:\n\nEligible transgender adults must:\n\n1. be 18 years of age or older;\n2. speak primarily English;\n3. live in the U.S.;\n4. have a gender identity different from their assumed gender, or sex assigned, at birth;\n5. identify as a person of transgender experience;\n6. endorse having experienced two or more problem(s) related to alcohol or other drug use within the past 12 months.",{"count":332,"type":22},124,[25],"This study is testing a new mutual-help group called \"the TLC program\" for transgender adults who use substances or are recently in recovery. The TLC Program is based on Acceptance and Commitment Therapy or \"ACT\" which is a type of mental health counseling that focuses on using mindfulness skills to connect a person to their values and improve their mental health. The TLC Program was developed by transgender and gender diverse community members, mental health providers, and researchers.",[30,267,336,337,338],"Substance Use Disorder (SUD)","Substance Use (Drugs, Alcohol)","Human Immunodeficiency Virus (HIV)",[340,341,342,343,344],"Substance misuse","HIV risk","Stigma","Psychological distress","Gender affirmation","2026-03-23",{"date":347,"type":42},"2026-03-27",{"date":349,"type":42},"2025-02-10",{"date":351,"type":22},"2027-07-31",{"name":353,"class":49},"Illinois Institute of Technology",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":384},"100498904","harm-reduction-services-100498904","NCT05776316","Harm Reduction Services","Culturally Response Integrated Harm Reduction Services for Black and Latinx People Who Use Drugs","HRS","Inclusion Criteria:\n\n* at least 18 years of age\n* self-identified as misusing opioids +\u002F- other substances (stimulants) in the past 30 days, confirmed by interview using DSM-5 criteria\n* English or Spanish speaking\n* able to provide informed consent.\n\nExclusion Criteria:\n\n* inability to provide informed consent or participate in the study procedures as proposed in the consent\n* active suicidal or homicidal ideation or an unstable psychotic disorder (schizophrenia, schizoaffective disorder) or mood disorder (bipolar disorder, severe major depressive disorder)\n* an unwillingness to be randomized.\n* are prisoners",{"count":223,"type":22},[25],"The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who use drugs (PWUD).",[366,30,367],"Drug Use","Mental Illness",[369,370,371,366,372,373,374],"Harm Reduction","Latinx\u002FHispanix","Black\u002FAfrican American","Cocaine","Opioids","Methamphetamines","2026-03-17",{"date":377,"type":42},"2026-03-19",{"date":379,"type":42},"2024-11-25",{"date":381,"type":22},"2028-03-28",{"name":383,"class":49},"NYU Langone Health",3,{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":391,"eligibilityCriteria":392,"healthyVolunteers":16,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":393,"targetDuration":4,"studyType":23,"phases":395,"briefSummary":396,"conditions":397,"keywords":404,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":50},"100581581","data2action-oregon-project-supporting-data-driven-decision-making-for-substance-use-services-policy-and-overdose-prevention-100581581","NCT06852170","Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention","Supporting Data-driven Decision-Making to Support Substance Use Service Expansion Policies and to Prevent Overdoses","D2A Oregon","Inclusion Criteria:\n\nSample 1: Local or Regional Decision Makers\n\n* At least 18 years old\n* Has decision-making authority within their professional role related to substance use service delivery, including leadership responsible for developing policy (e.g. executive directors) OR middle-managers (e.g., case managers, supervisor) and front-line workers responsible for service delivery decisions OR Responsible for developing local or state policy related to substance use\u002Fbehavioral health and\u002For the criminal justice system OR Advises these decision makers (e.g., legislative staff, data analysts)\n\nThese individuals will be drawn from organizations with the following perspectives: behavioral health, public health, health payer, first responders, health advocacy.\n\nSample 2: State or Local Decision Makers\n\n* At least 18 years old\n* Has decision-making authority within their professional role related to substance use service delivery, including leadership responsible for developing policy (e.g. executive directors) OR middle-managers (e.g., case managers, supervisor) and front-line workers responsible for service delivery decisions OR Responsible for developing local or state policy related to substance use\u002Fbehavioral health and\u002For the criminal justice system OR Advises these decision makers (e.g., legislative staff, data analysts)\n\nExclusion Criteria:\n\n* None.",{"count":394,"type":22},341,[25],"Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use services and mitigate the growing opioid and methamphetamine epidemics in their state. Consistent with the HEAL Data2Action call for Innovation projects that drive action with data in real-world settings, this study will refine and test the impact of a novel implementation strategy to engage cross- sector decision makers and make data that they identify as relevant to their decisions available to them in easy- to-use products. The proposed study aims to not only address critical knowledge gaps regarding how and when data can inform impactful, transparent decision-making, but to provide decision makers with the data that they need to achieve community-wide substance use prevention and treatment goals, including the increased delivery of high-quality, evidence-informed, services and the prevention of overdoses.",[30,398,399,400,401,402,403],"Decision Making, Shared","Implementation Science","Decision Making","Organizations","Substance-related Disorders","Policy",[405,406,407,30,399,408,409,410,403,398,401,411,369,412,413,414,415,416,417,418,419,420,421],"Health Services Research","Sequential","Stepped Wedge","Decision making","Substance-related disorders","Substance abuse treatment centers","Focus Groups","Policy Making","Law Enforcement","User-Centered Design","Public Health","Opioid-Related Disorders","Naloxone","Methamphetamine","Health Disparate, Minority and Vulnerable Populations","Health Policy","Stakeholder engagement","2026-03-12",{"date":424,"type":42},"2026-03-16",{"date":426,"type":42},"2025-02-06",{"date":428,"type":22},"2028-08-31",{"name":430,"class":49},"Chestnut Health Systems",{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":438,"enrollmentInfo":439,"targetDuration":4,"studyType":23,"phases":440,"briefSummary":442,"conditions":443,"keywords":447,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":50},"100576691","phase-2-feasibility-of-long-term-high-dose-stimulant-for-methamphetamine-use-disorder-100576691","NCT06788587","Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder","Exploring Feasibility and Acceptability of Prolonged Administration of High-Dose Stimulants in People With Methamphetamine Use Disorder: An Extension of a Randomized, Placebo-Controlled Trial","Inclusion Criteria:\n\n1. Between 18 and 55 years of age at enrollment in the parent ASCME trial;\n2. Diagnosed with a moderate to severe MUD as defined by the DSM-5 criteria;\n3. Enrolled in the parent ASCME trial and completed the study up to and including the end of study visit at Week 20, Day 1;\n4. Interested in avoiding relapse, decreasing methamphetamine use, or abstaining from methamphetamine use;\n5. Presence of ongoing substance use, craving, or significant risk of relapse that according to the study physician, warrants extended treatment for MUD;\n6. If female:\n\n   * Be of non-childbearing potential, defined as (i) postmenopausal (12 months of spontaneous amenorrhea and ≥ 45 years of age); or (ii) documented surgically sterilized (i.e., tubal ligation, hysterectomy, or bilateral oophorectomy); or\n   * Be of childbearing potential, have a negative pregnancy test at screening, and agree to use an acceptable method of birth control throughout the study;\n7. Willing to be randomized to one of 2 study arms and followed for the duration of the trial;\n8. Able to start the study intervention within 28 days after completing the ASCME main trial (study no. CRISM-002);\n9. Able to provide informed consent;\n10. Willing to comply with study procedures;\n11. Able to communicate in English or French\n\nExclusion Criteria:\n\n1. Symptomatic or advanced cardiovascular disease (e.g., advanced arteriosclerosis), moderate hypertension; confirmed current hyperthyroidism; known hypersensitivity or idiosyncrasy to the sympathomimetic amines or glaucoma or any disabling, severe, or unstable medical condition (including electrolyte disturbances) that, in the opinion of the study physician, precludes safe participation or the ability to provide fully informed consent;\n2. Any severe or unstable co-morbid substance use disorder that, in the opinion of the study physician, precludes safe participation in the study;\n3. Participants with Opioid Use Disorder (OUD) who have been on Opioid Agonist Treatment (OAT) for \\\u003C12 weeks, and not yet at stabilization dose, or at stabilization dose \\\u003C4 weeks;\n4. Current or a history of any serious psychiatric disorder (e.g., bipolar disorder, pre-existing psychosis, schizophrenia) that, in the opinion of the study physician, precludes safe participation in the study;\n5. History of a SAE, hypersensitivity or known allergic reaction to LDX-01 or other amphetamine drugs, or hypersensitivity to the sympathomimetic amines;\n6. Pregnant, nursing, or planning to become pregnant during the study period;\n7. Planned extended absence during the study period (e.g., pending legal action, surgery, incarceration, inpatient residential program) in the opinion of the study physician that might prevent completion of the study;\n8. Use of an investigational drug for stimulant use disorder during the 30 days before screening, confirmed via self-report or pharmacy records; excluding the use of study medication in the parent ASCME trial;\n9. Use of prescribed amphetamine-type medication or medication for the treatment of stimulant use disorder (e.g., methylphenidate, modafinil, bupropion, or mirtazapine) in the 4 weeks before screening;\n10. Current or anticipated need for treatment with any medication that may interact with LDX-01 (e.g., monoamine oxidase inhibitors \\[MAOIs\\]) used currently or within the past 14 days and that would preclude study participant at the discretion of the study physician;\n11. ECG measurement (Bazett method for the correction of QT interval) that indicates a prolonged QTc interval (≥460 milliseconds for females and ≥450 milliseconds for males) at screening;\n12. Any SAEs related to the study product in the parent trial phase that, in the opinion of the study physician, precludes safe participation in the extension study;\n13. Any compliance issues related to the study product and\u002For study procedures during the parent trial phase that, in the opinion of the study physician, precludes safe participation in the extension study.","55 Years",{"count":62,"type":22},[441],"PHASE2","Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on the maintenance therapy using stimulant agonist therapy is scarce and needs further investigation, especially in terms of long-term retention in treatment.\n\nThe goal of this clinical trial is to evaluate the feasibility of a long-term (25 weeks) administration of high-dose stimulant agonist therapy, using Lisdexamfetamine (LDX-01) on top of treatment-as-usual (TAU), in a population of people with moderate to severe MUD, as measured by study retention, treatment retention, treatment adherence and satisfaction compared against a placebo group.\n\nParticipants will be placed randomly into one of two groups:\n\n1. TAU and high-dose LDX-01\n2. TAU and placebo",[444,445,84,30,446],"Methamphetamine Abuse","Methamphetamine-dependence","Methamphetamine Use Disorder",[448,449,418,450,451,452,453],"Substance use disorder","Amphetamines","Lisdexamfetamine","Treatment","Agonist therapy","Feasibility","2026-02-19",{"date":456,"type":42},"2026-02-23",{"date":458,"type":42},"2025-07-18",{"date":460,"type":22},"2027-12",{"name":462,"class":49},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":464,"slug":465,"hasResults":11,"nctId":466,"briefTitle":467,"officialTitle":468,"acronym":4,"eligibilityCriteria":469,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":470,"targetDuration":4,"studyType":23,"phases":472,"briefSummary":473,"conditions":474,"keywords":476,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":488,"locationsCount":4},"100595122","exploring-substance-use-sleep-disturbances-and-reward-sensitivity-100595122","NCT07028346","Exploring Substance Use, Sleep Disturbances and Reward Sensitivity","An Exploratory Study of the Relationship Between Substance Use, Sleep Disturbances and Reward Sensitivity - A Randomized Control Trial of Cognitive Behavioral Therapy for Insomnia","Inclusion Criteria:\n\n1. Individuals who receive treatment services at Substance Abuse Assessment Clinic and other psychiatric out-patient clinics of Kwai Chung Hospital;\n2. Individuals who have problematic substance or alcohol use in the past 3 months, confirmed by scores higher than or equal to 1 in both part 1 and part 2 of Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS);\n3. Individuals who have sleep disturbances, confirmed by a score higher than or equal to 8 on the Insomnia Severity Index (ISI).\n\nExclusion Criteria:\n\n1. Individuals who cannot understand Cantonese, or cannot read Traditional Chinese\n2. Individuals who cannot provide informed consent due to, for example, intoxication or abnormal mental state\n3. Individuals who report abnormal or unstable mental states, such as active psychotic symptoms or acute intoxication, at any point of the study\n4. Individuals who work overnight or have rotating shifts\n5. Individuals who report pregnancy or medical conditions (including sleep apnea) that may have a severe impact on sleep\n6. Individuals who use hypnotics regularly",{"count":471,"type":22},154,[25],"According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve medical treatment and overall care for substance misuse in the future. Participants will be randomized into CBTi and sleep education groups, and their substance\u002F alcohol use, sleep parameters and reward sensitivity will be measured at multiple time points.",[30,475],"Sleep Disturbances",[477,478,479,480],"Substance abuse","substance misuse","sleep disturbances","sleep problem","2025-06-18",{"date":483,"type":42},"2025-06-24",{"date":485,"type":22},"2025-06-16",{"date":487,"type":22},"2026-08-31",{"name":489,"class":49},"Kwai Chung Hospital",{"id":491,"slug":492,"hasResults":11,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":4,"eligibilityCriteria":496,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":497,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":499,"conditions":500,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":508,"locationsCount":50},"100355886","treatment-outcomes-under-a-standardized-treatment-protocol-in-patients-suffered-substance-abuse-related-voiding-dysfunction-100355886","NCT03913819","Treatment Outcomes Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction","Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction","Inclusion Criteria:\n\n* Patients suffered substance abuse induced voiding dysfunction\n\nExclusion Criteria:\n\n* Patient not agreed for consent\n* Patient that will not comply to our treatment protocol",{"count":498,"type":22},1000,"With the increase of substance abuse over the world, substance abuse e.g. ketamine and methamphetamine related voiding dysfunction is becoming an important medical problem. However, while the clinical manifestation of the condition is becoming better defined, the underlying pathophysiology is still poorly understood. Moreover, majority of the current treatment is just based on the experience on some small case series and there is no treatment data for larger patient sample or standard recommended treatment in the literature. In order to improve the management of this condition, investigators have formulated a treatment protocol based on the current literatures on the management of voiding dysfunction and also a similar condition, interstitial cystitis \u002F painful-bladder syndrome (IC\u002FPBS). The protocol basically consists of the following modalities:\n\n* Basic information and education on the condition, principle of treatment and psychosocial support.\n* First line treatment will include a course of oral anti-inflammatory drugs (for the control of the inflammation process and pain) and anticholinergic agents (for the irritative urinary symptoms).\n* If these simple oral medication are found to be not effective, then further treatment will include other oral medications, such as amitriptyline and gabapentin, and some drugs that directly applied into the bladder cavity (hyaluronate) or bladder muscle (botulinum toxin).\n* For those patients with intractable symptoms and failed all the above treatments, surgical treatment (hydrodistension, augmentation cystoplasty) will be discussed.\n\nThe purpose of this research is to assess the effectiveness of the above treatment protocol in the management of substance induced voiding dysfunction and also assess any possible adverse events related to the usage of the drugs.",[501,30],"Voiding Dysfunction","2025-05-04",{"date":504,"type":42},"2025-05-06",{"date":506,"type":42},"2011-12-10",{"date":289,"type":22},{"name":509,"class":49},"Chinese University of Hong Kong",{"id":511,"slug":512,"hasResults":11,"nctId":513,"briefTitle":514,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":16,"sex":17,"minAge":111,"maxAge":516,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":518,"briefSummary":519,"conditions":520,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":528,"locationsCount":50},"100476830","functional-connectivity-alterations-in-suicidal-patients-among-opioid-users-100476830","NCT05489042","Functional Connectivity Alterations in Suicidal Patients Among Opioid Users","Inclusion Criteria Opioid Use Patients:\n\nEach potential subject will be eligible for inclusion in this study only if the specific criteria listed below are met:\n\n* Be male or female aged 18-60 years old\n* Participation in H-22611;\n* Meets a World Health Organization Alcohol, Smoking and Substance Involvement Screening Test (WHO-ASSIST) score of 4+ in the opioid category;\n* Has depressive symptoms according to the Patient Health Questionnaire (PHQ)-9;\n* Has active suicidal thoughts according to Suicide Behaviors Questionnaire-Revised (SBQ-R);\n* Be able to verbalize understanding of consent form, able to provide written informed consent, and verbalize willingness to complete study procedures;\n* Female subjects must be non-nursing and not pregnant at the times of fMRI experiments and rTMS treatment;\n* Has no contraindications to MRI (pacemaker, cochlear implants, metal in eyes, other metal implants, etc.); Meets the pre-screening magnetic resonance imaging (MRI) questions provided by the Center for Advanced MR Imaging (CAMRI);\n* Has no contraindications to TMS (any types of non-removable metal in their head except the mouth, or within 12 inches of the coil, etc.).\n\nInclusion Criteria Healthy Controls:\n\nEach potential subject will be eligible for inclusion in this study only if the specific criteria listed below are met:\n\n* Be male or female aged 18-60 years old;\n* No history of severe medical or neurological illnesses per history;\n* Be able to verbalize understanding of consent form, able to provide written informed consent, and verbalize willingness to complete study procedures;\n* Female subjects must be non-nursing and not pregnant at the time of fMRI experiments;\n* Has no contraindications to MRI (pacemaker, cochlear implants, metal in eyes, other metal implants, etc.): Meets the pre-screening MRI questions provided by the Center for Advanced MR Imaging (CAMRI);\n* Has no contraindications to TMS (any types of non-removable metal in their head except the mouth, or within 12 inches of the TMS coil, etc.).\n\nExclusion Criteria:\n\nAny potential subject who meets any of the following criteria will be excluded from participating in the study if s\u002Fhe has\n\n* In the opinion of the clinician and the research team at admission, be expected to fail to complete the study protocol due to not tolerable to receive rTMS;\n* Unable to understand the design and requirements of the study;\n* Unable to sign informed consent for any reason;\n* Has an unstable medical condition, including Acquired immunodeficiency syndrome (AIDS), acute hepatitis, active TB, unstable cardiac disease, unstable diabetes, hepatic or renal insufficiency;\n* Female subjects who are pregnant or nursing;\n* Contraindications to MRI (pacemaker, cochlear implants, metal in the eye, other metal implants, etc.): Do not meet the pre-screening MRI questions provided by the CAMRI;\n* Contraindications to the noninvasive brain stimulation (NIBS) (any types of non- removable metal in their head except the mouth, or within 12 inches of the coil, etc.) Additional exclusion criteria for the TMS experiments are based on the recommendations described by the international consensus panel on brain stimulation;\n* Non-English speaking subjects (we do not have the staff and resources to include other languages)","64 Years",{"count":62,"type":22},[25],"Suicide is the 10th leading cause of death for Americans of all ages and more people in the United States now die from suicide than die from car accidents. Although death by firearm remains the most common cause of suicide in the United States, an intentional overdose of substance usage such as prescription opioids accounts for over 5,000 suicides per year. In 2017, more than 70,000 drug overdose deaths occurred, making it the leading cause of injury-related death, and well over half (67.8%) involved opioids. The dramatic increase in opioid overdose raises concerns about their contribution to suicidal outcomes (e.g., suicidal behavior, ideation, and attempts). Abuse of prescription opioids is characterized by the persistence of opioid use despite negative consequences. The neurobiology of opioid abuse involves the mesolimbic dopamine systems as the main neural substrate for opioid reward, and altered dopamine release in this system plays a role in opioid abuse. Moreover, the cortico-striatal system, especially the orbitofrontal cortex (OFC), has been associated with the abuse of many substances, including opioids and alcohol. Structural brain alterations in frontal areas, particularly the OFC, may cause executive control dysfunctions of mood which are highly associated with suicidal ideation. Recent preclinical work has shown that higher input from the OFC to the dorsal striatum (dSTR) is associated with compulsive reward-seeking behavior despite negative effects (e.g., punishment). In this study, the investigators propose that OFC\u002FdSTR connectivity may be one neural differentiator that distinguishes between those who become compulsive users after initial opioid use and those that do not. Moreover, suicidal patients among those who become compulsive users may have higher OFC\u002FdSTR connectivity compared to non-suicidal patients.",[30,521,309],"Suicide","2025-04-02",{"date":524,"type":42},"2025-04-04",{"date":526,"type":42},"2022-01-04",{"date":183,"type":22},{"name":529,"class":49},"Baylor College of Medicine",{"id":531,"slug":532,"hasResults":11,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":537,"targetDuration":4,"studyType":23,"phases":539,"briefSummary":540,"conditions":541,"keywords":545,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":561,"locationsCount":50},"100581887","testing-strategies-to-improve-substance-misuse-prevention-research-use-in-state-policy-contexts-100581887","NCT06856148","Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts","Building the Science of Evidence-Informed Prevention Policy: a Multi-level Model for Supporting Substance Misuse Prevention","Inclusion Criteria:\n\n* State-level public officials\n\nExclusion Criteria:\n\n* Anyone who is not a state-level public official",{"count":538,"type":22},300,[25],"If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks an evidence-based model designed for this purpose. Accordingly, a state-level randomized controlled trial (N = 30 states) of a formal, theory-based approach for appropriately supporting policymakers' use of scientific evidence--known as the Research-to-Policy Collaboration (RPC) Model is proposed. This work has the potential to reduce population-level substance misuse by improving the use of scientific information in policymaking, thus increasing the availability of evidence-based prevention programs and policies.",[30,87,542,543,544],"Prevention","Legislation","Use of Research Evidence",[546,547,548,549,550,551,552,553,554,415],"Randomized Control Trial","Substance Abuse Prevention","Substance Misuse Prevention","Prevention Policy","Evidence-Based Policy","Policymaking","Research Communications","Research Translation","Public Policy","2025-03-03",{"date":557,"type":42},"2025-03-06",{"date":559,"type":42},"2023-04-01",{"date":183,"type":22},{"name":562,"class":49},"Penn State University",{"id":564,"slug":565,"hasResults":11,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":4,"eligibilityCriteria":569,"healthyVolunteers":16,"sex":17,"minAge":570,"maxAge":571,"enrollmentInfo":572,"targetDuration":4,"studyType":23,"phases":574,"briefSummary":575,"conditions":576,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":384},"100516454","effectiveness-of-school-based-substance-abuse-prevention-programme-among-adolescents--100516454","NCT06004726","\"Effectiveness of School-based Substance Abuse Prevention Programme Among Adolescents .","\"Effectiveness of School-based Substance Abuse Prevention Programme (SSPP) on Awareness, Attitude, Peer Pressure, and Life Skills Among Adolescents in Selected Public Schools of Pokhara, Nepal-A Cluster Randomized Trial\"","Inclusion Criteria:\n\n* Adolescents of 13-15 years age group.\n* Those who are studying in selected public Schools of Pokhara, Nepal.\n\nExclusion Criteria:\n\n* o Adolescents who are not willing to provide informed consent (assent) and parental consent.\n\n  * Adolescents who do not belong to Nepal.\n  * Adolescents who are absent during data collection","13 Years","15 Years",{"count":573,"type":22},210,[25],"The objectives of the study is to\n\n1. \"to explore the perception of teachers, parents \\& students in the prevention of substance abuse among adolescents\".\n2. \"to develop and determine the effectiveness of a School-based substance abuse Prevention Programme (SSPP) on awareness, attitude, peer pressure, and life skills towards prevention of substance abuse\".\n\nIn this study, SSPP refers to a Bilingual Multicomponent Training Programme which includes psychoeducation and video-assisted teaching to enhance awareness of substance abuse, role-play to develop a positive attitude towards prevention of substance abuse, Case based scenario to increase resistance to peer pressure and storytelling and demonstration to increase life skills towards prevention of substance abuse among adolescents of selected schools of Pokhara, Nepal.",[30],"2024-03-17",{"date":579,"type":42},"2024-03-19",{"date":581,"type":22},"2024-05-01",{"date":583,"type":22},"2027-07-01",{"name":585,"class":49},"Manipal College of Nursing",{"id":587,"slug":588,"hasResults":11,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":592,"eligibilityCriteria":593,"healthyVolunteers":16,"sex":17,"minAge":59,"maxAge":594,"enrollmentInfo":595,"targetDuration":4,"studyType":23,"phases":597,"briefSummary":598,"conditions":599,"keywords":605,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":50},"100536294","recognition-and-early-intervention-for-alcohol-and-substance-abuse-in-adolescence-in-adolescent-100536294","NCT06262958","Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent","REAL-SMART: Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence, REAL\u002FSystemic Metabolic Alterations Related to Different Psychiatric Disease Categories in Adolescent","REAL-SMART","Inclusion Criteria: Admitted to the Kuopio University Hospital (KUH) adolescent psychiatric outpatient clinic during the years 2016-2019\n\nExclusion Criteria: Unable to understand the questionnaires","19 Years",{"count":596,"type":22},800,[25],"ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it",[600,30,601,602,87,603,604],"Alcoholism","Alcohol Dependence","Alcohol-Related Disorders","Adolescent Behavior","Adolescent Problem Behavior",[606,607,608,609,610],"alcohol","substance","abuse","mini-intervention","adolescent","2024-02-08",{"date":613,"type":42},"2024-02-16",{"date":615,"type":42},"2017-08-07",{"date":617,"type":22},"2030-06-01",{"name":619,"class":49},"Kuopio University Hospital",{"id":621,"slug":622,"hasResults":11,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":4,"eligibilityCriteria":626,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":627,"enrollmentInfo":628,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":630,"conditions":631,"keywords":635,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":50},"100090609","substance-abuse-pre-treatment-screening-study-100090609","NCT00439049","Substance Abuse Pre-Treatment Screening Study","General Evaluation of Eligibility for Substance Abuse\u002FDependence Research","Inclusion Criteria:\n\n* Willing and able to participate in 3- to 6-month treatment program.\n* At least 18 years of age.\n* Seeking treatment for substances of abuse including (cocaine, opiates, and alcohol).\n* Generally physically healthy.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Mandated by the courts\u002Fparole officers to attend treatment.\n* Not seeking treatment for substances of abuse.\n* Plans to move from the Houston area within the 3- to 6-month treatment period.\n* Seeking treatment for a substance for which the Treatment Research Clinic (TRC) has no current trial.","60 Years",{"count":629,"type":22},7500,"The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for their presenting concerns or interests. A second purpose is to have a consolidated intake data base on which secondary analyses can be conducted.",[632,633,634,601,30],"Cocaine Abuse","Cocaine Dependence","Opiate Dependence",[30,451,636],"Eligibility","2023-12-19",{"date":639,"type":42},"2023-12-20",{"date":641,"type":4},"2005-10",{"date":643,"type":22},"2026-06",{"name":645,"class":49},"The University of Texas Health Science Center, Houston",{"id":647,"slug":648,"hasResults":11,"nctId":649,"briefTitle":650,"officialTitle":651,"acronym":652,"eligibilityCriteria":653,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":4,"enrollmentInfo":654,"targetDuration":4,"studyType":23,"phases":656,"briefSummary":657,"conditions":658,"keywords":660,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":667,"leadSponsor":668,"locationsCount":50},"100485860","drug-free-without-toothache-a-study-of-free-dental-treatment-as-a-part-of-substance-abuse-treatment-100485860","NCT05606562","Drug-free Without Toothache. A Study of Free Dental Treatment as a Part of Substance Abuse Treatment","Drug-free Without Toothache. A Non-randomized Intervention Study of Free Dental Treatment as a Part of Substance Abuse Treatment.","RUST","Inclusion Criteria:\n\nPeople who are hospitalized for drug abuse at Russeksjon UNN Narvik.\n\nExclusion Criteria:\n\nNon",{"count":655,"type":22},50,[25],"Objectives: The main objective of the study is to investigate\n\n1. How many patients will attend and complete dental care if they are offered it for free during the stay at \"The department of substance abuse treatment, University Hospital North Norway (UNN) in Narvik\".\n2. Explore whether a parallel dental treatment in addition to the other treatment at the department has a beneficial effect on the abuse treatment, or whether it can be disruptive to offer dental treatment in combination with admission for drug rehabilitation?",[30,659],"Dental Caries",[661],"Non Randomized Interventional study","2022-10-31",{"date":664,"type":42},"2022-11-04",{"date":666,"type":42},"2022-04-06",{"date":289,"type":22},{"name":669,"class":49},"University Hospital of North Norway"]