[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"substance-use-drugs-alcohol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:substance-use-drugs-alcohol":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,47,80,104,133,159,193,228,258,279,300,331],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100053892","early-phase-1-digital-intervention-delivered-via-street-medicine-to-increase-hiv-and-substance-use-care-among-survivors-of-sex-trafficking-100053892",false,"NCT07699484","Digital Intervention Delivered Via Street Medicine to Increase HIV and Substance Use Care Among Survivors of Sex Trafficking","Digital Intervention Delivered Via Street Medicine to Increase HIV and Substance Use Care Among Survivors of Sexual Trafficking","1. Age 18 years and above at enrollment\n2. Woman\n3. Screen positive for lifetime sexual trafficking","FEMALE","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The goal of this clinical trial is to learn if the CONNECT program helps women with a history of sex trafficking get connected to substance use, HIV\u002FSTI, and mental health services. It will also learn whether the program is practical to deliver and acceptable to participants. The main questions it aims to answer are:\n\nDoes CONNECT increase participants' engagement in substance use treatment (such as starting medication for opioid use disorder or therapy for alcohol use), HIV and STI prevention and treatment services (such as starting PrEP or getting tested for STIs), and mental health treatment (such as treatment for PTSD)? Is CONNECT feasible and acceptable for women with a history of sex trafficking?\n\nResearchers will compare CONNECT to usual care to see if CONNECT increases engagement in these health services. The program will be delivered in partnership with a Street Medicine team that provides care directly to unhoused women, with support from a trained care navigator.\n\nParticipants will:\n\nComplete the CONNECT program or receive usual care Work 1:1 with a care navigator who helps with referrals to substance use, HIV\u002FSTI, and mental health services (CONNECT group) Complete assessments at the start of the study and at a 2-month follow-up Answer questions about their substance use, health behaviors, mental health, and use of health services",[26,27,28,29,30,31],"Sex Trafficking","HIV","Substance Use (Drugs, Alcohol)","Mental Health","Sexual Violence","Treatment Engagement",[26,27,33,29,30,31],"Substance Use","NOT_YET_RECRUITING","2026-07-07",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":20},"2026-10-05",{"date":42,"type":20},"2028-06-30",{"name":44,"class":45},"Lifespan","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100594871","adaptation-of-the-family-check-up-online-100594871","NCT07025083","Adaptation of the Family Check-Up Online","Adaptation of Family Check-Up Online in the Latinx Community to Reduce Youth Substance Use","Parent Inclusion Criteria:\n\n* being a self-identified Latinx parent or guardian of a youth age 11-14\n* speaking Spanish\n* cognitively able to complete a brief screener\n* assessments at a 6th grade reading level\n* willing to participate in an online intervention\n* willing for their child to complete confidential assessments\n\nYouth Inclusion Criteria:\n\n* being a middle school student age 11-14\n* reading at the 2nd grade level in English or Spanish\n\nExclusion Criteria:\n\n* having low concerns on the Positive Family Support screener",true,"ALL","11 Years","14 Years",{"count":59,"type":20},108,[61],"NA","Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to community responsive preventative interventions to reduce substance use among youth. Effective implementation of evidence-based interventions that can be delivered online is critical to reduce substance use and problem behaviors among ethnic populations and to scale up for broad dissemination. Adaptation to address community needs has improved parenting practices and youth outcomes beyond the original evidence-based parenting interventions, and adapted parenting programs have the potential to improve cultural socialization, which is associated with improved behavioral outcomes among Latinx youth. However, ongoing tensions in the field highlight the question of whether deep adaptations compared to surface-level adaptations (e.g., translation only) are needed. The FCU is an evidence-based parenting program that has a strong history of reducing substance abuse and externalizing symptoms (e.g., problem behaviors). A community-based participatory approach will be employed to culturally adapt the FCU Online and identify implementation strategies to improve access to and adoption of the intervention, leveraging community and resiliency-promoting assets. Promotores de salud, Spanish-speaking community health workers in an existing community-based research network will deliver the program. To reach the goals of the study, the following aims will guide this research. In Aim 1, a community advisory board of 6 parents and 6 promotores de salud will meet monthly to guide the ecological adaptation of the FCU Online modules and implementation strategies with promotores. In Aim 2, the online version of the intervention will be adapted using iterative Plan-Do-Study-Act cycles to get usability feedback from members of the community advisory board, consistent with best practices designed to adapt interventions in community settings. In Aim 3, using a Hybrid 1, mixed methods design, researchers will assess feasibility, accessibility, adoption, and potential effectiveness of the adapted intervention, FCU-L Online. The team will recruit 108 Latinx families into a 3-arm wait-list randomized control trial: n=36 in the culturally adapted FCU-L Online (e.g., deep adaptation), n=36 in the FCU Online in Spanish without adaptation (e.g., surface level adaptation), and n= 36 in a waitlist control group. Feasibility, accessibility, and adoption will be assessed according to quantitative benchmarks, and qualitative feedback will assess the barriers and facilitators of implementation. Potential effectiveness will be assessed (p \\\u003C .15), including improvement of key intervention mechanisms (parenting practices, parenting efficacy, and cultural socialization) as well as child outcomes (substance use, intentions to use, and externalizing behavior). Findings from this study will inform a Hybrid II randomized controlled implementation trial to test effectiveness while scaling up dissemination of the FCU-L Online. This research could ultimately reduce lifetime risk for substance use among Latinx youth by improving parenting practices and supporting cultural socialization.",[28],[65,66,67,68,69],"adolescence","parenting","adaptation","family","substance use intent","RECRUITING","2026-06-03",{"date":73,"type":38},"2026-06-04",{"date":75,"type":38},"2025-12-19",{"date":77,"type":20},"2027-03-31",{"name":79,"class":45},"University of Oregon",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100633529","emergency-department-substance-use-screening-motivational-interviewing-and-active-referral-targeting-substance-use-disorder-and-overdose-prevention-100633529","NCT07527871","Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention","ED-SMART: Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention","ED-SMART","Inclusion Criteria:\n\n* Adult at least 18 years of age\n* Capacity and willingness to participate (including reliable phone or internet access for counseling session)\n* Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.\n\nExclusion Criteria:\n\n* A priori participant request for participation\n* Previously enrolled in this or other study of substance use disorder prevention\n* Language other than English\n* Expected\u002Factual ED disposition of hospitalization or non-independent status\n* Prisoner at time of enrollment\n* Known to be pregnant at time of enrollment\n* Past substance use disorder or substance use treatment\n* High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone",{"count":89,"type":20},650,[61],"The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.",[28],[94],"substance use","2026-05-19",{"date":97,"type":38},"2026-05-22",{"date":99,"type":20},"2026-06-01",{"date":101,"type":20},"2029-09",{"name":103,"class":45},"Purdue University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":54,"sex":55,"minAge":112,"maxAge":17,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":46},"100628387","nen-nkumbiedahiyedo-plus-we-are-here-now-plus-a-multi-level-intervention-to-reduce-health-disparities-among-american-indian-youth-100628387","NCT07460973","Nen ŨnkUmbi\u002FEdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth","Nen ŨnkUmbi\u002FEdaHiYedo Plus (NE+): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth","NE+","Inclusion Criteria:\n\n* 12 to 18 years old\n* Registered member of a federally recognized tribe or an associate tribal member\n* Resident of the Fort Peck Reservation with a caregiver who agrees for their child to participate in the intervention\n\nExclusion Criteria:\n\n* Not meeting any of the aforementioned inclusion criteria\n* Having a medically identified physical or cognitive impairment that would impede their understanding of and participation in the educational content, activities, and teachings of the intervention","12 Years",{"count":114,"type":20},843,[61],"We Are Here Now - Plus (NE+) is a holistic, culturally centered, and multilevel intervention for American Indian youth to improve sexual health, mental health, and substance use outcomes. The goal of this intervention is to learn if NE+ can decrease substance use during sex, decrease sexual activity, increase condom use, increase positive mental health, increase caregiver(parent)-youth communication, increase communication between school personnel and youth, and increase utilization of clinical services. Researchers will compare one intervention arm to one control arm to see if the aforementioned indicators improve among the intervention arm for youth participants.\n\nYouth participants (ages 12-18) will participate in a 9-month educational program consisting of 18 modules that discuss healthy relationships, puberty \\& physiology (separate girls \\& boys), parenting, pregnancy and sexually transmitted infections (STIs) and Human Immunodeficiency Virus (HIV) prevention, sexual avoidant behaviors with a focus on abstinence, substance use prevention with a focus on abstinence and refusal skills, \\& positive mental health, resources; skills (high school)- self-efficacy, refusal skills, decision making, communication, abstinence; skills (middle school) - health knowledge, self-efficacy, boundaries, communication, abstinence. Youth will also participate in six teachings offered by local cultural leaders that coincide with educational modules, including: kinship networks \\& family; cultural values; 7 sacred roles of tribal members; ceremonies; cultural teachings and responsibilities of women \\& men in tribe \\& ceremonies; Indigenous worldview; skills - knowledge of traditional ways, language \\& cultural people to go to for help; community members roles \\& responsibilities in tribe \\& ceremonies.\n\nCaregiver (parent) participants will participate in three in-person visits\u002Fmeetings to discuss the following: visit 1 - age specific physical, cognitive, emotional, spiritual development; visit 2: prevention of substance use, promoting positive mental health, promotion of healthy relationships; skills -communication with youth; visit 3 - pregnancy and STIs\u002FHIV prevention and abstinence from sex, parental monitoring, tribal resources.\n\nSchool personnel participants will participate in three workshops during teacher in-service training days, including the following information: Workshop 1 - cultural teachings on kinship \\& family networks, cultural values, cultural age \\& community roles; Workshop 2 - sexual risk avoidant behaviors, substance use prevention, positive mental health promotion, pregnancy STIs\u002FHIV prevention, tribal resources; Workshop 3 - culturally respectful communication skills by age \\& youth (boy\u002Fgirl) and age \\& caregiver (male\u002Ffemale); skills - knowledge of cultural ways, substance use prevention, positive mental health promotion, sexual risk avoidant behaviors, culturally respectful communication.",[118,119,29,28],"Healthy","Condom Use",[121,122,123],"Sexual and reproductive health","Mental health","Substance use","2026-05-09",{"date":126,"type":38},"2026-05-12",{"date":128,"type":38},"2026-03-23",{"date":130,"type":20},"2029-05-01",{"name":132,"class":45},"Montana State University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":46},"100635759","a-study-of-senyo-health-with-comorbid-alcohol-use-disorder-treatment-in-bipolar-patients-100635759","NCT07556861","A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients","Senyo Health App - Comorbid Substance Use Disorder Treatment In Bipolar Patients Using A Telehealth Collaborative Care Platform","Inclusion Criteria:\n\n* History of bipolar I disorder, bipolar II disorder, or schizoaffective disorder of the bipolar type\n* Alcohol use disorder.\n* Ability to read, write, and understand English;\n* Minimum DAST (1+) or AUDIT-C score (3+)\n* Access and willingness to use a mobile device for asynchronous (text) and synchronous (video) engagement with care;\n* Eligibility determined by ASAM Assessment\n\nExclusion Criteria:\n\n* Diagnosed personality pathology as the primary presenting concern based on clinical judgment, severe cognitive impairment (e.g., intellectual disability or dementia), or psychosis;\n* Inability to actively participate in and learn from psychotherapeutic interaction based on clinical evaluation and clinical judgment;\n* Needing a higher level of mental health care as demonstrated by ASAM\\[36\\] assessment;\n* Decline to answer suicidality questions;\n* Already admitted into or about to initiate treatment in another addiction treatment program.\n* Currently attending High School.\n* Pregnancy confirmed by self-report",{"count":141,"type":20},40,[61],"The purpose of this study is to examine the effectiveness of a digital integrated behavioral health (IBH) platform in improving substance use outcomes, including treatment retention and substance use frequency and severity in patients with Bipolar Disorder.",[145,28],"Bipolar Disorder",[147,33,148,149],"Bipolar","SUD","Alcohol","2026-04-22",{"date":152,"type":38},"2026-04-29",{"date":154,"type":20},"2026-05-16",{"date":156,"type":20},"2029-01-20",{"name":158,"class":45},"Mayo Clinic",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":175,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":192},"100609621","the-community-paramedic-response-and-overdose-outreach-with-supportive-medical-legal-services-study-100609621","NCT07216963","The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study","The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services (CROSSROADS) Study","CROSSROADS","Inclusion Criteria:\n\n* 18 years old or older;\n* Has interacted with a CP team (and, thus, experienced a non-fatal opioid and\u002For stimulant overdose) in the last 30 days;\n* Has independent legal agency\n* Able to independently provide informed consent; and\n* Able to speak and understand English.\n\nExclusion Criteria:\n\n\\- Active, severe, and untreated mental illness that would make providing consent impossible",{"count":168,"type":20},400,[61],"The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and\u002For stimulant-related non-fatal overdose and had contact with staff from a Community Paramedic (CP) program.\n\nParticipants will be randomly placed into one of two groups:\n\n1\\) Standard of care from the CP program, or 2) CROSSROADS, which includes CP care plus a Medical-Legal Partnership (MLP). The MLP helps people with legal problems that can affect their health-- like issues with housing or public benefits.\n\nResearchers will test if the CROSSROADS intervention reduces drug use and involvement with the criminal legal system.\n\nPeople in the study will be followed for one year and asked to complete surveys at the beginning, and again at 1 month, 6 months, and 12 months.",[172,173,174,28],"Opioid Use Disorder","Overdose, Drug","Overdose",[174,176,177,178,179,180,181,182],"Community Paramedic","Medical-Legal Services","Criminal Legal System","Consolidated Framework for Implementation Research","Paramedical Personnel","Human Centered Design","Criminal Legal","2026-04-07",{"date":185,"type":38},"2026-04-13",{"date":187,"type":20},"2026-09-01",{"date":189,"type":20},"2030-08-01",{"name":191,"class":45},"Duke University",4,{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":55,"minAge":201,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":46},"100632971","evaluation-of-the-addpro-vocational-reintegration-program-add-pro-eval-100632971","NCT07520617","Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)","Evaluation of the ADD'Pro Program: A Partnership-Based Approach to Support Vocational Reintegration of Patients Receiving Addiction Care (ADD-PRO-EVAL)","ADD-PRO-EVAL","Inclusion Criteria:\n\n* Adult of working age (18 years or older)\n* Diagnosed substance use disorder receiving medical care\n* Unemployed or on sick leave with a vocational reorientation project\n* Motivated to work in the competitive labour market\n* Living in or wishing to work in the Puy-de-Dôme department (63), France\n* Legally authorised to work\n* Capable of providing written informed consent\n* Affiliated with a French social security scheme\n\nExclusion Criteria:\n\n* Medical care provided under a court-ordered treatment obligation\n* Previously included in the ADD'Pro program\n* Residing outside the Puy-de-Dôme with no plan to work in the department\n* Under legal guardianship (tutelle, curatelle, or sauvegarde de justice)\n* Deprived of liberty","16 Years","70 Years",{"count":204,"type":20},100,[61],"The goal of this clinical trial is to evaluate whether an integrated medico-psychosocial vocational support program (ADD'Pro) can improve employment outcomes in adults with substance use disorders receiving care at a specialized addiction day hospital.\n\nThe main question it aims to answer is:\n\n\\- Does participation in the ADD'Pro program increase the rate of competitive employment (at least one day worked in the open labour market) at 6 months compared to standard employment services?\n\nResearchers will compare participants enrolled in the ADD'Pro program to participants referred to conventional employment services (France Travail or Cap Emploi) to see if structured, dual medico-psychosocial support leads to higher rates of vocational reintegration, better employment preparation, improved quality of life, and reduced physiological stress reactivity.\n\nParticipants will:\n\n* Be randomly assigned to either the ADD'Pro program or standard employment services\n* If assigned to ADD'Pro: receive immediate individualised support from a vocational counsellor (CIP) at the CeCler Association, running in parallel with their hospital addiction care, with no fixed end date\n* If assigned to standard care: be referred to conventional employment services with monthly follow-up interviews at the hospital, and the option to join ADD'Pro after 6 months\n* Complete structured interviews and validated questionnaires at inclusion, 3, 6, and 12 months\n* A sub-sample of up to 50 participants will additionally take part in a simulated job interview stress test (adapted TSST) with salivary biomarker collection and heart rate monitoring at inclusion and 6 months",[208,209,210,211,212,213,214,215,216,217,218,28],"Addiction","Addiction Disorders","Substance Use Recovery","Return to Work","Recovery","Recovery Outcomes","Substance Use Disorder (SUD)","Employment, Supported","Employment","Substance Related Disorders","Vocational Rehabilitation","2026-04-02",{"date":221,"type":38},"2026-04-09",{"date":223,"type":20},"2026-04",{"date":225,"type":20},"2029-04",{"name":227,"class":45},"University Hospital, Clermont-Ferrand",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":21,"phases":238,"briefSummary":239,"conditions":240,"keywords":244,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":46},"100583774","the-trans-led-care-study-100583774","NCT06880705","The Trans-Led Care Study","A Gender-Affirming Stigma Intervention to Improve Substance Misuse and HIV Risk Among Transgender Women","TLC","Inclusion Criteria:\n\nEligible transgender adults must:\n\n1. be 18 years of age or older;\n2. speak primarily English;\n3. live in the U.S.;\n4. have a gender identity different from their assumed gender, or sex assigned, at birth;\n5. identify as a person of transgender experience;\n6. endorse having experienced two or more problem(s) related to alcohol or other drug use within the past 12 months.",{"count":237,"type":20},124,[61],"This study is testing a new mutual-help group called \"the TLC program\" for transgender adults who use substances or are recently in recovery. The TLC Program is based on Acceptance and Commitment Therapy or \"ACT\" which is a type of mental health counseling that focuses on using mindfulness skills to connect a person to their values and improve their mental health. The TLC Program was developed by transgender and gender diverse community members, mental health providers, and researchers.",[241,242,214,28,243],"Substance Abuse","Substance Addiction","Human Immunodeficiency Virus (HIV)",[245,246,247,248,249],"Substance misuse","HIV risk","Stigma","Psychological distress","Gender affirmation",{"date":251,"type":38},"2026-03-27",{"date":253,"type":38},"2025-02-10",{"date":255,"type":20},"2027-07-31",{"name":257,"class":45},"Illinois Institute of Technology",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":21,"phases":267,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":4},"100627768","research-and-evaluation-of-link-up-dcr-in-brussels-100627768","NCT07452926","Research and Evaluation of Link-Up, DCR in Brussels","Research and Evaluation of Link-Up, Drug Consumption Room in Brussels","Inclusion Criteria:\n\n* user of the DCR Link-Up in Bruxelles\n* agree to participate\n* sufficient command of either French or Dutch\n\nExclusion Criteria:\n\n* Refusal to participate",{"count":266,"type":20},250,[61],"Link-Up is the second Safer Consumption Room (SCMR) to open in the Brussels-Capital Region. SCMRs are public health facilities designed for people who use drugs mainly in public places. They are hygienically safe spaces where users can safely consume the products they have acquired elsewhere without moral judgment, under the supervision of specially trained professional staff. It is a risk reduction facility. Before Link-Up, two other SCMRs were opened in Belgium, including one, GATE, in the Brussels region. These first two SCMRs are currently undergoing scientific evaluation as part of the REVE-DROOM project (approved by the CEHF (2024\u002F28MAI\u002F276, on 06\u002F18\u002F2024) of the \"Drugs\" research program funded by BELSPO (Federal Science Policy). The present project aims to replicate the study of the effects associated with the use of SCMRs on users, as implemented in the evaluation system currently underway at GATE in the new SCMR, Link-Up, with a view to also evaluating its effects. The RELINK study is being conducted at the request of Iriscare, the bicommunal social protection OIP (Public Interests Organization) of the Brussels-Capital Region.\n\nIt is a study based on a natural experiment (i.e., all Link-Up users who agree to participate in the study will be included) and measures various indicators concerning them. The measured indicators primarily concern risky consumption practices (injection, consumption in public spaces, reuse and\u002For sharing of consumption equipment, and other practices that endanger the health of people who use drugs). As secondary effects, the measures concern the sociodemographic and socioeconomic characteristics of the user population, drug-use profiles, level of social integration, quality of life, level of personal recovery, and care needs.\n\nThe analysis of these various indicators will make it possible to describe the profile of Link-up SCS users and to compare it with that of GATE users. In addition, the study design allows for an extension to conduct a cohort follow-up and, therefore, to measure changes associated with the use of the SCS service.\n\nThe current study aims for a sample of at least 250 people recruited within the service. Indicator measurement is carried out using a questionnaire administered with the assistance of the research team and supported by SCS staff. The questionnaire consists of various scales validated in the scientific literature and already used in the REVE-DROOM study.\n\nGiven the similarity of the proposed Link-Up system with the one implemented at GATE, the results of the two Brussels SCSs will be the subject of a comparative analysis.",[28],"2026-02-27",{"date":272,"type":38},"2026-03-05",{"date":274,"type":20},"2026-03",{"date":276,"type":20},"2026-09",{"name":278,"class":45},"Université Catholique de Louvain",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":21,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":4},"100599730","vr-mindfulness-for-people-with-hiv-and-substance-use-100599730","NCT07088289","VR Mindfulness for People With HIV and Substance Use","Virtual Reality Mindfulness Intervention for Supporting People With HIV and Substance Use","Inclusion Criteria:\n\n* Able to speak, read, and write in English\n* Aged 18 years or older\n* Diagnosed with HIV\n* Currently prescribed ART therapy\n* Reporting moderate to high risk related to alcohol, opioids, nicotine, cannabis, or stimulant use (score of 4 or higher on the Alcohol, Smoking, and Substance Involvement Screening Test - ASSIST). Participants may also use other substances, but the primary risk must fall within these categories, as these have the strongest research support for mindfulness-based interventions.\n* Having stable housing that allow using VR safely\n* Willing to provide contact information for at least one person whom the study team can reach if the participant becomes unreachable after repeated attempts\n\nExclusion Criteria:\n\n* Living in institutionalized settings or unsheltered\n* Terminal illness with a life expectancy of less than 6 months\n* Planning to move out of the area in the next eight weeks\n* Engaging in regular mindfulness practice outside of TRIPP\n* Experiencing fear of closed spaces or unable to tolerate wearing a VR headset (verified during orientation session)\n* Having visual or auditory impairments or severe physical disabilities that hinder VR use, history of seizures, severe cognitive impairment, severe motion sickness, severe unmanaged psychiatric symptoms, or currently pregnant\n* Participants without home internet access will not be excluded and will be provided either funding for internet service or VR headsets preloaded with TRIPP sessions for offline use.",{"count":287,"type":20},30,[61],"The goal of this clinical trial is to explore whether a virtual reality (VR) mindfulness app is acceptable, appropriate, and feasible for supporting people with HIV and substance use problems.\n\nParticipants will:\n\n* Use a VR headset with a mindfulness app at home;\n* Complete three online surveys over three months;\n* Take part in an individual interview or focus group to share their experiences.",[27,28],"2025-07-19",{"date":293,"type":38},"2025-07-28",{"date":295,"type":20},"2026-02",{"date":297,"type":20},"2027-06",{"name":299,"class":45},"Tulane University",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":54,"sex":55,"minAge":112,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":312,"conditions":313,"keywords":318,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":4},"100574072","options-for-navigating-talking-about-risk-and-adolescent-choices-100574072","NCT06754527","Options for Navigating Talking About Risk and Adolescent Choices","Emotion Regulation Intervention to Prevent Substance Use Among Youth in the Child Welfare System","ON-TRAC","Inclusion Criteria:\n\n* Contact with the Rhode Island child welfare system\n* Caregiver who is a parent\u002Fguardian of a child who experienced maltreatment\n* Caregiver who speaks English or Spanish\n* Caregiver who does not have developmental delays\n* Adolescent who is between 12-15 years of age\n* Adolescent who is fluent in English\n* Adolescent who has active follow-up with the Rhode Island child welfare system due to an indicated finding of abuse or neglect in the past year\n\nExclusion Criteria:\n\n* Adolescent who cannot read at a 4th grade level\n* Adolescent who has a sibling who has participated in the program\n* Adolescent who has developmental delays\n* Adolescent who lacks parental consent for the study","15 Years",{"count":310,"type":20},200,[61],"This study will examine the effectiveness of ON-TRAC (Options for Navigating Talking about Risk and Adolescent Choices), which is an online substance use prevention program that also teaches emotion regulation skills. 200 adolescents, 12-15 years of age, will be randomized to ON-TRAC or a wait list comparison group (who will be offered the intervention at the end of their study participation) to determine impact on substance use, emotion regulation abilities, mental health symptoms, and other risk behavior outcomes.",[28,314,33,315,316,317],"Substance Use Risk","Emotion Regulation","Risk Reduction Behavior","Risk Reduction",[319,320,321],"adolescent substance use","emotion regulation","risk reduction","2024-12-30",{"date":324,"type":38},"2025-01-01",{"date":326,"type":20},"2026-03-01",{"date":328,"type":20},"2029-02-01",{"name":330,"class":45},"Rhode Island Hospital",{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":340,"phases":4,"briefSummary":341,"conditions":342,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":46},"100566460","understanding-psychological-distress-and-therapeutic-environment-in-the-emergency-department-100566460","NCT06655467","Understanding Psychological Distress and Therapeutic Environment in the Emergency Department","UPDATE-ED","Inclusion Criteria:\n\n* Issues of mental health AND\u002FOR\n* Issues of substance use AND\u002FOR\n* Psychological distress (this refers to patients without an established mental health or substance use disorder who nonetheless present in a distressed state, where distress is not caused by a readily identifiable and treatable physical condition) AND\u002FOR\n* Where the treating ED team feel the patient would benefit from some form of mental health or addictions assessment or intervention, whether carried out by ED staff, specialist services or third sector agencies.\n\nExclusion Criteria:\n\n1. Patients aged 10 and under.\n2. Patients with distress caused by a physical condition, relieved by appropriate treatment.\n3. Delirium, unless caused by a mental health- or substance-related disorder.\n4. Patients with alcohol intoxication alone, without other evidence of harmful use of alcohol and without evidence of psychological distress.",{"count":339,"type":20},398,"OBSERVATIONAL","This research aims to establish the number of patients coming to Emergency Departments (EDs) with issues relating to mental health, alcohol or drugs, or in some form of psychological distress, including those for whom this was not the main reason for attending ED. We will collect anonymous information on age, gender, ethnicity, when and how they came to the ED, where and how they are cared for whilst in the ED, and what happens to them afterwards. With this information we hope to build a better picture of these patients so we can go on to design and test ways to improve their care in the future.",[29,28,343],"Psychological Distress","2024-12-08",{"date":346,"type":38},"2024-12-12",{"date":348,"type":20},"2025-02-03",{"date":350,"type":20},"2025-03-18",{"name":352,"class":353},"NHS Fife","OTHER_GOV"]