[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"substance-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:substance-use":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,64,0,25,[9,49,76,102,128,178,207,231,258,282,302,323,361,384,406,428,454,484,508,556,577,599,628,650,673],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053894","cultural-adaptation-of-drug-treatment-for-djj-youth-100053894",false,"NCT06003725","Cultural Adaptation of Drug Treatment for DJJ Youth","The Cultural Adaptation of an Alcohol and Other Drug Use Treatment for Black Justice Involved Youth","CAST","For Focus Groups and Interviews:\n\nBlack JIY Participants:\n\nInclusion Criteria:\n\n• 1) Between the ages of 13-17; 2) identify as Black or African American; and 3) on community probation.\n\nExclusion Criteria:\n\n• Will be excluded if they do not have parental consent to participate.\n\nFor Focus Groups and Interviews:\n\nAdult Participants\n\nInclusion Criteria:\n\n* A guardian of JIY\n* An advocate (someone who supports change and reform in the justice community) for Black JIY.\n\nExclusion Criteria:\n\n• Will be excluded if they do not provide consent to participate.\n\nFor pilot feasibility study:\n\nBlack JIY Participants:\n\nInclusion Criteria:\n\n* Between the ages of 13 and 17\n* Identify as Black or African American\n* Be on community probation\n* Meet criteria for alcohol, cannabis, or other drug misuse as defined by the DSM 5\n* Be experiencing at least 1 problem related to AOD;\n* The frequency of AOD must be weekly use over a 3-month period\n\nExclusion Criteria:\n\n* Will be excluded if they do not have parental consent to participate\n* Parole violation",true,"ALL","13 Years","17 Years",{"count":23,"type":24},55,"ESTIMATED","INTERVENTIONAL",[27],"NA","This project aims to improve the understanding of the impact of Ethnic and Racial Discrimination (ERD) on adolescent alcohol and other drug use (AOD) within the Black Justice-Involved Youth (JIY) population. Individual interviews with Black JIY and focus groups with parents and guardians of Black JIY and community members who support change and reform in the justice community for Black JIY will be conducted.",[30],"Substance Use",[32,33,34,35],"Substance use","substance misuse","adolescent","cultural adaptation","RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2024-05-15",{"date":44,"type":24},"2027-08-30",{"name":46,"class":47},"University of California, San Francisco","OTHER",2,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":25,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100645317","cbits-rtm-pilot-study-100645317","NCT07682441","CBITS-RTM Pilot Study","Preventing Substance Use Among Incarcerated Youth Through Addressing Posttraumatic Stress","Inclusion Criteria:\n\n* Youth must 1) be currently incarcerated in a partnering juvenile detention center, 2) be between 13-18 years of age, and 3) have a minimum of 3 months remaining on their sentence (i.e., sufficient time required to complete CBITS-RTM). Youth will complete a screening with a study team member involving the 2-item Abbreviated PTSD Checklist-Civilian version, with scores ≥4 considered a positive screen\n* Clinicians are eligible if they are behavioral health staff working with youth at the detention school..\n\nExclusion Criteria:\n\n* Observable cognitive or developmental delays or active psychosis that would interfere with completing consent, assessment or intervention.",{"count":57,"type":24},28,[27],"This pilot study, conducted in partnership with juvenile detention centers, evaluates an adapted CBITS-RTM intervention delivered in a detention school setting.",[61,30],"PTSD - Post Traumatic Stress Disorder",[63,64,65],"Incarcerated youth","Juvenile detention school","CBITS-RTM","NOT_YET_RECRUITING","2026-06-26",{"date":69,"type":40},"2026-07-02",{"date":71,"type":24},"2026-09-01",{"date":73,"type":24},"2027-12-31",{"name":46,"class":47},1,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":19,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":25,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":75},"100632639","feasibility-of-incorporating-a-standardized-substance-use-measure-with-linked-brief-intervention-into-routine-psychosocial-care-of-adult-childhood-cancer-survivors-100632639","NCT07516301","Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors","Piloting the Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors","Inclusion Criteria:\n\n* Followed in the ACT Clinic at St. Jude Children's Research Hospital\n* Greater than or equal to 15 years of age at time of evaluation\n* Able to speak and read English\n\nExclusion Criteria:\n\n* Significant mental or cognitive impairment that would impact ability to complete surveys or participate in the brief intervention","15 Years",{"count":85,"type":24},30,[27],"The ASSIST Study is designed to explore whether a brief, evidence based substance use screening and counseling approach can be easily integrated into routine survivorship care at St. Jude Children's Research Hospital.\n\nDuring a regularly scheduled psychosocial visit, participants complete the World Health Organization's Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). This short questionnaire helps identify patterns of use related to tobacco, alcohol, cannabis, prescription medications, and other substances. Survivors whose results show possible risk receive a brief, supportive counseling session during the same appointment. This session uses motivational interviewing techniques to help individuals reflect on their use and consider steps to reduce potential harm.\n\nPrimary Objective:\n\n\\- Assess the feasibility and acceptability of integrating a standardized substance use screening and brief intervention protocol into routine psychosocial workflows within a survivorship clinic.\n\nSecondary Objective:\n\n\\- Evaluate the fidelity of delivering a brief substance use intervention to reduce substance use behaviors among survivors.",[89,30],"Survivors of Childhood Cancer",[91,92],"Adult childhood cancer survivors (ACCS)","Cancer Survivorship","2026-06-25",{"date":95,"type":40},"2026-06-29",{"date":97,"type":24},"2026-07",{"date":99,"type":24},"2028-10",{"name":101,"class":47},"St. Jude Children's Research Hospital",{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":12,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":25,"phases":112,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":75},"100644783","substance-use-prevention-for-recently-displaced-adults---supra-r33-rct-100644783","NCT07672457","Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT","SUPRA RCT R33","Inclusion Criteria:\n\n1. Age 18 or over\n2. Have been displaced at least once due to Anti-Terrorist Operation (ATO) or full-scale invasion since 2014\n3. Self-reported use of at least one substance other than alcohol and tobacco within the past 3 months\n4. Ability to provide informed consent and speak Ukrainian or Russian\n\nExclusion Criteria:\n\n1. Self-reported diagnosis of a substance use disorder\n2. Inability to provide informed consent","18 Years",{"count":111,"type":24},144,[27],"This study is a randomized controlled trial among 144 internally displaced people to determine the feasibility, acceptability, and preliminary effectiveness of a single-session Acceptance of Commitment Therapy (ACT) group therapy on preventing or reducing substance use behaviors.",[115,30,116],"Prevention","Refugee Health",[118,119,30],"Displacement","Ukraine","2026-06-23",{"date":95,"type":40},{"date":123,"type":24},"2027-04",{"date":125,"type":24},"2028-12",{"name":127,"class":47},"Boston Medical Center",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":12,"sex":19,"minAge":136,"maxAge":21,"enrollmentInfo":137,"targetDuration":4,"studyType":25,"phases":139,"briefSummary":140,"conditions":141,"keywords":167,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":75},"100619125","neuroimaging-of-adolescent-cannabis-use-treatment-100619125","NCT07340554","Neuroimaging of Adolescent Cannabis Use Treatment","Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment","ACT","Inclusion Criteria:\n\n* 14-17 year old youth\n* Guardian 18 years or older\n* Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and\u002For hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant\n* Youth must endorse having used cannabis at least once per week over the past month OR youth must have been diagnosed with cannabis use disorder within the past three months\n\nExclusion Criteria:\n\n* Youth has a history of Fetal Alcohol Spectrum Disorder, intellectual disorders, pervasive development disorder or autism spectrum disorder, psychotic disorders, history of neurological problems (epilepsy, traumatic brain injury, brain tumor, cerebrovascular disease) by parent\u002Fguardian report\n* Youth or caretaker who is monolingual non-English speaker\n* Youth who is currently experiencing active psychosis symptoms or suicidal\u002Fhomicidal ideation or who has been hospitalized within the past 6 months for psychosis or suicidality\u002Fhomicidality\n* Youth who is currently undergoing contingency management treatment for cannabis use disorder","14 Years",{"count":138,"type":24},80,[27],"This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.",[142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,30,162,163,164,165,166],"Cannabis Use","Cannabis Dependence","Cannabis Use Disorder","Cannabis Abuse","Cannabis Intoxication","Cannabis Smoking","Cannabis Withdrawal","Cannabis-Related Disorder","Cannabis Abuse, in Remission","Cannabis Abuse, Episodic Use","Marijuana","Marijuana Abuse","Marijuana Use","Marijuana Smoking","Marijuana Dependence","Marijuana User","Marijuana-Related Disorder","Marijuana Use Disorder","Addiction","Addiction, Substance","Substance Use Disorders","Substance Dependence","Substance Abuse","Substance Related Problem","Substance Abuse Drug Chronic",[168,152,160],"Cannabis","2026-06-18",{"date":171,"type":40},"2026-06-22",{"date":173,"type":40},"2026-06-15",{"date":175,"type":24},"2030-05-01",{"name":177,"class":47},"Indiana University",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":25,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":75},"100622025","finding-emotional-empowerment-and-lifelong-strength-100622025","NCT07378254","Finding Emotional Empowerment and Lifelong Strength","Co-Producing a Trauma and Substance Use Mental Health Literacy Intervention","FEELS","Inclusion Criteria:\n\n1. Self-identify as Black or African American\n2. Be between the ages of 18 and 35 years old\n3. Endorse previous lifetime trauma exposure\n4. Participants must speak English\n5. Participants are capable of giving informed consent and capable of complying with study procedures.","35 Years",{"count":138,"type":24},[27],"This study will build a partnership with a Community Advisory Board to co-produce, and then pilot test, a theory-guided mental health literacy intervention focused on trauma and substance use. Participants will take part in educational group sessions for 12 weeks and complete assessments at baseline and two follow-up time points (mid-intervention and post-intervention). Intervention participants will be randomly invited to post-study focus groups to gather feedback on their experiences in the program.",[191,30],"Trauma and Stressor Related Disorders",[193,194,195,196,197,198],"mental health literacy","trauma","substance use","psychoeducation","Black and African American","young adults","2026-06-16",{"date":169,"type":40},{"date":202,"type":40},"2026-03-10",{"date":204,"type":24},"2028-06",{"name":206,"class":47},"Rutgers, The State University of New Jersey",{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":25,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":75},"100643328","development-of-a-mobile-health-intervention-to-support-functioning-of-veterans-with-substance-use-disorders-100643328","NCT07645131","Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders","Inclusion Criteria:\n\n* current SUD diagnosis according to chart review\n* current enrollment in VACHS residential SUD treatment program\n* competent to provide written informed consent\n* a working smartphone with wireless capabilities or willingness to use a study-provided smartphone\n\nExclusion Criteria:\n\n* current psychosis\n* current active suicidal\u002Fhomicidal ideation\n* physical disability (e.g., uncorrected vision) that would preclude use of smartphones and\u002For smartphone applications\n* cognitive impairment that would interfere with study participation or ability to provide informed consent, as determined by clinical interview",{"count":85,"type":24},[27],"This project will involve the development, refinement, and preliminary testing of a mobile health intervention (Motivational Enhancement Therapy Skills for Veterans; \"METS4Vets\"), which will be delivered through a smartphone app. The intervention will aim to support Veterans who are navigating the critical transition from structured residential substance use treatment to outpatient settings.",[30],[32,218,219,220],"mHealth","Functioning","Veterans","2026-06-08",{"date":223,"type":40},"2026-06-12",{"date":225,"type":24},"2026-10-01",{"date":227,"type":24},"2031-09-30",{"name":229,"class":230},"VA Office of Research and Development","FED",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":25,"phases":241,"briefSummary":242,"conditions":243,"keywords":245,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":48},"100600174","neurobehavioral-signatures-of-sign--and-goal-tracking-in-emerging-adults-translation-of-a-preclinical-model-100600174","NCT07094061","Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model","SIGN","Inclusion Criteria:\n\n* 18-22 years old at baseline\n* Right-handed\n* Medically\u002Fphysically able to give informed consent\n* English-speaking\n* Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)\n\nExclusion Criteria:\n\n* Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)\n* History of psychosis in self or first-degree relative\n* Current treatment for substance use disorder\n* Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)\n* Intelligence quotient (IQ) \\\u003C 70\n* Lifetime history of head trauma with loss of consciousness \\> 5 minutes\n* Reliance on glasses to be able to read small text at a distance of approximately 30 inches\n* Colorblindness\n* MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol","22 Years",{"count":240,"type":24},294,[27],"This study seeks to understand individual differences in personality, brain function, and behavior.\n\nStudy hypothesis:\n\n\\- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.",[30,244],"Healthy",[246,247,248,249],"Functional magnetic resonance imaging (fMRI)","Questionnaires","Interviews","Behavioral tasks",{"date":251,"type":40},"2026-06-10",{"date":253,"type":40},"2025-10-03",{"date":255,"type":24},"2028-08",{"name":257,"class":47},"University of Michigan",{"id":259,"slug":260,"hasResults":12,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":19,"minAge":265,"maxAge":266,"enrollmentInfo":267,"targetDuration":4,"studyType":25,"phases":269,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":75},"100496397","adaptation-and-evaluation-of-bright-horizons-100496397","NCT05743699","Adaptation and Evaluation of Bright Horizons","Adaptation and Evaluation of Bright Horizons: An Evidence Based Intervention for Prevention of Binge Drinking and Drug Use","Inclusion Criteria:\n\n* Aged 10-24\n* Confirmed binge alcohol use event reported to the surveillance system within 90 days\n* Self identify as Native American\n* Reside on or near the Fort Apache Indian Reservation\n* Have parental or legal guardian consent\u002Fprovide youth assent\n\nExclusion Criteria:\n\n* Unstable and severe medical, psychiatric or drug use problems that necessitates inpatient treatment\n* Acute suicidal or homicidal ideation requiring immediate intervention\n* Recent and severe stressful life events such as physical or sexual abuse, or violent crime victimization that requires specific and high intensity interventions or out of home placement\n* Doesn't speak English\n* Severally visually impaired","10 Years","24 Years",{"count":268,"type":24},100,[27],"This study will test if a program called 'Bright Horizons' is effective at reducing binge substance use among adolescents.\n\nBright Horizons is a culturally adapted intervention developed and tested through a partnership between The White Mountain Apache Tribe and Johns Hopkins University. Bright Horizons is a brief intervention that teaches emotion regulation, coping skills, and problem solving. The intervention also uses goal setting to reduce alcohol and other substance use and to connect to individuals with treatment.",[272,30],"Alcohol Abuse","2026-06-05",{"date":275,"type":40},"2026-06-09",{"date":277,"type":40},"2025-07-17",{"date":279,"type":24},"2027-01-31",{"name":281,"class":47},"Johns Hopkins Bloomberg School of Public Health",{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":18,"sex":19,"minAge":265,"maxAge":136,"enrollmentInfo":288,"targetDuration":4,"studyType":25,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":75},"100587525","the-development-and-evaluation-of-a-culturally-grounded-ends-intervention-for-rural-hawaiian-youth-100587525","NCT06929520","The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth","Inclusion Criteria:\n\n* 6th-8th grade students attending a public or public-charter school on Hawaii Island.\n\nExclusion Criteria:\n\n* K-5th grade students and 9th-12th grade students on Hawaii Island.",{"count":289,"type":24},500,[27],"The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims. AIM 1 (Years 1-3) are focused on pre-intervention and intervention development. In Year 1, youth focus groups will be conducted to assess the environmental demands related to ENDS use in rural Hawai'i. In Year 2, specific ENDS-related problem situations (i.e., situations that increase risk for ENDS use) will be extracted from the Year 1 focus groups and prioritized through survey methods with 200-250 predominately Native Hawaiian youth across 16 different middle\u002Fintermediate schools on Hawai'i Island. In Year 3, five situations found to be the most frequently experienced and\u002For difficult to manage by youth surveyed in Year 2 will serve as the foundation for the development of narrative scripts. Three of these scripts will be cast and filmed on location on Hawai'i Island by a professional film director, and will be edited into three short films, 6-8 video clips, and 6-8 professional photos or production stills. Similar to the investigators' prior drug prevention research in rural Hawai'i, classroom-based lessons will be created to support the short films. Additional lessons and videos from an evidence-based, culturally grounded substance abuse prevention curriculum for Hawaiian youth (Ho'ouna Pono) will be used to create a modular classroom curriculum. The video clips and professional photography\u002Fproduction stills will be embedded with prevention messaging, and will be used for a social and print media campaign to reinforce the classroom curriculum. AIM 2 (Years 4-5) is to evaluate the ENDS prevention intervention (classroom curriculum plus social\u002Fprint media campaign) across all middle\u002Fintermediate public or public-charter schools (N = 16) and up to 11 different cultural immersion charter schools on Hawai'i Island using a dynamic wait-listed control group design.",[293,30],"E-cigarette Use","2026-06-03",{"date":273,"type":40},{"date":297,"type":40},"2025-10-15",{"date":299,"type":24},"2027-05-15",{"name":301,"class":47},"University of Hawaii",{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":25,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":75},"100626290","project-reach-a-comprehensive-telehealth-intervention-at-syringe-service-programs-to-engage-people-who-use-drugs-100626290","NCT07433712","Project REACH: A Comprehensive Telehealth Intervention at Syringe Service Programs to Engage People Who Use Drugs","People Who Use Drugs Inclusion Criteria:\n\n* 18 years of age or older\n* able to speak and understand English\n* have used an illicit substance at least once in the past year\n* have lived in the study area (in or near their city of their recruitment) for at least 6 months\n* have active health insurance by the start of the Project REACH trial date\n\nPeople Who Use Drugs Exclusion Criteria:\n\n* Unable or unwilling to provide informed consent\n\nStakeholder Inclusion Criteria:\n\n* 18 years of age or older\n* able to speak and understand English\n* currently employed or volunteering with the PCC or an SSP enrollment site for at least one year at the time of the interview OR hired as a study navigator at one of the four enrollment sites\n\nStakeholder Exclusion Criteria:\n\n* Unable or unwilling to provide informed consent",{"count":309,"type":24},121,[27],"This trial will assess the feasibility, acceptability, and preliminary effectiveness of Project REACH (Remote Engagement \\& Access for Community Health), a telehealth intervention at syringe service programs (SSP) to improve access to HIV-related evidence-based interventions (EBI) for people who use drugs including those who inject them.",[30,313],"Drug Use","2026-05-18",{"date":316,"type":40},"2026-05-19",{"date":318,"type":40},"2026-05-06",{"date":320,"type":24},"2028-05-01",{"name":322,"class":47},"University of Minnesota",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":18,"sex":331,"minAge":83,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":25,"phases":335,"briefSummary":336,"conditions":337,"keywords":340,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":48},"100561090","the-collaborative-care-prtner-study-100561090","NCT06585631","The Collaborative Care PrTNER Study","The Collaborative Care PrTNER (Prevention, Treatment, Navigation, Engagement, Resource) Project","PrTNER","Inclusion Criteria:\n\nAim 1:\n\n* 15-24 years old;\n* Cisgender male;\n* History of condomless sex;\n* Moderate-to-high risk SU behaviors based upon a Car, Relax, Alone, Forget, Friends, Trouble (CRAFFT) score ≥2,\n* Living in Philadelphia, PA or Baltimore, MD, and surrounding areas;\n* Able to read and write in English\n\nAim 2:\n\n* 15-29 years old;\n* Cisgender male;\n* Living with a diagnosis of HIV;\n* CRAFFT score ≥2,\n* Living in Philadelphia, PA or Baltimore, MD, and surrounding areas;\n* Able to read and write in English\n\nAim 3\n\n• All randomized study participants will be included in Aim 3.\n\nExclusion Criteria:\n\nAim 2:\n\n* Participants will be excluded if they are:\n* Assigned female sex at birth\n* Identify as transgender\n* Outside the age criteria (\\\u003C15 or \\>29 years old)\n* Cognitively unable to complete study requirements\n* Living outside of the two geographic areas\n* Do not screen positive for SU\n* No prior substance use history\n* No prior condomless sex;\n* Unable to read or write in English,\n* Plan to move in the next 12 months.","MALE","29 Years",{"count":334,"type":24},275,[27],"A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among young aged 15 to 29 through engagement in SU treatment.",[338,162,30,339],"HIV","AIDS",[338,339,32,341,342,343,344,345,346,347,348,349,350,351,352],"Substances use disorder","drug use","alcohol use","preexposure prophylaxis","PrEP","peer coaches","community health worker","young men","adolescents","young male","young males","adolescent males","2026-05-15",{"date":314,"type":40},{"date":356,"type":40},"2025-01-02",{"date":358,"type":24},"2028-06-30",{"name":360,"class":47},"Children's Hospital of Philadelphia",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":367,"eligibilityCriteria":368,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":332,"enrollmentInfo":369,"targetDuration":4,"studyType":25,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":75},"100637993","mhealth-service-linkage-for-young-adults-impacted-by-the-criminal-legal-system-100637993","NCT07599722","mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System","Technology Enhanced Substance Use and HIV Service Navigation for Justice-Involved Young Adults","LYNX","Inclusion Criteria:\n\n* Self-report recent criminal legal involvement (past year);\n* Self-identify as HIV-negative\n* Endorse behaviors in the past 6 months indicating consideration of PrEP per the Center for Disease Control and Prevention's (CDC) risk indices\n* Meet the Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS) Tools' criteria for identifying the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) substance use disorder\n* Are conversant in English.\n\nExclusion Criteria:\n\n* Being on PrEP\n* Cognitive delays that would interfere with consent or participation\n* Inability to provide contact information for \\>2 locator individuals",{"count":370,"type":24},50,[27],"This study is designed to test Project LYNX, a program designed to help young adults (ages 18-29) with recent criminal legal system involvement can find and get connected to substance use and HIV-prevention services in the community. The program combines support from a trained peer navigator with easy-to-use digital tools.\n\nThe study will:\n\n* Adapt an existing navigator program by adding new digital (eHealth) tools that were co-developed with young adults. These tools will help navigators refer participants to the right health services.\n* Refine and test the updated program to make sure it works well and is easy to use.\n* Evaluate whether the program is feasible, acceptable, and helpful in linking young adults to substance use treatment and HIV-prevention services.\n\nThe overall goal is to create a practical, user-friendly system that supports young adults find and get connected to services for substance use and HIV prevention that they need.",[374,30],"HIV Prevention","2026-05-13",{"date":377,"type":40},"2026-05-20",{"date":379,"type":24},"2026-07-01",{"date":381,"type":24},"2027-02-01",{"name":383,"class":47},"University of Pittsburgh",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":331,"minAge":109,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":25,"phases":393,"briefSummary":394,"conditions":395,"keywords":396,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":405,"locationsCount":48},"100559103","the-hastiin-bidziil-strong-man-intervention-100559103","NCT06559774","The Hastiin Bidziil (Strong Man) Intervention","The Hastiin Bidziil (Strong Man) Intervention: A Study to Measure the Effectiveness of a Secondary Prevention Program Aimed at Reducing Substance Use Among Adult Native Men","Inclusion Criteria:\n\n* Self-identify as American Indian\n* Self-identify as a man\n* Age 18 years or older at time of enrollment\n* Screen positive for lifetime use of alcohol and\u002For drugs, except for tobacco use only\n* Reside within \\~60 miles of a study community (Fort Defiance, AZ; Chinle, AZ)\n\nExclusion Criteria:\n\n* Any condition that would affect successful participation (e.g., planned move)\n* Profound disability that limits the ability to participate in assessments or interventions\n* Participated in the preliminary phase of this study to adapt CETA for this project",{"count":392,"type":24},160,[27],"The Hastiin Bidziil (Strong man) Intervention study is part of a larger project called, Community-Driven Indigenous Research, Cultural Strengths \\& Leadership to Advance Equity in Substance Use Outcomes (CIRCLE) Center of Excellence. CIRCLE aims to address drug use related health problems in collaboration with diverse Indigenous communities. This study is a randomized controlled trial study to measure the effectiveness of a secondary prevention program, called Hastiin Bidziil (Strong Man), aimed at reducing substance use among Native American Indian (AI) men ages 18 years and older",[30],[397,398],"Young Men","Common Elements Treatment Approach (CETA)","2026-05-12",{"date":401,"type":40},"2026-05-14",{"date":403,"type":40},"2025-06-18",{"date":204,"type":24},{"name":281,"class":47},{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":412,"eligibilityCriteria":413,"healthyVolunteers":12,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":25,"phases":416,"briefSummary":417,"conditions":418,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":426,"locationsCount":75},"100609433","permanent-supportive-housing-overdose-prevention-study-100609433","NCT07214519","Permanent Supportive Housing Overdose Prevention+ Study","Preventing Overdose in Supportive Housing: Stepped Wedge Randomized Controlled Trial of a Multi-Sector, Upstream Intervention","POP+","We will be enrolling supportive housing agencies from NY and NJ to participate in this study. Trial enrollment and intervention delivery will occur at the level of the agency. There are anticipated to be 24 supportive housing agencies total that will be enrolled in the study; approximately 6 agencies will be randomly assigned to each of the four intervention waves in the stepped wedge randomized controlled trial.\n\nInclusion Criteria:\n\nSupportive Housing Agencies\u002FIndividuals who Work at Supportive Housing Agencies:\n\n* Serve at least 40 tenants in New York and\u002For New Jersey\n* Have a significant concern for overdose (as demonstrated by past year tenant overdose)\n* Be willing to complete all activities required for participation in the trial\n\nTenants who Live in Supportive Housing Agencies:\n\n* Must live in an enrolled Supportive Housing Agency\n* Must be 18 years and older\n\nExclusion Criteria:\n\n* See inclusion criteria.",{"count":415,"type":24},2940,[27],"This community-partnered study examines a technical assistance intervention designed to help permanent supportive housing agencies implement evidence-based practices to prevent tenant overdose and improve tenant health.",[419,30],"Overdose","2026-05-05",{"date":318,"type":40},{"date":423,"type":24},"2027-07-01",{"date":425,"type":24},"2031-03-31",{"name":427,"class":47},"NYU Langone Health",{"id":429,"slug":430,"hasResults":12,"nctId":431,"briefTitle":432,"officialTitle":432,"acronym":433,"eligibilityCriteria":434,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":435,"targetDuration":4,"studyType":25,"phases":437,"briefSummary":438,"conditions":439,"keywords":440,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":453},"100636271","linking-individuals-needing-care-for-substance-use-disorders-to-peer-coaches--across-incarceration-settings-100636271","NCT07563517","Linking Individuals Needing Care for Substance Use Disorders to Peer Coaches & Across INcarceration Settings","LINCS UP & IN","Inclusion Criteria:\n\n* Incarcerated at participating jail\n* Able to speak and understand English\n* Score of 3 or greater - \"moderate level\", \"substantial level\", or \"severe level\" of problems related to drug abuse - on DAST-10.\n* Willing to follow study procedures and complete research follow-up calls\n* Have at least two reliable contact numbers, e.g. participant and one or more relatives or close friends\n\nExclusion Criteria:\n\n* Cognitive impairment (inability to comprehend the informed consent document as assessed by study staff during enrollment)\n* Prior participation in the study\n* Awaiting transfer to prison or jail outside the state of Georgia",{"count":436,"type":24},550,[27],"The goal of this study is to learn whether a virtual peer recovery coach (PRC) intervention can improve engagement in addiction treatment among incarcerated adults with substance use disorders.\n\nThe main questions it aims to answer are:\n\n* Does the PRC intervention increase engagement with at least one recovery resource at 30 and 90 days?\n* Does it improve secondary outcomes such as substance use, recovery capital, overdose events, and recidivism?\n\nResearchers will compare Treatment-as-Usual with the PRC telehealth intervention to see if PRC support improves engagement in addiction care.\n\nParticipants will:\n\n* Complete baseline and follow-up assessments\n* Receive either Treatment-as-Usual or a virtual PRC session focused on motivational interviewing and linkage to recovery resources",[30],[441,442,443],"Support groups","Recovery","Substance use disorders during incarceration","2026-04-29",{"date":446,"type":40},"2026-05-04",{"date":448,"type":24},"2026-06",{"date":450,"type":24},"2030-03",{"name":452,"class":47},"Emory University",3,{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":460,"eligibilityCriteria":461,"healthyVolunteers":18,"sex":19,"minAge":462,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":25,"phases":465,"briefSummary":467,"conditions":468,"keywords":472,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":483},"100541012","phase-2-parenting-in-2-worlds-multisite-trial-100541012","NCT06324318","Parenting in 2 Worlds Multisite Trial","A Multiregional RCT of Parenting in 2 Worlds for Urban American Indian Families","(P2W)","Inclusion Criteria:\n\nAdult participants:\n\n* Must be American Indian parents or guardians of American Indian children aged 12 to 17 who attend urban schools\n* Must reside in the service areas of the four urban Indian centers who are participating in this study\n* Self-identifies as American Indian\n* Must be primary caregiver responsible for day-to-day decisions for an American Indian child ages 12 to 17\n\nChild Participants:\n\n* Aged 12 - 17\n* Identified by their parent\u002Fguardian as American Indian\n* Attends an urban school\n\nExclusion Criteria:\n\n* Not applicable","12 Years",{"count":464,"type":24},1440,[466],"PHASE2","This research study will test the effectiveness of a culturally grounded parenting intervention called Parenting in 2 Worlds (P2W). This intervention is designed for American Indian \u002F Alaska Native (AI) parents\u002Fguardians of adolescents who reside in urban areas. This will be a multi-regional effectiveness trial across four regions: Northeast (Buffalo\u002FNiagara), Midwest (St. Paul\u002FMinneapolis), Mountain (Denver), and Southwest (Phoenix). There are four specific aims. First, this study will test the effectiveness of Parenting in Two Worlds (P2W) as compared to an informational family health intervention, Healthy Families in 2 Worlds (HF2W), in improving parenting and family functioning. Second, this study will test if the relative effectiveness of P2W, compared to HF2W, varies by parent's\u002Fguardian's level of socioeconomic vulnerability, experiences of historical loss, or AI cultural identity. Third, this study will examine if P2W can reduce adolescent (ages 12 - 17) risky health behaviors including substance use, depressive symptoms, suicidality, and risky sexual behaviors. Fourth, this study will examine whether positive changes in parenting and family functioning that result from P2W lead to positive changes in adolescent's health behaviors.",[469,470,30,471],"Parenting","Mental Health Wellness 1","Risky Health Behavior",[473,474],"family functioning","risky sexual behavior","2026-04-27",{"date":444,"type":40},{"date":478,"type":40},"2023-09-14",{"date":480,"type":24},"2028-06-01",{"name":482,"class":47},"Arizona State University",4,{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":18,"sex":491,"minAge":109,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":25,"phases":494,"briefSummary":495,"conditions":496,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":75},"100532729","women-focused-encounters-for-resilience-independence-strength-and-eudaimonia-100532729","NCT06216600","Women Focused Encounters for Resilience Independence Strength and Eudaimonia","WE RISE","Inclusion Criteria:\n\n1. Is a woman\n2. Able to read and understand English\n3. Able to participate in a low intensity exercise program\n4. HIV-seropositive\n5. At risk substance use (any illegal or unprescribed drug), tobacco, marijuana or alcohol use (four or more drinks in one day or 8 or more in one week).\n6. Reports missing more ART doses than previous months, or \\> 5 in a month, or has a detectable HIV viral load\n7. Experienced interpersonal violence\n8. Able and willing to provide informed consent\n\nExclusion Criteria:\n\n1. Unwilling to participate in video record sessions (used to evaluate the quality of the intervention)\n2. Enrolled in hospice\n3. Not willing or not able to comply with study advisory board group participation agreement.","FEMALE",{"count":493,"type":24},300,[27],"The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and commitment therapy (ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS\u002FHIV (SAVA) to improve medication adherence for women living with HIV (WLWH). This intervention will be implemented by community based organizations that focus on WLWH across four counties. The main question it aims to answer are:\n\n* Will peer provision of ACT, exercise, and social support improve medication adherence for WLWH?\n* Will community based organizations be able to sustain the intervention after research is completed, and what changes will need to be made to sustain the intervention.",[497,30,498,499],"HIV Infections","Trauma","Medication Adherence",{"date":501,"type":40},"2026-05-01",{"date":503,"type":40},"2024-09-19",{"date":505,"type":24},"2028-05-31",{"name":507,"class":47},"University of California, San Diego",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":518,"phases":4,"briefSummary":519,"conditions":520,"keywords":533,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":548,"lastUpdatePostDateStruct":549,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":48},"100585203","health-surveillance-at-constructor-university-bremen-cub-and-among-haw-hamburg-employees-100585203","NCT06899308","Health Surveillance at Constructor University Bremen (CUB) and Among HAW-Hamburg Employees","Health Surveillance at Constructor University Bremen (CUB) to Assess Students' and HAW-Hamburg Employees' Health and Wellbeing - Explanatory Sequential Mixed-Methods Approach","CUB-HS2025","Inclusion Criteria:\n\n* English language skills\n* Reading and writing skills\n* Internet access\n* Student status\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Illiteracy\n* Massively limited cognitive abilities ( i.e. linguistic components of the digital offerings must be able to be used, and questionnaires completed, or interviews participated in) and severe psychiatric disorders (e.g., severe depression)",{"count":517,"type":24},363,"OBSERVATIONAL","The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.",[521,522,523,524,525,526,527,528,529,530,531,164,532,163,30],"Social Isolation or Loneliness","Anxiety","Anxiety Depression (Mild or Not Persistent)","Health Behavior","Observational Study","Stress, Psychological","Emotional Stress","Life Stress","Psychological Stress","Stress, Emotional","Stress (Psychology)","Substance Addiction",[534,535,536,537,538,539,540,541,542,543,544,545,546,547],"Healthy students","Health literacy","Disability","Age","Gender","Study characteristics","PHQ-4","Self-efficacy","Satisfaction with Life Scale (SWLS)","Subjective health status","Student satisfaction","UCLA-LS","HEI-Stress","Mixed Method","2026-04-25",{"date":501,"type":40},{"date":551,"type":40},"2025-03-17",{"date":553,"type":24},"2026-12-31",{"name":555,"class":47},"Jacobs University Bremen gGmbH",{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":18,"sex":19,"minAge":265,"maxAge":136,"enrollmentInfo":564,"targetDuration":4,"studyType":25,"phases":566,"briefSummary":567,"conditions":568,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":573,"leadSponsor":575,"locationsCount":4},"100561692","mindfulness-based-substance-use-prevention-minds-up-100561692","NCT06593470","Mindfulness-Based Substance Use Prevention (MINDS-UP)","Mindfulness-Based Substance Use Prevention (MINDS-UP): a Randomized Controlled Trial","MINDS-UP","Inclusion Criteria:\n\n* Youth is ages 10-14 years on the day of screening \\[i.e., does not turn 15 before or on the day of screening\\]\n* Access to a smart phone, tablet, or computer with Wi-Fi\n* English-speaking\n\nExclusion Criteria:\n\n* Has been diagnosed with or received treatment for one of the following mental health problems: depression, bipolar disorder, schizophrenia, autism spectrum disorder, intellectual disability, or substance use disorder.\n* Youth is actively involved in another Boricua Youth Study (BYS)\n* Youth's sibling is or has previously been enrolled in MINDS-UP.",{"count":565,"type":24},45,[27],"The goal of this clinical trial is to test the feasibility, behavioral\u002Fneural mechanisms, and preliminary efficacy of \"MINDfulness-based Substance Use Prevention Program,\" or \"MINDS-UP\", a novel substance use prevention meditation intervention for children and adolescents between the ages of 10 and 14. The main questions it aims to answer are:\n\n1. Is MINDS-UP feasible and what is its preliminary efficacy?\n2. Are MRI protocol and procedures feasible?\n\nAn additional exploratory question is:\n\nAre there neural and psychopathological mechanisms through which MINDS-UP might work?\n\nResearchers will compare Sport - Prevention Plus Wellness (PPW) (an evidence based substance use prevention program) to Sport - Prevention Plus Wellness + MINDS-UP to examine the preliminary efficacy of MINDS-UP.\n\nParticipants will\n\n* take assessment #1\n* have 2 MRIs and take MINDS-UP, just take MINDS-UP or have a delayed start\n* take assessment #2\n* take PPW, a single remote and research assistant-delivered 45-minute session\n* take assessment #3\n* take assessment #4",[30],"2026-04-21",{"date":571,"type":40},"2026-04-24",{"date":225,"type":24},{"date":574,"type":24},"2028-01-01",{"name":576,"class":47},"New York State Psychiatric Institute",{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":4,"eligibilityCriteria":583,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":584,"targetDuration":4,"studyType":518,"phases":4,"briefSummary":586,"conditions":587,"keywords":590,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":593,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":598,"locationsCount":453},"100470353","harm-reduction-in-hiv-primary-care-for-plwh-who-use-drugs-100470353","NCT05404750","Harm Reduction in HIV Primary Care for PLWH Who Use Drugs","Impact of Harm Reduction Care in HIV Clinical Settings on Stigma and Health Outcomes","Inclusion Criteria:\n\n1. Providers' Inclusion Criteria\n\n   * Working at one of our 3 study sites (UPMC HIV\u002FAIDS Program, Positive Health Clinic, or 1917 Clinic) or one of their partner sites offering substance use treatment (Internal Medicine Recovery Engagement Program, Center for Inclusion Health, or UAB's Outpatient-Based Opioid Treatment Clinic) for at least one year\n   * Providing service or care to PLWH or people who use drugs at high risk for HIV acquisition\n   * Working in one of the following positions: front desk\u002Fpatient engagement, social worker, nurse, medical assistant, advanced practice provider, or physician\n   * Able to verbally consent, read, and speak English\n2. Patient Inclusion Criteria\n\n   * Living with HIV\n   * Age 18 or older\n   * Able to verbally consent, read, and speak English\n   * Receiving HIV medical care from one of the study sites for at least one year\n   * Lifetime or recent use (past 3 months) of illicit substances (excluding marijuana) or prescription drugs for non-medical reasons in accordance with the NIDA-Modified ASSIST 2.0.\n\nExclusion Criteria:\n\n\\-",{"count":585,"type":24},768,"People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) the relationship between healthcare providers' attitudes towards working with PLWH who use drugs and providers' acceptance and practice of structural and relational harm reduction; (b) the degree to which relational harm reduction moderates the effect of intersectional stigma experienced in healthcare settings on patients' perceptions of their relationship with providers; (c) the degree to which structural HR moderates the relationship between the patient-provider relationship and clinical outcomes, and (d) whether patient-perceived HR approaches to care are directly associated with HIV clinical outcomes. The study will also use these findings to inform the development and pre-testing of an intervention to operationalize harm reduction in HIV clinical settings, using stakeholder-engaged and human-centered design approaches, presenting a novel path to reducing HIV health inequities for PLWH who use drugs.",[588,30,589],"Human Immunodeficiency Virus","Stigma, Social",[591,592],"Harm Reduction","Patient-Provider Relationship",{"date":571,"type":40},{"date":595,"type":40},"2022-04-20",{"date":597,"type":24},"2027-06-30",{"name":383,"class":47},{"id":600,"slug":601,"hasResults":12,"nctId":602,"briefTitle":603,"officialTitle":603,"acronym":604,"eligibilityCriteria":605,"healthyVolunteers":18,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":606,"targetDuration":4,"studyType":25,"phases":608,"briefSummary":609,"conditions":610,"keywords":615,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":626,"locationsCount":75},"100552784","j-rise-relevant-implementation-strategies-to-eliminate-the-social-and-structural-barriers-to-hiv-services-among-justice-involved-black-men-who-have-sex-with-men-and-other-key-populations-100552784","NCT06477588","J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations","J-RISE","Inclusion Criteria:\n\n1. be at least 18 years of age;\n2. currently reside or intend to reside in one of the study communities (i.e., Cook County, Baton Rouge, and the New Orleans area);\n3. be able to provide informed consent in English and complete the study in English. In addition, potential participants must:\n4. be currently incarcerated in jail or prison and report an expected release within 90 days, or under community supervision or drug court, or report a recent incarceration within the last three years, or in the last 12 months has had an interaction with law enforcement that did not lead to an arrest or jail or prison time, AND has not already been linked and\u002For retained in HIV or PrEP care in the community;\n5. report needing employment-related services; and\n6. have a confirmed HIV positive or negative status (within 90 days of enrollment) and if HIV negative meets one of CDC's PrEP indications (i.e., sexually active, needle sharing, previous STI history in the last 24 months) or plans to have sex in the next 12 months or wants more information about PrEP.\n\nExclusion Criteria:\n\n1. unwilling\u002Funable to provide informed consent,\n2. does not live or intend to live in one of the study locations,\n3. unable to confirm HIV status,\n4. unable to conduct the study in English, and\n5. currently enrolled in another intervention to support HIV care, PrEP care, and economic stability.",{"count":607,"type":24},350,[27],"The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system.\n\nThe main question it aims to answer is:\n\n• Compared with the Health Navigation group, are participants in the Health Navigation Plus group more likely to a) access HIV care, treatment, and prevention services and employment services and b) access employment services and be employed in community?\n\nParticipants on the study will be:\n\n* Randomly assigned (like a flip of a coin) to participate in either Health Navigation or Health Navigation Plus. Participants will have an equal chance of being placed in either group.\n* Complete three surveys over the course of 13 months\n* Participants in the Health Navigation group will have two in person meetings and seven check-ins with the health navigator over 6 months\n* Participants in the Health Navigation Plus group will have two in person meetings and seven check-ins with the health navigator over 6 months, two in person and 10 check ins with the employment navigator over 12 months and up to $200 to support employment and career development needs and receive up to $140 to support health goals. Samples of blood, urine and swabs may be collected to meet the health goals.",[338,611,612,613,614,30],"Contingency Management","Justice Involved Populations","Status Neutral Interventions","Mental Health",[338,616,617,618,619,195,620,345],"Contingency management","Justice involved populations","Status neutral interventions","mental health","employment","2026-04-17",{"date":569,"type":40},{"date":624,"type":40},"2024-08-13",{"date":358,"type":24},{"name":627,"class":47},"University of Chicago",{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":632,"acronym":633,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":491,"minAge":136,"maxAge":4,"enrollmentInfo":635,"targetDuration":4,"studyType":25,"phases":637,"briefSummary":638,"conditions":639,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":649,"locationsCount":453},"100503502","family-spirit-strengths-100503502","NCT05836090","Family Spirit Strengths","FSS","Inclusion Criteria:\n\n* Self-identify as female; and\n* Pregnant or be a primary caregiver of a child that is 24 months or younger; and\n* 14 years or older at time of enrollment; and\n* Report a family history of high-risk substance use and\u002For report high-risk levels of personal substance use; and\n* Have elevated symptoms of depression and\u002For anxiety and\u002For risk of substance use disorder; and\n* Be part of the service population of one of the participating sites.\n\nExclusion Criteria:\n\n* Profound disability that limits the ability to participate in assessments or interventions; and\n* Unlikely to be residing in or near the research service area for the next 6 months.",{"count":636,"type":24},188,[27],"This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigators aim to address this gap by testing the effectiveness of a trans-diagnostic secondary prevention program, Family Spirit Strengths (FSS) that can be embedded within home visiting services. The FSS program is a skills-based program that incorporates elements of evidence-based practice, the Common Elements Treatment Approach (CETA), and materials informed and developed based on an Indigenous advisory group. The FSS program aims to help participants build self-efficacy and coping skills, as well as build stronger connections to others, the participants' community, and cultural resources. The investigators will use a randomized controlled trial, whereby half of the participants will receive FSS and the other half will receive an evidence-based nutrition education program. The investigators' study is grounded in participatory processes and led by a team of Indigenous and allied researchers.",[640,641,30,642],"Depressive Symptoms","Anxiety Disorders and Symptoms","Mental Health Issue","2026-04-10",{"date":645,"type":40},"2026-04-13",{"date":647,"type":40},"2023-04-20",{"date":358,"type":24},{"name":281,"class":47},{"id":651,"slug":652,"hasResults":12,"nctId":653,"briefTitle":654,"officialTitle":654,"acronym":655,"eligibilityCriteria":656,"healthyVolunteers":12,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":657,"targetDuration":4,"studyType":25,"phases":659,"briefSummary":660,"conditions":661,"keywords":663,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":670,"leadSponsor":671,"locationsCount":75},"100493078","enhancing-wellness-through-affirming-services-and-education-100493078","NCT05700474","Enhancing Wellness Through Affirming Services and Education","EASE","Inclusion Criteria:\n\n1. HIV diagnosis or seeking HIV prevention services\n2. Any alcohol or illicit substance use in the last 90 days\n3. 18 or older\n4. Residing in Mecklenburg County or surrounding areas.\n\nExclusion Criteria:\n\n1\\) Inability to consent for services due to reduced mental or physical capacity",{"count":658,"type":24},200,[27],"The goal of this treatment study is to learn about the mental health, substance use and physical health outcomes associated with participating in the EASE holistic behavioral health and wellness program for individuals seeking HIV prevention and\u002For living with HIV. The main questions it aims to answer are:\n\n1. Do important health outcomes, including substance use, mental health and social support related outcomes of individuals who participated in the holistic behavioral health and wellness program change after study participation?\n2. Does a tailored approach to meet the specific needs of different subpopulations including 1) older (40+) PLWH with or at risk for additional health comorbidities and 2) PLWH and\u002For young adults (18-40) seeking HIV prevention to improve health outcomes including improvement in health and health behaviors .\n\nParticipants will be asked to:\n\n* participate in 6 months of behavioral health treatment tailored to their needs, which may include individual counseling, group counseling, case management, peer support, and related education.\n* Complete surveys at the time of study entry and 6 months later to measure changes in health outcomes over time.",[338,662,30],"Mental Health Disorder",[338,614,30,345,664],"Comorbidity","2026-04-06",{"date":667,"type":40},"2026-04-09",{"date":669,"type":40},"2023-02-13",{"date":423,"type":24},{"name":672,"class":47},"Duke University",{"id":674,"slug":675,"hasResults":12,"nctId":676,"briefTitle":677,"officialTitle":677,"acronym":678,"eligibilityCriteria":679,"healthyVolunteers":12,"sex":19,"minAge":109,"maxAge":4,"enrollmentInfo":680,"targetDuration":4,"studyType":25,"phases":681,"briefSummary":682,"conditions":683,"keywords":686,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":688,"lastUpdatePostDateStruct":689,"startDateStruct":691,"completionDateStruct":693,"leadSponsor":694,"locationsCount":75},"100632143","integrating-sexual-pleasure-into-harm-reduction-services-for-men-who-have-sex-with-men-and-transgender-persons-who-engage-in-chemsex-or-substance-use-in-thailand-100632143","NCT07509853","Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand","PLEASURE","Inclusion Criteria:\n\n* MSM, transgender women, transgender men, or non-binary persons\n* Age ≥18 years\n* Engaged in chemsex or substance use within past 12 months\n* Able to provide informed consent\n\nExclusion Criteria:\n\n• Unable to communicate in Thai sufficiently to complete study procedures",{"count":493,"type":24},[27],"The study evaluates the integration of a sexual pleasure-based approach into harm reduction services for MSM and transgender persons engaging in chemsex or substance use in Thailand, using the \"Pleasuremeter\" tool to improve sexual health and related outcomes.",[374,30,614,684,685],"Sexually Transmitted Infections (STIs)","Chemsex",[687],"PrEP, Harm reduction, Chemsex, Transgender, Sexual pleasure","2026-04-02",{"date":690,"type":40},"2026-04-08",{"date":692,"type":40},"2025-05-01",{"date":320,"type":24},{"name":695,"class":47},"Institute of HIV Research and Innovation Foundation, Thailand"]