[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"subthreshold-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:subthreshold-depression":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,72,103,124,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100617478","the-effect-of-transcranial-direct-current-stimulation-tdcs-in-improving-emotion-health-100617478",false,"NCT07319143","The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health","Utilizing Transcranial Direct Current Stimulation (tDCS) to Alleviate Subthreshold Depression Via Distinct Positive and Negative Emotion Pathways","Inclusion Criteria:\n\n* Age 18-35 years\n* Fluency in Cantonese or Mandarin\n* Normal or corrected-to-normal vision and hearing\n* IQ \\> 75% Quantile in Raven's SPM\n* At least 9 years of formal education\n* Right-handedness\n\nExclusion Criteria:\n\n* Past or current major physical illness or psychiatric disorders\n* Use of psychotropic medication in the past 6 months\n* Pregnancy (for women)\n* Any condition that prevents safe tDCS use (e.g., brain injury, implants)\n* Previous participation in neuromodulation in the past 3 months",true,"ALL","18 Years","35 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to investigate how transcranial direct current stimulation (tDCS) affects emotion functions in young adults aged 18-35 from the local community, including both male and female participants. The main question\\[s\\] it aims to answer are:\n\n* Does tDCS improve emotional functions, such as mood regulation and motivation, in individuals with subthreshold depression (StD)?\n* Can tDCS enhance emotional regulation compared to a sham stimulation (placebo)?\n\nResearchers will compare participants receiving tDCS on either the left dorsolateral prefrontal cortex (lDLPFC) or right ventrolateral prefrontal cortex (rVLPFC) with those receiving sham stimulation to see if tDCS has a stronger effect on emotional functions.\n\nParticipants will:\n\n* Complete online and in-person screening to assess depressive symptoms using the Chinese version of the Beck Depression Inventory II (C-BDI-II) and be selected based on their depressive symptoms (C-BDI-II score ≥ 13).\n* Be randomly assigned to one of three groups: lDLPFC tDCS, rVLPFC tDCS, or Sham control group (1:1:1 ratio).\n* Receive 10 sessions of tDCS or Sham tDCS over 2 weeks, with each session lasting 20 minutes.\n* Complete assessments at baseline, post-intervention, 1-month follow-up, and 3-month follow-up, with each assessment lasting 2-2.5 hours. This includes questionnaires and perform emotional and cognitive tasks.",[28,29,30,31],"Subthreshold Depression","Positive Emotions","Negative Emotions","Anhedonia",[33,28,34,35],"Transcranial Direct Current Stimulation","Emotion","Neuromodulation","RECRUITING","2026-04-28",{"date":39,"type":40},"2026-05-04","ACTUAL",{"date":42,"type":40},"2026-01-08",{"date":44,"type":22},"2027-09-01",{"name":46,"class":47},"The University of Hong Kong","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":48},"100582546","behavioral-activation-for-the-prevention-of-post-stroke-depression-in-low-income-older-stroke-survivors-100582546","NCT06864715","Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors","Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors (LIVE-WEL)","LIVE-WEL","Inclusion Criteria:\n\n* Enrollment within 3-months +2 weeks of a first-time ischemic or hemorrhagic stroke\n* 24-item HDRS score \\\u003C 15 indicating subthreshold depression defined as the absence of depressive symptoms or presence of mild symptoms of depression\n* Single person income less than or equal to $45,000\n* Residing in a community residence\n* Ability to speak and read in English or Spanish\n* Mini-MoCA score \\> or equal to 11\n\nExclusion Criteria:\n\n* Stroke event unrelated to vascular risk factors (e.g., drug use) or transient ischemic attack\n* 24-item HDRS score \\> or equal to 15 indicating moderate to severe depression\n* Actively participating in psychotherapy\n* high suicide risk or severe psychiatric illness (e.g., bipolar disorder and active psychosis) and\u002For actively taking antipsychotics\n* Diagnosed dementia and\u002For currently taking cognitive enhancers, amyloid-targeting medications, or orexin receptor antagonists\n* Patient Health Questionnaire 9 score \\> or equal to 10 and\u002For answers positive to Q9\n* Diagnosed aphasia and\u002For severe cognitive impairments\n* high-risk alcohol or drug misuse\n* receiving medications for mood disorders and a change in dose or type within the last 4 weeks","55 Years",{"count":59,"type":22},350,[25],"The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD).",[63,28],"Post-stroke Depression","2026-04-22",{"date":37,"type":40},{"date":67,"type":40},"2026-04-10",{"date":69,"type":22},"2029-11-01",{"name":71,"class":47},"The University of Texas Health Science Center, Houston",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":48},"100602020","a-pilot-study-to-examine-the-efficacy-of-internet-delivered-skills-training-in-affective-and-interpersonal-regulation-i-stair-for-individuals-with-adverse-childhood-experiences-and-subsyndromal-depression-100602020","NCT07118072","A Pilot Study to Examine the Efficacy of Internet-Delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) for Individuals With Adverse Childhood Experiences and Subsyndromal Depression","Internet-Delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) for Individuals With Adverse Childhood Experiences and Subsyndromal Depression: A Pilot Study","Inclusion Criteria:\n\n* Exposed to mild, moderate or severe adverse childhood experiences (ACEs)\n* Screened positive for subsyndromal depression\n* Singapore citizens or permanent residents (PRs)\n* Aged 21 years to 65 years\n* Able to speak and understand English\n* Willing and able to undergo intervention and assessment online\n\nExclusion Criteria:\n\n* Currently diagnosed with any mental disorder diagnoses;\n* Experience cognitive impairment as determined by attending physician\n* Have received or currently receiving dialectical behavior therapy (DBT) due to similarities with i-STAIR\n* Female participants who are pregnant","21 Years","65 Years",{"count":82,"type":22},150,[25],"The present study aims to pilot internet-delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) as a transdiagnostic emotion dysregulation intervention to prevent progression to depression in individuals with adverse childhood experiences (ACEs) and subsyndromal depression. The aims of the study are: (i) to examine the effectiveness of i-STAIR on emotion dysregulation, interpersonal skills, depressive and PTSD symptoms at post-intervention i.e. on completion of the intervention (8 weeks); (ii) to examine if gains were maintained at 3 month post- intervention follow-up.",[28],[87,88,89,90,91,92,93],"skills training in affective and interpersonal regulation","emotion regulation","subthreshold depression","prevention intervention","digital intervention","transdiagnostic intervention","Singapore","2026-02-25",{"date":96,"type":40},"2026-02-27",{"date":98,"type":40},"2025-10-31",{"date":100,"type":22},"2028-12",{"name":102,"class":47},"Institute of Mental Health, Singapore",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":48},"100555825","tdcs-in-people-with-subthreshold-depression-100555825","NCT06517121","tDCS in People With Subthreshold Depression","Personalised Transcranial Direct Current Stimulation to Reduce Daily Loneliness in People With Subthreshold Depression","Inclusion Criteria:\n\n* No histories of learning impairment, major psychiatric disorders including Major Depressive Disorder or neurological disorders\n* At least primary school education\n* Subthreshold depression\n\nExclusion Criteria:\n\n* On medication or treatments within 2 weeks prior to the beginning of the study that would affect the individual's brain, cognitive and affective functions",{"count":111,"type":22},204,[25],"This study evaluates the effects of multi-session transcranial direct current stimulation on loneliness, mood and depressiveness in people with subthreshold depression.",[28],"2026-01-29",{"date":117,"type":40},"2026-02-02",{"date":119,"type":40},"2026-01-16",{"date":121,"type":22},"2027-01",{"name":123,"class":47},"Education University of Hong Kong",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":16,"sex":17,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":48},"100614087","a-virtual-reality-based-horticultural-planting-program-for-elderly-with-subthreshold-depression-100614087","NCT07275034","A Virtual Reality-Based Horticultural Planting Program for Elderly With Subthreshold Depression","A Virtual Reality-Based Horticultural Planting Program for Elderly With Subthreshold Depression：A Randomized Controlled Pilot Study","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Meets subthreshold depression diagnostic criteria: CES-D score ≥ 16 on the Center for Epidemiological Survey, Depression Scale (CES-D) used in epidemiological surveys (this criterion is widely adopted in comparable studies)\n* No communication barriers in vision, hearing, or speech\n* Informed consent\n\nExclusion Criteria:\n\n* Insulin dependent diabetes\n* Thyroid disease\n* Recent exposure to a major traumatic stress event, with no risk of suicide\n* Currently participating in other similar studies\n* Clinically diagnosed with mental disorders such as depression or schizophrenia\n* Currently taking antidepressant medication\n* Severe cognitive impairment\n* Severe physical illness or organic disorder with impaired self-care abilities","60 Years",{"count":133,"type":22},36,[25],"Subthreshold depression represents a state of psychological sub-health between normal individuals and clinical depression. It constitutes a high-risk stage for developing clinical depression and a critical phase for alleviating depressive symptoms. However, current research predominantly focuses on treating depression in the elderly, with insufficient attention to interventions for high-risk populations or limited to cross-sectional investigations of subthreshold depression risk factors. Therefore, prioritizing subthreshold depression in the elderly and implementing early interventions is essential. A 2024 article in The Lancet suggests that subthreshold depression treatment should prioritize psychotherapy and lifestyle adjustments over medication. Horticultural therapy, an interdisciplinary approach integrating horticulture, medicine, and psychology, demonstrates unique advantages over traditional medical treatments. In practical application, however, limited resources may hinder adequate support for horticultural activities, compromising activity quality, reducing therapeutic efficacy, and restricting the widespread adoption of horticultural therapy. Integrating VR technology with horticultural therapy can provide patients with more comprehensive, personalized, and effective mental health treatment plans, empowering them toward healthier, more positive lives. Therefore, the research team designed a VR horticultural intervention system for elderly individuals with subthreshold depression based on the Social Participation Competence Framework.",[28],[138,28,139,140],"older adults","virutal reality","Gardening","NOT_YET_RECRUITING","2025-12-09",{"date":144,"type":40},"2025-12-10",{"date":146,"type":22},"2026-02-01",{"date":148,"type":22},"2026-04-20",{"name":150,"class":47},"Fujian Medical University",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":16,"sex":17,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":161,"briefSummary":162,"conditions":163,"keywords":165,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":48},"100538695","tdcs-interventions-for-subthreshold-depressive-symptoms-in-young-individuals-100538695","NCT06294184","TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Transcranial Direct Current Stimulation Interventions for Subthreshold Depressive Symptoms in Young Individuals.","Inclusion Criteria:\n\n* 1\\) Be between the ages of 12-25;\n* 2\\) is right-handed on the Edinburgh Handedness Inventory;\n* 3\\) 2-4 of the 9 depressive symptoms defined by the American Diagnostic and Statistical Manual of Diseases, Fifth Edition (DSM-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by DSM-5 Clinical Semi-Definitive Interview (K-SADS-PL) (Gilbody et al., 2017, JAMA);\n* 4\\) Hamilton Depression Scale (HAMD-24) 24 points≥ 8 points, \\< 24 points;\n* 5\\) Gender is not limited;\n* 6\\) Subjects and their families voluntarily participate and sign the informed consent form.\n\nExclusion Criteria:\n\n* 1\\) Individuals with the following diagnoses according to DSM-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by K-SADS-PL);\n* 2\\) Have two or more DSM-V-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the DSM-V defined criteria for hypomanic symptoms for only 2-3 days;\n* 3\\) Severe or unstable physical illness;\n* 4\\) have a moderate or higher risk of suicide (as assessed by the Columbia Suicide Severity Scale);\n* 5\\) Received transcranial direct current stimulation in the past three months (continuous intervention time: \\>2 weeks);\n* 6\\) Contraindications to transcranial direct current stimulation, such as brain implants, personal or family history of epilepsy;\n* 7\\) Magnetic resonance scanning is contraindicated, such as in vivo metal implants.","12 Years","25 Years",{"count":82,"type":22},[25],"The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.",[28,164,33],"Young People",[166,167],"Resting-state brain functional network","Social emotion","2024-12-07",{"date":170,"type":40},"2024-12-12",{"date":172,"type":40},"2023-11-01",{"date":174,"type":22},"2025-12",{"name":176,"class":177},"Guangzhou Psychiatric Hospital","OTHER_GOV"]