[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"sugammadex\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:sugammadex":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,38,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100507348","quantitative-neuromuscular-monitoring-and-gastric-bypass-surgery-100507348",false,"NCT05886218","Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery","A Before\u002FAfter Study of the Impact of Quantitative Neuromuscular Monitoring and Sugammadex Reversal Following Gastric Bypass Surgery","Inclusion Criteria:\n\n* age greater than 18 years\n* scheduled for an elective laparoscopic gastric bypass procedure\n\nExclusion Criteria:\n\n* age less than 18 years\n* pregnancy\n* prisoners\n* significant co-existing lung disease including asthma or chronic obstructive pulmonary disease (COPD) requiring regular medication\n* patients who require supplemental oxygen pre-operatively to maintain a hemoglobin saturation (SpO2\\>98%)","ALL","18 Years",{"count":19,"type":20},215,"ESTIMATED","OBSERVATIONAL","This is a single site, prospective, non-blinded, non-randomized, before\u002Fafter study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative outcomes for patients undergoing laparoscopic gastric bypass surgery.",[24],"Sugammadex","RECRUITING","2025-05-13",{"date":28,"type":29},"2025-05-15","ACTUAL",{"date":31,"type":29},"2023-02-08",{"date":33,"type":20},"2025-07",{"name":35,"class":36},"University of California, Davis","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":4},"100568225","sugammadex-on-laparoscopic-bariatric-surgery-100568225","NCT06678451","Sugammadex on Laparoscopic Bariatric Surgery","Effect of Sugammadex on Quality of Recovery Following Laparoscopic Bariatric Surgery","Inclusion Criteria:\n\n* Age 18-50 years\n* Body Mass Index (BMI) ≥ 40kg\u002Fm²\n* American Society of Anesthesiologists (ASA) grade I to III classification\n* NYHA cardiac function grade I - II\n\nExclusion Criteria:\n\n* Patients with neuromuscular disease or respiratory system disease\n* Patients with severe abnormal liver and renal function\n* Perioperative use of drugs known to interact with rocuronium\n* Patients with unstable mental illness or refusal to participate","50 Years",{"count":47,"type":20},60,"INTERVENTIONAL",[50],"NA","Laparoscopic bariatric surgery has been recognized as the most effective treatment for obesity and related metabolic diseases. Because obesity patients often associated with sleep apnea syndrome or obesity hypoventilation syndrome, combined with the residual effect of muscle relaxants during the operation is easy to lead to respiratory obstruction and respiratory insufficiency, and hypoxemia and carbon dioxide retention are easy to occur after surgery, Post-extubation is prone to upper respiratory tract obstruction such as retrolingual fall, thus increase the risk of perioperative respiratory complications. Therefore, it is very important to achieve a rapid and effective antagonistic muscle relaxant effect, reduce the postoperative muscle relaxation residue, and maintain the patency of the patient's airway.\n\nCompared with the traditional cholinesterase inhibitor neostigmine, sugammadex is a specific antagonist of novel aminosteroid muscle blockers, which rapidly reverses moderate and deep neuromuscular block by combining with rocuronium or vecuronium 1:1,without compatibility with due to its no effect on muscarinic receptors or plasma cholinesterase. The absence of cholinergic and cardiovascular effects during awakening from anesthesia would be significant benefit for patients with cardiovascular or respiratory diseases.\n\nThe pharmacological effect of sugammadex is its ability to form a tight 1:1 complex with amino steroid neuromuscular blockers, which causes a lower plasma concentration of free neuromuscular blockers and promotes the transfer of neuromuscular blockers from the peripheral compartment (including the neuromuscular junction) to the plasma gradient. A meta-analysis by Vaghiri et al showed that reversal of neuromuscular block by sugammadex accelerated postoperative recovery of intestinal peristalsis in patients undergoing colorectal surgery compared with acetylcholinesterase inhibitors. Deljou et al confirmed that reversal of neuromuscular blockade with sugammadex shortened the time to first postoperative defecation in patients compared with neostigmine \u002F glononium bromide. The study will investigate the effect of sugammadex in patients undergoing laparoscopic bariatric surgery.",[53,24],"Laparoscopic Bariatric Surgery","NOT_YET_RECRUITING","2024-11-05",{"date":57,"type":29},"2024-11-07",{"date":59,"type":20},"2024-12",{"date":61,"type":20},"2025-05",{"name":63,"class":36},"Shanxi Bethune Hospital",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":48,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100497004","effectiveness-on-smooth-extubation-according-to-the-administration-time-of-sugammadex-100497004","NCT05751603","Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex","Comparison of Smooth Emergence During Extubation After Anesthesia When Sugammadex is Administered Before and After Extubation","Inclusion Criteria:\n\n* patients undergoing general anesthesia for thyroid surgery.\n* aged between 19 and 64 years\n* American Society of Anesthesiologists physical status I and II\n\nExclusion Criteria:\n\n* patients with malformation or tumor of the upper respiratory tract\n* patients with risk of aspiration\n* obese cases with a BMI \\> 35\n* patients in which tracheal intubation was difficult\n* refusal to participate in research","19 Years","64 Years",{"count":74,"type":20},66,[50],"After surgery is completed under general anesthesia, extubation is performed after recovery from anesthesia, and during this process, bucking, coughing, and rapid and excessive hemodynamic fluctuations occur very often. These phenomena can lead to high intrathoracic pressure, venous congestion, hematoma formation, or increased bleeding after major neck surgery. (1) They can also increase the risk of aerosol generation, which can transmit infection to health care workers. (2) For this, smooth extubation is required. Methods of administering drugs such as lidocaine, opioids, or dexmedetomidine have been proposed for smooth extubation. (3-5) As a disadvantage, the use of these drugs may be associated with deep sedation and reduced airway reflexes .\n\nRecently, Babu et al. (6) reported that bucking and coughing during extubation could be reduced by changing the timing of administering a muscle relaxant antagonist rather than using these sedative drugs, and thus complications related to extubation could be reduced. In general, in the awakening process, it was common to administer the muscle relaxant at the point of recovery of spontaneous breathing. However, Babu et al. demonstrated the possibility of safe and smooth extubation by changing the timing of administering neostigmine without the use of sedatives or narcotic analgesics, but there are few studies on sugammadex.\n\nTherefore, when recovering from general anesthesia, sugammadex was administered before and immediately after extubation to evaluate and compare smooth extubation (ie, comparison of the frequency of bucking and coughing).",[24,78,79],"Extubation","Smooth Emergence","2024-07-23",{"date":82,"type":29},"2024-07-25",{"date":84,"type":20},"2024-10-03",{"date":86,"type":20},"2025-10-03",{"name":88,"class":36},"Ajou University School of Medicine"]