[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"suicidal-and-self-injurious-behavior\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:suicidal-and-self-injurious-behavior":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,86,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100587688","suicide-preventive-psychosocial-treatment-for-youths-100587688",false,"NCT06931639","Suicide Preventive Psychosocial Treatment for Youths","Suicide Preventive Psychosocial Treatment for Youths: A Randomized Controlled Trial","Inclusions criteria:\n\n1. Suicide attempt in the last 3 months\n2. Age 10-17 years\n3. At least one primary caregiver (multiple is allowed) willing to participate in treatment\n\nExclusion criteria:\n\n1. Symptoms obstructing participation in assessments or treatment\n2. Insufficient understanding of the Swedish language in youth and\u002For caregiver\n3. Enrolled in Dialectical Behavioral Therapy","ALL","10 Years","17 Years",{"count":20,"type":21},282,"ESTIMATED","INTERVENTIONAL",[24],"NA","Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal costs, making suicide attempts a critical target in psychiatric intervention research. Although youths attempting suicide are typically assessed and treated for potential comorbid psychiatric conditions, there is currently no trans-diagnostic evidence-based treatment specifically targeting suicidal behavior. To fill this gap, the Safe Alternatives for Teens and Youths (SAFETY) was developed. SAFETY is a transdiagnostic family-based cognitive-behavioral suicide prevention program that has shown promise but more studies are needed.\n\nThe overall objective of this project is to evaluate the efficacy, durability, and cost-effectiveness of the SAFETY intervention, a scalable suicide prevention intervention that can be offered immediately following a youth suicide attempt, in a fully powered single-blind randomized controlled superiority trial. Our primary hypothesis is that the SAFETY intervention will be superior to Enhanced Treatment As Usual (enhanced with the evidence-based intervention safety planning) in reducing the proportion of suicide reattempts. Moreover, we predict that these improvements will be maintained for up to 60 months post-treatment. Finally, we expect that SAFETY will be cost-effective compared to the control intervention, both at the primary endpoint and in the longer term.",[27,28,29,30],"Suicide Attempt","Suicidal and Self-injurious Behavior","Suicide Attempted","Suicide, Attempted",[32,33,27,34],"Safe Alternatives for Teens and Youths","Self-injurious Behavior","Suicidal Behavior","RECRUITING","2026-04-14",{"date":38,"type":39},"2026-04-17","ACTUAL",{"date":41,"type":39},"2025-05-28",{"date":43,"type":21},"2032-09",{"name":45,"class":46},"Karolinska Institutet","OTHER",5,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100611344","culturally-adapted-dialectical-behavior-therapy-for-low-middle-income-countries-100611344","NCT07239362","CULTURALLY ADAPTED DIALECTICAL BEHAVIOR THERAPY FOR LOW-MIDDLE-INCOME COUNTRIES","Culturally Adapted Dialectical Behavior Therapy (DBT) for Mental Health in LMICs: A Randomized Controlled Trial (RCT)","Inclusion Criteria:\n\n* Adults aged 18-45 years\n* Adults who are diagnosed with or have significant traits of borderline personality disorder (BPD)\n* Adults who are willing to provide written informed consent\n\nExclusion Criteria:\n\n* Severe psychiatric comorbidity (e.g., active psychosis, substance use, etc.)\n* Acute medical conditions interfering with participation\n* Lack of basic reading and writing, or any learning disability","18 Years","45 Years",{"count":58,"type":21},220,[24],"The study aims to assess the efficacy of culturally adapted dialectical behaviour therapy (DBT) for addressing emotional dysregulation in a low- and middle-income country, as well as to evaluate the impact of DBT on secondary outcomes such as borderline personality traits, self-harm or suicide, depression, anxiety, and individuals' functioning and disability.\n\nThrough a rigorous Randomised Controlled Trial (RCT), the research seeks to assess how cultural adaptations of dialectical behaviour therapy improve its applicability, engagement, and outcomes in diverse socio-cultural settings, contributing to more accessible and effective mental health interventions in resource-limited regions.",[62,63,64,65,28,66],"Borderline Personality Disorder (BPD)","Dialectical Behavior Therapy","Emotional Dysregulation","Self Harm","Depression Anxiety Disorder",[68,69,70,71,72,73,74],"BPD","DBT","Self harm","Suicide","Borderline personality","Dialectical behavior therapy","Emotional dysregulation","NOT_YET_RECRUITING","2025-11-22",{"date":78,"type":39},"2025-11-28",{"date":80,"type":21},"2025-11-20",{"date":82,"type":21},"2026-07-31",{"name":84,"class":46},"Pakistan Association of Cognitive Therapists",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":94,"maxAge":18,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":85},"100600042","an-adaptive-intervention-to-increase-engagement-to-community-based-care-after-an-ed-admission-100600042","NCT07092345","An Adaptive Intervention to Increase Engagement to Community-Based Care After an ED Admission","An Adaptive Intervention to Increase Engagement to Community-based Care After an ED Admission: For Youth at Risk for Suicide and Self-injurious Behavior","ED_SMART","Inclusion Criteria:\n\n* Youth 8 to 17 years\n* Youth presenting to the ED with suicide and self-injurious behavior\n* Youth living at home with at least one legal guardian\u002Fcaregiver\n\nExclusion Criteria:\n\n* Youth presenting to the ED with psychosis, sexual assault, child abuse\n* Youth in police custody,\n* Youth with an active investigation with the department of child and youth services (DCYF)\n* Youth unable to assent due to severity of illness or developmental disabilities,\n* Youth who cannot communicate in English or Spanish,\n* Youth without a caregiver\u002Flegal guardian who can provide consent","8 Years",{"count":96,"type":21},186,[24],"The goal of this study is to develop a feasible brief, family-based adaptive intervention, via SMART design, for youth with suicidal and non-suicidal self-injurious behavior (SSIB) to increase community-based mental health (MH) care attendance and reduce SSIB risk post emergency department (ED) admission. The intervention will focus to increase understanding on youth MH literacy, MH communication, and MH engagement. Integrating an adaptive intervention via a SMART design in the ED could address subsequent barriers to youth obtaining appropriate level of community-based MH care and therefore reduce ED readmissions.",[28,100],"Linkage to Care",[102,103,104,105,106,107],"suicidality","self-injurious behavior","adaptive intervention","emergency department","caregivers","youth","2025-07-22",{"date":110,"type":39},"2025-07-29",{"date":112,"type":39},"2025-03-17",{"date":114,"type":21},"2029-03",{"name":116,"class":46},"Rhode Island Hospital",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":123,"sex":16,"minAge":124,"maxAge":55,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":85},"100421620","harry-potter-as-a-novel-educational-paradigm-to-improve-mental-wellness-in-children-a-prospective-trial-100421620","NCT04770168","Harry Potter as a Novel Educational Paradigm to Improve Mental Wellness in Children: A Prospective Trial","Inclusion Criteria:\n\n* Only schools with Grade 7 and 8 classrooms (if requested, we may allow high school teachers\u002Fstudents in Grade 9 - 12 to participate as well)\n* Participants must be able to speak and read fluent English\n* Participants must be willing to complete demographic and clinical self-report questionnaires on anxiety, depression, and general well-being before the intervention and at each timepoint.\n\nExclusion Criteria:\n\n\\-",true,"11 Years",{"count":126,"type":21},3204,[24],"School-based mental health literacy interventions have been shown to reduce and\u002For prevent suicidal ideation and attempts. Most programs to date include an adapted version of Cognitive Behavioural Therapy (CBT) - the gold standard treatment for youth and adult mood and anxiety disorders. CBT teaches youth about the relationship between their thoughts, feelings, and behaviours, and provides strategies for managing distress. However, there is no established standard mental health literacy curriculum in Ontario. The investigators developed a school-based mental health literacy program that uses the third book in the Harry Potter series ('Harry Potter and the Prisoner of Azkaban') to teach students how to cope with distress through CBT skills. This study will determine whether the Harry Potter-based mental health literacy curriculum diminishes suicidality in students. The study will also determine whether the curriculum decreases depression and anxiety symptoms and improves well-being.\n\nThe 3-month intervention is a manual-based curriculum which teaches CBT skills in English class. The website includes video and text-based onboarding to train teachers on all the lessons. Youth complete online exercises for each unit and teachers follow a manual with checklists to preserve high fidelity and standardization of core learning.\n\nParticipating classes will be randomized in 1:1 fashion to receive the curriculum in the fall (\\~Oct-Dec) or the winter (\\~Feb-Apr). The study will use a stepped-wedge design to introduce the curriculum to classes sequentially testing whether students who receive it in fall will improve at mid-year and those in winter will catch up by year-end. The winter group is included as a \"maturational\" control to account for changes over the school year that are independent of the intervention and so that order effects of curriculum delivery can be tested. For this design, questionnaires will be administered four times throughout the school year (once before and after each semester), and once more the following year to measure duration of response. At each timepoint, subjects will complete validated questionnaires about suicide attempts and self-harm, anxiety, depression, well-being, and health services usage. Students may also choose to participate in focus groups to collect qualitative data on their experience with the curriculum. With additional consent (Ontario youth only), we will also collect aggregate lists of the Ontario Health Insurance Plan (OHIP) numbers for participating students. These will be provided to the Institute of Clinical Evaluative Sciences (ICES) who will identify sex, age and pre-existing healthcare utilization matched controls from regions that do not adopt the curriculum.",[130,28,27],"Suicidal Ideation",[132,133,134,135,136,137],"Suicidal ideation","Suicide attempts","Self-harm","Mental health literacy curriculum","School-based intervention","Cognitive behavioral therapy","2024-07-24",{"date":140,"type":39},"2024-07-25",{"date":142,"type":39},"2021-09-01",{"date":144,"type":21},"2026-09",{"name":146,"class":46},"Sunnybrook Health Sciences Centre"]