[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"suicide-attempted\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:suicide-attempted":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,50,75,108,128,154,187,218,245,269,299,321,345,368,390,418,440,458,485,504,526,549,573,596,619],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100053248","neural-derived-plasma-exosomal-micrornas-as-promising-novel-biomarkers-for-suicidality-and-treatment-outcome-in-adolescents-100053248",false,"NCT05437588","Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents","Inclusion Criteria:\n\nAll participants:\n\n1. Physically healthy\n2. willing and able to provide informed consent (if under 18 also parent or guardian consent)\n\nMDD participants:\n\n1. A definite diagnosis of DSM-5\n2. a Children's Depression Rating Scale-Revised (CDRS-R) score \\>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS) score \\>=4 rated over the last two weeks.\n\nSuicide attempt group:\n\n1\\. Participants will have had an attempt in the previous two weeks that is serious enough to require medical attention and shows evidence of at least a medium level of intent on the Suicide Intent Scale.\n\nNon-psychiatric controls:\n\n1\\. No history of any major mental illness (excluding specific phobia) or substance use disorder.\n\nExclusion Criteria:\n\n* Exclusion criteria:\n\n  1. Pregnancy or lactation\n  2. post-partum state (being within 2 months of delivery or miscarriage);\n  3. homicide risk as determined by clinical interview\n  4. any of the following DSM-V diagnoses or categories: a) a lifetime history of psychotic disorder; b) alcohol or drug use disorder (except nicotine\u002Fcaffeine) within the last month; the use of any hallucinogen (except cannabis), including phencyclidine in the last month; c) bipolar disorder; d) pervasive developmental disorder; e) cognitive disorder; f) DSM-5 paranoid, schizoid, or schizotypal personality disorders (PDs) (participants with other PDs will be allowed as long as MDD criteria are met); g) anorexia nervosa.\n  5. recent myocardial infarction or unstable angina, active neoplasm in the past 6 months, immunosuppressive or corticosteroid therapy within the last month, chemotherapy, and head injury or loss of consciousness in the past 6 months\n  6. use of hallucinogens (except for cannabis), methamphetamine, or cocaine in the last 2 weeks.",true,"ALL","10 Years","24 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.",[28,29,30,31,32,33,34,35,36],"Major Depressive Disorder","Suicidal Ideas","Suicide, Attempted","MDD","Depression","Depression, Teen","Depression and Suicide","Depression in Adolescence","Suicide","RECRUITING","2026-07-10",{"date":40,"type":41},"2026-07-13","ACTUAL",{"date":43,"type":41},"2022-10-01",{"date":45,"type":22},"2027-06-30",{"name":47,"class":48},"University of Alabama at Birmingham","OTHER",2,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100538044","enhancing-the-effectiveness-of-prolonged-exposure-among-suicidal-individuals-with-ptsd-100538044","NCT06285708","Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD","Inclusion Criteria:\n\n* Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.\n\nExclusion Criteria:\n\n* Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).","18 Years",{"count":58,"type":22},100,[25],"The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the effectiveness of PE augmented with CRP as compared to PE with care as usual (self-guided treatment plan), an active comparator, for the reduction of suicide ideations and attempts for individuals with comorbid PTSD.",[62,63,30,64],"PTSD","Suicidal Ideation","Trauma, Psychological","2026-06-24",{"date":67,"type":41},"2026-06-29",{"date":69,"type":41},"2024-02-26",{"date":71,"type":22},"2027-06",{"name":73,"class":48},"Ohio State University",1,{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":74},"100609805","virtual-reality-lethal-means-safety-training-100609805","NCT07219355","Virtual Reality Lethal Means Safety Training","Expanding Provider Capacity to Prevent Rural Veteran Suicide: Virtual Reality Lethal Means Safety Training","Inclusion Criteria:\n\n* Age 18 or older\n* healthcare providers serving rural Veterans in Texas (e.g., physicians, physician assistants, nurse practitioners, nurses, pharmacists, social workers, healthcare case managers)\n* English-speaking\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Self-reported pregnancy\n* History of motor or balance disorders\n* Color blindness\n* Neurological or cognitive disorders\n* Cardiovascular issues that may be worsened by VR use\n* Use of cardiac pacemakers, defibrillators, or hearing aids incompatible with VR equipment\n* Significant discomfort in virtual reality environments (e.g., severe motion sickness, vertigo)",{"count":83,"type":22},36,[25],"The goal of this randomized clinical trial is to determine whether a virtual reality (VR) training program can help healthcare providers improve their skills in discussing suicide prevention and safe storage of firearms and medications with Veterans. The study will test whether VR training increases providers' self-efficacy, confidence, and comfort in conducting lethal means safety counseling, and whether it improves their intention to use these counseling practices in their clinical work. Researchers will compare healthcare providers who complete the VR training to those who complete a 2D video training to determine whether the VR approach is more effective. Participants will complete online surveys before and after the training and again three months later. They will be randomly assigned to one of two groups: VR training group: Participants use a VR headset to interact with a virtual Veteran patient in a simulated rural clinic and practice suicide prevention counseling skills; Video training group: Participants use the same headset to watch a \\~10-minute 2D video depicting the lethal means safety counseling session. After the training, participants will also provide feedback about their experience, including how realistic and useful they found the training.",[30,87,88,89,90,91],"Suicide, Completed","Suicide Prevention","Mental Health Training","Rural Health","Veterans",[91,93,88,94,95,96,97,98,99,90],"Rural Veterans","Suicide Risk","Firearm Safety","Medication Safety","Lethal Means Safety Counseling","Virtual Reality (VR)","VR Training Simulation","2026-06-23",{"date":65,"type":41},{"date":103,"type":41},"2026-02-23",{"date":105,"type":22},"2026-09-30",{"name":107,"class":48},"The University of Texas at Arlington",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":74},"100490823","effectiveness-and-implementation-of-a-clinician-decision-support-system-to-prevent-suicidal-behaviors-100490823","NCT05671133","Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors","Inclusion Criteria:\n\n* Adult status (≥18 years-old);\n* Willing to provide an email address;\n* Presentation at the APS\n\nExclusion Criteria:\n\n* Inability to understand the study procedures and provide informed consent such as those with gross cognitive impairment (including florid psychosis), intellectual disability, dementia, acute intoxication, or the presence of extremely agitated or violent behavior\n* Decisions about inclusion\u002Fexclusion criteria will be made by the emergency department providers on duty at the time. These broad inclusion criteria maximize the clinical applicability of obtained results while the exclusion criteria ensure the ethical principle of respect for persons.",{"count":115,"type":22},4000,[25],"The primary aim of this project are to evaluate a comprehensive, practice-ready, and deployment-focused strategy for improving the prediction and prevention of suicide attempts among a sample of 4,000 patients presenting to an ED with a psychiatric concern. The first aim is to evaluate the effects of providing information about risk of patient suicidal behavior to ED clinicians. The investigators hypothesize that patients randomly assigned to have their clinician receive their risk score will have a lower rate of suicide attempts during 6-month follow-up and that this effect will be mediated by changes in clinician decision-making.",[36,30],"2026-06-16",{"date":121,"type":41},"2026-06-22",{"date":123,"type":41},"2025-02-25",{"date":125,"type":22},"2028-09-28",{"name":127,"class":48},"Massachusetts General Hospital",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":74},"100506777","written-exposure-therapy-for-suicide-prevention-100506777","NCT05878795","Written Exposure Therapy for Suicide Prevention","Written Exposure Therapy for Suicide Prevention (WET-SP)","Inclusion Criteria:\n\n* Current active duty military service member, veteran, and beneficiaries\n* Admitted to Carl R. Darnall Army Medical Center (CRDAMC) for suicidal thoughts, a suicide plan, or a suicide attempt\n* Elevated levels of suicidal ideation severity in the past two weeks, as indicated by a score \\>= 3 on the Depressive Symptom Index-Suicidality Subscale (DSI-SS)\n* Ability to read, write, and speak English\n\nExclusion Criteria:\n\n* Active psychosis as the priority of care for hospitalization\n* Moderate or greater cognitive impairment (as determined by the inability to comprehend the baseline screening questionnaires)\n* Unable to provide informed consent",{"count":136,"type":22},160,[25],"Military service members admitted to inpatient psychiatry for self-injurious thoughts and behaviors (SITBs) represent an at-risk group for continued SITBs and rehospitalizations in the post-discharge period. However, there is an absence of evidence-based interventions designed to be delivered on inpatient psychiatric units to reduce the risk of post-discharge SITBs. To address this gap, the investigator's research group developed Written Exposure Therapy for Suicide Prevention (WET-SP), a brief, scalable, suicide-specific psychotherapy based on the written disclosure paradigm. Written disclosure, in which an individual writes about a personally stressful experience and the related thoughts and feelings, yields improvements across physical and psychiatric domains. Pilot data suggest that written exposure also yields reductions in SITBs. Yet, no study has adapted the written exposure paradigm specifically to target the amelioration of distress associated with suicidal crises and examined whether implementing WET-SP reduces the risk of subsequent SITBs and suicide-related hospitalizations.\n\nThe primary objective of this randomized controlled trial (RCT) is to evaluate the efficacy of WET-SP, in reducing the incidence and severity of SITBs in active duty military service members following a psychiatric hospitalization due to suicidal ideation, suicide plans, or a suicide attempt. Secondary objectives are to evaluate a potential mechanism of change (i.e., decreases in thwarted belongingness \\[cf. social disconnectedness\\]) and moderator of outcomes (i.e., arc of narrative \\[cf. linguistical parameters of the written narratives generated during treatment\\]). Participants randomized to WET-SP + TAU will receive five sessions of WET-SP delivered by the study team during their psychiatric hospitalization plus treatment-as-usual (TAU). Participants randomized to TAU will receive daily contact and patient-centered care delivered by the acute psychiatric inpatient unit provider team (e.g., psychiatrists, therapists, case managers). TAU includes psychiatric assessment, initial stabilization, nurse case management, medication management, treatment of medical comorbidities, group and individual therapy, and discharge planning. Outcome assessments will be administered at pretreatment, posttreatment, and 10-, 20-, and 30-week follow-ups.",[30,140],"Suicide Threat",[142,133,143,144],"Self-injurious thoughts and behaviors (SITBs)","Military service members","Treatment as usual (TAU)","2026-05-27",{"date":147,"type":41},"2026-05-29",{"date":149,"type":41},"2024-08-20",{"date":151,"type":22},"2027-09",{"name":153,"class":48},"Boston University",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":171,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":186},"100489612","ifd-survive-functional-efficacy-and-biological-correlates-reconcile-study-100489612","NCT05655390","iFD-SuRvivE funCtiONal effiCacy and bIologicaL corrElates (RECONCILE Study)","The SURVIVE 2 Project: An Extended Cohort Study to Investigate Suicidal Behavior in Spain and the Efficacy of Secondary Prevention Strategies: iFD-SuRvivE funCtiONal effiCacy and bIologicaL corrElates (RECONCILE Study)","RECONCILE","Inclusion Criteria:\n\n* Age over 18 years old\n* Having attempted suicide\n* Provide written informed consent\n* No claustrophobia\u002Fmetallic objects\u002Fimplants\n\nExclusion Criteria:\n\n* Intelligence quotient below 70 and impaired functioning\n* Any medical condition that could affect neuropsychological performance (such as neurological diseases) or a history of head trauma with loss of consciousness\n* Participation in any structured psychological intervention within the past 6 months\n* Patients who received electroconvulsive therapy within the past 6 months\n* Inability to give inform consent",{"count":163,"type":22},120,[25],"The goal of this clinical trial is to assess the effectiveness of an original intervention 'Functional Recovery in Depression and Suicide Risk Prevention Based on Emotion Regulation and Values: A Group Program' (from the original Spanish version: Programa Grupal De Recuperación Funcional En Depresión Y Prevención De Riesgo Suicida Basado En Regulación Emocional Y Valores) in depressed patients who have recently attempted suicide by improving their psychosocial functioning and therefore enhancing their ability to perform activities of daily living. As secondary objectives, the effectiveness of the intervention will be evaluated by determining cognitive performance (particularly decision-making, inhibition, and attention), quality of life, clinical status, and their relationship with neuroimaging correlates. Main target neuroimaging areas include the orbitofrontal cortex and dorsal prefrontal cortex.",[30,167,168,169,170],"Functioning, Psychosocial","Cognition","Neuroimaging","Quality of Lifte",[172,173,174,175,176],"suicide","cognition","neuroimaging","psychosocial functioning","quality of life","2026-05-08",{"date":179,"type":41},"2026-05-12",{"date":181,"type":41},"2025-09-16",{"date":183,"type":22},"2027-10",{"name":185,"class":48},"Iria Grande",4,{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":12,"sex":17,"minAge":195,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":198,"briefSummary":199,"conditions":200,"keywords":202,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":74},"100623370","youth-suicide-and-self-harm-intervention-clinical-and-biological-outcomes-study-100623370","NCT07395752","Youth Suicide and Self-Harm Intervention: Clinical and Biological Outcomes Study","Development and Biological Efficacy Validation of Youth Suicide and Self-Harm Intervention Program","SHIELD","Inclusion Criteria:\n\n1. General Criteria\n\n   * Aged between 15 and 30 years\n   * Obtained informed consent from a parent or legal guardian for participants under 19 years of age\n2. For the Self-Harm Group\n\n   * At least one incident of non-suicidal self-injury (NSSI) within the last 6 months\n   * Self-Harm Screening Inventory (SHSI) score of at least 1 (at least one \"Yes\" response)\n3. For the Suicide Attempt Group\n\n   * Suicide attempt within the last 6 months\n   * Depressive Symptom Inventory-Suicidality Subscale (DSI-SS) score of 3 or higher\n\nExclusion Criteria:\n\n1. Psychiatric and Developmental Conditions\n\n   * History of developmental disorders, including intellectual disability or autism spectrum disorder\n   * Diagnosis of schizophrenia or bipolar disorder\n   * Currently in an acute psychotic state\n2. Medical and Physical Conditions\n\n   * Presence of severe physical illness that interferes with daily life\n   * Presence of metallic substances in the body (e.g., cardiac pacemakers, artificial heart valves) that are incompatible with fMRI\n   * Diagnosis of claustrophobia\n   * Current Treatment and Intervention\n   * Currently receiving regular and active cognitive behavioral therapy (CBT)\n   * Initiation of pharmacological treatment within the last 2 months\n3. Communication and Consent\n\n   * Inability to communicate fluently in Korean\n   * Failure to obtain informed consent from a parent or legal guardian for participants under 19 years of age","15 Years","30 Years",{"count":58,"type":22},[25],"The goal of this clinical trial is to develop and evaluate youth-focused intervention programs for suicide and self-harm that are tailored to the psychological, developmental, and cultural characteristics of Korean adolescents and young adults. The study examines whether two structured, mindfulness-based intervention programs-one for middle and high school students and one for young adults-reduce suicidal ideation, self-harm behaviors, depressive symptoms, and emotion-regulation difficulties.\n\nThe study also aims to determine whether these clinical improvements are associated with biological changes, including alterations in resting-state functional brain activity (e.g., ALFF, ReHo, and functional connectivity) and social rhythm patterns.\n\nThe main questions this study seeks to answer are:\n\n* Does the youth suicide and self-harm intervention program reduce suicidal ideation and self-injurious thoughts\u002Fbehaviors?\n* Does the program improve mood, sleep, hopelessness, and emotion regulation?\n* Are improvements in clinical outcomes accompanied by changes in biological markers of suicide risk?\n* Researchers will compare the intervention program to usual care provided in hospitals, schools, and community mental health settings.\n\nParticipants will:\n\n* Participate in the structured suicide\u002Fself-harm intervention program or receive usual care.\n* Complete standardized assessments of mood, sleep, emotion regulation and suicide\u002Fself-harm risk.\n* Undergo biological assessments, including resting-state fMRI and rhythm-related measures, at baseline and follow-up.\n* Be followed for up to 12 weeks.",[63,201,30],"Self-Injurious Behavior",[203,204,205,206,207,208,209],"Youth suicide","Suicidal ideation","Suicide attempt","fMRI","Social rhythm","Adolescents","Young adults","2026-05-04",{"date":177,"type":41},{"date":213,"type":41},"2025-07-30",{"date":215,"type":22},"2026-12-31",{"name":217,"class":48},"Ajou University School of Medicine",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":12,"sex":17,"minAge":224,"maxAge":19,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":244},"100527699","preventing-suicidal-behavior-with-diverse-high-risk-youth-in-acute-care-settings-100527699","NCT06151158","Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings","Inclusion Criteria:\n\n* Suicide Risk During Acute Care Visit (At least one item in risk assessment is required; check all that apply): \\_\\_\\_ Chief complaint of suicide-related concern (via Medical Record\u002FOther), \\_\\_\\_ Active suicidal ideation endorsed in past 1 month on validated suicide screener, \\_\\_\\_ Suicidal behavior in the past 3 months on validated suicide screener, \\_\\_\\_ Clinician indicated SI in past month or SA in past 3 months.\n* Have access to a cellular phone with the ability to receive phone calls and text messages over the 12-month follow- up period\n* Adolescent must be verbally fluent and can communicate, understand, and read in either English or Spanish\n* Adolescent has been\u002Fwill be discharged from a higher level of care (i.e. inpatient, day hospital, partial hospitalization program (PHP), or residential treatment program) and back in the community within 4 weeks of their acute care visit. \\[Note: this criterion does not apply to all patients - select N\u002FA if this is the case.\n\nExclusion Criteria:\n\n* Significant cognitive or developmental delays that prevent understanding or using SPI+ or IPT-A-SCI (includes inability to communicate verbally)\n* Altered mental status (acute psychosis, intoxication, or mania)\n* Unable or unwilling to provide informed consent (adults), assent (minors), or permission (parents\u002Fcaregivers)\n* The services offered through the study are not in the best clinical interest of the patient (e.g., presenting problem requires a different level of care or treatment approach).","12 Years",{"count":226,"type":22},1000,[25],"The study will compare the effectiveness of two relatively brief and scalable evidence-based interventions: the Stanley Brown Safety Planning Intervention and Follow-up Contacts (SPI+), a suicide-specific intervention that helps people prevent suicidal crises from escalating, and Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention (IPT-A SCI), a psychotherapeutic crisis intervention treatment for suicidal adolescents that teaches youth skills to prevent suicidal crises and addresses interpersonal problems that lead to suicidal crises. The results will inform the future standard of care for youth at risk for suicide presenting in the ED setting. This project focuses on suicidal youth ages 12-24 in five ethnically and racially diverse urban areas: Philadelphia, Pennsylvania; Baltimore, Maryland; Chapel Hill, North Carolina; St. Petersburg, Florida; and Northern Manhattan\u002Flower Bronx\u002Feastern Queens communities in New York City, New York.",[30,230,36,88],"Suicide Ideation",[232,233,234,235,88],"Safety Planning Intervention","Ultra-Brief Crisis","Interpersonal Psychotherapy for Adolescents","Emergency Department","2026-04-28",{"date":210,"type":41},{"date":239,"type":41},"2025-03-10",{"date":241,"type":22},"2028-10-14",{"name":243,"class":48},"Johns Hopkins University",6,{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":254,"phases":4,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":267,"locationsCount":49},"100598956","long-term-follow-up-of-depressive-disorders-in-psychiatric-care-100598956","NCT07078227","Long-term Follow-up of Depressive Disorders in Psychiatric Care","5 Years Follow-up of the Study: \"Pharmacogenetics in Depressed Patients With Specific Focus on Difficult-to-treat Depresssion, Suicide Attempt and CYP2D6\"","Inclusion Criteria:\n\nParticipation in the study \"Pharmacogenetics in depressive patients with specific focus on difficult-to-treat depression, suicide attempt and CYP2D6\"\n\nExclusion Criteria:\n\nNot wanting to participate in the follow-up study",{"count":253,"type":22},415,"OBSERVATIONAL","The project investigates long-term prognosis and predictors of treatment outcomes for difficult-to-treat depression in patients in secondary psychiatric care. The current patient cohort was collected in 2012-2021 in the study \"Pharmacogenetics in patients with depression with specific focus on difficult-to-treat depression, suicide attempt and CYP2D6\". The cohort consists of 415 patients, examined carefully regarding diagnostic assessment and earlier treatment. All participants were also genotyped for the drug metabolizing enzymes CYP2D6 and CYP2C19. Blood samples were stored in biobank for other analyses linked to prognostic markers.\n\nThe patient cohort will now be followed up with a review of medical records and extraction of register data for a period of 5 years after their participation in the original study. The purpose of the study is to improve treatment and increase knowledge about long-term prognosis in difficult-to-treat depression. This is done by examining symptom profiles, monitoring clinical course and suicidality, and examining prognostic markers.",[32,257,258,30,259,260],"Psychiatric Diagnosis","Personality Disorders","CYP2D6 Polymorphism","Anhedonia","2026-04-24",{"date":263,"type":41},"2026-04-30",{"date":265,"type":41},"2025-06-01",{"date":215,"type":22},{"name":268,"class":48},"Region Skane",{"id":270,"slug":271,"hasResults":12,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":276,"enrollmentInfo":277,"targetDuration":4,"studyType":23,"phases":279,"briefSummary":280,"conditions":281,"keywords":285,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":298},"100587688","suicide-preventive-psychosocial-treatment-for-youths-100587688","NCT06931639","Suicide Preventive Psychosocial Treatment for Youths","Suicide Preventive Psychosocial Treatment for Youths: A Randomized Controlled Trial","Inclusions criteria:\n\n1. Suicide attempt in the last 3 months\n2. Age 10-17 years\n3. At least one primary caregiver (multiple is allowed) willing to participate in treatment\n\nExclusion criteria:\n\n1. Symptoms obstructing participation in assessments or treatment\n2. Insufficient understanding of the Swedish language in youth and\u002For caregiver\n3. Enrolled in Dialectical Behavioral Therapy","17 Years",{"count":278,"type":22},282,[25],"Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal costs, making suicide attempts a critical target in psychiatric intervention research. Although youths attempting suicide are typically assessed and treated for potential comorbid psychiatric conditions, there is currently no trans-diagnostic evidence-based treatment specifically targeting suicidal behavior. To fill this gap, the Safe Alternatives for Teens and Youths (SAFETY) was developed. SAFETY is a transdiagnostic family-based cognitive-behavioral suicide prevention program that has shown promise but more studies are needed.\n\nThe overall objective of this project is to evaluate the efficacy, durability, and cost-effectiveness of the SAFETY intervention, a scalable suicide prevention intervention that can be offered immediately following a youth suicide attempt, in a fully powered single-blind randomized controlled superiority trial. Our primary hypothesis is that the SAFETY intervention will be superior to Enhanced Treatment As Usual (enhanced with the evidence-based intervention safety planning) in reducing the proportion of suicide reattempts. Moreover, we predict that these improvements will be maintained for up to 60 months post-treatment. Finally, we expect that SAFETY will be cost-effective compared to the control intervention, both at the primary endpoint and in the longer term.",[282,283,284,30],"Suicide Attempt","Suicidal and Self-injurious Behavior","Suicide Attempted",[286,287,282,288],"Safe Alternatives for Teens and Youths","Self-injurious Behavior","Suicidal Behavior","2026-04-14",{"date":291,"type":41},"2026-04-17",{"date":293,"type":41},"2025-05-28",{"date":295,"type":22},"2032-09",{"name":297,"class":48},"Karolinska Institutet",5,{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":17,"minAge":224,"maxAge":56,"enrollmentInfo":306,"targetDuration":4,"studyType":23,"phases":308,"briefSummary":309,"conditions":310,"keywords":311,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":319,"locationsCount":49},"100552525","efficacy-of-ebpsi-on-future-suicide-risk-among-adolescent-suicide-attempters-100552525","NCT06474221","Efficacy of EBPSI on Future Suicide Risk Among Adolescent Suicide Attempters","A Multi-centric Trial to Evaluate the Efficacy of Electronic-Based Psychosocial Interventions on Future Suicide Risk Among Adolescent Suicide Attempters","Inclusion Criteria:\n\n* All adolescents who have attempted suicide within the last thirty days and presented to the study site\n* Between ages of 12-18 years\n* Participants of all gender will be included\n* Medically stable patients who have stable blood pressure, breathing rates without fever, and intact orientation to time, place, and person\n\nExclusion Criteria:\n\n* A current or a lifetime diagnosis of psychosis. We will confirm the same using a detailed clinical interview according to ICD-10 diagnostic guidelines.\n* A history of mental retardation and any neurological condition causing cognitive impairment.\n* A diagnosis of substance dependence as confirmed by M.I.N.I. KID 6.0 over the last six months. We will include those with tobacco dependence.\n* A diagnosis of serious medical illness like end-stage cancer, AIDS, less than a month following acute cardiovascular and cerebrovascular events.",{"count":307,"type":22},168,[25],"Our study is designed to study the efficacy of an Electronic based psycho-social intervention targeting healthy coping and problem solving skills to mitigate suicidal behaviour. This would integrate existing systems and bridge the gap in accessibility to care for suicidal behaviour.",[30],[205,312],"Electronic Based Psychosocal Intervention(EBPSI)","2026-04-06",{"date":315,"type":41},"2026-04-07",{"date":317,"type":41},"2024-08-31",{"date":215,"type":22},{"name":320,"class":48},"University of Pittsburgh",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":23,"phases":330,"briefSummary":331,"conditions":332,"keywords":334,"overallStatus":335,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":74},"100563344","improving-coping-to-reduce-suicide-risk-following-ed-discharge-100563344","NCT06614946","Improving Coping to Reduce Suicide Risk Following ED Discharge","Facilitating Effective Coping to Reduce Suicide Risk Following ED Discharge: A Micro-randomized Trial to Develop an Adaptive Text-based Intervention","Inclusion Criteria:\n\nIndividuals presenting to an ED with either:\n\n1. actual, interrupted, or aborted attempt in the last 4 weeks\n2. suicidal ideation within the last week\n\nExclusion Criteria:\n\n* Severe cognitive impairment or altered mental status (psychosis, manic state)\n* Severe aggression\u002Fagitation,\n* Being admitted or transferred into inpatient care,\n* Patient not owning a cell phone with text messaging capability","65 Years",{"count":163,"type":22},[25],"The researchers hope to learn whether an electronic safety plan (ESP) and a supportive text messaging program are feasible and acceptable to adult patients with recent suicidal thoughts or behavior after emergency department (ED) discharge. From this study, the researchers also hope to learn how to best carry out the ESP and text messaging program to improve outcomes for patients after ED discharge.",[333,30,63],"Suicidal",[235],"NOT_YET_RECRUITING","2026-03-30",{"date":338,"type":41},"2026-03-31",{"date":340,"type":22},"2026-05",{"date":342,"type":22},"2027-02",{"name":344,"class":48},"University of Michigan",{"id":346,"slug":347,"hasResults":12,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":12,"sex":17,"minAge":352,"maxAge":196,"enrollmentInfo":353,"targetDuration":4,"studyType":23,"phases":355,"briefSummary":357,"conditions":358,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":49},"100421097","phase-3-ketamine-treatment-of-youth-suicide-attempters-100421097","NCT04763343","Ketamine Treatment of Youth Suicide Attempters","Ketamine Treatment of Youth Suicide Attempters for Fast Reduction of Severe Suicide Risk and Facilitation of Long-term Collaborative Clinical Engagement: A Double Blind Randomized Placebo Controlled Trial","Inclusion Criteria:\n\n* Subjects must be 14 to 30 years of age\n* Subjects must have been admitted to Cleveland Clinic Hospital (Fairview or Lutheran Hospital) after a suicide attempt (any intentional, non-fatal self- injury regardless of medical lethality, if intent to die was indicated) with continued suicidal ideation or endorsing ongoing suicidal ideation and unable to contract for safety placing them at an increased risk to attempt suicide. Subjects will need a clinical rated Scale for Suicidal Ideation (SSI) score ≥ 6.\n* Subjects must have the ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Subjects with known history of autistic spectrum disorder; non-verbal patients.\n* Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education full-time).\n* Subjects with schizophrenia or history of any type of psychosis including mood disorder related psychosis and brief reactive psychosis.\n* Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for management of ADHD will not be excluded)\n* Subjects with history of moderate or severe substance or alcohol use per DSM- V criteria in the past 6 months.\n* Subjects with any contraindication to ketamine such as allergic reaction to ketamine or medical or neurological condition with a contraindication for use of ketamine or on any drugs associated with significant interaction with ketamine.\n* Subjects who are currently pregnant and\u002For breast feeding.\n* Subjects with previous recreational ketamine use. Subjects with previous therapeutic Ketamine use that exceeds the maximum cumulative lifetime exposure of 60 mg daily and 8 administrations maximum (or 480 mg) during both previous treatment and the proposed inclusion of this study.\n* Subjects with hypertension, history of myocardial infarction, congestive heart failure of Stage 2 or higher, angina, or QTcF of at least 450 msec as indicated by chart review and\u002For standard of care EKG performed upon admission to inpatient unit.\n* Subjects in the custody of Children's Services.","14 Years",{"count":354,"type":22},60,[356],"PHASE3","Ketamine, an NMDA antagonist, has been shown to have rapid anti- suicidal effects. However, its safety and efficacy and special populations has not been investigated and documented. Several reports in adults suggest rapid decrease of suicidal ideation. In the last decade there is an alarming increase of the number of suicide attempts in patients ages 14-30. Suicide is the second leading cause of death in this population. Patients with previous history of suicide attempt, are even in a higher risk category. The present study focus in this high risk group of suicide attempters. This will be a randomized controlled trial enrolling 60 youth between the ages 14-30 after a suicide attempt; patients will be randomized to receive Ketamine 0.5 mg\u002Fkg over 40 minutes or normal saline. Patients will receive all Ketamine or placebo infusions while admitted in the Inpatient Psychiatry Service. Patients will receive up to 6 ketamine or placebo infusions until, for 3 consecutive sessions, they have a clinician rated Scale for Suicidal Ideation (SSI) score of\\\u003C4, and \\>50% decrease from baseline, and clinical assessment of patient not being suicidal, or they have been discharged from the inpatient unit. Patients will participate in weekly sessions of Collaborative Assessment for the management of Suicidality (CAMS), from the first week of the study while admitted to the hospital and will continue it on a weekly basis post-discharge until the patient has three consecutive outpatient CAMS sessions with an overall risk \\\u003C 2 (# 6 on the SSF Core Assessment) along with a positive response regarding their thoughts\u002Ffeelings and clinician indicating behavioral stability (suicidal behavior).",[30],"2026-03-18",{"date":361,"type":41},"2026-03-20",{"date":363,"type":41},"2022-06-27",{"date":365,"type":22},"2026-08-31",{"name":367,"class":48},"Tatiana Falcone, MD",{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":74},"100492690","brief-cognitive-behavioral-therapy-for-people-with-physical-disabilities-100492690","NCT05695430","Brief Cognitive Behavioral Therapy for People With Physical Disabilities","Telehealth-delivered Brief Cognitive Behavioral Therapy to Prevent Suicides in People With Physical Disabilities","Inclusion Criteria:\n\n* 18 years of age\n* Disability impacting vision, hearing, or mobility\n* Past-week suicidal ideation or past-month suicide attempt\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Lack of internet connection and web camera",{"count":354,"type":22},[25],"The purpose of this study is to examine the effectiveness of a psychotherapy (non-medication) treatment, Brief Cognitive Behavioral Therapy for Suicide Prevention, in reducing suicide ideation and attempts for people with physical disabilities.",[36,30,63,379,380,381],"Disability Physical","Disability Hearing","Disability, Vision","2026-02-16",{"date":384,"type":41},"2026-02-19",{"date":386,"type":41},"2022-03-01",{"date":388,"type":22},"2026-03",{"name":73,"class":48},{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":17,"minAge":397,"maxAge":56,"enrollmentInfo":398,"targetDuration":4,"studyType":23,"phases":400,"briefSummary":401,"conditions":402,"keywords":404,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":416,"locationsCount":74},"100469293","targeting-adolescent-insomnia-to-lessen-overall-risk-of-suicidal-behavior-100469293","NCT05390918","Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior","TAILOR","Inclusion:\n\n* Nationwide Children's Hospital patients\n* Between the ages of 11 years, 0 months, and 18 years, 11 months, inclusive at time of consent\n* Endorse both recent (past 90 days) suicidal ideation and sleep problems (past 30 days)\n* Resides with primary caregiver who has legal authority to consent to research participation\n\nExclusion:\n\n* Suicide attempt in the past 3 months\n* Diagnosis of Bipolar Disorder or Psychosis\n* Having a change to an antipsychotic and\u002For mood stabilizer medication regimen within the last 2 months\n* Snoring at least 3 nights per week that can be heard a room or two away, even without a cold or flu or during allergy season\n* Gasping for air while sleeping, diagnosis of Obstructive Sleep Apnea, or turning blue within the past year\n* Body Mass Index \\> 40\n* Daytime symptoms of Restless Leg Syndrome\n* Diagnosis of Narcolepsy\n* Diagnosis of Seizures or Epilepsy, or prescribed anticonvulsant medication, within the past 4 years\n* Significant substance use in the past month\n* Currently receiving sleep disorder services from a sleep clinic\n* Inability to speak\u002Fread English adequately to understand and complete study consent and procedures\n* No access to a telephone or internet-connecting device\n* Sibling already in the study","11 Years",{"count":399,"type":22},235,[25],"This study will test the effectiveness of a sleep-related primary suicide prevention program entitled TAILOR (Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior), which includes specific behavior-change strategies for adolescents at risk of suicidal behavior who suffer from difficulties falling asleep, staying asleep, and\u002For insufficient sleep.",[403,63,30],"Insomnia",[405,63,406,407,408,409],"Sleep Initiation and Maintenance Disorders","Adolescent","Motivational Interviewing","Cognitive Behavioral Therapy","Telemedicine","2026-02-03",{"date":412,"type":41},"2026-02-05",{"date":414,"type":41},"2022-10-20",{"date":342,"type":22},{"name":417,"class":48},"Jeff Bridge",{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":23,"phases":427,"briefSummary":428,"conditions":429,"keywords":430,"overallStatus":335,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":4},"100503574","a-health-systemcommunity-partnership-for-enhanced-outreach-to-prevent-suicide-attempts-100503574","NCT05837026","A Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts","Randomized Controlled Trial of Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts","Inclusion Criteria:\n\n1. Currently a patient being treated and evaluated by psychiatry service in an MGB ED\n2. Participants enrolled in another study (NCT05671133; PI Nock) conducted by the research team who fall into the top 50% of risk based on the suicide risk prediction algorithm used in that study\n3. Able to read English\n4. Ownership of a smartphone (iOS or Android) and consistent access to their smartphone following discharge from the current treatment unit or program; ability to be reliably contacted\n5. Willing to provide contact information for collateral contact\n6. Willing to share contact information and key clinical information with Samaritans of Boston\n7. Consent to unencrypted text or email communications\n8. Willing to provide social security number (SSN) or individual taxpayer identification number (ITIN) for study compensation\n\nExclusion Criteria:\n\n1. Any factor that impairs an individual's ability to comprehend and effectively participate in informed consent, including the presence of gross cognitive impairment due to florid psychosis, intellectual disability, dementia, or acute intoxication\n2. Presence of extremely agitated or violent behavior at the time of consent or enrollment",{"count":426,"type":22},300,[25],"The goal of this study is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an emergency department (ED) visit for suicidal thoughts. The main questions it aims to answer are:\n\n* Does the EOI reduce suicide-related behaviors?\n* Does the EOI increase outpatient treatment attendance?\n* Is the EOI acceptable and feasible?\n* Can the EOI be delivered with fidelity by Samaritans?\n\nParticipants will be randomized to the EOI plus care as usual or care as usual alone. Participants in the EOI plus care as usual group will:\n\n* Receive outreach (by call or text) at a planned time once per week for the next 12 weeks. During these conversations, Samaritans staff will ask participants questions about their suicidal thoughts and behaviors, develop and review a list of coping skills to use if they have suicidal thoughts, and discuss plans for receiving mental health care.\n* Receive caring messages from Samaritans staff at least once per week.\n* Receive standard care that hospitals give for patients who present with suicidal thoughts.\n* Be asked to complete monthly self-report questionnaires.\n\nFor care as usual alone, participants will:\n\n* Receive standard care that hospitals give for patients who present with suicidal thoughts.\n* Be asked to complete monthly self-report questionnaires.",[36,30,63],[36,431],"Suicidal Thoughts","2026-01-26",{"date":434,"type":41},"2026-01-27",{"date":436,"type":22},"2026-06",{"date":438,"type":22},"2027-11",{"name":127,"class":48},{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":448,"briefSummary":449,"conditions":450,"keywords":451,"overallStatus":335,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":452,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":4},"100502712","pilot-study-of-health-systemcommunity-partnership-for-enhanced-outreach-to-prevent-suicide-attempts-100502712","NCT05825820","Pilot Study of Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts","Pilot Study Health System\u002FCommunity Partnership for Enhanced Outreach to Prevent Suicide Attempts",{"count":447,"type":22},20,[25],"The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an emergency department (ED) visit for suicidal thoughts. The main questions the trial aims to answer are:\n\n* Is the EOI feasible and acceptable?\n* Can the EOI be delivered with fidelity by Samaritans staff?\n\nParticipants will:\n\n* Receive outreach (by call or text) once per week for 12 weeks after ED visit. During these conversations, Samaritans staff will ask participants questions about their suicidal thoughts and behaviors, develop and review a list of coping skills to use if they have suicidal thoughts, and discuss plans for receiving mental health care.\n* Receive caring messages from Samaritans staff at least once per week.\n* Be asked to complete monthly self-report questionnaires, and participate in a phone interview with study staff at the end of the study.",[36,30,63],[36,431],{"date":434,"type":41},{"date":454,"type":22},"2026-04",{"date":456,"type":22},"2026-07",{"name":127,"class":48},{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":481,"leadSponsor":483,"locationsCount":74},"100536352","differences-between-suicide-attempters-and-suicide-ideators-influence-of-the-brief-therapy-attempted-suicide-short-intervention-program-assip-on-neuropsychological-correlates-and-psychological-process-factors---project-2-100536352","NCT06263712","Differences Between Suicide Attempters and Suicide Ideators. Influence of the Brief Therapy Attempted Suicide Short Intervention Program (ASSIP) on Neuropsychological Correlates and Psychological Process Factors - Project 2","Differences Between Suicide Attempters and Suicide Ideators. Influence of the Brief Therapy ASSIP on Neuropsychological Correlates and Psychological Process Factors (NePsyASSIP HT) - Project 2","NePsyAssip HT","Inclusion Criteria for Project 2:\n\nSubjects fulfilling the following inclusion criteria are eligible for the study:\n\n* Informed consent as documented by signature\n* Age ≥ 18 years\n* At least one previous suicide attempt\n* Willingness to attend the ASSIP brief therapy\n* Owns a smartphone\n\nExclusion Criteria for Project 2:\n\nThe presence of any one of the following exclusion criteria will lead to exclusion of the subject:\n\n* Serious cognitive impairment\n* Any psychotic disorder\n* Any current medication, which substantially impairs the attention span, reaction, rate or any other relevant cognitive functions\n* Inability to follow the procedures of the study (e.g., insufficient mastery of the German language, previous enrolment into the current study)",{"count":467,"type":22},156,[25],"The present study consists of 3 projects in total and aims to investigate the (neuro-) psychological patterns from suicidal ideation to suicidal behavior as well as the effects and feasibility of ASSIP Home Treatment.\n\nThe overall aim of project 2 is to investigate how the (neuro-) psychological patterns are modulated by the Attempted Suicide Short Intervention Program (ASSIP). Therefore, suicide attempters participating in this project 2 will be randomly assigned to either the intervention group ASSIP or a standard care plus resource interview (STAR) group. The ASSIP and STAR interventions take place at the University Hospital of Psychiatry and Psychotherapy Bern (Switzerland).\n\nAt the end of the assessment in project 1 participants who reported a history of past suicide attempt (SUAT) will be informed about project 2.\n\nOnly if participants agreed to take part in project 2 and have signed the informed consent, they are randomized into two conditions: The ASSIP intervention (ASSIP) versus standard of care plus resource interview (STAR). Participants of both groups will be assessed again 4 weeks and 12 months after their first baseline assessment of project 1.",[471,472,230,30,473,474,475],"Inhibitory Control","Self Efficacy","Locus of Control","Process Factors","Movement Synchrony","2026-01-19",{"date":478,"type":41},"2026-01-22",{"date":480,"type":41},"2024-03-25",{"date":482,"type":22},"2026-12",{"name":484,"class":48},"University of Bern",{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":464,"eligibilityCriteria":491,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":254,"phases":4,"briefSummary":494,"conditions":495,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":503,"locationsCount":74},"100535164","neuropsychological-patterns-of-suicide-ideators-and-suicide-attempters-100535164","NCT06248268","Neuropsychological Patterns of Suicide Ideators and Suicide Attempters","Differences Between Suicide Attempters and Suicide Ideators. Influence of the Brief Therapy ASSIP on Neuropsychological Correlates and Psychological Process Factors (NePsyASSIP HT) - Project 1","Inclusion Criteria:\n\nSubjects fulfilling the following inclusion criteria are eligible for the study:\n\n* Informed consent as documented by signature\n* Age ≥ 18 years\n\nAdditional inclusion criterion for the SUAT group in project 1:\n\n• At least one previous suicide attempt\n\nAdditional inclusion criterion for the SUID group in project 1:\n\n• Suicidal ideation\n\nAdditional inclusion criterion for the CLIN group in project 1:\n\n• Current psychiatric disorder treated on an inpatient, day-care or outpatient basis For the HLTH group, no further inclusion criteria are formulated.\n\nExclusion Criteria:\n\nThe presence of any one of the following exclusion criteria leads to exclusion of the subject:\n\n* Serious cognitive impairment\n* Any current psychotic disorder\n* Any current medication, which substantially impairs the attention span, reaction rate or any other relevant cognitive functions\n* Inability to follow the procedures of the study (e.g., insufficient mastery of the German language, previous enrolment into the current study)\n\nAdditional exclusion criterion for the SUID group:\n\n• Previous suicidal behavior\n\nAdditional exclusion criteria for the CLIN and HLTH groups:\n\n* Previous suicidal behavior\n* Suicidal ideation\n\nAdditional exclusion criterion for the HLTH group:\n\n• Current psychiatric disorder treated on an inpatient, day-care or outpatient basis",{"count":493,"type":22},180,"The present study consists of 3 projects in total and aims to investigate the (neuro-) psychological patterns from suicidal ideation to suicidal behavior as well as the effects and feasibility of ASSIP Home Treatment.\n\nThe overall aim of project 1 is to determine (neuro-) psychological differences between suicide attempters, suicide ideators, a clinical control group, and healthy controls. Study participants in project 1 will participate in a one-time (neuro-) psychological assessment.\n\nProject 1 of this study is an observational cross-sectional study with four groups that will be conducted at the University Hospital of Psychiatry and Psychotherapy Bern (Switzerland): Patients with at least one suicide attempt in their past (SUAT), patients with suicidal ideation (SUID), patients from the same clinical cohort, without neither suicidal behavior or ideation (CLIN) and the healthy group (HLTH). The cohorts to be examined (SUAT \\& SUID) will be compared to the two control groups (CLIN \\& HLTH). Only people who have signed the informed consent and meet the eligibility criteria can participate in this study.",[471,473,472,30,63,496],"Attention","2026-01-15",{"date":499,"type":41},"2026-01-16",{"date":501,"type":41},"2024-08-08",{"date":215,"type":22},{"name":484,"class":48},{"id":505,"slug":506,"hasResults":12,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":510,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":23,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":523,"locationsCount":74},"100507214","randomized-clinical-trial-of-re-evaluating-suicidal-thoughts-in-veterans-100507214","NCT05884476","Randomized Clinical Trial of Re-Evaluating Suicidal Thoughts in Veterans","Effects of a Targeted Web-Based Suicide Prevention Intervention on Suicidal Ideation and Self-Directed Violence: A Randomized Controlled Trial in Veterans","REST-V","Inclusion Criteria:\n\n* Veteran\n* 18 years or older\n* Past two-week suicidal ideation as indicated by positive reply to C-SSRS questions (\"Have you had any actual thoughts of killing yourself,\" or, \"Have you been thinking about how you might do this?\")\n\nExclusion Criteria:\n\n* Active psychosis\n* Unmedicated bipolar disorder\n* Instances in which a substance use disorder would indicate inpatient detoxification prior to engaging in other outpatient mental health interventions",{"count":493,"type":22},[25],"Suicide prevention is a top priority for VA as all continue to seek new and inventive ways to reduce suicide rates among Veterans. Many experts agree that suicide prevention efforts could be improved by making suicide-specific interventions easier to access. The current project aims to move toward that goal by testing a web-based suicide prevention intervention using an experimental design. The roughly 40-minute intervention aims to teach Veterans coping skills that are designed to ease the emotional distress that often comes with thoughts of suicide. The project will evaluate whether Veterans who receive this intervention report more improvement in suicidal thoughts and behaviors than Veterans who receive a standard course of health care visits. Suicidal thoughts and behaviors will be measured over the course of one month. The investigators hypothesize that Veterans who receive the intervention will report lower suicidal thoughts and behaviors than those who receive the standard course of health care.",[63,30],[63,30],"2025-12-10",{"date":519,"type":41},"2025-12-18",{"date":521,"type":41},"2024-01-08",{"date":45,"type":22},{"name":524,"class":525},"VA Office of Research and Development","FED",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":532,"eligibilityCriteria":533,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":534,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":546,"locationsCount":548},"100488291","effectiveness-of-the-suicidal-crisis-intervention-sci-100488291","NCT05638204","Effectiveness of the Suicidal Crisis Intervention (SCI)","A Randomized Controlled Study on the Effectiveness of the Suicidal Crisis Intervention (SCI)","RCT SCI","Inclusion Criteria Patient:\n\n* After a suicide attempt or suicidal crisis\n* ≥ 18 years\n* Availability of a smartphone, tablet and\u002For computer with internet access,\n* Dutch-speaking.\n\nExclusion Criteria Patient:\n\n* Limited comprehension, cognitive impairment\n* Psychotic disorder\n* Unsuitable for individual therapy\n* Receiving other forms of care is not an exclusion criterion.\n\nInclusion Criteria Close one:\n\n* close one of the patient\n* ≥ 18 years\n* Dutch- speaking",{"count":535,"type":22},390,[25],"The main objective of this project is to be able to offer a new, specific evidence-based short-term treatment method, the Suicidal Crisis Intervention (SCI), to reduce suicidality. In addition, this study aims to investigate the influence of SCI on other important aspects of suicidality (secondary goal) such as hopelessness, defeat, entrapment, and interpersonal needs.",[36,63,30],"2025-11-14",{"date":541,"type":41},"2025-11-18",{"date":543,"type":41},"2023-07-11",{"date":545,"type":22},"2026-09-01",{"name":547,"class":48},"University Hospital, Ghent",12,{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":553,"acronym":4,"eligibilityCriteria":554,"healthyVolunteers":12,"sex":17,"minAge":555,"maxAge":556,"enrollmentInfo":557,"targetDuration":4,"studyType":23,"phases":559,"briefSummary":560,"conditions":561,"keywords":562,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":571,"locationsCount":49},"100453337","wellpath-prevent-a-mobile-intervention-for-middle-aged-and-older-adults-hospitalized-for-suicidal-ideation-or-attempt-100453337","NCT05183230","WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt","Inclusion Criteria:\n\n* 50-90 years old\n* Diagnosis (based on a modified SCID-5 Clinical Trials Version to assess DSM-5 diagnoses): Any DSM-5 except: current diagnosis of Psychotic Disorder; diagnosis of Dementia\n* Recent hospitalization for suicidal ideation or suicide attempt; at hospital admission, Columbia Suicide Severity Rating Scale (CSSR-S) ≥ 2, \"Non-specific Active Suicidal Thoughts.\"\n* We will also include patients on psychotropics and on after-care community psychotherapy.\n\nExclusion Criteria:\n\n* Current diagnosis of Psychotic Disorders; Diagnosis of Dementia\n* Cognitive Impairment (MMSE ≤ 24)\n* Acute or severe medical illness (i.e., delirium; decompensated cardiac, liver or kidney failure; major surgery; stroke or myocardial infarction during the three months prior to entry\n* Aphasia, sensory problems, and\u002For inability to speak English.","50 Years","90 Years",{"count":558,"type":22},115,[25],"The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in middle-aged and older adults (50-90 years old) who have been discharged after a suicide-related hospitalization (i.e. for suicidal ideation or suicide attempt).",[30,63,32],[563,564],"Older Adults","Middle Aged Adults","2025-10-27",{"date":567,"type":41},"2025-10-29",{"date":569,"type":41},"2022-04-22",{"date":105,"type":22},{"name":572,"class":48},"Weill Medical College of Cornell University",{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":578,"acronym":579,"eligibilityCriteria":580,"healthyVolunteers":12,"sex":17,"minAge":224,"maxAge":581,"enrollmentInfo":582,"targetDuration":4,"studyType":23,"phases":584,"briefSummary":585,"conditions":586,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":587,"lastUpdatePostDateStruct":588,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":593,"locationsCount":595},"100438867","skills-to-enhance-positivity-in-suicidal-youth-100438867","NCT04994873","Skills to Enhance Positivity in Suicidal Youth","Skills to Enhance Positivity in Adolescents at Risk for Suicide","STEP","Inclusion Criteria: Patients\n\n* Ages 12- 60 years\n* hospitalized on an inpatient psychiatric unit due to suicide risk\n* past month suicide attempts or suicidal ideation\n* proficient in English (parent either English or Spanish\n* access to a smart phone.\n\nInclusion Criteria: Stakeholders\n\nAges 22 - 60 years\n\n* work with adolescents hospitalized on an inpatient psychiatric unit due to suicide risk\n* proficient in English or Spanish\n\nExclusion Criteria:\n\n* active psychotic disorder\n* significant cognitive impairment or deficits\n* ward of the State\n* discharge to residential facility.","60 Years",{"count":583,"type":22},216,[25],"This is a Hybrid Type I Effectiveness-Implementation design. Specifically, this study proposes to test the effectiveness of STEP in reducing suicidal events and ideation in 216 adolescents, admitted to inpatient psychiatric care due to suicide risk. Participants will be randomized to either STEP or ETAU. STEP involves 4 in-person sessions (3 individual, 1 family) focused on psychoeducation regarding positive and negative affect, mindfulness meditation, gratitude, and savoring. Mood monitoring prompts and skill reminders will be sent daily for the first month post-discharge and three times a week for the following two months. The ETAU condition will receive reminders to log into a safety resource app, matched in frequency to the STEP group. Effectiveness aspects of the design include using clinical staff as interventionists and having very few exclusion criteria.",[30],"2025-10-11",{"date":589,"type":41},"2025-10-15",{"date":591,"type":41},"2021-10-04",{"date":545,"type":22},{"name":594,"class":48},"Brown University",3,{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":604,"enrollmentInfo":605,"targetDuration":4,"studyType":23,"phases":606,"briefSummary":607,"conditions":608,"keywords":4,"overallStatus":335,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":74},"100607434","youth-suicide-risk-factors-reduction-of-suicide-risk-factor-in-youth-people-100607434","NCT07188506","Youth Suicide Risk Factors, Reduction of Suicide Risk Factor in Youth People","Youth Suicide Risk Factors: Clinical, Neuroimaging, Genetic, and Microbiome Insights, and Predictors of Response to Deep Transcranial Magnetic Stimulation (dTMS)","YOU-SURF","Inclusion Criteria:\n\n* Diagnosis of mood disorder (major depressive episode, major depressive disorder, or bipolar disorder) according to DSM-5;\n* Age between 18 and 25 years;\n* Eligibility for magnetic resonance imaging;\n* Proficiency in the Italian language.\n\nExclusion Criteria:\n\n* Comorbidity with severe neurological or medical conditions;\n* Diagnosis of cognitive impairment;\n* Inability to provide informed consent.\n\nFor the control group:\n\nInclusion Criteria:\n\nthe same as the experimental group.\n\nExclusion Criteria:\n\n* subjects with DSM-5 disorders\n* subjects with a family history of psychiatric disorders will be excluded.","25 Years",{"count":493,"type":22},[25],"The YOU-SURF project is at the forefront of youth suicide prevention, with the goal of integrating multimodal clinical and neurobiological data to comprehensively identify risk factors and the most effective intervention strategies. Suicide is one of the leading causes of death among young people, with particularly alarming incidence rates during adolescence and early adulthood. Suicidal risk is a complex phenomenon, determined by a multiplicity of clinical, environmental, and biological factors. Emerging evidence suggests that information derived from neuroimaging, genetics, and the microbiome may also play a significant role. However, studies conducted to date have not yet adopted a truly multimodal approach that jointly integrates these dimensions in the identification of risk factors for suicide in youth. The YOU-SURF project aims to fill this critical gap.\n\nYOU-SURF will also pioneer the use of deep transcranial magnetic stimulation (dTMS), an innovative neuromodulation technique, whose effectiveness in reducing suicidal risk in young people will be assessed within a longitudinal design. Although some preliminary evidence suggests a potential benefit of neuromodulation treatments in this population, the specific effects of dTMS on suicidal risk in youth remain largely unexplored. Furthermore, there is a significant lack of knowledge regarding predictors of response to dTMS in young individuals at risk for self-harming behaviors.\n\nThe specific objectives of the project are as follows:\n\n1. To identify youth suicide risk factors through the integration of clinical, environmental, neuroimaging, genetic, and microbiome data;\n2. To longitudinally evaluate the effectiveness of dTMS in the treatment of young people at risk of suicide;\n3. To develop a predictive model based on machine learning techniques, grounded in multimodal data, to estimate the individual response to dTMS in this population.\n\nThe results of the project will provide a solid scientific basis for the development of personalized prevention and treatment interventions, improving clinical effectiveness and resource allocation in youth mental health services.",[609,30,63,88],"Mood Disorders","2025-09-23",{"date":612,"type":41},"2025-09-29",{"date":614,"type":22},"2025-10-31",{"date":616,"type":22},"2028-10-31",{"name":618,"class":48},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":23,"phases":627,"briefSummary":628,"conditions":629,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":636,"locationsCount":49},"100419786","a-randomized-clinical-study-of-attempted-suicide-short-intervention-program-in-swedish-healthcare---assip-100419786","NCT04746261","A Randomized Clinical Study of \"Attempted Suicide Short Intervention Program\" in Swedish Healthcare - ASSIP","Inclusion Criteria:\n\n* Age ≥18 years.\n* Signed informed consent to participate in the study.\n* Contact with psychiatric health care after a suicide attempt within 3 months before the baseline visit\n* Booked meeting or visit in psychiatry or primary care after visit 1\n\nExclusion Criteria:\n\n* Psychotic illness with current delusions, hallucinations or other negative symptoms that may affect the therapy.\n* Known emotionally unstable personality disorder (ICD 10) noted in the medical record\n* Inability to undergo therapy without an interpreter\n* Mental retardation, dementia, or other circumstances that make it difficult to understand the meaning of participating in the study and giving informed consent.",{"count":626,"type":22},460,[25],"This is a randomized study of ASSIP as a treatment for patients who have recently made a suicide attempt. Six psychiatric clinics from four regions in Sweden are included. Together 460 patients will be recruited. Patients will be randomized to ASSIP as a supplement to treatment as usual or to treatment as usual only.\n\nThe overall aim of the study is to evaluate whether ASSIP, a short-term clinical intervention, can prevent future suicidal behavior in people who have attempted suicide better than just conventional treatment. The project also investigates whether there are any specific factors that may be related to ASSIP's potential effectiveness and whether ASSIP has health economic benefits.\n\nOnly patients who give their written consent will be included in the study. Those who meet the inclusion and no exclusion criteria at screening \u002F visit 1 undergo an assessment according to an interview protocol, self-assessment form, and self-assessment scales. Thereafter, the patient is randomized via an electronic system to either ASSIP plus standard treatment or only standard treatment. All patients, regardless of which treatment they are randomized to, will be followed up for two years with a telephone interview and self-assessment scales month 3, 12 and 24. Data from medical records and registers will also be collected.",[30],"2025-08-19",{"date":632,"type":41},"2025-08-20",{"date":634,"type":41},"2020-10-15",{"date":105,"type":22},{"name":268,"class":48}]