[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"suicide-risk\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:suicide-risk":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,69,102,126,160,191,218,253],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100559501","improving-mental-health-treatment-for-individuals-in-crisis-interacting-with-the-criminal-legal-system-100559501",false,"NCT06564948","Improving Mental Health Treatment for Individuals in Crisis Interacting With the Criminal-Legal System","Inclusion Criteria:\n\n1. Treatment as Usual (TAU) arm\n\n   1. Cambridge Health Alliance (CHA) patients from the cities other than Cambridge considered to be in the \"catchment area\" of CHA (Everett, Chelsea, Somerville, Medford, Malden, and Winthrop)\n   2. Ages 18-100\n   3. Identified as having police involvement between 2009 and 2025. Treatment as Usual patients will be identified using \"targeted limited chart review methods\" used in our prior studies, \"scraping\" clinical notes in the Electronic Health Records for criminal legal involvement. Initial Identification terms, \"police\", \"arrest\", \"court\", \"summons\", \"jail\", and \"crime\" will be used to identify candidates for police involvement, downloading the sentence in which the keyword appeared and the sentence before and after. Next, an iterative process of editing of the search terms will be conducted to remove patients with negation of the keyword (\"did not commit a crime\"), and other sentence characteristics that generate false positives (\"cardiac arrest\"). Samples of the resulting dataset will be taken, accuracy assessed by examining the surrounding sentences, leading to further iterations and repetition of the process until a high level of accuracy is achieved.\n2. FSJS arm\n\n   1. Cambridge Health Alliance patients from Cambridge\n   2. Ages 18-100\n   3. Individuals who have come into contact with the Cambridge Police Department (as identified in the FSJS data) between 2009 and 2025.\n3. FSJS+Navigator arm\n\n   1. Recruited during the study period in the CHA ED\n   2. Ages 18-100\n   3. Individuals who are brought into the Emergency Department under police supervision (excluding individuals currently incarcerated)\n\n      * involuntarily brought to the Emergency Department for psychiatric evaluation because they are considered to be a risk to themselves or others (MA Law 123(12)); or\n      * the subject of a police call for service for a mental health issue who are willingly admitted to the Emergency Department\n\nExclusion Criteria\n\n1. Treatment as Usual (TAU) arm\n\n   1. Cambridge Health Alliance patients residing in the City Cambridge are excluded from the TAU arm\n   2. Under the age of 18\n   3. Individuals with no identified criminal legal system contact during the study time period (no criminal legal involvement found in the targeted limited chart review method).\n   4. Any individual incarcerated at the Middlesex Jail\u002FPrison that has not been released by the end of the period of data collection (December 31, 2025).\n2. FSJS arm\n\n   1. Cambridge Health Alliance patients outside of Cambridge will be excluded from the FSJS arm\n   2. Under the age of 18\n   3. Any individual incarcerated at the Middlesex Jail\u002FPrison that has not been released by the end of the period of data collection (December 31, 2025)\n3. FSJS+Navigator arm\n\n   1. Under the age of 18\n   2. Any individual who becomes incarcerated during the course of the study\n   3. Individuals who enter the Emergency Department not under police supervision\n\n      * For example, individuals will be excluded who voluntarily come to the ED seeking psychiatric care because they feel they may be a risk to themselves or others\n      * Individuals brought to the ED from a jail or court ordered to the ED as an alternative to jail or prison","ALL","18 Years","100 Years",{"count":19,"type":20},1040,"ESTIMATED","INTERVENTIONAL",[23],"NA","The proposed Center will leverage burgeoning real-time data linkage capabilities among health systems, Medicaid payors, and criminal legal (e.g., jail booking data, jail release data) systems, to identify individuals coming in and out of jail for suicide assessment and prevention, and to better coordinate care across these disparate systems. This Center will advance the fields of suicide prevention and criminal legal system-based mental health by solving a well-known, central problem in both fields: the inability to track and intervene with individuals moving in and out of both and often multiple systems. The goal is near-term reductions in the U.S. suicide rate.",[26,27],"Suicide Risk","Psychiatric Disorders","RECRUITING","2026-06-02",{"date":31,"type":32},"2026-06-04","ACTUAL",{"date":34,"type":32},"2025-02-01",{"date":36,"type":20},"2027-09-30",{"name":38,"class":39},"Cambridge Health Alliance","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":68},"100614960","phase-3-testing-the-use-of-va-peer-specialists-to-prevent-veteran-suicide-100614960","NCT07286383","Testing the Use of VA Peer Specialists to Prevent Veteran Suicide","PREVAIL","Inclusion Criteria:\n\nThere are two Inclusion criteria:\n\n* Moderate to high suicide risk according to one of the following occurring in the prior 3 months:\n\n  * a completed Comprehensive Suicide Risk Evaluation (CSRE) indicating intermediate or high acute or chronic risk\n  * a high-risk suicide PRF\n  * a suicide attempt indicated on a Suicide Behavior or Overdose Report (SBOR)\n  * a suicide safety plan completed in the past 6 months\n\nAND\n\n* Current suicidal ideation according to the 9th item of the Patient health questionnaire (PHQ-9) \\> 0 at enrollment\n\n  * While a positive 9th item usually precedes the CSRE, because the CSRE could have been administered in the 3 months prior to enrollment, the purpose of requiring a positive 9th item is to ensure more recent suicidal ideation.\n  * It may be more difficult to show an intervention effect if the investigators enroll participants with no suicidal ideation at baseline.\n\nExclusion Criteria:\n\n* Inability to provide informed consent for any reason, including due to acute psychosis or mania, dementia, or active guardianship or durable power of attorney\n\n  * These criteria will be determined according to medical record review and, if clarification needed, consultation with a treating provider.\n  * The investigators will also screen for decision-making capacity using the Blessed Orientation, Memory, Concentration (BOMC) Test and a brief quiz about the study.\n  * This quiz will involve an iterative process of querying the participants' understanding of consent information with a 10-item true\u002Ffalse test and providing feedback until an acceptable level of understanding is achieved (must get 100% correct after 3 tries to enroll).\n* Current or planned receipt of residential or intensive outpatient treatment\n* Plan to transfer or terminate care in the next 3 months\n* Homicidal ideation in the past 6 months or violent behavior in the past 12 months",{"count":49,"type":20},306,[51],"PHASE3","This study examines a novel way to prevent suicide among Veterans with serious mental illness (SMI). It will assess the efficacy of PREVAIL-VA, a 3-month intervention of 12, one-on-one sessions between a Peer Specialist (PS) and a Veteran that involve semi-structured conversations focused on hope, belongingness, support, and safety. PSs are Veterans with SMI trained to use their own experience and recovery to help other Veterans with SMI. PSs have improved mental health outcomes in other research, but this study would be the first to test their efficacy for suicide prevention in VHA. The project will compare outcomes of Veterans at risk for suicide receiving usual care, to PREVAIL-VA. This work is responsive to national calls for Veterans with SMI to receive support that is evidence-based, improves recovery (not just symptoms), and is tailored to individual needs. If successful, PREVAIL-VA could be adopted by the 1400 Peer Specialists employed in VA, greatly increasing the delivery of evidence-based services to Veterans at risk for suicide.",[26],[55,56],"suicide","peer support","NOT_YET_RECRUITING","2026-04-03",{"date":60,"type":32},"2026-04-09",{"date":62,"type":20},"2026-07-01",{"date":64,"type":20},"2029-12-31",{"name":66,"class":67},"VA Office of Research and Development","FED",3,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":15,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100629834","a-text-based-expressive-writing-program-for-adolescents-at-risk-of-suicide-100629834","NCT07479823","A Text-Based Expressive Writing Program for Adolescents at Risk of Suicide","Effectiveness of a Text-Based Expressive Writing Intervention for Suicidal Adolescents and Young Adults: A Randomized Controlled Trial","WRITE-SAFE","Inclusion Criteria:\n\n* Adolescents or young adults aged 13 to 24 years.\n* Individuals with a history of suicidal ideation, suicide attempts, or non-suicidal self-injury.\n* Individuals currently receiving mental health services or who have been evaluated as having suicide risk within the past 6 months.\n* Ability to read and write in Korean.\n* For participants under 19 years of age, both participant assent and parental consent are required.\n\nExclusion Criteria:\n\n* Individuals requiring immediate psychiatric hospitalization.\n* Severe intellectual disability or neurodevelopmental disorder that prevents participation in writing activities.\n* Acute psychosis or manic episode that would interfere with participation in the study.\n* Participation in another suicide prevention clinical trial during the study period.","13 Years","24 Years",{"count":80,"type":20},160,[23],"The goal of this clinical trial is to learn if a structured expressive writing program can help reduce suicidal thoughts in adolescents and young adults who have experienced suicidal thoughts, suicide attempts, or self-harm. The study will include participants aged 13 to 24 years who are receiving mental health care or have recently been identified as being at risk for suicide.\n\nThe main questions the study aims to answer are:\n\n* Does a structured expressive writing program lower suicidal thoughts compared with usual care alone?\n* Does the program improve depression, impulsivity, and self-esteem?\n\nResearchers will compare participants who receive the expressive writing program together with treatment as usual to participants who receive treatment as usual alone.\n\nParticipants will:\n\n* Be randomly assigned to one of two groups: a writing program group or a usual care group\n* Complete questionnaires about mood, suicidal thoughts, and well-being at the start of the study, after 4 weeks, and after 8 weeks\n* If assigned to the writing program group, complete guided writing activities several times per week for 4 weeks. Each writing session will take about 15 to 20 minutes and will focus on understanding emotions, personal experiences, relationships, and meaning in difficult experiences.\n\nResearchers will study whether this writing program is a helpful and practical way to support young people who are experiencing suicidal thoughts or emotional distress.",[84,26,85,86],"Suicidal Ideation","Self-Injurious Behavior","Adolescent Mental Health",[88,89,90,91,92],"Expressive Writing","Suicide Prevention","Adolescent Suicide","Self-Harm","Youth Mental Health","2026-03-13",{"date":95,"type":32},"2026-03-18",{"date":97,"type":20},"2026-04-01",{"date":99,"type":20},"2028-03",{"name":101,"class":39},"Hallym University Medical Center",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":109,"minAge":16,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":40},"100625068","cognitive-behavioral-and-digital-therapy-for-suicide-risk-in-eating-disorders-100625068","NCT07417826","Cognitive-Behavioral and Digital Therapy for Suicide Risk in Eating Disorders","Efficacy of Cognitive-behavioral Therapy (CBT) and Digital Therapy (DT) in the Prevention of Suicide Risk in Patients With Eating Disorders (ED): a Randomized Clinical Trial.","Inclusion Criteria:\n\n* Gender: Female.\n* Age between 18 and 65 years old.\n* Clinically stable and able to provide written informed consent.\n* Subjects included in the \"Suicide Risk Code\" (Codi Risc Suïcidi - CRS) program due to recent suicidal ideation or suicide attempts.\n* Patients with a diagnosis of an Eating Disorder (ED).\n\nExclusion Criteria:\n\n* Presence of intellectual disability or cognitive impairment that prevents understanding the therapy or the study requirements.\n* Diagnosis of Bipolar Disorder or any Psychotic Disorder.\n* Current active substance abuse or dependence.\n* Any medical condition that, in the investigator's opinion, makes participation unsafe or unfeasible.","FEMALE","65 Years",{"count":112,"type":20},150,[23],"The purpose of this study is to determine if adding a digital intervention to standard cognitive-behavioral therapy (CBT) is more effective in preventing suicide risk and reducing eating disorder symptoms. Participants will be women between 18 and 65 years old who have recently experienced suicidal ideation or attempts. One group will receive standard group therapy, while the other will receive group therapy plus a mobile application and digital monitoring devices. The goal is to see if digital tools can improve clinical outcomes and safety for patients.",[116,26],"Eating Disorders","2026-02-13",{"date":119,"type":32},"2026-02-18",{"date":121,"type":32},"2025-10-22",{"date":123,"type":20},"2028-10",{"name":125,"class":39},"Universitat Autonoma de Barcelona",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":133,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":142,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":40},"100618126","crisis-response-planning-in-military-personnel-with-mild-traumatic-brain-injury-100618126","NCT07327567","Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury","A Randomized Clinical Trial Utilizing Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury","Inclusion Criteria:\n\n* Adult male and female active duty military service members aged 18 or older.\n* Diagnosis of at least one mTBI\n* Ability to read, write, and speak English\n* Owns and regularly uses an Apple iPhone or Android smartphone\n\nExclusion Criteria:\n\n* Active psychosis as determined by clinical assessment.\n* Moderate or greater cognitive impairment as indicated by evaluation by the Intrepid Spirit Center clinical team.\n* Completed a Crisis Response Plan within the past year.",true,{"count":135,"type":20},120,[23],"The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI). CRP will be compared to usual treatment. The treatment will be a 30 to 60 minute session to one person at a time either in-person or using telehealth.",[139,89,140,26,141],"Mild Traumatic Brain Injury","Suicide Risk | Patient","Suicide Risk Factor",[143,144,145,146,147,148,149,150],"Clinical Response Planning","CRP","Treatment as Usual","TAU","Military personnel","suicide prevention","traumatic brain injury","TBI","2026-01-02",{"date":153,"type":32},"2026-01-08",{"date":155,"type":20},"2026-12",{"date":157,"type":20},"2027-08",{"name":159,"class":39},"The University of Texas Health Science Center at San Antonio",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":168,"targetDuration":170,"studyType":171,"phases":4,"briefSummary":172,"conditions":173,"keywords":177,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":40},"100614795","suicidal-ideation-framework-grounded-theory-study-catalonia-100614795","NCT07284238","Suicidal Ideation Framework: Grounded Theory Study, Catalonia","Process of Configuring the Suicidal Ideation Framework: A Grounded Theory Study in Catalonia, Spain","SUIF-GT-CAT","Inclusion Criteria:\n\n* Adults ≥18 years of age.\n* Usual residence in Catalonia (Spain).\n* Ability to understand, speak, read, and write in Catalan or Spanish.\n* Belonging to one of the three defined analytical groups:\n\n(A) Individuals who have attempted suicide within the past 6 months to 3 years. (B) Members of their family, social, or community support networks. (C) Healthcare professionals directly involved in the care of individuals who have attempted suicide.\n\n* Demonstrated clinical\u002Femotional stability ensuring safe participation, as confirmed by the referring clinician.\n* For individuals with lived experience (Group A): at least 6 months since the last suicide attempt or acute clinical crisis.\n* For support networks (Group B): having maintained meaningful proximity or involvement during or after the suicide attempt.\n* For healthcare professionals (Group C): minimum of 1 year of professional experience in mental health care.\n\nExclusion Criteria:\n\n* Presence of acute clinical decompensation preventing safe participation.\n* Active suicidal risk or acute crisis at the time of recruitment.\n* Acute vulnerability identified during screening.\n* Inability to provide informed consent.\n* Direct hierarchical dependence or conflict of interest with the research team (for Group C).",{"count":169,"type":20},45,"1 Day","OBSERVATIONAL","This doctoral project aims to develop a comprehensive theoretical model of the process through which the suicidal ideation framework is configured as a symbolic, narrative, and relational expression, adopting a multiperspective approach that spans the suicide attempt and the stages of care and recovery. Moving away from biomedical reductionisms, this investigation seeks to identify shared meaning-making nuclei and discursive fractures that reflect the inherent conflictuality of the suicidal act.\n\nGrounded in the integration of the theoretical frameworks previously outlined, this study adopts an interpretive-constructivist approach. Phase 1 will include studies conducted in OECD countries, providing a broad and conceptually diverse interpretive foundation. Phase 2, conducted in Catalonia, will deepen situated configurations, assuming that local sociocultural frameworks act as interpretive prisms for globally relevant phenomena.\n\nOverall, this theoretical-methodological architecture not only ensures conceptual robustness and coherence, but also articulates an ethical and epistemic commitment to understanding suicide through the complexity of its human textures. By centering suffering, listening to historically silenced voices, honoring the singularity of each life trajectory, and grounding the inquiry in an ethics of care, this study aims to transcend a merely technical-instrumental logic of knowledge.",[174,175,176,26,89],"Suicide","Suicide Attempt","Suicide Ideation",[84,174,178,179,180,181],"Meta-synthesis","Grounded Theory","Mental Health Nursing","High-Income Countries","2025-12-02",{"date":184,"type":32},"2025-12-16",{"date":186,"type":20},"2026-03",{"date":188,"type":20},"2027-09",{"name":190,"class":39},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":133,"sex":15,"minAge":16,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":40},"100429892","long-term-observation-of-participants-with-mood-disorders-100429892","NCT04877977","Long-term Observation of Participants With Mood Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Participants who signed consent for Protocol 01-M-0254: The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers over a year ago.\n2. Age 18 years or older\n3. Able to provide informed consent online using study website or over the telephone\n4. Able to read and write English\n\nEXCLUSION CRITERIA:\n\nNone.","99 Years",{"count":199,"type":20},1000,"Background:\n\nMore than 12,000 people have taken part in research at the Experimental Therapeutics \\& Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led to advances in the treatment of depression, bipolar disorder, and suicide risk. Researchers want to follow up with this group to see if they continue to have mental health symptoms and receive psychiatric treatments.\n\nObjective:\n\nTo learn the long-term impact of depression, bipolar disorder, and suicide risk.\n\nEligibility:\n\nAdults ages 18 and older who signed consent for Protocol 01-M-0254 over a year ago.\n\nDesign:\n\nThis study has 2 phases: an online phase and a telephone phase. It has no in-person or face-to-face contact.\n\nIn Phase 1, participants will fill out online surveys. They will access the surveys through the study website. The questions will focus on their current thoughts and feelings. The surveys will also ask about their current treatments for their mental health symptoms. At the end of the surveys, they will be asked if they would like to take part in Phase 2. If so, they will mark yes. Phase 2 includes a phone interview. They will be contacted by email to schedule the interview.\n\nIn Phase 2, participants will be asked more in-depth questions about how they are feeling. They will also be asked which psychiatric medicines and treatments they have used since they left NIH.\n\nIn both phases, participants can skip any questions they do not want to answer.\n\nThe online surveys will take 30 minutes to complete. The phone interview will last 1-4 hours.\n\nThe information that participants give in this study may be linked to their other NIH research records.",[202,26],"Depression",[202,174,204,205,206,207],"Ketamine","Neuroimaging","Treatment Resistant Depression","Natural History","2025-11-26",{"date":210,"type":32},"2025-11-28",{"date":212,"type":32},"2021-08-17",{"date":214,"type":20},"2028-10-01",{"name":216,"class":217},"National Institute of Mental Health (NIMH)","NIH",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":133,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":21,"phases":227,"briefSummary":228,"conditions":229,"keywords":236,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":40},"100600344","get-better-together-relationship-education-for-military-couples-100600344","NCT07096271","Get Better Together: Relationship Education For Military Couples","Better Together: A Relationship Enrichment Program Targeting Transdiagnostic Interpersonal Emotion Regulation Among Military Couples","GBT RCT","Inclusion Criteria:\n\n* Couple is in a committed romantic relationship of at least six months\n* At least one partner is a military Service member on active duty\n* Both partners are age 18 or older\n* Couple has not previously attended a relationship enrichment retreat or workshop together (e.g., CREDO, Strong Bonds, BSRT). This does not include couples therapy or pre-marital counseling.\n\nExclusion Criteria:\n\n* One or both partners decline to provide informed consent\n* Required command endorsement for retreat attendance is not received (for Service members E-6 and below)\n* Couple is unable or unwilling to attend any of the scheduled retreats during the study period",{"count":199,"type":20},[23],"This study is testing a program called Get Better Together, a relationship education program designed to help military couples effectively navigate life stressors as a team. The goal is to find out if attending Get Better Together improves mental health and relationship skills, and reduces problems like alcohol misuse, aggression, and suicide risk. Couples who join the study will be randomly placed into one of two groups. One group will attend Get Better Together at a weekend retreat. The other group will continue their usual activities and later receive access to an online relationship education program. All participants will complete surveys before the retreat and again 2, 4, and 6 months later.",[230,231,26,232,233,234,235],"Emotion Regulation","Relationship Conflict","Alcohol Use","Intimate Partner Violence (IPV)","Relationship Distress","Interpersonal Emotion Regulation",[237,238,239,148,240,241,242,243],"Behavioral: Get Better Together (GBT)","military","intimate relationships","primary prevention","emotion regulation","relationship education","interpersonal emotion regulation","2025-10-15",{"date":246,"type":32},"2025-10-20",{"date":248,"type":32},"2025-09-22",{"date":250,"type":20},"2028-07",{"name":252,"class":39},"Henry M. Jackson Foundation for the Advancement of Military Medicine",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":260,"enrollmentInfo":261,"targetDuration":4,"studyType":21,"phases":263,"briefSummary":265,"conditions":266,"keywords":268,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":40},"100581739","phase-2-orexin-antagonism-for-suicide-risk-a-proof-of-concept-clinical-trial-100581739","NCT06854224","Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial","Orexin Antagonism to Target Mechanisms of Suicide Risk: A Proof-of-Concept Clinical Trial","Inclusion Criteria:\n\n* Veteran\n* At least 18 years of age (up to 70 years)\n* Primary diagnosis of Major Depressive Disorder as determined by the study psychiatrist and confirmed by the Mini-International Neuropsychiatric Interview (MINI)\n* Lifetime suicide attempt history and suicidal ideation at baseline as determined by a score ≥2 on the Columbia-Suicide Severity Rating Scale (C-SSRS)\n\nExclusion Criteria:\n\n* Clinically significant medical or neurological condition\n* Current use of strong CYP3A live enzymes or moderate CYP3A inhibitors or strong CYP3A inducers\n* Current use of digoxin\n* Currently pregnant, not using contraception, nursing, or trying to become pregnant\n* Active substance use disorder in the last six months, disorder, or current or past psychotic disorder, bipolar disorder, or obsessive-compulsive disorder\n* Severe traumatic brain injury\n* Imminent suicidal or homicidal risk\n* Free of unstable medical conditions or any contraindication to suvorexant (per FDA prescribing label) as determined by patient interview and review of available medical records.","70 Years",{"count":262,"type":20},30,[264],"PHASE2","The goal of this proof-of-concept clinical trial is to evaluate the initial safety, feasibility, and tolerability of the orexin mixed antagonist suvorexant in a sample of veteran adults with Major Depressive Disorder and elevated suicide risk. The main question it aims to answer is: Is Suvorexant safe, feasible, and tolerable for participants?\n\nParticipants will:\n\n* Take Surovexant every day for four weeks (10mg in the first two weeks and 20mg in the second two weeks)\n* Visit the medical center at the beginning of the study (week 1), after taking Suvorexant for two weeks (week 3) and following the full Suvorexant dose (week 5) for in-person assessments.\n* Fill out self-report assessments (remotely) at week 2 (after one week of Suvorexant) and week 4 (after three weeks of Surovexant)",[26,267],"Major Depressive Disorder (MDD)",[269,270,271,272],"Suicide risk","Proof-of-concept clinical trial","Suvorexant","Orexin antagonist",{"date":274,"type":32},"2025-09-25",{"date":276,"type":32},"2025-09-01",{"date":278,"type":20},"2027-07-01",{"name":280,"class":39},"Marianne Goodman"]