[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supine-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supine-hypertension":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100476871","cpap-for-the-treatment-of-supine-hypertension-100476871",false,"NCT05489575","CPAP for the Treatment of Supine Hypertension","Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic Hypotension","Inclusion Criteria:\n\n* Male and female subjects, age 40-80 years, with autonomic failure including pure autonomic failure, multiple system atrophy and Parkinson disease.\n* Neurogenic orthostatic hypotension, defined as a ≥20-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes.\n* Nocturnal supine hypertension (nighttime systolic blood pressure ≥140 mmHg) during the overnight screening for supine hypertension.\n* Patients who are willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Patients with history of recent facial trauma or surgery or intolerance to CPAP or to the CPAP mask.\n* Patients who cannot tolerate the medication withdrawal, defined as those who are unable to stand for at least one minute or those with sustained supine blood pressure ≥180\u002F110 mmHg after the medication withdrawal period.\n* Bedridden patients or those who are unable to stand due to motor impairment or severe orthostatic hypotension.\n* Smokers, patients who are pregnant, or have clinically unstable coronary artery disease, or major cardiovascular or neurological event in the past 6 months; heart failure; and other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical or laboratory testing.","ALL","40 Years","80 Years",{"count":20,"type":21},59,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways.\n\nThe study includes 3-5 days spent in the Vanderbilt Clinical Research Center (CRC): at least one day of screening tests, followed by up to 3 study days. Subjects may be able to participate in daytime and\u002For overnight studies. The Daytime study consists of 2 study days: one with active CPAP and one with sham CPAP applied for up to 2 hours. The Overnight study consists of 3 study nights: one with active CPAP, one with sham CPAP, both applied for up to 9 hours and one night sleeping with the bed tilted head-up.",[27,28,29,30,31,32],"Autonomic Failure","Pure Autonomic Failure","Multiple System Atrophy","Parkinson Disease","Supine Hypertension","Neurogenic Orthostatic Hypotension",[34,35,36],"CPAP","Hypertension","Orthostatic hypotension","RECRUITING","2026-03-31",{"date":40,"type":41},"2026-04-07","ACTUAL",{"date":43,"type":41},"2022-06-23",{"date":45,"type":21},"2027-08-31",{"name":47,"class":48},"Vanderbilt University Medical Center","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100401052","effect-of-raised-head-of-the-bed-on-lying-blood-pressure-in-autonomic-failure-100401052","NCT04502225","Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure","Impact of Decreased Venous Return on Supine Blood Pressure","Inclusion Criteria:\n\n* Patients with autonomic failure and with supine hypertension from all races\n* Males and females, between 18 to 85 years\n\nExclusion Criteria:\n\n* All medical students\n* Pregnant women\n* High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)\n* History of serious allergies or asthma.","18 Years","85 Years",{"count":60,"type":21},44,[24],"Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.",[31,27],"2025-11-04",{"date":66,"type":41},"2025-11-06",{"date":68,"type":41},"2020-08-21",{"date":70,"type":21},"2026-12-31",{"name":47,"class":48},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":49},"100309761","treatment-of-supine-hypertension-in-autonomic-failure-cpap-100309761","NCT03312556","Treatment of Supine Hypertension in Autonomic Failure (CPAP)","Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure","Inclusion Criteria:\n\n* Patients with autonomic failure and with supine hypertension from all races\n\nExclusion Criteria:\n\n* All medical students\n* Pregnant women\n* High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)\n* History of serious allergies or asthma.",{"count":80,"type":21},12,[24],"Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.",[31,27],[85,86,87,88,89,90],"hypertension","supine hypertension","autonomic failure","pure autonomic failure","multiple system atrophy","cpap",{"date":66,"type":41},{"date":93,"type":41},"2017-09-21",{"date":95,"type":21},"2026-12-21",{"name":47,"class":48}]