[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supraclavicular-lymph-node-metastasis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supraclavicular-lymph-node-metastasis":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100639876","xr-assisted-petct-navigation-for-cervical-lymph-node-dissection-in-lung-cancer-100639876",false,"NCT07593872","XR-Assisted PET\u002FCT Navigation for Cervical Lymph Node Dissection in Lung Cancer","Application of Extended Reality (XR)-Assisted PET\u002FCT Fusion Navigation in Supraclavicular-to-Cervical Lymph Node Dissection for Lung Cancer","XR-NeckLND","Inclusion Criteria:\n\n* Age 18 to 80 years.\n* Confirmed or highly suspected lung cancer with supraclavicular or cervical lymph node metastasis requiring lymph node dissection.\n* Willing to undergo preoperative PET\u002FCT imaging.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Prior high-dose radiation therapy to the neck causing severe distortion of cervical anatomy.\n* Inability to undergo imaging studies, or known allergy to iodinated contrast media.\n* Vulnerable populations as defined by local IRB regulations (e.g., pregnant women, prisoners, individuals lacking decisional capacity).","ALL","18 Years","80 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","This single-arm, prospective feasibility study evaluates an Extended Reality (XR) headset-based preoperative surgical planning workflow that fuses 18F-FDG PET metabolic hotspots with CT anatomy on the OpVerse platform, in patients with non-small cell lung cancer (NSCLC) and supraclavicular or cervical lymph node metastasis (N3 disease) requiring lymph node dissection. Ten participants will undergo standard preoperative contrast-enhanced CT and whole-body PET. Synapse 3D software is used to segment key anatomic structures (clavicle, sternocleidomastoid, internal jugular vein, subclavian vessels, brachial plexus) and to project PET SUV hotspots onto the high-resolution CT model, yielding a patient-specific digital twin of functional tumor boundaries and at-risk neurovascular structures.\n\nImmediately prior to skin incision, the operating surgeon dons an XR head-mounted display (HoloLens via OpVerse) and registers the digital twin to the patient's neck using stable bony landmarks (clavicular head, sternal notch, mastoid). The surgeon plans the optimal incision and initial dissection trajectory, avoiding superficial veins and projecting the location of deep PET-positive nodes. The XR device is then removed, and the planned cervical or supraclavicular lymph node dissection is performed using standard surgical technique without further intraoperative XR guidance.\n\nThe primary endpoint is a composite of safety and feasibility: absence of Grade ≥2 (Clavien-Dindo) phrenic nerve, brachial plexus, chyle leak, Horner syndrome, or major vascular injury through 30 days postoperatively, together with successful XR registration and incision planning. Secondary endpoints include incision planning accuracy, PET hotspot clearance rate, target registration error, operative time, estimated blood loss, and lymph node yield.",[28,29,30],"Non-Small Cell Lung Cancer","Lymph Node Metastasis","Supraclavicular Lymph Node Metastasis",[32,33,34,35,36,37,38,39],"Extended Reality","Augmented Reality","Surgical Navigation","PET\u002FCT Fusion","Image-Guided Surgery","Digital Twin","Lymph Node Dissection","Mixed Reality","NOT_YET_RECRUITING","2026-05-14",{"date":43,"type":44},"2026-05-18","ACTUAL",{"date":46,"type":22},"2026-06-01",{"date":48,"type":22},"2027-04-01",{"name":50,"class":51},"National Taiwan University Hospital","OTHER"]