[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supranuclear-palsy-progressive\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supranuclear-palsy-progressive":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100398499","transcranial-magnetic-stimulation-in-progressive-supranuclear-palsy-100398499",false,"NCT04468932","Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy","Cerebellar Transcranial Magnetic Stimulation for Motor Control in Progressive Supranuclear Palsy","Inclusion Criteria:\n\n* probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)\n* age 40-85 at time of screening\n* ability to understand and cooperate with simple instructions in English\n* ability to read at 6th grade reading level in English\n* ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker\n* ability to refrain from new physical and speech therapy programs for the duration of the study\n* ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study\n* females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study\n\nExclusion Criteria:\n\n* other significant neurological or vestibular disorders\n* presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body","ALL","40 Years","85 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.",[27,28],"Palsy Supranuclear","Supranuclear Palsy, Progressive",[30],"repetitive transcranial magnetic stimulation","RECRUITING","2025-05-23",{"date":34,"type":35},"2025-05-29","ACTUAL",{"date":37,"type":35},"2020-01-17",{"date":39,"type":21},"2027-04-20",{"name":41,"class":42},"Oregon Health and Science University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":75,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100561944","neurodegenerative-diseases-progression-markers-markers-ndd-100561944","NCT06596746","Neurodegenerative Diseases Progression Markers (MARKERS-NDD)","Neurodegenerative Diseases Progression Markers (MARKERS-NDD): a Real-world Data Longitudinal Prospective Study","MARKERS-NDD","Inclusion Criteria:\n\n* Patients with diagnosis of Parkinson's Disease, Parkinsonism and Movement Disorders\n\n  * Patients with diagnosis of Parkinson's Disease\n\n    * Diagnosis of Parkinson's Disease according to the United Kingdom (UK) Parkinson's Disease Society Brain Bank\n  * Diagnosis of Movement Disorder not related to Parkinson's Disease\n\n    * Diagnosis of Multiple System Atrophy (MSA) in accordance with Second Consensus Statement on Diagnosis of Multiple System Atrophy;\n    * Diagnosis of Progressive Supranuclear Palsy according to Movement Disorder Society for Diagnosis of Progressive Supranuclear Palsy;\n    * Diagnosis of Essential Tremor\n    * Willing to participate in the study, understand the procedures and sign the informed consent.\n* Patients affected by cognitive impairment (CI) and dementia\n\n  * Diagnosis of probable:\n\n    * Lewy Body Dementia\n    * Alzheimer's Disease\n    * Mild Cognitive Decline\n    * Subjective memory complaints\n    * Willing to participate in the study, understand the procedures and sign the informed consent.\n\nExclusion Criteria:\n\n* There are no restrictions for participation in the study based on age, severity of illness or presence of cognitive impairment, as long as the person is able to complete the research assessments.","10 Years",{"count":54,"type":21},600,"OBSERVATIONAL","MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal clinical practice. Data collected from clinical evaluations, movement analysis, brain imaging, neuropsychological and electroencephalographic assessments, blood chemistry tests will be analysed to carry out statistical investigations and predictive analyses, also using artificial intelligence systems, which allow the identification of new early markers of diagnosis and prognosis of neurodegenerative diseases.",[58,59,60,61,62,63,64,65,28,66,67,68,69,70,71,72,73,74],"Neurodegenerative Diseases","Parkinson Disease","Synucleinopathies","Lewy Body Disease","Multiple System Atrophy","Tauopathies","Alzheimer Disease","Corticobasal Degeneration","Atypical Parkinsonism","TDP-43 Proteinopathies","Amyotrophic Lateral Sclerosis","Frontotemporal Lobar Degeneration","Movement Disorders","Cognitive Impairment","Dementia","Iron Overload","Neurodegeneration With Brain Iron Accumulation (NBIA)",[58,76,77,78,79,80,81,82,83,84,85,86,87,88,89],"Markers","Gait analysis","Wearable inertial sensors","IMU","Artificial intelligence","AI-Video gait analysis","Handwriting analysis","Voice-based artificial intelligence systems","imaging","multimodal analysis","electroencephalogram","cortical activity","gut microbiota","laboratory blood chemistry parameters","2024-09-11",{"date":92,"type":35},"2024-09-19",{"date":94,"type":21},"2024-09-09",{"date":96,"type":21},"2034-09-09",{"name":98,"class":99},"Casa di Cura San Raffaele Cassino","NETWORK"]