[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supratentorial-brain-tumor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supratentorial-brain-tumor":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053656","ketamine-versus-dexmedetomidine-as-an-adjuvant-in-scalp-block-in-supratentorial-brain-tumor-excision-surgeries-100053656",false,"NCT07698665","Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries","Efficacy of Ketamine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block in Adults Undergoing Supratentorial Brain Tumor Excision Surgeries for Hemodynamics and Pain Control, Double-blinded Randomized Study","Inclusion Criteria:\n\n* Age from 20 to 60 years, both sexes, American Society of Anesthesiologists (ASA) physical status II-III, Supratentorial tumor excision, Supine Position.\n\nand operation time: less than 6 hours.\n\nExclusion Criteria:\n\n* Patient refusal, disturbed consciousness level (Glasgow Coma Scale \\[GCS\\] \\\u003C 15). Patients who required reintubation during the study period, those not extubated. immediately after surgery, or those who awoke with neurological deficits impairing. pain assessments were excluded from the final analysis, history of psychotic disorders or previous surgeries, Poor cognitive function.\n\nPostictal state or uncontrolled\u002Frecurrent seizures, known allergy to dexmedetomidine or ketamine, difficult intubation (Mallampati score \\> III) or multiple intubation attempts, operation duration \\> 6 hours, renal dysfunction (creatinine \\> 1.2 mg\u002FdL, BUN \\> 20 mg\u002FdL), heart block and patients with chronic headache disorders or those receiving chronic analgesic therapy (for \\>3 months) were excluded.",true,"ALL","20 Years","60 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Supratentorial brain tumor surgeries are associated with significant nociceptive stimulation and postoperative pain, which may adversely affect patient outcomes. Scalp block has emerged as an effective regional anesthetic technique to improve analgesia and reduce opioid consumption.\n\nObjective: To compare efficacy of ketamine versus dexmedetomidine as adjuvants to bupivacaine in scalp blocks for supratentorial brain tumor surgeries, focusing on analgesia, opioid consumption, and hemodynamic stability.\n\nMethods:\n\nThis randomized double-blinded controlled trial included 80 patients undergoing supratentorial tumor excision, allocated equally into two groups: Group K received bupivacaine with ketamine (2 mg\u002Fkg), and Group D received bupivacaine with dexmedetomidine (1 µg\u002Fkg). Intraoperative hemodynamics, fentanyl consumption, postoperative pain scores (NRS), analgesic requirements, and complications were assessed.",[28,29,30],"Regional Anesthesia Morbidity","Supratentorial Brain Tumor","Acute Pain",[32,33,34],"Scalp block","Dexemetomedine","Supratentorial","RECRUITING","2026-07-07",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":22},"2026-07-30",{"name":45,"class":46},"Cairo University","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100626883","perioperative-multimodal-analgesia-for-supratentorial-craniotomy-100626883","NCT07441421","Perioperative Multimodal Analgesia for Supratentorial Craniotomy","Perioperative Multimodal Analgesia for Supratentorial Craniotomy：Protocol for a 2× 2 Factorial Randomized Trial","Inclusion Criteria:\n\n* Aged from 18 to 65 years\n* American Society of Anesthesiologists physical status I to III\n* Scheduled to undergo elective supratentorial tumor resection\n\nExclusion Criteria:\n\n* Incision-area skin infection\n* A history of previous craniotomy\n* Allergy to study medications\n* A history of preoperative change in consciousness or cognitive function\n* Inability to communicate,\n* Preoperative pain in the surgical region\n* Severe hepatic or renal dysfunction\n* Severe bradycardia (heart rate\\\u003C40 beats\u002Fmin)\n* Sick sinus syndrome or second- to-third degree atrioventricular block","18 Years","65 Years",{"count":58,"type":22},2000,[25],"This randomized clinical trial aims to evaluate the effectiveness of scalp nerve blocks and dexmedetomidine in reducing opioid use and preventing postoperative delirium in patients undergoing supratentorial brain tumor surgery. A total of 2000 patients will be randomly assigned to one of four groups, receiving either active treatments, placebos, or their combinations. The main outcome measured will be the amount of opioid pain medication needed after surgery.",[62,63,29],"Postoperative Pain","Analgesia",[65,66],"multimodal analgesia","postoperative acute pain","NOT_YET_RECRUITING","2026-02-25",{"date":70,"type":39},"2026-03-02",{"date":72,"type":22},"2026-03-01",{"date":74,"type":22},"2027-12-31",{"name":76,"class":46},"Beijing Tiantan Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":96,"locationsCount":4},"100547350","perioperative-multimodal-analgesia-protocol-for-supratentorial-craniotomy-100547350","NCT06406829","Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy","Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy：a 2× 2 Factorial Randomized Clinical Trial","Inclusion Criteria:\n\n* Aged from 18 to 65 years\n* American Society of Anesthesiologists physical status I to III\n* Scheduled to undergo elective supratentorial tumor resection\n\nExclusion Criteria:\n\n* Incision-area skin infection\n* A history of previous craniotomy\n* Allergy to study medications\n* A history of preoperative change in consciousness or cognitive function\n* Severe hepatic or renal dysfunction\n* Severe bradycardia (heart rate\\\u003C40 beats\u002Fmin)\n* Sick sinus syndrome or second- to-third degree atrioventricular block",{"count":58,"type":22},[25],"Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure, favoring bleeding and cerebral cerebral hypoperfusion. The ideal analgesia for neurosurgery requires complete pain relief, eliminates the side effects of opioid drugs and no influence for neurological function. Previous studies have proposed a multimodal analgesic strategy, combining analgesics and local anaesthesia, it is expected to achieve the above benefits.",[62,63,29],[65,89],"Postoperative acute pain","2026-02-08",{"date":92,"type":39},"2026-02-11",{"date":94,"type":22},"2026-02-09",{"date":74,"type":22},{"name":76,"class":46}]