[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"supraventricular-tachycardia-svt\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:supraventricular-tachycardia-svt":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100599597","perceptions-of-diltiazem-versus-adenosine-for-treatment-of-supraventricular-tachycardia-in-the-emergency-department-100599597",false,"NCT07086560","PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department","PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department: PERVADE-ED Study","PERVADE-ED","Inclusion Criteria:\n\n1. ED encounter for acute SVT\n2. Age \\>\u002F= 18 years\n3. Receipt of IV adenosine and\u002For IV diltiazem for SVT in the ED or prehospital setting\n\nExclusion Criteria:\n\n1. Neurologic status precluding survey participation due to medical instability\n2. Pregnant\n3. Incarcerated\n4. Non-English speaking","ALL","18 Years","100 Years",{"count":21,"type":22},20,"ESTIMATED","1 Day","OBSERVATIONAL","Supraventricular tachycardia (SVT) is a dysrhythmia characterized rapid heart rate, typically with rapid onset. SVT accounts for over 50,000 emergency department visits per year. Of patients with regular, narrow-complex SVT, the mainstay of therapy includes adenosine and diltiazem. Adenosine is recommend by American and European guidelines as first-line therapy, however adenosine carries unique side effects that are potentially distressing to patients, including: \"feeling of impending death or doom\", flushing, anxiety, shortness of breath, and chest discomfort. Diltiazem does not carry this side effect profile, but has typically been reserved as second-line treatment due to side effects of low blood pressure associated with this class of medications. Diltiazem and adenosine have not been well studied head-to-head to compare safety and efficacy of their treatment for SVT. The purpose of this study is to evaluate safety and efficacy of adenosine and diltiazem for SVT in the ED (as completed through chart review of specific patient-level outcomes) and capture patient and clinician perspectives of medication satisfaction (through administration of questionnaires).",[27],"Supraventricular Tachycardia (SVT)",[29,30,31,32],"diltiazem","adenosine","emergency medicine","supraventricular tachycardia","RECRUITING","2026-05-26",{"date":36,"type":37},"2026-05-28","ACTUAL",{"date":39,"type":37},"2025-04-04",{"date":41,"type":22},"2027-12",{"name":43,"class":44},"University of Iowa","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":65,"locationsCount":45},"100592408","phase-4-adenosine-vs-diltiazem-for-treatment-of-svt-in-the-ed-100592408","NCT06993038","Adenosine vs Diltiazem for Treatment of SVT in the ED","COMparison of Adenosine Versus Diltiazem FOR Supraventricular Tachycardia in the ED (COMFORT-ED) - Pilot Trial","COMFORT-ED","Inclusion Criteria:\n\n1. Adult patients (18 years and older)\n2. Diagnosis of acute, stable SVT in the emergency department\n\nExclusion Criteria:\n\n1. Receipt of IV AV-nodal blocking agents prior to study enrollment (includes adenosine, non-dihydropyridine calcium channel blockers, beta-antagonists in pre-hospital and\u002For hospital setting).\n2. Reported or confirmed personal history of Wolff-Parkinson-White (WPW) syndrome\n3. History of heart failure with reduce ejection fraction (HFrEF) (LVEF\\\u003C\u002F= 40%)\n4. Severe bronchoconstrictive lung disease\n5. Prior hypersensitivity to study medication\n6. Previously enrolled in pilot study\n7. Pregnant\n8. Incarcerated",{"count":21,"type":22},"INTERVENTIONAL",[57],"PHASE4","This is a small, pilot study with a primary goal of assessing patient perceptions of two medication treatments for supraventricular tachycardia in adult patients treated in the Emergency Department.",[27],[29,30,31],{"date":36,"type":37},{"date":63,"type":37},"2025-08-01",{"date":41,"type":22},{"name":66,"class":44},"Anne E. Zepeski"]