[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgery-cardiac\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgery-cardiac":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,74,103,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100480998","phase-4-pragmatic-amiodarone-trial-to-reduce-postoperative-atrial-fibrillation-in-patients-undergoing-cardiac-surgery-100480998",false,"NCT05543278","Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery","PATRONUS","Inclusion Criteria:\n\n* \\>= 18 years of age\n* All genders\n* All non-coronary artery bypass cardiac surgery patients\n* Preoperative normal sinus rhythm\n\nExclusion Criteria:\n\n* Pre-existing atrial fibrillation or atrial arrhythmias\n* Pre-existing heart block\n* Cardiogenic shock\n* Sick sinus syndrome\n* Marked sinus bradycardia\n* Preoperative amiodarone use\n* Contraindication to amiodarone use\n\n  * PR interval \\> 240 ms\n  * QTc \\> 550 ms\n  * 2nd or 3rd degree heart block\n  * Liver impairment (INR \\> 1.7, AST\u002FALT \\> 2x normal)\n  * Uncontrolled hyperthyroidism or hypothyroidism\n  * Interstitial lung disease\n  * Pregnancy and\u002For breastfeeding\n  * Known hypersensitivity to any components of amiodarone, including iodine\n* Emergent operation\n* Planned MAZE or Pulmonary Vein Isolation procedure","ALL","18 Years",{"count":19,"type":20},242,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Postoperative atrial fibrillation is quite common after cardiac surgery with up to 1 in 3 patients experiencing this abnormal heart rhythm. Amiodarone, a medication commonly used to treat atrial fibrillation, has been previously shown to be an effective prophylactic agent at decreasing the occurrence of postoperative atrial fibrillation in patients who underwent coronary artery bypass surgery. However, despite many studies which have demonstrated its effectiveness, it has not been widely used due to the concern of side effects that can occur such as slow heart rate, low blood pressure, and lung toxicity. We have designed a study to test the effectiveness and safety of a short course of postoperative prophylactic amiodarone for patients undergoing non-coronary artery bypass cardiac surgery. We hypothesize that patients who receive the prophylactic amiodarone will have decreased rates of postoperative atrial fibrillation without significantly increased side effects compared to patients who receive the standard postoperative care after non-coronary artery bypass cardiac surgery.",[26,27],"Surgery, Cardiac","Atrial Fibrillation",[29,30],"Postoperative atrial fibrillation","POAF","NOT_YET_RECRUITING","2026-06-26",{"date":34,"type":35},"2026-06-30","ACTUAL",{"date":37,"type":20},"2027-01",{"date":39,"type":20},"2028-12",{"name":41,"class":42},"Massachusetts General Hospital","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":73},"100633308","a-chinese-multicenter-study-on-surgical-techniques-and-outcomes-across-the-lifespan-in-congenital-heart-disease-100633308","NCT07524998","A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease","Evaluation of Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease Based on a Chinese Multicenter Database","Inclusion Criteria:\n\n* Clinical diagnosis of Complex Congenital Heart Disease (CCHD) who underwent surgical intervention and were enrolled in the 13th Five-Year Plan National Congenital Heart Disease Surgery Database\n* Clinical diagnosis of CCHD requiring surgical\u002Fintrauterine intervention or cardiac rehabilitation\n* Willing to sign informed consent and complete follow-up\n\nExclusion Criteria:\n\n* Lost to follow-up\n* \\>30% missing core clinical data\n* Severe extracardiac malformations, systemic dysfunction, or other conditions precluding study participation, per sub-study specific exclusion criteria",{"count":51,"type":20},3000,"1 Year","OBSERVATIONAL","The goal of this observational study is to learn about recovery after heart surgery for people with Complex Congenital Heart Disease (CCHD), build a comprehensive data platform for CCHD care across a person's whole life, and create a China-specific quality control system to improve CCHD surgical care.\n\nThe main questions it aims to answer are:\n\nWhat are the main risk factors that affect how well people with CCHD recover after heart surgery? Can a whole life course, multi-dimensional data platform for CCHD care be built to support better clinical quality control? Can a China-specific system to evaluate and control the quality of CCHD heart surgery be developed to guide national health policies and improve patient outcomes?\n\nParticipants in this study are people with CCHD who have had or will have heart surgery at participating medical centers. This includes two groups:\n\nA retrospective group: People who already had CCHD heart surgery and were included in the existing National Congenital Heart Disease Surgery Database.\n\nA prospective group: People who are scheduled to have CCHD heart surgery as part of related sub-studies of this project.\n\nPeople who are lost to follow-up or have more than 30% missing data will not be included.\n\nParticipants will:\n\nFor the retrospective group: Have their past medical records (from surgery and follow-up) analyzed by researchers to find risk factors linked to recovery after CCHD heart surgery.\n\nFor the prospective group: Have their pre-surgery tests, surgery details, care during and after surgery, and follow-up data (including up to 1 year after surgery) collected as part of their regular medical care.\n\nResearchers will combine data from both groups into a new registry, work with a third-party committee to check data quality, and use this combined data to build a quality control and evaluation system for CCHD heart surgery. This system will help show the current state of CCHD care in China and guide national health decisions.",[56,57,58,59,60,61],"Congenital Heart Disease","Complex Congenital Heart Disease","Surgery (Cardiac)","Perioperative Care","Quality Control","Health Care","RECRUITING","2026-04-10",{"date":65,"type":35},"2026-04-13",{"date":67,"type":35},"2025-02-01",{"date":69,"type":20},"2029-01-31",{"name":71,"class":72},"China National Center for Cardiovascular Diseases","OTHER_GOV",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":73},"100623710","ai-generated-video-feedback-to-improve-technical-skills-in-coronary-artery-bypass-grafting-100623710","NCT07400172","AI-Generated Video Feedback to Improve Technical Skills in Coronary Artery Bypass Grafting","Inclusion Criteria:\n\n* Baseline AI-assessed technical performance ranked in the lower 50% within the scoring system in CAMERA study (NCT06739005)\n\nExclusion Criteria:\n\n* Unwilling to attend",true,{"count":82,"type":20},100,[84],"NA","This study aims to evaluate whether targeted video feedback generated by an artificial intelligence (AI)-based surgical performance assessment model can support improvement in technical skills among cardiac surgeons performing coronary artery bypass grafting (CABG). This is a single-group, self-controlled, pre-post interventional study. Participating surgeons will submit a baseline CABG surgical video, which will be assessed by both an AI model and blinded human expert raters using standardized scoring criteria. Based on the AI assessment, surgeons will receive personalized video feedback highlighting operative steps associated with lower technical performance. After a one-month self-directed review period, a follow-up CABG surgical video will be submitted and evaluated using the same process. Changes in human-rated technical skill scores between baseline and follow-up will be used to assess the potential educational impact of AI-generated video feedback.",[87,58,88,89],"Cardiac","Education","Artificial Intelligence (AI)",[91,92,93,94],"Coronary Artery Bypass Grafting","Surgical Education","Video-Based Feedback","Artificial Intelligence","2026-02-03",{"date":97,"type":35},"2026-02-10",{"date":99,"type":20},"2026-01-31",{"date":101,"type":20},"2026-04-30",{"name":71,"class":72},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":73},"100558730","sex-specific-differences-in-cardiac-surgery-patients-secs-100558730","NCT06554925","SEx-specific Differences in Cardiac Surgery Patients (SECS).","SEx-specific Differences in Cardiac Surgery Patients (SECS). A Retrospective Registration and Evaluation of Characteristics and Perioperative Management of Cardiac Surgery Patients","SECS","Inclusion Criteria:\n\n* Patients \\> 18 years\n* All patients who underwent cardiac surgery from 1 January 1998 in the AUMC, location VUmc, until 1 June 2021.\n\nExclusion Criteria:\n\n* None",{"count":112,"type":20},10000,"The aim of this study is to evaluate the differences between females and males undergoing cardiac surgery. The investigators will look at perioperative factors such as adaption of body weight, previous medical history, pharmacokinetics, transfusion, coagulation, cardiopulmonary bypass (CPB) related factors, cardiac function, inotropic requirements, risk, and outcome scores as well as morbidity and mortality at sort-term (within 30 days) and long-term (90 days and 1 year).",[115,116,26],"Female","Male",[118,119,120,121],"anesthesia","sex-specific differences","cardiac surgery","care pathways","2024-08-12",{"date":124,"type":35},"2024-08-15",{"date":126,"type":35},"2022-03-01",{"date":128,"type":20},"2031-03-01",{"name":130,"class":42},"Jennifer Breel",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":21,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":156},"100524471","phase-4-the-effect-of-act-and-tranexamic-acid-on-bleeding-in-cardiac-surgery-100524471","NCT06109155","The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery","The Dose Effect of Activated Clotting Time and Tranexamic Acid on Bleeding in Adult Cardiac Surgery","Inclusion Criteria:\n\n* adult, cardiac surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* pregnant\n* emergency procedure\n* immune compromised\n* aortic surgery\n* end-stage renal disease\n* liver disease\n* critical status\n* incomplete clinical data",{"count":139,"type":20},150,[23],"The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery.\n\nThe main questions it aims to answer are:\n\n1. Does higher dose of tranexamic acid reduce the amount of bleeding and blood transfusion?\n2. Does lower ACT level during cardiac surgery reduce the amount of bleeding and blood transfusion?\n\nParticipants will divided into four groups which have different tranexamic acid dose and ACT level during cardiac surgery to see if there is any different in the amount of bleeding and blood transfusion.",[26,143,144,145,146],"Tranxemic Acid","Activated Clotting Time","Heparin","Cardiopulmonary Bypass","2024-02-20",{"date":149,"type":35},"2024-02-21",{"date":151,"type":35},"2024-02-08",{"date":153,"type":20},"2026-12-31",{"name":155,"class":42},"Taichung Veterans General Hospital",2]